LOCUS       NM_028133               2693 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus egl-9 family hypoxia-inducible factor 3 (Egln3), mRNA.
ACCESSION   NM_028133
VERSION     NM_028133.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2693)
  AUTHORS   Duan,M., Ru,X., Zhou,J., Li,Y., Guo,P., Kang,W., Li,W., Chen,Z.,
            Feng,H. and Chen,Y.
  TITLE     Endothelial EGLN3-PKM2 signaling induces the formation of acute
            astrocytic barrier to alleviate immune cell infiltration after
            subarachnoid hemorrhage
  JOURNAL   Fluids Barriers CNS 21 (1), 42 (2024)
   PUBMED   38755642
  REMARK    GeneRIF: Endothelial EGLN3-PKM2 signaling induces the formation of
            acute astrocytic barrier to alleviate immune cell infiltration
            after subarachnoid hemorrhage.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2693)
  AUTHORS   Nolan,N.D., Cui,X., Robbings,B.M., Demirkol,A., Pandey,K., Wu,W.H.,
            Hu,H.F., Jenny,L.A., Lin,C.S., Hass,D.T., Du,J., Hurley,J.B. and
            Tsang,S.H.
  TITLE     CRISPR editing of anti-anemia drug target rescues independent
            preclinical models of retinitis pigmentosa
  JOURNAL   Cell Rep Med 5 (4), 101459 (2024)
   PUBMED   38518771
REFERENCE   3  (bases 1 to 2693)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2693)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2693)
  AUTHORS   Wulf,S., Mizko,L., Herrmann,K.H., Sanchez-Carbonell,M., Urbach,A.,
            Lemke,C., Berndt,A., Loeffler,I. and Wolf,G.
  TITLE     Targeted Disruption of the MORG1 Gene in Mice Causes Embryonic
            Resorption in Early Phase of Development
  JOURNAL   Biomolecules 13 (7), 1037 (2023)
   PUBMED   37509073
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2693)
  AUTHORS   Takeda,K., Ho,V.C., Takeda,H., Duan,L.J., Nagy,A. and Fong,G.H.
  TITLE     Placental but not heart defects are associated with elevated
            hypoxia-inducible factor alpha levels in mice lacking prolyl
            hydroxylase domain protein 2
  JOURNAL   Mol Cell Biol 26 (22), 8336-8346 (2006)
   PUBMED   16966370
REFERENCE   7  (bases 1 to 2693)
  AUTHORS   Nakayama,K., Frew,I.J., Hagensen,M., Skals,M., Habelhah,H.,
            Bhoumik,A., Kadoya,T., Erdjument-Bromage,H., Tempst,P.,
            Frappell,P.B., Bowtell,D.D. and Ronai,Z.
  TITLE     Siah2 regulates stability of prolyl-hydroxylases, controls
            HIF1alpha abundance, and modulates physiological responses to
            hypoxia
  JOURNAL   Cell 117 (7), 941-952 (2004)
   PUBMED   15210114
REFERENCE   8  (bases 1 to 2693)
  AUTHORS   Lieb,M.E., Menzies,K., Moschella,M.C., Ni,R. and Taubman,M.B.
  TITLE     Mammalian EGLN genes have distinct patterns of mRNA expression and
            regulation
  JOURNAL   Biochem Cell Biol 80 (4), 421-426 (2002)
   PUBMED   12234095
REFERENCE   9  (bases 1 to 2693)
  AUTHORS   Taylor,M.S.
  TITLE     Characterization and comparative analysis of the EGLN gene family
  JOURNAL   Gene 275 (1), 125-132 (2001)
   PUBMED   11574160
REFERENCE   10 (bases 1 to 2693)
  AUTHORS   Moschella,M.C., Menzies,K., Tsao,L., Lieb,M.A., Kohtz,J.D.,
            Kohtz,D.S. and Taubman,M.B.
  TITLE     SM-20 is a novel growth factor-responsive gene regulated during
            skeletal muscle development and differentiation
  JOURNAL   Gene Expr 8 (1), 59-66 (1999)
   PUBMED   10543731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044787.1, AK011502.1 and BQ175570.1.
            
            On Nov 20, 2009 this sequence version replaced NM_028133.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ310548.1, AF421882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AK044787.1         2-288
            288-1998            AK044787.1         290-2000
            1999-2541           AK011502.1         1303-1845
            2542-2693           BQ175570.1         1-152               c
FEATURES             Location/Qualifiers
     source          1..2693
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 22.9 cM"
     gene            1..2693
                     /gene="Egln3"
                     /gene_synonym="2610021G09Rik; Hif-p4h-3; Phd3; SM-20"
                     /note="egl-9 family hypoxia-inducible factor 3"
                     /db_xref="GeneID:112407"
                     /db_xref="MGI:MGI:1932288"
     exon            1..670
                     /gene="Egln3"
                     /gene_synonym="2610021G09Rik; Hif-p4h-3; Phd3; SM-20"
                     /inference="alignment:Splign:2.1.0"
     exon            671..790
                     /gene="Egln3"
                     /gene_synonym="2610021G09Rik; Hif-p4h-3; Phd3; SM-20"
                     /inference="alignment:Splign:2.1.0"
     exon            791..927
                     /gene="Egln3"
                     /gene_synonym="2610021G09Rik; Hif-p4h-3; Phd3; SM-20"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1001
                     /gene="Egln3"
                     /gene_synonym="2610021G09Rik; Hif-p4h-3; Phd3; SM-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..2676
                     /gene="Egln3"
                     /gene_synonym="2610021G09Rik; Hif-p4h-3; Phd3; SM-20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1980..1985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Egln3"
                     /gene_synonym="2610021G09Rik; Hif-p4h-3; Phd3; SM-20"
                     /note="hexamer: AATAAA"
     polyA_site      2000
                     /gene="Egln3"
                     /gene_synonym="2610021G09Rik; Hif-p4h-3; Phd3; SM-20"
                     /note="major polyA site"
     regulatory      2655..2660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Egln3"
                     /gene_synonym="2610021G09Rik; Hif-p4h-3; Phd3; SM-20"
                     /note="hexamer: AATAAA"
     polyA_site      2676
                     /gene="Egln3"
                     /gene_synonym="2610021G09Rik; Hif-p4h-3; Phd3; SM-20"
                     /note="major polyA site"
ORIGIN      
        1 cctcccccgg ccacggccgc cgcggcggtg gctctgcatc tccaaaaagg gccctccgac
       61 ttctcactgg gccagtccgg cgctgggtgg cggagcccta cactgctccc gccggtccca
      121 gagccgggat cccttctctt cagagtttcg agcaactttc cccgcctctg gagctaaagt
      181 ggctcgggga ctgtgaccac cgcaggtggg agagtccccg gcccggctct ccgcatcttc
      241 gctgtgcgct cgcgctggga aagccctggg tgcgtgcacc ctgggggtcc ccggcctcgg
      301 ctctgtgggc gagatgcctc tgggacacat catgaggctg gatctggaga agatcgccct
      361 ggagtacatc gtgccctgtc tgcacgaggt cggcttctgc tacctggaca acttcctagg
      421 cgaggtggtg ggcgactgcg tgctggagcg agtcaagcag ctgcactaca acggggccct
      481 gcgtgacggc cagctggccg ggccgtgcgc cggcgtctcc aagcggcacc tgcgaggcga
      541 ccagatcacg tggatcgggg gcaacgagga gggctgcgag gccatcaact tcctcctgtc
      601 cctcatcgac cggctggtcc tgtactgcgg gagccggctg ggcaaatact atgtcaagga
      661 gcggtccaag gcaatggtgg cttgctatcc aggaaatggg acaggttatg ttcgccatgt
      721 ggacaacccc aatggtgatg gccgctgtat cacctgtatc tactacctga ataagaattg
      781 ggacgccaag ttacacggag gggtcctgcg gatatttccg gaagggaaat cgtttgtagc
      841 agacgtggag cccatttttg acagacttct gttcttctgg tcagaccgca ggaatccaca
      901 tgaagtccag ccctcctatg ccaccaggta cgctatgact gtctggtact tcgatgctga
      961 agaaagggca gaagccaaaa agaaattcag gaatttaact agaaaaactg aatctgctct
     1021 tgctaaagac tgactgtggt gtgcaatccg ctggccgcat tcgtgtagta acagttccgg
     1081 aaatgttaag tgtcaagatc caaagaatcc atacaatccc ctctgcccac gtcgttcagc
     1141 tccccacctt gtttgtggta cttcatgttt tcttgccggg actgcggtga ccttcagaca
     1201 ctctctttgc cagatgaact catttgctaa ctccagaaat acctgcagac gacatcctag
     1261 ctggccagcg gtttaaagat agatttggga attcggctgt tgagcccagg actgcttctt
     1321 attcgcactt tatgtatgcg tcctgatttg aagggaggag gttcgcaaag aaataaagtt
     1381 ggtgacagat gccacgaagg ggtaccctcc aaaccctcac agcaagaaag agaaatatct
     1441 gaacgatttc cagatgttgt taaccagagt ctagacagtg acgacgacct aatgacatta
     1501 tcacctctag aaagggctgc tgcttagcaa tcgatttata gatatcccac ggtggatgct
     1561 ccattttcct ggtttacgac ccgtactttc tgaaggtcat tgctaagtca atggctctct
     1621 tgtggaagat gatcccagca tttattatgc actatgttta cttcttactt ggggaaccta
     1681 attatccaga gaataaaatt cgccaggtag tttgggttgt ttttctggta ttgaaatttg
     1741 aagttaaatc agaggataga aagcttcctg gtaattcagc actggattct gctaactcta
     1801 tgggaagagc aaagcccaac ttacatgatt cgtccgagca tccccatccc gagcagttca
     1861 gttcggggag ggagatgggg ttggaagtgc agacagggtc ctttcatccg tgtgtgttcc
     1921 ctttaacggt tcatcgtcca taacaaagaa cagtgtgctg tactcttaaa agagatggaa
     1981 ataaaaagac ctcagagcta ttggagttct tccacatcat ctgctctgcc agcctcactt
     2041 gagtcgtctt gatccttgac tgcaactggc tggtaggacg gccagagttg tgggatttcc
     2101 cagaaccgtg ggagggtctc ctgctgcagg gggcaggtgt cgcttcctcc cgaactctgt
     2161 acgaaacacc tattttacga aagttagcca ccctcgtttc tgctgctact tccccaactt
     2221 tcaaacctct ttaatttcct agctagaatc ccacaagcag catagacctg aaagtgtttt
     2281 atttcgtcat gttcagacag atagacagac agactttcca agacagaagt tgatactttt
     2341 cctctaattg ttttggaaag tgtccaggaa gaactgtcat cccaccccca cccccaacac
     2401 cccacccccg cccccaacac ccccacccgt gccccgtccc gtggctcagt tttgttttat
     2461 ttagtatttc ccaccttcta acttgcaatg tcatgtcctt atttattttg tttattgtct
     2521 ctttagcctg tgatgcctag agtgttaagt acaacgaaga cagggatttt gtacattttt
     2581 gacccatgca atattcccag cgcctaacct aatgcctggc atatagcaag aaagggctta
     2641 gtaaatacat gctcaataaa ctcagtctcc tctgtaaaaa aaaaaaaaaa aaa
//
