LOCUS       NM_001373986            2809 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus early growth response 2 (Egr2), transcript variant 5,
            mRNA.
ACCESSION   NM_001373986 XM_006513213
VERSION     NM_001373986.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2809)
  AUTHORS   Strobl,K., Klufa,J., Jin,R., Artner-Gent,L., Krauss,D.,
            Novoszel,P., Strobl,J., Stary,G., Vujic,I., Griss,J., Holcmann,M.,
            Farlik,M., Homey,B., Sibilia,M. and Bauer,T.
  TITLE     JAK-STAT1 as therapeutic target for EGFR deficiency-associated
            inflammation and scarring alopecia
  JOURNAL   EMBO Mol Med 16 (12), 3142-3168 (2024)
   PUBMED   39521937
REFERENCE   2  (bases 1 to 2809)
  AUTHORS   Ohman,L.C., Huang,T., Unwin,V.A., Singh,A., Walters,B.,
            Whiddon,Z.D. and Krimm,R.F.
  TITLE     Deciphering Peripheral Taste Neuron Diversity: Using Genetic
            Identity to Bridge Taste Bud Innervation Patterns and Functional
            Responses
  JOURNAL   J Neurosci 44 (46), e0583242024 (2024)
   PUBMED   39379155
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2809)
  AUTHORS   Midorikawa,M., Sakamoto,H., Nakamura,Y., Hirose,K. and Miyata,M.
  TITLE     Developmental refinement of the active zone nanotopography and axon
            wiring at the somatosensory thalamus
  JOURNAL   Cell Rep 43 (10), 114770 (2024)
   PUBMED   39321021
REFERENCE   4  (bases 1 to 2809)
  AUTHORS   Ghotbi,E., Tchegnon,E., Chen,Z., Li,S., Shipman,T., Wang,Y.,
            Raman,J., Zhang,Y., McKay,R.M., Liao,C.P. and Le,L.Q.
  TITLE     Transcription factor KROX20 marks epithelial stem cell ancestors
            for hair follicle formation
  JOURNAL   J Clin Invest 134 (23), e180160 (2024)
   PUBMED   39361422
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2809)
  AUTHORS   Li,W., He,S., Tan,J., Li,N., Zhao,C., Wang,X., Zhang,Z., Liu,J.,
            Huang,J., Li,X., Zhou,Q., Hu,K., Yang,P. and Hou,S.
  TITLE     Transcription factor EGR2 alleviates autoimmune uveitis via
            activation of GDF15 to modulate the retinal microglial phenotype
  JOURNAL   Proc Natl Acad Sci U S A 121 (39), e2316161121 (2024)
   PUBMED   39298490
  REMARK    GeneRIF: Transcription factor EGR2 alleviates autoimmune uveitis
            via activation of GDF15 to modulate the retinal microglial
            phenotype.
REFERENCE   6  (bases 1 to 2809)
  AUTHORS   Nieto,M.A., Gilardi-Hebenstreit,P., Charnay,P. and Wilkinson,D.G.
  TITLE     A receptor protein tyrosine kinase implicated in the segmental
            patterning of the hindbrain and mesoderm
  JOURNAL   Development 116 (4), 1137-1150 (1992)
   PUBMED   1295734
REFERENCE   7  (bases 1 to 2809)
  AUTHORS   Conlon,R.A. and Rossant,J.
  TITLE     Exogenous retinoic acid rapidly induces anterior ectopic expression
            of murine Hox-2 genes in vivo
  JOURNAL   Development 116 (2), 357-368 (1992)
   PUBMED   1363087
REFERENCE   8  (bases 1 to 2809)
  AUTHORS   Vesque,C. and Charnay,P.
  TITLE     Mapping functional regions of the segment-specific transcription
            factor Krox-20
  JOURNAL   Nucleic Acids Res 20 (10), 2485-2492 (1992)
   PUBMED   1598206
REFERENCE   9  (bases 1 to 2809)
  AUTHORS   Gilardi,P., Schneider-Maunoury,S. and Charnay,P.
  TITLE     Krox-20: a candidate gene for the regulation of pattern formation
            in the hindbrain
  JOURNAL   Biochimie 73 (1), 85-91 (1991)
   PUBMED   1674431
  REMARK    Review article
REFERENCE   10 (bases 1 to 2809)
  AUTHORS   Murphy,P. and Hill,R.E.
  TITLE     Expression of the mouse labial-like homeobox-containing genes, Hox
            2.9 and Hox 1.6, during segmentation of the hindbrain
  JOURNAL   Development 111 (1), 61-74 (1991)
   PUBMED   1673098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153379.1.
            
            On Sep 6, 2019 this sequence version replaced XM_006513213.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.96625.1,
                                           SRR11927934.635932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               AC153379.1         58091-58346
            257-365             AC153379.1         58806-58914
            366-2809            AC153379.1         60270-62713
FEATURES             Location/Qualifiers
     source          1..2809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 34.96 cM"
     gene            1..2809
                     /gene="Egr2"
                     /gene_synonym="Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25;
                     Zfp-6"
                     /note="early growth response 2"
                     /db_xref="GeneID:13654"
                     /db_xref="MGI:MGI:95296"
     exon            1..256
                     /gene="Egr2"
                     /gene_synonym="Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25;
                     Zfp-6"
                     /inference="alignment:Splign:2.1.0"
     exon            257..365
                     /gene="Egr2"
                     /gene_synonym="Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25;
                     Zfp-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..1609
                     /gene="Egr2"
                     /gene_synonym="Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25;
                     Zfp-6"
                     /note="isoform 2 is encoded by transcript variant 5; early
                     growth response protein 2; zinc finger protein Krox-20; E3
                     SUMO-protein ligase EGR2; E3 SUMO-protein transferase
                     ERG2"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase EGR2 isoform 2"
                     /protein_id="NP_001360915.1"
                     /db_xref="CCDS:CCDS83706.1"
                     /db_xref="GeneID:13654"
                     /db_xref="MGI:MGI:95296"
                     /translation="MNGVAGDGMINIDMTGEKRPLDLPYPSSFAPISAPRNQTFTYMG
                     KFSIDPQYPGASCYPEGIINIVSAGILQGVTPPASTTASSSVTSASPNPLATGPLGVC
                     TMSQTQPELDHLYSPPPPPPPYSGCTGDLYQDPSAFLSPPSTTSTSSLAYQPPPSYPS
                     PKPAMDPGLIPMIPDYPGFFPSPCQRDPHGAAGPDRKPFPCPLDSLRVPPPLTPLSTI
                     RNFTLGGPGAGVTGPGASGGGEGPRLPGSGSAAVTATPYNPHHLPLRPILRPRKYPNR
                     PSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTT
                     HIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSAPPSAQSSASGPG
                     GSQAGGSLCGNSAIGGPLASCTSRTRTP"
     exon            366..2809
                     /gene="Egr2"
                     /gene_synonym="Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25;
                     Zfp-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2789..2794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Egr2"
                     /gene_synonym="Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25;
                     Zfp-6"
                     /note="hexamer: AATAAA"
     polyA_site      2809
                     /gene="Egr2"
                     /gene_synonym="Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25;
                     Zfp-6"
                     /note="major polyA site"
ORIGIN      
        1 gtgggtgaac tcacggcggc cgcgctaggg tcggtgctcg cgccttcttc ccgctgaact
       61 ctgcagtccg gagtccccgc tgcaggcagg ggccgagagc cccagacccg ggtggttgtc
      121 caccggctgc aaatcgttcc tggcgagctc agcggagccc gcgcagccaa gcccgtatgc
      181 aaattggcca tgtgacggca aaagctgcca ggcccagccc tgttcctcag tccatatatg
      241 ggcagcgacg tcacggctgc ctgacagcct ctacccggtg gaagacctcg ccgcctcgtc
      301 ggtgaccatc ttccccaatg gtgaactggg aggccccttt gaccagatga acggagtggc
      361 gggagatggc atgatcaaca ttgacatgac tggagagaag agacccctgg atctcccgta
      421 tccgagtagc ttcgctccca tctctgcacc tagaaaccag accttcactt acatgggcaa
      481 attctccatt gacccacagt accctggtgc cagctgctat ccagaaggta tcatcaatat
      541 tgtgagtgcg ggcatcttgc aaggggtcac ccctccagct tcaaccacag cctcctccag
      601 cgtcacctcc gcctccccca acccactggc cacgggaccc ctgggtgtgt gtaccatgtc
      661 ccagactcag cctgaactgg accacctcta ctctccgcca ccacctcctc ctccttattc
      721 gggctgtaca ggagatctct accaggatcc ttcagcattc ttatcgccgc catccaccac
      781 ttccacctcc tctctggcct accagccacc tccttcctac ccatccccca agccagctat
      841 ggacccaggt ctcattccta tgatcccaga ctatcctgga ttttttccat ctccgtgcca
      901 gagagatcca cacggtgctg ctggcccaga tcgaaagccg tttccctgtc ctctggactc
      961 cctgcgagtg ccccctccac tcacgccact ctctaccatc cgtaatttta ctctgggggg
     1021 tcccggtgct ggagtcacgg gaccaggagc aagtggaggt ggtgagggac ctcggctgcc
     1081 tggcagtggg tctgcagcag tgactgccac cccttataat ccgcaccacc tgccattgcg
     1141 gcccatcctg cgacctcgaa agtaccctaa caggcccagc aaaacgccag tgcacgaaag
     1201 gccctatccc tgcccagcag aaggttgtga taggaggttc tcacgctctg atgagctgac
     1261 caggcacatc cgaatccaca cgggccacaa gcccttccag tgtcggatct gcatgcgaaa
     1321 cttcagccga agtgaccacc ttactactca catccgaacc cacaccgggg agaagccctt
     1381 tgcctgtgac tattgtggcc gcaagtttgc caggagtgac gaaaggaagc gccacaccaa
     1441 gatccacctt cggcagaagg aacggaagag cagtgctccc tctgcacctc catctgccca
     1501 gtcttcagcc tctggtcctg ggggctcgca ggccgggggc agcctgtgcg gtaacagcgc
     1561 cattggagga ccactggcct cctgcacctc tcgaaccagg acaccgtgag atgaagctct
     1621 ggctgacaca ccagtttctc caggccccag aggccctctg tccgagctgc caacactacc
     1681 acccttccct gttcctcccc atgatcccgt gatctgggca aaggaccttg atggagccca
     1741 gctctgtccc accttctcac ggacggcctt ccgaaaactt aggccatttg aagggagttg
     1801 actgtcactc caagaaatgg gggagcaaaa agagggctgg gtgagggccc ctggcctaca
     1861 gggctgcgct ctgaccctga ctgagagatg tctgactatg gtctgctagc cctttccgtt
     1921 gaccctggat gccagttgtt ctgagacttt ttctacaata ggttgggagt tgctgattcc
     1981 tttgatcgag gacagcggaa aagactaaat taaagcaaaa ctgatgtggc actttaatgg
     2041 cttgggactg acttgggggt gggggtgggg agttgtacag tgagcagagc ctcatcctgg
     2101 ctgctgcact ctggccctag agcagtgaat ggaggtttct ctggccatct caacccttaa
     2161 gcaatatgtc ctagaaactc aagagaatgg aagtgcaatg tcgggcagga caaagcaata
     2221 ttggctcctt tttttgttgt agttgaggaa caaagattat tttttcagtg tatatccatt
     2281 tagattttgt gtatttttga tgtgcactgc tctccgagtt ctgaaccttc gggaaaaaaa
     2341 tgtaaagcat ttatgatctc ttgaaatgag tcaaaggtta actaacttat ttaaaggggg
     2401 acgtacatag gatgcatgca gtgagtggtg ttgcaagtgt cctctgtgcc ttgtgtgatg
     2461 tgggcagtgt taacagggtc tgcatgtgta caggatgcct tactatggga acagaaaaat
     2521 cactccttgg gtttaagtat ggctgtatat ttctgcctat taatatttgg aattttttta
     2581 gaaagtatat ttttgtatgc tctgttttgt gacttaaaag tgttaccttt gtagccaaat
     2641 ttcaggtgag aatgtgcttc aatgtcactg ccgctgattt gtttggttat tagctcttaa
     2701 tagttgtgga gagagaaaca atctattcta acataaaaaa accactaact ggagttcaga
     2761 taatggatgg cttattgact atggtgtaaa taaatacttt tcaacaata
//
