LOCUS       NM_198724               1387 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus EGF-like domain 7 (Egfl7), transcript variant b, mRNA.
ACCESSION   NM_198724
VERSION     NM_198724.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1387)
  AUTHORS   Sun,B., Lei,X., Cao,M., Li,Y. and Yang,L.Y.
  TITLE     Hepatocellular carcinoma cells remodel the pro-metastatic tumour
            microenvironment through recruitment and activation of fibroblasts
            via paracrine Egfl7 signaling
  JOURNAL   Cell Commun Signal 21 (1), 180 (2023)
   PUBMED   37480091
  REMARK    GeneRIF: Hepatocellular carcinoma cells remodel the pro-metastatic
            tumour microenvironment through recruitment and activation of
            fibroblasts via paracrine Egfl7 signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1387)
  AUTHORS   Chang,J., Sun,Y., Meng,X., Zeng,F. and Wang,X.
  TITLE     EGFL7 affects the migration of epidermal stem cells in refractory
            diabetic wounds by regulating Notch signaling pathway
  JOURNAL   Regen Med 18 (2), 137-153 (2023)
   PUBMED   36530156
  REMARK    GeneRIF: EGFL7 affects the migration of epidermal stem cells in
            refractory diabetic wounds by regulating Notch signaling pathway.
REFERENCE   3  (bases 1 to 1387)
  AUTHORS   Barth,K., Vasic,V., McDonald,B., Heinig,N., Wagner,M.C.,
            Schumann,U., Rohlecke,C., Bicker,F., Schumann,L., Radyushkin,K.,
            Baumgart,J., Tenzer,S., Zipp,F., Meinhardt,M., Alitalo,K.,
            Tegeder,I. and Schmidt,M.H.H.
  TITLE     EGFL7 loss correlates with increased VEGF-D expression,
            upregulating hippocampal adult neurogenesis and improving spatial
            learning and memory
  JOURNAL   Cell Mol Life Sci 80 (2), 54 (2023)
   PUBMED   36715759
  REMARK    GeneRIF: EGFL7 loss correlates with increased VEGF-D expression,
            upregulating hippocampal adult neurogenesis and improving spatial
            learning and memory.
            Erratum:[Cell Mol Life Sci. 2023 Jul 13;80(8):201. doi:
            10.1007/s00018-023-04835-3.. PMID: 37439854]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1387)
  AUTHORS   Rusidze,M., Faure,M.C., Sicard,P., Raymond-Letron,I., Giton,F.,
            Vessieres,E., Prevot,V., Henrion,D., Arnal,J.F., Cornil,C.A. and
            Lenfant,F.
  TITLE     Loss of function of the maternal membrane oestrogen receptor
            ERalpha alters expansion of trophoblast cells and impacts mouse
            fertility
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36239412
REFERENCE   5  (bases 1 to 1387)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   6  (bases 1 to 1387)
  AUTHORS   Fitch,M.J., Campagnolo,L., Kuhnert,F. and Stuhlmann,H.
  TITLE     Egfl7, a novel epidermal growth factor-domain gene expressed in
            endothelial cells
  JOURNAL   Dev Dyn 230 (2), 316-324 (2004)
   PUBMED   15162510
  REMARK    GeneRIF: EGFL7 protein is localized to the endoplasmic reticulum
            and Golgi apparatus, suggesting that the protein is targeted for
            secretion
REFERENCE   7  (bases 1 to 1387)
  AUTHORS   Parker,L.H., Schmidt,M., Jin,S.W., Gray,A.M., Beis,D., Pham,T.,
            Frantz,G., Palmieri,S., Hillan,K., Stainier,D.Y., De Sauvage,F.J.
            and Ye,W.
  TITLE     The endothelial-cell-derived secreted factor Egfl7 regulates
            vascular tube formation
  JOURNAL   Nature 428 (6984), 754-758 (2004)
   PUBMED   15085134
  REMARK    GeneRIF: regulator that controls a specific and important step in
            vasculogenesis
REFERENCE   8  (bases 1 to 1387)
  AUTHORS   Soncin,F., Mattot,V., Lionneton,F., Spruyt,N., Lepretre,F.,
            Begue,A. and Stehelin,D.
  TITLE     VE-statin, an endothelial repressor of smooth muscle cell migration
  JOURNAL   EMBO J 22 (21), 5700-5711 (2003)
   PUBMED   14592969
  REMARK    GeneRIF: is the first identified inhibitor of mural cell migration
            specifically produced by endothelial cells.
REFERENCE   9  (bases 1 to 1387)
  AUTHORS   Xiong,J.W., Leahy,A., Lee,H.H. and Stuhlmann,H.
  TITLE     Vezf1: A Zn finger transcription factor restricted to endothelial
            cells and their precursors
  JOURNAL   Dev Biol 206 (2), 123-141 (1999)
   PUBMED   9986727
REFERENCE   10 (bases 1 to 1387)
  AUTHORS   Xiong,J.W., Battaglino,R., Leahy,A. and Stuhlmann,H.
  TITLE     Large-scale screening for developmental genes in embryonic stem
            cells and embryoid bodies using retroviral entrapment vectors
  JOURNAL   Dev Dyn 212 (2), 181-197 (1998)
   PUBMED   9626494
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX649422.2 and AL732311.13.
            
            On Apr 11, 2019 this sequence version replaced NM_198724.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY239290.1, BC024610.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               BX649422.2         59541-59724
            185-275             BX649422.2         61261-61351
            276-400             BX649422.2         64721-64845
            401-517             BX649422.2         65006-65122
            518-633             BX649422.2         66056-66171
            634-729             BX649422.2         66333-66428
            730-894             BX649422.2         66575-66739
            895-959             AL732311.13        2410-2474
            960-1122            AL732311.13        2864-3026
            1123-1387           AL732311.13        3164-3428
FEATURES             Location/Qualifiers
     source          1..1387
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 18.95 cM"
     gene            1..1387
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /note="EGF-like domain 7"
                     /db_xref="GeneID:353156"
                     /db_xref="MGI:MGI:2449923"
     exon            1..184
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..275
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..400
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1145
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant b; epidermal growth factor-like protein 7;
                     EGF-like protein 7; NOTCH4-like protein; vascular
                     endothelial statin; multiple EGF-like domains protein 7;
                     multiple epidermal growth factor-like domains protein 7;
                     NEU1 protein"
                     /codon_start=1
                     /product="epidermal growth factor-like protein 7 isoform 1
                     precursor"
                     /protein_id="NP_942017.3"
                     /db_xref="CCDS:CCDS15807.3"
                     /db_xref="GeneID:353156"
                     /db_xref="MGI:MGI:2449923"
                     /translation="MWGSGELLVAWFLVLAADGTTEHVYRPSRRVCTVGISGGSISET
                     FVQRVYQPYLTTCDGHRACSTYRTIYRTAYRRSPGVTPARPRYACCPGWKRTSGLPGA
                     CGAAICQPPCGNGGSCIRPGHCRCPVGWQGDTCQTDVDECSTGEASCPQRCVNTVGSY
                     WCQGWEGQSPSADGTRCLSKEGPSPVAPNPTAGVDSMAREEVYRLQARVDVLEQKLQL
                     VLAPLHSLASRSTEHGLQDPGSLLAHSFQQLDRIDSLSEQVSFLEEHLGSCSCKKDL"
     exon            401..517
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..633
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..729
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..894
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..959
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1122
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1387
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1370..1375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /note="hexamer: AATAAA"
     polyA_site      1387
                     /gene="Egfl7"
                     /gene_synonym="VE-statin; Zneu1"
                     /note="major polyA site"
ORIGIN      
        1 aggagcctct gtgcactggc aggctgctgt gcagtccacg aggaaggctt cggtcgacag
       61 gacaggcgtg cagacttcag gagggaccct gggcagcaga cattccctgg aagggcaggt
      121 tgcattgcat ggttggctca tggaggcagc agaggtggcc tcagccaggc ctgggcagca
      181 tcagcccccg gcagcagcaa gacgctggct gttccacctg cccacaagaa cagccaccac
      241 cagtacccag gggatgacta gcggccggac cacaggccac aaaaagaaga aggctacccc
      301 acttacagat gcagaccatg tggggctccg gagaactgct tgtagcatgg tttctagtgt
      361 tggcagcaga tggtactact gagcatgtct acagacccag ccgtagagtg tgtactgtgg
      421 ggatttccgg aggttccatc tcggagacct ttgtgcagcg tgtataccag ccttacctca
      481 ccacttgcga cggacacaga gcctgcagca cctaccgaac catctaccgg actgcctatc
      541 gccgtagccc tggggtgact cccgcaaggc ctcgctatgc ttgctgccct ggttggaaga
      601 ggaccagtgg gctccctggg gcttgtggag cagcaatatg ccagcctcca tgtgggaatg
      661 gagggagttg catccgccca ggacactgcc gctgccctgt gggatggcag ggagatactt
      721 gccagacaga tgttgatgaa tgcagtacag gagaggccag ttgtccccag cgctgtgtca
      781 atactgtggg aagttactgg tgccagggat gggagggaca aagcccatct gcagatggga
      841 cgcgctgcct gtctaaggag gggccctccc cggtggcccc aaaccccaca gcaggagtgg
      901 acagcatggc gagagaggag gtgtacaggc tgcaggctcg ggttgatgtg ctagaacaga
      961 aactgcagtt ggtgctggcc ccactgcaca gcctggcctc tcggtccaca gagcatgggc
     1021 tacaagatcc tggcagcctg ctggcccatt ccttccagca gctggaccga attgattcac
     1081 tgagtgagca ggtgtccttc ttggaggaac atctggggtc ctgctcctgc aaaaaagatc
     1141 tgtgataacc tctcaccacc caggctggat agagcagtca tccctagatc ccttgtagcc
     1201 agagttcagg cgctgtctgg tggtgcctat gagcagaagg ccctgcctca ttgtccctct
     1261 ttcttaggag gttcctagga cttgggcatg gggagtgggg tcttgtgtga ctcttcagtg
     1321 gggctccctg tctaagtggt aaggtgggga ttgtctccat ctttgtcata ataaagctga
     1381 gacttga
//
