LOCUS       NM_007913               3072 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus early growth response 1 (Egr1), mRNA.
ACCESSION   NM_007913
VERSION     NM_007913.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3072)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3072)
  AUTHORS   Han,X., Xu,S., Hu,K., Yu,Y., Wang,X., Qu,C., Yang,B. and Liu,X.
  TITLE     Early growth response 1 exacerbates thoracic aortic aneurysm and
            dissection of mice by inducing the phenotypic switching of vascular
            smooth muscle cell through the activation of Kruppel-like factor 5
  JOURNAL   Acta Physiol (Oxf) 240 (11), e14237 (2024)
   PUBMED   39345002
  REMARK    GeneRIF: Early growth response 1 exacerbates thoracic aortic
            aneurysm and dissection of mice by inducing the phenotypic
            switching of vascular smooth muscle cell through the activation of
            Kruppel-like factor 5.
REFERENCE   3  (bases 1 to 3072)
  AUTHORS   Wang,J., Gu,D., Jin,K., Shen,H. and Qian,Y.
  TITLE     Egr1 promotes Nlrc4-dependent neuronal pyroptosis through phlda1 in
            an in-vitro model of intracerebral hemorrhage
  JOURNAL   Neuroreport 35 (9), 590-600 (2024)
   PUBMED   38652514
  REMARK    GeneRIF: Egr1 promotes Nlrc4-dependent neuronal pyroptosis through
            phlda1 in an in-vitro model of intracerebral hemorrhage.
REFERENCE   4  (bases 1 to 3072)
  AUTHORS   Sancho-Balsells,A., Borras-Pernas,S., Flotta,F., Chen,W., Del
            Toro,D., Rodriguez,M.J., Alberch,J., Blivet,G., Touchon,J.,
            Xifro,X. and Giralt,A.
  TITLE     Brain-gut photobiomodulation restores cognitive alterations in
            chronically stressed mice through the regulation of Sirt1 and
            neuroinflammation
  JOURNAL   J Affect Disord 354, 574-588 (2024)
   PUBMED   38490587
  REMARK    Erratum:[J Affect Disord. 2024 Sep 15;361:799. doi:
            10.1016/j.jad.2024.07.001.. PMID: 38969582]
REFERENCE   5  (bases 1 to 3072)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3072)
  AUTHORS   Coleman,D.L., Bartiss,A.H., Sukhatme,V.P., Liu,J. and
            Rupprecht,H.D.
  TITLE     Lipopolysaccharide induces Egr-1 mRNA and protein in murine
            peritoneal macrophages
  JOURNAL   J Immunol 149 (9), 3045-3051 (1992)
   PUBMED   1401930
REFERENCE   7  (bases 1 to 3072)
  AUTHORS   Karavanova,I., Vainio,S. and Thesleff,I.
  TITLE     Transient and recurrent expression of the Egr-1 gene in epithelial
            and mesenchymal cells during tooth morphogenesis suggests
            involvement in tissue interactions and in determination of cell
            fate
  JOURNAL   Mech Dev 39 (1-2), 41-50 (1992)
   PUBMED   1489725
REFERENCE   8  (bases 1 to 3072)
  AUTHORS   Johnson,K.R. and Davisson,M.T.
  TITLE     A multipoint genetic linkage map of mouse chromosome 18
  JOURNAL   Genomics 13 (4), 1143-1149 (1992)
   PUBMED   1354640
REFERENCE   9  (bases 1 to 3072)
  AUTHORS   Iwabuchi,N., Williams,D.B., Nguyen,H.P. and Hozumi,N.
  TITLE     Egr-1 mRNA expression is independent of regulatory proliferative
            responses in the immature B cell line WEHI-231
  JOURNAL   Mol Immunol 29 (5), 619-624 (1992)
   PUBMED   1584230
REFERENCE   10 (bases 1 to 3072)
  AUTHORS   Shimizu,N., Ohta,M., Fujiwara,C., Sagara,J., Mochizuki,N., Oda,T.
            and Utiyama,H.
  TITLE     A gene coding for a zinc finger protein is induced during
            12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell
            differentiation
  JOURNAL   J Biochem 111 (2), 272-277 (1992)
   PUBMED   1569051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040925.1 and AK037837.1.
            
            On Sep 29, 2005 this sequence version replaced NM_007913.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037837.1, AK146322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2803              AK040925.1         1-2803
            2804-3072           AK037837.1         2782-3050
FEATURES             Location/Qualifiers
     source          1..3072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.76 cM"
     gene            1..3072
                     /gene="Egr1"
                     /gene_synonym="A530045N19Rik; egr; Egr-1; ETR103; Krox-1;
                     Krox-24; Krox24; NGF1-A; NGFI-A; NGFIA; TIS8; Zenk; Zfp-6;
                     Zif268"
                     /note="early growth response 1"
                     /db_xref="GeneID:13653"
                     /db_xref="MGI:MGI:95295"
     exon            1..580
                     /gene="Egr1"
                     /gene_synonym="A530045N19Rik; egr; Egr-1; ETR103; Krox-1;
                     Krox-24; Krox24; NGF1-A; NGFI-A; NGFIA; TIS8; Zenk; Zfp-6;
                     Zif268"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..1884
                     /gene="Egr1"
                     /gene_synonym="A530045N19Rik; egr; Egr-1; ETR103; Krox-1;
                     Krox-24; Krox24; NGF1-A; NGFI-A; NGFIA; TIS8; Zenk; Zfp-6;
                     Zif268"
                     /note="Krox-24 nuclear protein; transcription factor
                     Zif268; nerve growth factor-induced protein A; zinc finger
                     protein Krox-24"
                     /codon_start=1
                     /product="early growth response protein 1"
                     /protein_id="NP_031939.1"
                     /db_xref="CCDS:CCDS29136.1"
                     /db_xref="GeneID:13653"
                     /db_xref="MGI:MGI:95295"
                     /translation="MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNG
                     APQFLGAAGTPEGSGGNSSSSTSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTTESF
                     SDIALNNEKAMVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVS
                     MTNPPTSSSSAPSPAASSSSSASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEP
                     QSQAFPGSAGTALQYPPPAYPATKGGFQVPMIPDYLFPQQQGDLSLGTPDQKPFQGLE
                     NRTQQPSLTPLSTIKAFATQSGSQDLKALNTTYQSQLIKPSRMRKYPNRPSKTPPHER
                     PYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEK
                     PFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASPAASSLSSYPSPVATSYPS
                     PATTSFPSPVPTSYSSPGSSTYPSPAHSGFPSPSVATTFASVPPAFPTQVSSFPSAGV
                     SSSFSTSTGLSDMTATFSPRTIEIC"
     exon            581..3072
                     /gene="Egr1"
                     /gene_synonym="A530045N19Rik; egr; Egr-1; ETR103; Krox-1;
                     Krox-24; Krox24; NGF1-A; NGFI-A; NGFIA; TIS8; Zenk; Zfp-6;
                     Zif268"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagatccc agcgcgcaga acttggggag ccgccgccgc gattcgccgc cgccgccagc
       61 ttccgccgcc gcaagatcgg cccctgcccc agcctccgcg gcagccctgc gtccaccacg
      121 ggccgcggct accgccagcc tgggggccca cctacactcc ccgcagtgtg cccctgcacc
      181 ccgcatgtaa cccggccaac ccccggcgag tgtgccctca gtagcttcgg ccccgggctg
      241 cgcccaccac ccaacatcag ttctccagct cgctggtccg ggatggcagc ggccaaggcc
      301 gagatgcaat tgatgtctcc gctgcagatc tctgacccgt tcggctcctt tcctcactca
      361 cccaccatgg acaactaccc caaactggag gagatgatgc tgctgagcaa cggggctccc
      421 cagttcctcg gtgctgccgg aaccccagag ggcagcggcg gtaatagcag cagcagcacc
      481 agcagcgggg gcggtggtgg gggcggcagc aacagcggca gcagcgcctt caatcctcaa
      541 ggggagccga gcgaacaacc ctatgagcac ctgaccacag agtccttttc tgacatcgct
      601 ctgaataatg agaaggcgat ggtggagacg agttatccca gccaaacgac tcggttgcct
      661 cccatcacct atactggccg cttctccctg gagcccgcac ccaacagtgg caacactttg
      721 tggcctgaac cccttttcag cctagtcagt ggcctcgtga gcatgaccaa tcctccgacc
      781 tcttcatcct cggcgccttc tccagctgct tcatcgtctt cctctgcctc ccagagcccg
      841 cccctgagct gtgccgtgcc gtccaacgac agcagtccca tctactcggc tgcgcccacc
      901 tttcctactc ccaacactga catttttcct gagccccaaa gccaggcctt tcctggctcg
      961 gcaggcacag ccttgcagta cccgcctcct gcctaccctg ccaccaaagg tggtttccag
     1021 gttcccatga tccctgacta tctgtttcca caacaacagg gagacctgag cctgggcacc
     1081 ccagaccaga agcccttcca gggtctggag aaccgtaccc agcagccttc gctcactcca
     1141 ctatccacta ttaaagcctt cgccactcag tcgggctccc aggacttaaa ggctcttaat
     1201 accacctacc aatcccagct catcaaaccc agccgcatgc gcaagtaccc caaccggccc
     1261 agcaagacac ccccccatga acgcccatat gcttgccctg tcgagtcctg cgatcgccgc
     1321 ttttctcgct cggatgagct tacccgccat atccgcatcc acacaggcca gaagcccttc
     1381 cagtgtcgaa tctgcatgcg taacttcagt cgtagtgacc accttaccac ccacatccgc
     1441 acccacacag gcgagaagcc ttttgcctgt gacatttgtg ggaggaagtt tgccaggagt
     1501 gatgaacgca agaggcatac caaaatccat ttaagacaga aggacaagaa agcagacaaa
     1561 agtgtggtgg cctccccggc tgcctcttca ctctcttctt acccatcccc agtggctacc
     1621 tcctacccat cccctgccac cacctcattc ccatcccctg tgcccacttc ctactcctct
     1681 cctggctcct ccacctaccc atctcctgcg cacagtggct tcccgtcgcc gtcagtggcc
     1741 accacctttg cctccgttcc acctgctttc cccacccagg tcagcagctt cccgtctgcg
     1801 ggcgtcagca gctccttcag cacctcaact ggtctttcag acatgacagc gaccttttct
     1861 cccaggacaa ttgaaatttg ctaaagggaa taaaagaaag caaagggaga ggcaggaaag
     1921 acataaaagc acaggaggga agagatggcc gcaagagggg ccacctctta ggtcagatgg
     1981 aagatctcag agccaagtcc ttctactcac gagtagaagg accgttggcc aacagccctt
     2041 tcacttacca tccctgcctc ccccgtcctg ttccctttga cttcagctgc ctgaaacagc
     2101 catgtccaag ttcttcacct ctatccaaag gacttgattt gcatggtatt ggataaatca
     2161 tttcagtatc ctctccatca catgcctggc ccttgctccc ttcagcgcta gaccatcaag
     2221 ttggcataaa gaaaaaaaaa tgggtttggg ccctcagaac cctgccctgc atctttgtac
     2281 agcatctgtg ccatggattt tgttttcctt ggggtattct tgatgtgaag ataatttgca
     2341 tactctattg tattatttgg agttaaatcc tcactttggg ggagggggga gcaaagccaa
     2401 gcaaaccaat gatgatcctc tattttgtga tgactctgct gtgacattag gtttgaagca
     2461 tttttttttt caagcagcag tcctaggtat taactggagc atgtgtcaga gtgttgttcc
     2521 gttaattttg taaatactgc tcgactgtaa ctctcacatg tgacaaagta tggtttgttt
     2581 ggttgggttt tgtttttgag aatttttttg cccgtccctt tggtttcaaa agtttcacgt
     2641 cttggtgcct tttgtgtgac acgccttgcc gatggcttga catgcgcaga tgtgagggac
     2701 acgctcacct tagccttaag ggggtaggag tgatgttttg ggggaggctt tgagagcaaa
     2761 aacgaggaag agggctgagc tgagctttcg gtctccagaa tgtaagaaga aaaaatttaa
     2821 acaaaaatct gaactctcaa aagtctattt ttctaaactg aaaatgtaaa tttatacatc
     2881 tattcaggag ttggagtgtt gtggttacct actgagtagg ctgcagtttt tgtatgttat
     2941 gaacatgaag ttcattattt tgtggtttta ttttactttg tacttgtgtt tgcttaaaca
     3001 aagtaacctg tttggcttat aaacacattg aatgcgctct attgcccatg ggatatgtgg
     3061 tgtgtatcct tc
//
