LOCUS       NM_018781               4000 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus early growth response 3 (Egr3), transcript variant 1,
            mRNA.
ACCESSION   NM_018781
VERSION     NM_018781.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4000)
  AUTHORS   Peng,L., Sun,X., Yi,X., Wang,Z. and Chen,K.
  TITLE     EGR3 reduces podocyte inflammatory damage in obesity related
            glomerulopathy by inhibiting the PRMT1/p-STAT3 pathway
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 49 (3), 349-358 (2024)
   PUBMED   38970508
  REMARK    GeneRIF: EGR3 reduces podocyte inflammatory damage in obesity
            related glomerulopathy by inhibiting the PRMT1/p-STAT3 pathway.
REFERENCE   2  (bases 1 to 4000)
  AUTHORS   Gao,Y., Wang,Y., Chauss,D., Villarino,A.V., Link,V.M.,
            Nagashima,H., Spinner,C.A., Koparde,V.N., Bouladoux,N., Abers,M.S.,
            Break,T.J., Chopp,L.B., Park,J.H., Zhu,J., Wiest,D.L.,
            Leonard,W.J., Lionakis,M.S., O'Shea,J.J., Afzali,B., Belkaid,Y. and
            Lazarevic,V.
  TITLE     Transcription factor EGR2 controls homing and pathogenicity of TH17
            cells in the central nervous system
  JOURNAL   Nat Immunol 24 (8), 1331-1344 (2023)
   PUBMED   37443284
REFERENCE   3  (bases 1 to 4000)
  AUTHORS   Meyers,K.T., Damphousse,C.C., Ozols,A.B., Campbell,J.M.,
            Newbern,J.M., Hu,C., Marrone,D.F. and Gallitano,A.L.
  TITLE     Serial electroconvulsive Seizure alters dendritic complexity and
            promotes cellular proliferation in the mouse dentate gyrus; a role
            for Egr3
  JOURNAL   Brain Stimul 16 (3), 889-900 (2023)
   PUBMED   37146791
  REMARK    GeneRIF: Serial electroconvulsive Seizure alters dendritic
            complexity and promotes cellular proliferation in the mouse dentate
            gyrus; a role for Egr3.
REFERENCE   4  (bases 1 to 4000)
  AUTHORS   Cao,R., Chen,P., Wang,H., Jing,H., Zhang,H., Xing,G., Luo,B.,
            Pan,J., Yu,Z., Xiong,W.C. and Mei,L.
  TITLE     Intrafusal-fiber LRP4 for muscle spindle formation and maintenance
            in adult and aged animals
  JOURNAL   Nat Commun 14 (1), 744 (2023)
   PUBMED   36765071
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4000)
  AUTHORS   Khan,M.N., Cherukuri,P., Negro,F., Rajput,A., Fabrowski,P.,
            Bansal,V., Lancelin,C., Lee,T.I., Bian,Y., Mayer,W.P., Akay,T.,
            Muller,D., Bonn,S., Farina,D. and Marquardt,T.
  TITLE     ERR2 and ERR3 promote the development of gamma motor neuron
            functional properties required for proprioceptive movement control
  JOURNAL   PLoS Biol 20 (12), e3001923 (2022)
   PUBMED   36542664
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4000)
  AUTHORS   Arber,S., Ladle,D.R., Lin,J.H., Frank,E. and Jessell,T.M.
  TITLE     ETS gene Er81 controls the formation of functional connections
            between group Ia sensory afferents and motor neurons
  JOURNAL   Cell 101 (5), 485-498 (2000)
   PUBMED   10850491
REFERENCE   7  (bases 1 to 4000)
  AUTHORS   Herdegen,T. and Leah,J.D.
  TITLE     Inducible and constitutive transcription factors in the mammalian
            nervous system: control of gene expression by Jun, Fos and Krox,
            and CREB/ATF proteins
  JOURNAL   Brain Res Brain Res Rev 28 (3), 370-490 (1998)
   PUBMED   9858769
  REMARK    Review article
REFERENCE   8  (bases 1 to 4000)
  AUTHORS   Tourtellotte,W.G. and Milbrandt,J.
  TITLE     Sensory ataxia and muscle spindle agenesis in mice lacking the
            transcription factor Egr3
  JOURNAL   Nat Genet 20 (1), 87-91 (1998)
   PUBMED   9731539
REFERENCE   9  (bases 1 to 4000)
  AUTHORS   Swirnoff,A.H. and Milbrandt,J.
  TITLE     DNA-binding specificity of NGFI-A and related zinc finger
            transcription factors
  JOURNAL   Mol Cell Biol 15 (4), 2275-2287 (1995)
   PUBMED   7891721
REFERENCE   10 (bases 1 to 4000)
  AUTHORS   Patwardhan,S., Gashler,A., Siegel,M.G., Chang,L.C., Joseph,L.J.,
            Shows,T.B., Le Beau,M.M. and Sukhatme,V.P.
  TITLE     EGR3, a novel member of the Egr family of genes encoding
            immediate-early transcription factors
  JOURNAL   Oncogene 6 (6), 917-928 (1991)
   PUBMED   1906159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123867.4.
            
            On Jun 20, 2019 this sequence version replaced NM_018781.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.4240472.1,
                                           ERR3363660.621840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               AC123867.4         196741-197022
            283-4000            AC123867.4         198320-202037
FEATURES             Location/Qualifiers
     source          1..4000
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.2 cM"
     gene            1..4000
                     /gene="Egr3"
                     /gene_synonym="EGR-3; Pilot"
                     /note="early growth response 3"
                     /db_xref="GeneID:13655"
                     /db_xref="MGI:MGI:1306780"
     exon            1..282
                     /gene="Egr3"
                     /gene_synonym="EGR-3; Pilot"
                     /inference="alignment:Splign:2.1.0"
     exon            283..4000
                     /gene="Egr3"
                     /gene_synonym="EGR-3; Pilot"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3913..3918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Egr3"
                     /gene_synonym="EGR-3; Pilot"
                     /note="hexamer: AATATA"
     polyA_site      3937
                     /gene="Egr3"
                     /gene_synonym="EGR-3; Pilot"
     regulatory      3977..3982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Egr3"
                     /gene_synonym="EGR-3; Pilot"
                     /note="hexamer: TATAAA"
     polyA_site      4000
                     /gene="Egr3"
                     /gene_synonym="EGR-3; Pilot"
                     /note="major polyA site"
ORIGIN      
        1 ccctctcgca tgcttttccc ctgcaccacg gatcgcctct cggatgccgc tcgcctggaa
       61 gctgcgttag gaacaggcgg cggcggcggt ggcggcggcg gcggtggcgg cggtagctcg
      121 ggagtgctat gaccggcaaa ctcgccgaga agctgccggt gaccatgagc agtttgctaa
      181 atcaattgcc tgacaatctg taccccgagg agatccccag cgcgctcaac ctcttctccg
      241 gcagcagcga ctcggtagcc cattacaatc agatggctac agagaatgtg atggacatcg
      301 gtctgaccaa cgagaagccc aatccggaac tctcttattc gagctctttc cagccagccc
      361 ccggcaacaa gaccgtgacc tacttgggaa agttcgcttt cgactctcct tccaactggt
      421 gccaggacaa catcattagc ctcatgagtg ccggcatctt gggggtgccc ccggcctcag
      481 gggcgctcag tacgcagacg tccacggcta gcatggtgca gcctcctcag ggagacgtgg
      541 aggccatgta tccggcgctg cctccttatt ccaactgcgg cgatctctac tcggagcccg
      601 tgtctttcca cgacccccag ggaaaccctg ggctcgccta ttccccccag gattaccaat
      661 cggccaagcc ggccttggac agcaatcttt tccccatgat tcctgactac aacctgtacc
      721 accatcccaa cgacatgggc tccattccgg aacataagcc cttccagggc atggacccca
      781 tccgggtcaa cccaccccct attaccccac tggagaccat caaggccttc aaagacaagc
      841 agatccaccc gggattcggc agcctgcccc aaccgccgct cactctcaag cccatccggc
      901 cccgcaagta ccccaatcgg cctagcaaga ccccgctcca cgagcggccc cacgcgtgtc
      961 ccgcggaagg ctgtgaccgc cgtttcagcc gctcagacga gctgacccgg cacctgcgca
     1021 tccacacggg ccacaagccc ttccagtgtc ggatctgcat gcgcagcttc agccgcagcg
     1081 accacctcac cactcacatc cgcacgcaca ccggggagaa gccctttgcc tgtgagttct
     1141 gtgggcgcaa gtttgcgcgc agcgacgagc gcaagcgcca cgccaagatc cacctcaagc
     1201 aaaaggagaa gaagtcggag aaagggggtg cgccctctgc atcctcggcg cccaccgtgt
     1261 ccctggcccc tgtggtcacc acctgcgcct gaggatccgg cacccagatc ccttcttttc
     1321 ccttccagtg cctcctggct ggtcgcctga aagcagaggg gaaagccagt cactgaggcg
     1381 caggggccgc gccctgatct cgccctggac gtgcggcccc cttgcctccc ccttcgacgc
     1441 cccccatttc caccctttca caccggccgg cggttggggg ctagggctgg aggcactttc
     1501 tccttgctgc ccccctctta gccaaggcgt gggggcggaa aggtggcgtc tagcccgctt
     1561 tgttcagtta ggatcgcctt gatccagggg ccgctgagcc acgccaagga cctacggggg
     1621 actgaaggcg gggcccatct aaccttcgcc agacccaagc acctcactgt tttccccctc
     1681 cagtgtctcc ctgtgttccc cctcgaacac ccgagagggg gagggggtaa ggagcgcacc
     1741 aaagcgcaga gcttgctgcc cgccgcacgc acgcgcgctt gcgtgcggtg atgcgcgcga
     1801 gtgtgtgcgt gctcgcctgt gtgtagtgtg cgtgtgtatg tgtgtgtgtg tgagtgagtg
     1861 cggtgtgtgc gcgcgcgcac gcgtgtgtga gactcttgag ctgaactggg ctgtgtctac
     1921 ccctaaactc ttcttcacat agggtcccca agccgttggg agatgtccca agctaaggac
     1981 ctgcatgtga ccggaggaga tggtcttcca tctgctcctt aaataatgtt tcttacagaa
     2041 atgcctcgga tgctgcagct gcagtggtgc tgctgccgcc gcctcgggtt tggcccctta
     2101 gagccccctc cctttccgag cgcttccctc ttaggcctca ggacaggttg atctttgggg
     2161 gagaaagagc caccttttaa aaaaagaaat cattgctccg tcccactttt caaaatctat
     2221 gttcttgagc ttgccctctg cctttctctc tcccatcttc tctttttccc tctcaggttc
     2281 tcactgagtc tctcaagatc tttacccaga aaggcaggcc tcaatcaacc acccaagagt
     2341 ttgtctctgt cacataccca ctccccattc ctgggaaggc tggctctatt catttgccct
     2401 ctctgatcac caacacaaca gatagaagtg aagtgtatgt atatgatatt tgcgtgtgta
     2461 tgtagatgta tgtgtgtgtt tctttagaca catatattta cataacacac actccgtatt
     2521 cctagcaaga tcaaacctaa ggcatttggt tagccagcgc agtgcactgg aataaagaga
     2581 atttgtaggc atatacagct taaatgattt atttttatga aaatgttaac tgatgagatt
     2641 atatctactt gtgtatgtgt gtggatatat gtgcactcgt gtgtgtatat gcatacacat
     2701 tctgttcaaa ttttcctcaa aaaaatagat ggggattttt gcatgaatct gtgttgctga
     2761 atgaggcaca tctgttccat ggccccatcg cacctccctg ccctacctca cctcttctca
     2821 ggagccctca accccagttg tcctgtccag cccttccaca cagggtggcc cttttgaagt
     2881 ggagacttaa gagaagggtg ctctctgaca cagcttccag cagtcttgac tgaatgtatc
     2941 cttcctattt agcaccactt ctcctgtggc cagtaagctg cccagagaga agcgacaaaa
     3001 ggtctggagt ttacagaatg tctgttttta aagtcacttt atgcgtttcc cacgtttttt
     3061 ttttttttaa ttaaaaaagc accgtctttt ggtggtggat aaataatact aaaaggactc
     3121 tagtgcaagg gaggaaaaac tcgaagagcg gggattgcgg gggattatgg gggattgtga
     3181 atttccaggt actcgggctt tttgtagaag gagaagtttg ccaggagggc ccatattttt
     3241 tcagctgaag ggtaaaatct ttctttgcag agacagtatt ttgctgaata ctttttataa
     3301 tgtgatgatt atttaaaaaa cacacacaaa atttggtcag ttcaaagctg gaaggaggaa
     3361 tcaaatatcc tttaatattt tttcttcctc cttctggaat atgcatgtca ctgcatgata
     3421 actctgactt ttcctttgtt ttaataaaac tgttctcaga catttaagct aaactaagag
     3481 aaaaaaaaac tttgttgcca aaaggttgtg ctatcccgat ttttttatat gtctgcatgt
     3541 ttaaaaaaca aaagaaaatg cactctaact tatgtgaact gagagaaaaa atcaggtttt
     3601 aaacaggaaa acctatgggg aatgatattt tttgaaagac ttttgtatac agttgagtac
     3661 ttagaaaaag acaaaccaga tgtaatatat tttgtggatg tttttatttc ttggatttat
     3721 agtaccttat actaaggtta aaaaaatgct tgatattgtg aaaaggtgag gttcttcacc
     3781 aacatttcat ttacttcttg tcacattgtt atgccaatat aatatagtta atgaaaacag
     3841 catttttaaa agcaaatatt gaagcggtgt aatgttgccc catttgcctt gtgagcaaat
     3901 gccaatacag taaatatatt gtgtttgctg acaatcagcc gggctttaaa tctcatttta
     3961 tttcttgttt tcatggtata aagttttggt ttggcctggg
//
