LOCUS       NM_010118               2972 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus early growth response 2 (Egr2), transcript variant 1,
            mRNA.
ACCESSION   NM_010118
VERSION     NM_010118.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2972)
  AUTHORS   Strobl,K., Klufa,J., Jin,R., Artner-Gent,L., Krauss,D.,
            Novoszel,P., Strobl,J., Stary,G., Vujic,I., Griss,J., Holcmann,M.,
            Farlik,M., Homey,B., Sibilia,M. and Bauer,T.
  TITLE     JAK-STAT1 as therapeutic target for EGFR deficiency-associated
            inflammation and scarring alopecia
  JOURNAL   EMBO Mol Med 16 (12), 3142-3168 (2024)
   PUBMED   39521937
REFERENCE   2  (bases 1 to 2972)
  AUTHORS   Ohman,L.C., Huang,T., Unwin,V.A., Singh,A., Walters,B.,
            Whiddon,Z.D. and Krimm,R.F.
  TITLE     Deciphering Peripheral Taste Neuron Diversity: Using Genetic
            Identity to Bridge Taste Bud Innervation Patterns and Functional
            Responses
  JOURNAL   J Neurosci 44 (46), e0583242024 (2024)
   PUBMED   39379155
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2972)
  AUTHORS   Midorikawa,M., Sakamoto,H., Nakamura,Y., Hirose,K. and Miyata,M.
  TITLE     Developmental refinement of the active zone nanotopography and axon
            wiring at the somatosensory thalamus
  JOURNAL   Cell Rep 43 (10), 114770 (2024)
   PUBMED   39321021
REFERENCE   4  (bases 1 to 2972)
  AUTHORS   Ghotbi,E., Tchegnon,E., Chen,Z., Li,S., Shipman,T., Wang,Y.,
            Raman,J., Zhang,Y., McKay,R.M., Liao,C.P. and Le,L.Q.
  TITLE     Transcription factor KROX20 marks epithelial stem cell ancestors
            for hair follicle formation
  JOURNAL   J Clin Invest 134 (23), e180160 (2024)
   PUBMED   39361422
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2972)
  AUTHORS   Li,W., He,S., Tan,J., Li,N., Zhao,C., Wang,X., Zhang,Z., Liu,J.,
            Huang,J., Li,X., Zhou,Q., Hu,K., Yang,P. and Hou,S.
  TITLE     Transcription factor EGR2 alleviates autoimmune uveitis via
            activation of GDF15 to modulate the retinal microglial phenotype
  JOURNAL   Proc Natl Acad Sci U S A 121 (39), e2316161121 (2024)
   PUBMED   39298490
  REMARK    GeneRIF: Transcription factor EGR2 alleviates autoimmune uveitis
            via activation of GDF15 to modulate the retinal microglial
            phenotype.
REFERENCE   6  (bases 1 to 2972)
  AUTHORS   Nieto,M.A., Gilardi-Hebenstreit,P., Charnay,P. and Wilkinson,D.G.
  TITLE     A receptor protein tyrosine kinase implicated in the segmental
            patterning of the hindbrain and mesoderm
  JOURNAL   Development 116 (4), 1137-1150 (1992)
   PUBMED   1295734
REFERENCE   7  (bases 1 to 2972)
  AUTHORS   Conlon,R.A. and Rossant,J.
  TITLE     Exogenous retinoic acid rapidly induces anterior ectopic expression
            of murine Hox-2 genes in vivo
  JOURNAL   Development 116 (2), 357-368 (1992)
   PUBMED   1363087
REFERENCE   8  (bases 1 to 2972)
  AUTHORS   Vesque,C. and Charnay,P.
  TITLE     Mapping functional regions of the segment-specific transcription
            factor Krox-20
  JOURNAL   Nucleic Acids Res 20 (10), 2485-2492 (1992)
   PUBMED   1598206
REFERENCE   9  (bases 1 to 2972)
  AUTHORS   Gilardi,P., Schneider-Maunoury,S. and Charnay,P.
  TITLE     Krox-20: a candidate gene for the regulation of pattern formation
            in the hindbrain
  JOURNAL   Biochimie 73 (1), 85-91 (1991)
   PUBMED   1674431
  REMARK    Review article
REFERENCE   10 (bases 1 to 2972)
  AUTHORS   Murphy,P. and Hill,R.E.
  TITLE     Expression of the mouse labial-like homeobox-containing genes, Hox
            2.9 and Hox 1.6, during segmentation of the hindbrain
  JOURNAL   Development 111 (1), 61-74 (1991)
   PUBMED   1673098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY742929.1, AK155585.1 and X06746.1.
            
            On Apr 18, 2008 this sequence version replaced NM_010118.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY742929.1, AK155585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               BY742929.1         1-126
            127-2961            AK155585.1         128-2962
            2962-2972           X06746.1           2852-2862
FEATURES             Location/Qualifiers
     source          1..2972
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 34.96 cM"
     gene            1..2972
                     /gene="Egr2"
                     /gene_synonym="Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25;
                     Zfp-6"
                     /note="early growth response 2"
                     /db_xref="GeneID:13654"
                     /db_xref="MGI:MGI:95296"
     exon            1..521
                     /gene="Egr2"
                     /gene_synonym="Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25;
                     Zfp-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..1765
                     /gene="Egr2"
                     /gene_synonym="Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25;
                     Zfp-6"
                     /note="isoform 1 is encoded by transcript variant 1; early
                     growth response protein 2; zinc finger protein Krox-20; E3
                     SUMO-protein ligase EGR2; E3 SUMO-protein transferase
                     ERG2"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase EGR2 isoform 1"
                     /protein_id="NP_034248.2"
                     /db_xref="CCDS:CCDS35927.2"
                     /db_xref="GeneID:13654"
                     /db_xref="MGI:MGI:95296"
                     /translation="MMTAKAVDKIPVTLSGFMHQLPDSLYPVEDLAASSVTIFPNGEL
                     GGPFDQMNGVAGDGMINIDMTGEKRPLDLPYPSSFAPISAPRNQTFTYMGKFSIDPQY
                     PGASCYPEGIINIVSAGILQGVTPPASTTASSSVTSASPNPLATGPLGVCTMSQTQPE
                     LDHLYSPPPPPPPYSGCTGDLYQDPSAFLSPPSTTSTSSLAYQPPPSYPSPKPAMDPG
                     LIPMIPDYPGFFPSPCQRDPHGAAGPDRKPFPCPLDSLRVPPPLTPLSTIRNFTLGGP
                     GAGVTGPGASGGGEGPRLPGSGSAAVTATPYNPHHLPLRPILRPRKYPNRPSKTPVHE
                     RPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGE
                     KPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSAPPSAQSSASGPGGSQAGGSL
                     CGNSAIGGPLASCTSRTRTP"
     exon            522..2965
                     /gene="Egr2"
                     /gene_synonym="Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25;
                     Zfp-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2945..2950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Egr2"
                     /gene_synonym="Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25;
                     Zfp-6"
                     /note="hexamer: AATAAA"
     polyA_site      2965
                     /gene="Egr2"
                     /gene_synonym="Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25;
                     Zfp-6"
                     /note="major polyA site"
ORIGIN      
        1 tgagagagca gcgattgatt aatagctggg cgaggggaca cactgactgt tataataaca
       61 ctacaccagc aactcctggc tccccaacag ccggatcaca ggcaggagag agtcagtgac
      121 ggatagactt ttttttttct ttaagaagcc aacaacttgg ttgctagttt tatttctgtt
      181 aatttttttc ttttttttgg tgtgtgtgga tgtgttgtgg tggtcttttc taagtgtgga
      241 gggcaaaagg agataccatc ctaggctcag ttcaacccct ctccaaaaaa aacggcttct
      301 ctggcgctcc aggtagcgag ggagttgggt ctccaggttg tgcgaggagc aaatgatgac
      361 cgccaaggcc gtagacaaaa tcccagtaac tctcagtggt tttatgcacc agctgcctga
      421 cagcctctac ccggtggaag acctcgccgc ctcgtcggtg accatcttcc ccaatggtga
      481 actgggaggc ccctttgacc agatgaacgg agtggcggga gatggcatga tcaacattga
      541 catgactgga gagaagagac ccctggatct cccgtatccg agtagcttcg ctcccatctc
      601 tgcacctaga aaccagacct tcacttacat gggcaaattc tccattgacc cacagtaccc
      661 tggtgccagc tgctatccag aaggtatcat caatattgtg agtgcgggca tcttgcaagg
      721 ggtcacccct ccagcttcaa ccacagcctc ctccagcgtc acctccgcct cccccaaccc
      781 actggccacg ggacccctgg gtgtgtgtac catgtcccag actcagcctg aactggacca
      841 cctctactct ccgccaccac ctcctcctcc ttattcgggc tgtacaggag atctctacca
      901 ggatccttca gcattcttat cgccgccatc caccacttcc acctcctctc tggcctacca
      961 gccacctcct tcctacccat cccccaagcc agctatggac ccaggtctca ttcctatgat
     1021 cccagactat cctggatttt ttccatctcc gtgccagaga gatccacacg gtgctgctgg
     1081 cccagatcga aagccgtttc cctgtcctct ggactccctg cgagtgcccc ctccactcac
     1141 gccactctct accatccgta attttactct ggggggtccc ggtgctggag tcacgggacc
     1201 aggagcaagt ggaggtggtg agggacctcg gctgcctggc agtgggtctg cagcagtgac
     1261 tgccacccct tataatccgc accacctgcc attgcggccc atcctgcgac ctcgaaagta
     1321 ccctaacagg cccagcaaaa cgccagtgca cgaaaggccc tatccctgcc cagcagaagg
     1381 ttgtgatagg aggttctcac gctctgatga gctgaccagg cacatccgaa tccacacggg
     1441 ccacaagccc ttccagtgtc ggatctgcat gcgaaacttc agccgaagtg accaccttac
     1501 tactcacatc cgaacccaca ccggggagaa gccctttgcc tgtgactatt gtggccgcaa
     1561 gtttgccagg agtgacgaaa ggaagcgcca caccaagatc caccttcggc agaaggaacg
     1621 gaagagcagt gctccctctg cacctccatc tgcccagtct tcagcctctg gtcctggggg
     1681 ctcgcaggcc gggggcagcc tgtgcggtaa cagcgccatt ggaggaccac tggcctcctg
     1741 cacctctcga accaggacac cgtgagatga agctctggct gacacaccag tttctccagg
     1801 ccccagaggc cctctgtccg agctgccaac actaccaccc ttccctgttc ctccccatga
     1861 tcccgtgatc tgggcaaagg accttgatgg agcccagctc tgtcccacct tctcacggac
     1921 ggccttccga aaacttaggc catttgaagg gagttgactg tcactccaag aaatggggga
     1981 gcaaaaagag ggctgggtga gggcccctgg cctacagggc tgcgctctga ccctgactga
     2041 gagatgtctg actatggtct gctagccctt tccgttgacc ctggatgcca gttgttctga
     2101 gactttttct acaataggtt gggagttgct gattcctttg atcgaggaca gcggaaaaga
     2161 ctaaattaaa gcaaaactga tgtggcactt taatggcttg ggactgactt gggggtgggg
     2221 gtggggagtt gtacagtgag cagagcctca tcctggctgc tgcactctgg ccctagagca
     2281 gtgaatggag gtttctctgg ccatctcaac ccttaagcaa tatgtcctag aaactcaaga
     2341 gaatggaagt gcaatgtcgg gcaggacaaa gcaatattgg ctcctttttt tgttgtagtt
     2401 gaggaacaaa gattattttt tcagtgtata tccatttaga ttttgtgtat ttttgatgtg
     2461 cactgctctc cgagttctga accttcggga aaaaaatgta aagcatttat gatctcttga
     2521 aatgagtcaa aggttaacta acttatttaa agggggacgt acataggatg catgcagtga
     2581 gtggtgttgc aagtgtcctc tgtgccttgt gtgatgtggg cagtgttaac agggtctgca
     2641 tgtgtacagg atgccttact atgggaacag aaaaatcact ccttgggttt aagtatggct
     2701 gtatatttct gcctattaat atttggaatt tttttagaaa gtatattttt gtatgctctg
     2761 ttttgtgact taaaagtgtt acctttgtag ccaaatttca ggtgagaatg tgcttcaatg
     2821 tcactgccgc tgatttgttt ggttattagc tcttaatagt tgtggagaga gaaacaatct
     2881 attctaacat aaaaaaacca ctaactggag ttcagataat ggatggctta ttgactatgg
     2941 tgtaaataaa tacttttcaa caataaaaaa aa
//
