LOCUS       NM_020596               2161 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus early growth response 4 (Egr4), mRNA.
ACCESSION   NM_020596 XM_914850
VERSION     NM_020596.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2161)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2161)
  AUTHORS   Dutta Banik,D., Martin,L.J., Tang,T., Soboloff,J.,
            Tourtellotte,W.G. and Pierchala,B.A.
  TITLE     EGR4 is critical for cell-fate determination and phenotypic
            maintenance of geniculate ganglion neurons underlying sweet and
            umami taste
  JOURNAL   Proc Natl Acad Sci U S A 120 (22), e2217595120 (2023)
   PUBMED   37216536
REFERENCE   3  (bases 1 to 2161)
  AUTHORS   Rigkou,A., Magyar,A., Speer,J.M. and Roussa,E.
  TITLE     TGF-beta2 Regulates Transcription of the K+/Cl- Cotransporter 2
            (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in
            Differentiated Neurons
  JOURNAL   Cells 11 (23), 3861 (2022)
   PUBMED   36497119
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2161)
  AUTHORS   Mookerjee-Basu,J., Hooper,R., Gross,S., Schultz,B., Go,C.K.,
            Samakai,E., Ladner,J., Nicolas,E., Tian,Y., Zhou,B., Zaidi,M.R.,
            Tourtellotte,W., He,S., Zhang,Y., Kappes,D.J. and Soboloff,J.
  TITLE     Suppression of Ca2+ signals by EGR4 controls Th1 differentiation
            and anti-cancer immunity in vivo
  JOURNAL   EMBO Rep 21 (5), e48904 (2020)
   PUBMED   32212315
  REMARK    GeneRIF: Suppression of Ca(2+) signals by EGR4 controls Th1
            differentiation and anti-cancer immunity in vivo.
REFERENCE   5  (bases 1 to 2161)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2161)
  AUTHORS   Patel,A., Rochelle,J.M., Jones,J.M., Sumegi,J., Uhl,G.R.,
            Seldin,M.F., Meisler,M.H. and Gregor,P.
  TITLE     Mapping of the taurine transporter gene to mouse chromosome 6 and
            to the short arm of human chromosome 3
  JOURNAL   Genomics 25 (1), 314-317 (1995)
   PUBMED   7774940
REFERENCE   7  (bases 1 to 2161)
  AUTHORS   Swaroop,A., Yang-Feng,T.L., Liu,W., Gieser,L., Barrow,L.L.,
            Chen,K.C., Agarwal,N., Meisler,M.H. and Smith,D.I.
  TITLE     Molecular characterization of a novel human gene, SEC13R, related
            to the yeast secretory pathway gene SEC13, and mapping to a
            conserved linkage group on human chromosome 3p24-p25 and mouse
            chromosome 6
  JOURNAL   Hum Mol Genet 3 (8), 1281-1286 (1994)
   PUBMED   7987303
REFERENCE   8  (bases 1 to 2161)
  AUTHORS   Barrow,L.L., Simin,K., Jones,J.M., Lee,D.C. and Meisler,M.H.
  TITLE     Conserved linkage of early growth response 4, annexin 4, and
            transforming growth factor alpha on mouse chromosome 6
  JOURNAL   Genomics 19 (2), 388-390 (1994)
   PUBMED   8188273
REFERENCE   9  (bases 1 to 2161)
  AUTHORS   Holst,C., Skerka,C., Lichter,P., Bialonski,A. and Zipfel,P.F.
  TITLE     Genomic organization, chromosomal localization and promoter
            function of the human zinc-finger gene pAT133
  JOURNAL   Hum Mol Genet 2 (4), 367-372 (1993)
   PUBMED   8504297
REFERENCE   10 (bases 1 to 2161)
  AUTHORS   Crosby,S.D., Veile,R.A., Donis-Keller,H., Baraban,J.M., Bhat,R.V.,
            Simburger,K.S. and Milbrandt,J.
  TITLE     Neural-specific expression, genomic structure, and chromosomal
            localization of the gene encoding the zinc-finger transcription
            factor NGFI-C
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4739-4743 (1992)
   PUBMED   1584812
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6663. doi:
            10.1073/pnas.89.14.6663. PMID: 1631170]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141637.1 and BX528200.1.
            
            On Feb 16, 2018 this sequence version replaced NM_020596.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141637.1, CX201112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2138              AK141637.1         1-2138
            2139-2161           BX528200.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..2161
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.48 cM"
     gene            1..2161
                     /gene="Egr4"
                     /gene_synonym="NGF1-C; NGFI-C; NGFIC; pAT133"
                     /note="early growth response 4"
                     /db_xref="GeneID:13656"
                     /db_xref="MGI:MGI:99252"
     exon            1..325
                     /gene="Egr4"
                     /gene_synonym="NGF1-C; NGFI-C; NGFIC; pAT133"
                     /inference="alignment:Splign:2.1.0"
     exon            326..2148
                     /gene="Egr4"
                     /gene_synonym="NGF1-C; NGFI-C; NGFIC; pAT133"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2123..2128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Egr4"
                     /gene_synonym="NGF1-C; NGFI-C; NGFIC; pAT133"
                     /note="hexamer: ATTAAA"
     polyA_site      2143
                     /gene="Egr4"
                     /gene_synonym="NGF1-C; NGFI-C; NGFIC; pAT133"
                     /note="major polyA site"
ORIGIN      
        1 gagccctgtt gcactttgga gaagccagga gccgccaccc gaggcaggtg ccggtgagcc
       61 agggcgccgc ggccccccaa ccctcgtgcc ccagccaagc gcccggagcc tggaactggg
      121 gcgcccggat tccctgccag ccgcgcgcgc cccagtccag cgaggccccg ggcgccccgc
      181 cgccaccgcg ccatgctcca cctgagcgac ttctccggct ccgacgcgct tctctccaag
      241 cccaccgaag gctgcgccca cgccagcccc gagctgcccc ggctgcctgc tagggacgct
      301 ccctcggccg ccgcgtatcc tggaggcgac ttcttgagct gggctttgag cagctgcggc
      361 gccggggggg acttaacaga ctcctgcttc ctggagggcc ctgcacccac gcccccttcg
      421 ggcctcagct acagcggcag cttcttcatc caggcggttc ccgaacaccc gcacgacccg
      481 gaggccctct tcaacctcat gtctggcatc ttgggcctgg cacccttccc cggtcccgag
      541 gcggcagcgt ctcggtcccc cctggatgtc cctttccccg cgggccccga tgccttgctg
      601 ccggacctct actccccaga tctgagttcg gccgcctttc cggaggcgtt ttgggaggca
      661 gcgccttcgg cgggcgctcc ctcgcagtgc ctgttcgagc cccagctctc cccgcccgac
      721 gtcaagccag ggctgcgggc gcctcccgct tcgccagcgc tggacgctgc tgcttcagcc
      781 ttcaaagggc cctatgcccc ctgggagctg ctgtcggccg gggtcccggg gaactgtggg
      841 tcgcagggga gcttccagac caccccggag gcccgcttct ctgcagtagg gaccaaggtc
      901 gaggacctgc tgtccatcag ctgccccgcc gagctgcccg gcccggccgc cagactctac
      961 caggcagggg cctacgacac cttctcgttg gccccaggtg acttagggga ggggaccgag
     1021 ggcctcccgg cgctgctgac ccctcccggc ggggagggag ggagcggcgg cgaaggcgga
     1081 gagttcctgg ccgcccctcc ggcgcagctg tcccctctag gcctgcgcgg tgccgccacg
     1141 gcggacttct ccaaacccct ggtggccgat ctcccggggg gcagcggcgt ggccgcgccc
     1201 tcatcccccg ccgcatcctt ccccgcggcc aaagcccgac gcaagggacg ccggggcggc
     1261 aagtgcagcg cgcgctgctt ctgcccgcgg ccgcacgtca aggccttcgc ctgcccggtg
     1321 gagagctgcg tgcggagctt cgcgcgctcc gacgagctca accgccacct gcgcatccac
     1381 acgggccaca agcccttcca gtgccgcatc tgcctgcgca acttcagccg cagcgaccac
     1441 ctcaccacgc acgtgcgcac ccacacgggc gagaagccct tcgcctgcga cgtgtgtggc
     1501 cgccgcttcg cgcgcagtga cgagaagaaa cggcacagca aggtgcacct aaagcagaag
     1561 gcgcgcgcgg aggagcgcct caagggcctg ggcttctact cgctgggcct ctccttcgcc
     1621 gcgctgtaac cggagctggc cccgtaggtc gggggcgccg ggtgctcggc gcacgcggca
     1681 cggtccggcc ggtccctcgt tccccgctgc cctccctgcc tcttccacgc acgtccgggg
     1741 ccacccgcag tccagctcca gtttcccccg aagcgcccgc cgctcacgcc cttcagcacg
     1801 ggttccgcgg acagcgcccg ctgttcggga gccgccttcc tccagccagc ctctctgggg
     1861 acagtcctct cggtccaccc acagaacagg cacttccttg ggactgaaga aagtgttttt
     1921 gtaactggcg tacgccccac gccttcctct ttatccctcc ccagagacaa gctggggatg
     1981 taccgagccg gtctcttaag aactttgtac agcaagtctt tggatgtgat gtttttgctt
     2041 tggggttatt tcctttttgt tgttcatttt ttgtaaagca gacgctactc tcaagcattt
     2101 gacaaaactg tttatttttg caattaaaat tattgtgcta aaagcttaaa aaaaaaaaaa
     2161 a
//
