LOCUS       NM_053252               3888 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus EH domain binding protein 1-like 1 (Ehbp1l1),
            transcript variant B, mRNA.
ACCESSION   NM_053252
VERSION     NM_053252.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3888)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3888)
  AUTHORS   Wu,J., Moriwaki,K., Asuka,T., Nakai,R., Kanda,S., Taniguchi,M.,
            Sugiyama,T., Yoshimura,S.I., Kunii,M., Nagasawa,T., Hosen,N.,
            Miyoshi,E. and Harada,A.
  TITLE     EHBP1L1, an apicobasal polarity regulator, is critical for nuclear
            polarization during enucleation of erythroblasts
  JOURNAL   Blood Adv 7 (14), 3382-3394 (2023)
   PUBMED   37042948
  REMARK    GeneRIF: EHBP1L1, an apicobasal polarity regulator, is critical for
            nuclear polarization during enucleation of erythroblasts.
            Erratum:[Blood Adv. 2024 Mar 12;8(5):1151. doi:
            10.1182/bloodadvances.2023011838.. PMID: 38421726]
REFERENCE   3  (bases 1 to 3888)
  AUTHORS   Urbanek,M.E. and Zuo,J.
  TITLE     Genetic predisposition to tinnitus in the UK Biobank population
  JOURNAL   Sci Rep 11 (1), 18150 (2021)
   PUBMED   34518561
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3888)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3888)
  AUTHORS   Sobajima,T., Yoshimura,S.I., Maeda,T., Miyata,H., Miyoshi,E. and
            Harada,A.
  TITLE     The Rab11-binding protein RELCH/KIAA1468 controls intracellular
            cholesterol distribution
  JOURNAL   J Cell Biol 217 (5), 1777-1796 (2018)
   PUBMED   29514919
REFERENCE   6  (bases 1 to 3888)
  AUTHORS   Nakajo,A., Yoshimura,S., Togawa,H., Kunii,M., Iwano,T., Izumi,A.,
            Noguchi,Y., Watanabe,A., Goto,A., Sato,T. and Harada,A.
  TITLE     EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed
            transport in polarized epithelial cells
  JOURNAL   J Cell Biol 212 (3), 297-306 (2016)
   PUBMED   26833786
  REMARK    GeneRIF: Data demonstrate that EHBP1L1 links Rab8 and the
            Bin1-dynamin complex, which generates membrane curvature and
            excises the vesicle at the endocytic recycling compartment for
            apical transport.
REFERENCE   7  (bases 1 to 3888)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3888)
  AUTHORS   Chauhan,B.K., Reed,N.A., Zhang,W., Duncan,M.K., Kilimann,M.W. and
            Cvekl,A.
  TITLE     Identification of genes downstream of Pax6 in the mouse lens using
            cDNA microarrays
  JOURNAL   J Biol Chem 277 (13), 11539-11548 (2002)
   PUBMED   11790784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY749669.1, AK089917.1, AC134563.5 and AK087817.1.
            
            On Feb 13, 2008 this sequence version replaced NM_053252.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF305088.1, BC004660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                BY749669.1         1-68
            69-581              AK089917.1         30-542
            582-589             AC134563.5         59157-59164
            590-760             AK089917.1         551-721
            761-3366            AK087817.1         3-2608
            3367-3888           AC134563.5         73251-73772
FEATURES             Location/Qualifiers
     source          1..3888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..3888
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /note="EH domain binding protein 1-like 1"
                     /db_xref="GeneID:114601"
                     /db_xref="MGI:MGI:3612340"
     exon            1..401
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..2931
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /note="isoform B is encoded by transcript variant B;
                     tangerin; EH domain-binding protein 1-like protein 1"
                     /codon_start=1
                     /product="EH domain-binding protein 1-like protein 1
                     isoform B"
                     /protein_id="NP_444482.2"
                     /db_xref="CCDS:CCDS89316.1"
                     /db_xref="GeneID:114601"
                     /db_xref="MGI:MGI:3612340"
                     /translation="MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKWQPDKLVVVW
                     TRRNRRICSKAHSWQPGIQNPYRGTVVWMVPENVDISVTLYRDPHVDQYETKEWTFII
                     ENESKGQRKVLATVDVNLAHHAGPVPAQVPLRLRLKPKSVKVVHAELSLTLSGVLLRE
                     GRATDDDMQSLASLMSVKPSDVGNLDDFAESDEEEANGPGAPEVRTRGPQSDLSRELK
                     TLCEEEDEGHIRPQQAAARPSSAEDTSPAPVSAPAPPVRAFRGQGSEPAAITGGQVGP
                     ETPEPPPSPPETRSTGQPGQTMVPTPAPRLRKGSDAPSSPVPCSGDEVPNTSEDPPTG
                     MGSSGETQAQISSQEGTEAHEARPEPDIEAPPTLVSSSQSLLEWCQEVTNGYRGVCIT
                     NFTTSWRNGLAFCAILHRFYPDKIDYFSLDPLNIKQNNKQAFDGFAALGVSRLLEPAD
                     MVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGSGTYRVGNAQPSLPDCLDAG
                     DLAQRLREHGAEVPTEPKEAVNRGTGAIPKVASRDTDLSCSSKDGEAEVAQEAIPQEA
                     PTDGPRARSSTTPVVPAEGLVNGVGASGGVSGVRLRRSSVNGEAGPVPPPRAHGSFSH
                     VRDADLLKKRRSRLRNSNSFSVDDQDSGAAVGAGPAGPGAVEGPNPASSPDANPLPAP
                     APQQPPGGPPPTEESSPSLGEETGLQRFQDTSQYVCAELQALEQEQGQIDGRAAEVEK
                     QLRSLMESGANRLQEEVLIQEWFTLVNKKNALIRRQDQLQLLIEEQDLERRFELLSRE
                     LRAMLAIEEWQKTVAQQHREQLLLEELVSLVNQRDELVRDLDQKERIALEEDERLERG
                     LEQRRRKVSRQLSRRERCTLS"
     exon            402..459
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            460..555
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            556..609
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            610..788
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            789..931
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1000
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1163
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1386
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1544
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1593
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..2292
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2362
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2418
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2542
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2642
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2716
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2831
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..3888
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3187..3192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3208
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /note="major polyA site"
     polyA_site      3380
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
     regulatory      3863..3868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3876
                     /gene="Ehbp1l1"
                     /gene_synonym="G430002G23Rik"
ORIGIN      
        1 ttcggacgcg gggcgagggg ggggggtgcg gctccaggaa acggcgcgct cgctactctt
       61 gagctgagac cagctcgacg cgccgcgacg gccccgcaga ctcagccagc ccaccaggcg
      121 gaccccgggc aaactcagcc taggtctaaa cctcagacat atctacacgg acggggcgga
      181 cagatccggt gacaaagaaa agagctccag agaccatggg gaccctggct gagccagcag
      241 tggtgggcaa gagggagtcc caagcctgag aagagatccg gcagagttcc tcaggccatg
      301 acttcagtgt ggaagcgcct gcagcgggtt ggcaagcggg ccgccaagtt ccagtttgtg
      361 gcgtgttacc atgaactggt gttggagtgc accaagaagt ggcagcctga caagctggtg
      421 gtggtatgga ctcggcggaa ccgaaggatc tgctccaagg cccacagctg gcagcctggc
      481 atccagaacc cataccgtgg caccgtggta tggatggttc ctgagaacgt ggacatctcg
      541 gtgaccttgt acagggaccc tcatgtggac cagtatgaaa ccaaagagtg gacttttatt
      601 attgaaaatg agtccaaggg acagcggaag gtactggcca cagttgatgt gaacctagcc
      661 caccatgcag ggcctgtgcc tgctcaggtt ccacttcgac tgcggctgaa gcccaaatct
      721 gtgaaggtgg tgcatgccga actgagcctc accctttctg gggtgctgct gcgagaaggc
      781 cgtgccacgg atgatgacat gcagagtctg gccagcctca tgagtgtgaa gcctagtgac
      841 gtgggaaacc tggatgactt tgctgagagt gatgaggagg aagctaatgg ccctggggct
      901 cctgaggtcc ggactcgagg cccccagtca gatctgtctc gagagctgaa gacactctgt
      961 gaagaagaag atgaaggcca catacggccc cagcaggcag ctgccagacc ctctagtgct
     1021 gaagacacca gccctgcccc agtgagtgcc cctgcacccc cggtcagggc cttccggggc
     1081 caggggtcag aaccagctgc tataaccggg ggccaggtgg ggcctgaaac cccagagccc
     1141 ccgccatccc caccagagac aaggtccact gggcagccag gccagaccat ggtccccacc
     1201 ccagcccctc ggctccggaa aggctctgat gcaccctcgt ccccagtccc ctgcagtggg
     1261 gatgaggtcc ccaatacctc agaggatcct ccaacaggaa tgggctcttc tggggagacc
     1321 caggctcaga taagctctca ggaagggaca gaggcccatg aagccaggcc agaaccagac
     1381 attgaggcac cacctaccct ggtcagctcc agccagtccc tgttggagtg gtgccaagag
     1441 gtcaccaacg gctaccgtgg tgtctgcatc accaacttca ccacgtcctg gcgcaatggc
     1501 ctggccttct gtgctatttt acatcgattc tacccagaca agatcgatta tttctccctt
     1561 gatcccctca acatcaaaca gaacaacaag caggcttttg atggcttcgc tgccctgggt
     1621 gtgtctcggc tgctcgagcc ggcggacatg gtacttctgt ccgtacctga caagctcatc
     1681 gtcatgacgt acctgtgcca gatccgtgcc ttctgcactg ggcaggagct gcagctggtg
     1741 caactggagg gcggcggtgg ctctggcact tatcgtgtgg gcaacgccca gccgagcctg
     1801 cccgactgtc tggacgcagg agacctggcg cagcgattac gcgagcatgg ggctgaagtg
     1861 cccacagaac ctaaggaggc tgtgaaccgc gggactgggg caataccaaa ggtggcctcc
     1921 agggacacgg acctgagctg ctcctctaag gatggggagg cagaggttgc ccaggaagca
     1981 atccctcaag aggcgcccac cgacggccct agagccaggt cgtccacaac cccggtggtc
     2041 cctgcagagg ggctggtgaa cggagtgggg gcgtcaggtg gtgtgagtgg tgtgagactg
     2101 agacggtcct ctgtcaatgg ggaggctggg ccagtacctc caccccgagc acatggctct
     2161 ttctcccacg tgcgggacgc cgatttgcta aagaagaggc gatcgaggtt aaggaatagc
     2221 aactctttct ctgtggatga ccaggactct ggagctgcag ttggagcagg gcctgcaggg
     2281 cctggagctg tggaaggtcc aaaccctgcc tccagccctg acgctaaccc actcccagcc
     2341 ccagccccac agcagccgcc cggtgggccc cctcctactg aggagtcatc acccagcctg
     2401 ggggaagaga caggcctgca acggttccag gacacaagtc agtacgtgtg cgcagagctg
     2461 caagccctgg agcaggaaca gggacagata gatgggaggg ccgctgaggt ggagaagcag
     2521 ctgaggagcc tcatggaatc aggtgccaac aggctgcagg aggaggtgct gattcaggaa
     2581 tggttcaccc tggtcaacaa gaagaatgcg ctcatccgga ggcaggacca gctgcagctg
     2641 ctcatcgagg agcaggactt ggagcggagg tttgaactgc tgagccgaga gttgcgggcc
     2701 atgctggcca ttgaagagtg gcagaaaaca gttgcgcagc agcaccgcga gcaactcctg
     2761 ttggaggagc tggtgtctct ggtgaaccag agggatgaac tggtccggga cctggaccag
     2821 aaggaacgga tcgctctgga ggaagatgag cgcctagaac gaggcctgga gcagagacgt
     2881 cgcaaggtga gccggcagct gagcaggcgg gaacgctgta ccctgagctg agtctcctgt
     2941 ctggtttgtc cctttctctg gtcgtggacc gtcttcgcca ctcccccagc ctgcacagca
     3001 gaggccaggt ccccatgctc cttcagcgag cagaagcaag actgaccaga ctctcgggct
     3061 ggagcagtga gcctgctagt gtttatttat ccgagtgtat gtgaatgttt tggcggtggc
     3121 caggatccca ggcaagggat ggtgtgggga ctgacaccca catcctcctt ctcttctgga
     3181 gggagcaata aagttggagt agaacaaacc agcgcctgcc ctttctcaac agggcctcaa
     3241 tggaaggaag agggtgggac ttagctaata acgctgatgc tgtgtatagg attctaaccc
     3301 ggagccagtt gagtttagcg gttcacagat gtgaccttcc aaggatggag gccagaggga
     3361 aagcccattt tgaaagaaaa tctgaaaaca caagtgtggt ggtgtacacc tataaaacct
     3421 ttcaatccag tatttggggt gatgctggag gacgaaggat caagagttcc aggccagtct
     3481 cagctatgtt ggtggtgcga gagaggcaga tctctgtgag ttcaaggctg gtctcattta
     3541 cattgctctc atgtttgttt gcttttgttt ttgagacagg gtttctctgt acggccttat
     3601 ctatcctgca actcactctg tagaccaggc tgtcctcaaa ctcagtgatg ttgttctaaa
     3661 gaaaaaaact attgaaatgg gtcattaaga tagctcagta ggggtggaga gatggctcag
     3721 cagttaagag cactgactgc tcttccagag gtcctgagtt caattctcag cagtcacatg
     3781 gtggctcaca accatctgta atgggatccg atgccctatt ctggtgtgtc tgaagacagc
     3841 tacagtgtac ttacatacat aaaataaata aataaatctt taaaaaaa
//
