LOCUS       NM_207655               5983 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus epidermal growth factor receptor (Egfr), transcript
            variant 1, mRNA.
ACCESSION   NM_207655
VERSION     NM_207655.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5983)
  AUTHORS   Liu,K., Kang,Z., Yang,M., Chen,F., Xia,M., Dai,W., Zheng,S.,
            Chen,H., Lu,Q.R., Zhou,W. and Lin,Y.
  TITLE     The role of oligodendrocyte progenitor cells in the spatiotemporal
            vascularization of the human and mouse neocortex
  JOURNAL   Glia 73 (1), 140-158 (2025)
   PUBMED   39392208
REFERENCE   2  (bases 1 to 5983)
  AUTHORS   Amato,C.M., Xu,X. and Yao,H.H.
  TITLE     An extragenital cell population contributes to urethra closure
            during mouse penis development
  JOURNAL   Sci Adv 10 (49), eadp0673 (2024)
   PUBMED   39642224
REFERENCE   3  (bases 1 to 5983)
  AUTHORS   Strobl,K., Klufa,J., Jin,R., Artner-Gent,L., Krauss,D.,
            Novoszel,P., Strobl,J., Stary,G., Vujic,I., Griss,J., Holcmann,M.,
            Farlik,M., Homey,B., Sibilia,M. and Bauer,T.
  TITLE     JAK-STAT1 as therapeutic target for EGFR deficiency-associated
            inflammation and scarring alopecia
  JOURNAL   EMBO Mol Med 16 (12), 3142-3168 (2024)
   PUBMED   39521937
REFERENCE   4  (bases 1 to 5983)
  AUTHORS   Patritti-Cram,J., Rahrmann,E.P., Rizvi,T.A., Scheffer,K.C.,
            Phoenix,T.N., Largaespada,D.A. and Ratner,N.
  TITLE     NF1-dependent disruption of the blood-nerve-barrier is improved by
            blockade of P2RY14
  JOURNAL   iScience 27 (7), 110294 (2024)
   PUBMED   39100928
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5983)
  AUTHORS   Bano,S., Copeland,M.A., Stoops,J.W., Orr,A., Jain,S., Paranjpe,S.,
            Mooli,R.G.R., Ramakrishnan,S.K., Locker,J., Mars,W.M.,
            Michalopoulos,G.K. and Bhushan,B.
  TITLE     Hepatocyte-specific Epidermal Growth Factor Receptor Deletion
            Promotes Fibrosis but has no Effect on Steatosis in Fast-food Diet
            Model of Metabolic Dysfunction-associated Steatotic Liver Disease
  JOURNAL   Cell Mol Gastroenterol Hepatol 18 (4), 101380 (2024)
   PUBMED   39038606
REFERENCE   6  (bases 1 to 5983)
  AUTHORS   Dardik,A., Smith,R.M. and Schultz,R.M.
  TITLE     Colocalization of transforming growth factor-alpha and a functional
            epidermal growth factor receptor (EGFR) to the inner cell mass and
            preferential localization of the EGFR on the basolateral surface of
            the trophectoderm in the mouse blastocyst
  JOURNAL   Dev Biol 154 (2), 396-409 (1992)
   PUBMED   1426645
REFERENCE   7  (bases 1 to 5983)
  AUTHORS   Avivi,A., Skorecki,K., Yayon,A. and Givol,D.
  TITLE     Promoter region of the murine fibroblast growth factor receptor 2
            (bek/KGFR) gene
  JOURNAL   Oncogene 7 (10), 1957-1962 (1992)
   PUBMED   1408137
REFERENCE   8  (bases 1 to 5983)
  AUTHORS   Karls,U., Muller,U., Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and
            Harbers,K.
  TITLE     Structure, expression, and chromosome location of the gene for the
            beta subunit of brain-specific Ca2+/calmodulin-dependent protein
            kinase II identified by transgene integration in an embryonic
            lethal mouse mutant
  JOURNAL   Mol Cell Biol 12 (8), 3644-3652 (1992)
   PUBMED   1321343
REFERENCE   9  (bases 1 to 5983)
  AUTHORS   Kaupmann,K., Simon-Chazottes,D., Guenet,J.L. and Jockusch,H.
  TITLE     Wobbler, a mutation affecting motoneuron survival and gonadal
            functions in the mouse, maps to proximal chromosome 11
  JOURNAL   Genomics 13 (1), 39-43 (1992)
   PUBMED   1349581
REFERENCE   10 (bases 1 to 5983)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004883.1, AF275367.1, BQ553815.1, BY725722.1 and AK163338.1.
            
            On Mar 24, 2006 this sequence version replaced NM_207655.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF275367.1, X78987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2160              AK004883.1         2-2161
            2161-3078           AF275367.1         2104-3021
            3079-3309           BQ553815.1         327-557
            3310-3854           BY725722.1         74-618
            3855-5930           AK163338.1         619-2694
            5931-5983           AF275367.1         5874-5926
FEATURES             Location/Qualifiers
     source          1..5983
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 9.41 cM"
     gene            1..5983
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /note="epidermal growth factor receptor"
                     /db_xref="GeneID:13649"
                     /db_xref="MGI:MGI:95294"
     exon            1..368
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..3913
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; waved 2; avian erythroblastic leukemia viral
                     (v-erb-b) oncogene homolog"
                     /codon_start=1
                     /product="epidermal growth factor receptor isoform 1
                     precursor"
                     /protein_id="NP_997538.1"
                     /db_xref="CCDS:CCDS24443.1"
                     /db_xref="GeneID:13649"
                     /db_xref="MGI:MGI:95294"
                     /translation="MRPSGTARTTLLVLLTALCAAGGALEEKKVCQGTSNRLTQLGTF
                     EDHFLSLQRMYNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLE
                     NLQIIRGNALYENTYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMD
                     TIQWRDIVQNVFMSNMSMDLQSHPSSCPKCDPSCPNGSCWGGGEENCQKLTKIICAQQ
                     CSHRCRGRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQ
                     MDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCR
                     KVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPREL
                     EILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGL
                     RSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNP
                     LCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQA
                     MNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANC
                     TYGCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLR
                     RLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKV
                     KIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYG
                     CLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKIT
                     DFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS
                     KPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSK
                     MARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQQGFFNSPS
                     TSRTPLLSSLSATSNNSTVACINRNGSCRVKEDAFLQRYSSDPTGAVTEDNIDDAFLP
                     VPEYVNQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVGNPEYLNTAQPTC
                     LSSGFNSPALWIQKGSHQMSLDNPDYQQDFFPKETKPNGIFKGPTAENAEYLRVAPPS
                     SEFIGA"
     exon            369..520
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            521..704
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            705..839
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            840..908
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1027
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1169
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1286
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1413
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1487
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1578
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1778
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1911
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2002
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2160
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2205
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2347
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2470
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2569
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2755
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2911
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..2987
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3134
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3232
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3400
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3448
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3551
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..5965
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4541..4546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /note="hexamer: TATAAA"
     polyA_site      4564
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
     regulatory      5941..5946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /note="hexamer: AATAAA"
     polyA_site      5965
                     /gene="Egfr"
                     /gene_synonym="9030024J15Rik; Erbb; Errb1; Errp; wa-2;
                     wa2; Wa5"
                     /note="major polyA site"
ORIGIN      
        1 ctcccccagt cccgacccga gctaactaga cgtctgggca gccccagcgc aacgcgcagc
       61 agcctccctc ctcttcttcc cgcactgtgc gctcctcctg ggctagggcg tctggatcga
      121 gtcccggagg ctaccgcctc ccagacagac gacaggtcac ctggacgcga gcctgtgtcc
      181 gggtctcgtc gttgccggcg cagtcactgg gcacaaccgt gggactccgt ctgtctcgga
      241 ttaatcccgg agagccagag ccaacctctc ccggtcagag atgcgaccct cagggaccgc
      301 gagaaccaca ctgctggtgt tgctgaccgc gctctgcgcc gcaggtgggg cgttggagga
      361 aaagaaagtc tgccaaggca caagtaacag gctcacccaa ctgggcactt ttgaagacca
      421 ctttctgagc ctgcagagga tgtacaacaa ctgtgaagtg gtccttggga acttggaaat
      481 tacctatgtg caaaggaatt acgacctttc cttcttaaag accatccagg aggtggccgg
      541 ctatgtcctc attgccctca acaccgtgga gagaatccct ttggagaacc tgcagatcat
      601 caggggaaat gctctttatg aaaacaccta tgccttagcc atcctgtcca actatgggac
      661 aaacagaact gggcttaggg aactgcccat gcggaactta caggaaatcc tgattggtgc
      721 tgtgcgattc agcaacaacc ccatcctctg caatatggat actatccagt ggagggacat
      781 cgtccaaaac gtctttatga gcaacatgtc aatggactta cagagccatc cgagcagttg
      841 ccccaaatgt gatccaagct gtcccaatgg aagctgctgg ggaggaggag aggagaactg
      901 ccagaaattg accaaaatca tctgtgccca gcaatgttcc catcgctgtc gtggcaggtc
      961 ccccagtgac tgctgccaca accaatgtgc tgcggggtgt acagggcccc gagagagtga
     1021 ctgtctggtc tgccaaaagt tccaagatga ggccacatgc aaagacacct gcccaccact
     1081 catgctgtac aaccccacca cctatcagat ggatgtcaac cctgaaggga agtacagctt
     1141 tggtgccacc tgtgtgaaga agtgcccccg aaactacgtg gtgacagatc atggctcatg
     1201 tgtccgagcc tgtgggcctg actactacga agtggaagaa gatggcatcc gcaagtgtaa
     1261 aaaatgtgat gggccctgtc gcaaagtttg taatggcata ggcattggtg aatttaaaga
     1321 cacactctcc ataaatgcta caaacatcaa acacttcaaa tactgcactg ccatcagcgg
     1381 ggaccttcac atcctgccag tggcctttaa gggggattct ttcacgcgca ctcctcctct
     1441 agacccacga gaactagaaa ttctaaaaac cgtaaaggaa ataacaggct ttttgctgat
     1501 tcaggcttgg cctgataact ggactgacct ccatgctttc gagaacctag aaataatacg
     1561 tggcagaaca aagcaacatg gtcagttttc tttggcggtc gttggcctga acatcacatc
     1621 actggggctg cgttccctca aggagatcag tgatggggat gtgatcattt ctggaaaccg
     1681 aaatttgtgc tacgcaaaca caataaactg gaaaaaactc ttcgggacac ccaatcagaa
     1741 aaccaaaatc atgaacaaca gagctgagaa agactgcaag gccgtgaacc acgtctgcaa
     1801 tcctttatgc tcctcggaag gctgctgggg ccctgagccc agggactgtg tctcctgcca
     1861 gaatgtgagc agaggcaggg agtgcgtgga gaaatgcaac atcctggagg gggaaccaag
     1921 ggagtttgtg gaaaattctg aatgcatcca gtgccatcca gaatgtctgc cccaggccat
     1981 gaacatcacc tgtacaggca ggggaccaga caactgcatc cagtgtgccc actacattga
     2041 tggcccacac tgtgtcaaga cctgcccagc tggcatcatg ggagagaaca acactctggt
     2101 ctggaagtat gcagatgcca ataatgtctg ccacctatgc cacgccaact gtacctatgg
     2161 atgtgctggg ccaggtcttc aaggatgtga agtgtggcca tctgggccaa agataccatc
     2221 tattgccact gggattgtgg gtggcctcct cttcatagtg gtggtggccc ttgggattgg
     2281 cctattcatg cgaagacgtc acattgttcg aaagcgtaca ctacgccgcc tgcttcaaga
     2341 gagagagctc gtggaacctc tcacacccag cggagaagct ccaaaccaag cccacttgag
     2401 gatattaaag gaaacagaat tcaaaaagat caaagttctg ggttcgggag catttggcac
     2461 agtgtataag ggtctctgga tcccagaagg tgagaaagta aaaatcccgg tggccatcaa
     2521 ggagttaaga gaagccacat ctccaaaagc caacaaagaa atccttgacg aagcctatgt
     2581 gatggctagt gtggacaacc ctcatgtatg ccgcctcctg ggcatctgtc tgacctccac
     2641 tgtccagctc attacacagc tcatgcccta cggttgcctc ctggactacg tccgagaaca
     2701 caaggacaac attggctccc agtacctcct caactggtgt gtgcagattg caaagggcat
     2761 gaactacctg gaagatcggc gtttggtgca ccgtgacttg gcagccagga atgtactggt
     2821 gaagacacca cagcatgtca agatcacaga ttttgggctg gccaaactgc ttggtgctga
     2881 agagaaagaa tatcatgccg aggggggcaa agtgcctatc aagtggatgg ctttggaatc
     2941 aattttacac cgaatttata cacaccaaag tgatgtctgg agctatggtg tcactgtgtg
     3001 ggaactgatg acctttgggt ccaagcctta tgatggaatc ccagcaagtg acatctcatc
     3061 catcctagag aaaggagagc gccttccaca gccacctatc tgcaccatcg atgtctacat
     3121 gatcatggtc aagtgctgga tgatagatgc tgatagccgc ccaaagttcc gagagttgat
     3181 tcttgaattc tccaaaatgg cccgagaccc acagcgctac cttgttatcc agggggatga
     3241 aagaatgcat ttgccaagcc ctacagactc caacttttac cgagccctga tggatgaaga
     3301 ggacatggag gatgtagttg atgctgatga gtatcttatc ccacagcaag gcttcttcaa
     3361 cagcccgtcc acgtcgagga ctcccctctt gagttctctg agtgcaacta gcaacaattc
     3421 cactgtggct tgcattaata gaaatgggag ctgccgtgtc aaagaagacg ccttcttgca
     3481 gcggtacagc tccgacccca caggtgctgt aacagaggac aacatagatg acgcattcct
     3541 ccctgtacct gaatatgtaa accaatctgt tcccaagagg ccagcaggct ctgtgcagaa
     3601 ccctgtctat cacaatcagc ccctgcatcc agctcctgga agagacctgc attatcaaaa
     3661 tccccacagc aatgcagtgg gcaaccctga gtatctcaac actgcccagc ctacctgtct
     3721 cagtagtggg tttaacagcc ctgcactctg gatccagaaa ggcagtcacc aaatgagcct
     3781 agacaaccct gactaccagc aggacttctt ccccaaggaa accaagccaa atggcatatt
     3841 taagggcccc acagctgaaa atgcagagta cctacgggtg gcacctccaa gcagtgagtt
     3901 tattggagca tgacaagaag gggcatcata ccagctataa aatgtctgga ctttctagaa
     3961 tcccaggacc aactatggca gcacctccac ttctggtagc catgcccacg ctgtgtcaaa
     4021 tgtcactcag actggcttta aagcataact ctgatgggct ttgtcactga gccaagaagt
     4081 gggcctctct cctgatgcac tttgggaagt tgaaggtaca tcaattgatc ttcgaactgt
     4141 gaagattcca caaaaaaggt atccatcgag aacattgtcc attggaacag aagtttgcct
     4201 catggtgagg tacatatggg aaaaaaacag acatatggag cttatattta gggaactttg
     4261 ggattcttgt ctttattgat ttgattgatg cactcttgta gtctggtaca cagagttgcc
     4321 tggagccaac tgaccagaca gttggttcca ccagctctgc atcaagacac ttccgtggca
     4381 agacaactaa atgtataaga agtccatgga tgccctgagc aggccacact tgtacagcat
     4441 taaaccatgg cagatacaat aggataagcc actttgttac ttactggggc tgggagaaga
     4501 ggaatgacgg ggtagaattt tccctcagac gtacttttta tataaatatg tccctggcac
     4561 ctaacacgcg ctagtttacc agtgttttct attagacttc cttctatgtt ttctgtttca
     4621 ttgttttgag ttgtaaatat gtgttcctgt cttcatttca tgaagtaaac aaacaaacaa
     4681 aaaacccagt attaagtatt atcaaagaac aaccatgatt ccacattcga acccattcaa
     4741 accatcagta ttgtgaccaa aagcctttaa ctaagaagga gtaaccatgc aaaaatccat
     4801 agaggaattt aacccaaaat tttagtctca gcattgtgtc tgctgaggtg tgtatatgag
     4861 actacgaaag tgaactactc ttcaaatcca ctttgccttc actcctctat accctaaatc
     4921 tagtgtaaac cacacatgga ggataacttt tttttttaat tttaaaagtg tttattagat
     4981 atgtttttct tcctggtaaa ctgcagccaa acatcagtta agagccattt ttgataaaca
     5041 ctatcacaat gatctcggga tccatccttt ccgatttacc aagtgatgga tagacgtgaa
     5101 ctcataaaca ctacccataa gacaaaacaa tgagtgccag acaagacatc agccaggcac
     5161 cagagcacag agcaggactg ggcaatctgt tggagatatc tagaaagttc acaaaggaaa
     5221 caagattgtc cactaccttg tgagatctag cagtcataaa taccagggaa atggaaagtg
     5281 tgtttcctta cagcaccagg tcttcgatct tcctaatgct gtgacccttt aatacagttt
     5341 gccatgttgt ggtgaccccc aaccataaaa ttatttttgt tgctacttca taactgtaaa
     5401 tttgctactc ttacagacca caatgtaaat atctgatatg ctatctgata tgcaggctat
     5461 ctgacagagg tcgcaacccg caggttgaga gccactgcct tcaaggcttt aatcaagaga
     5521 gtagtgagct gagggcttta ctggtaagtc aggggcaagt ccaactcaat catcctcaca
     5581 tactggctgc tccctcaggc ctgagaatga ggcttgcagc atcctctggt ttcctaaccg
     5641 ttatccatcc ctgactctca tctctgaaaa tagatgtcat ccatgaaatt aaggagtgag
     5701 aatattaagc agcatttata gagctcaaaa ttccatgtca tcaccaggaa gtgccatgtt
     5761 gatcacagag aacacagagg agacatatag acagggtttt gctcaaaatt gggatataga
     5821 atgagcctgt caggtaccta tcaggagcgg taatccgtga gagagaaccg ttgcaagcca
     5881 ctctaactgt agcaatgaaa ccctagtatt tttgtacttt gaaatacttt cttataacaa
     5941 aataaagtag caaaaaaact gttcaaaaaa aaaaaaaaaa aaa
//
