LOCUS       NP_062270                550 aa            linear   ROD 02-JUN-2024
DEFINITION  epidermal growth factor-like protein 6 precursor [Mus musculus].
ACCESSION   NP_062270
VERSION     NP_062270.1
DBSOURCE    REFSEQ: accession NM_019397.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 550)
  AUTHORS   Wilson,C.L., Hung,C.F., Burkel,B.M., Ponik,S.M., Gharib,S.A. and
            Schnapp,L.M.
  TITLE     Nephronectin is required to maintain right lung lobar separation
            during embryonic development
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 324 (3), L335-L344 (2023)
   PUBMED   36719987
REFERENCE   2  (residues 1 to 550)
  AUTHORS   Angelozzi,M., Pellegrino da Silva,R., Gonzalez,M.V. and Lefebvre,V.
  TITLE     Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly
            proliferative, and myofibroblast-like osteodermal progenitors
  JOURNAL   Cell Rep 40 (2), 111045 (2022)
   PUBMED   35830813
REFERENCE   3  (residues 1 to 550)
  AUTHORS   Chen,K., Liao,S., Li,Y., Jiang,H., Liu,Y., Wang,C., Kuek,V.,
            Kenny,J., Li,B., Huang,Q., Hong,J., Huang,Y., Chim,S.M.,
            Tickner,J., Pavlos,N.J., Zhao,J., Liu,Q., Qin,A. and Xu,J.
  TITLE     Osteoblast-derived EGFL6 couples angiogenesis to osteogenesis
            during bone repair
  JOURNAL   Theranostics 11 (20), 9738-9751 (2021)
   PUBMED   34815781
  REMARK    GeneRIF: Osteoblast-derived EGFL6 couples angiogenesis to
            osteogenesis during bone repair.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 550)
  AUTHORS   Bian,Q., Cheng,Y.H., Wilson,J.P., Su,E.Y., Kim,D.W., Wang,H.,
            Yoo,S., Blackshaw,S. and Cahan,P.
  TITLE     A single cell transcriptional atlas of early synovial joint
            development
  JOURNAL   Development 147 (14) (2020)
   PUBMED   32580935
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 550)
  AUTHORS   Abbasi,F., Kodani,M., Emori,C., Kiyozumi,D., Mori,M., Fujihara,Y.
            and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Genome Editing Reveals Oosp Family Genes are
            Dispensable for Female Fertility in Mice
  JOURNAL   Cells 9 (4), 821 (2020)
   PUBMED   32231122
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 550)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (residues 1 to 550)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   8  (residues 1 to 550)
  AUTHORS   Osada,A., Kiyozumi,D., Tsutsui,K., Ono,Y., Weber,C.N., Sugimoto,N.,
            Imai,T., Okada,A. and Sekiguchi,K.
  TITLE     Expression of MAEG, a novel basement membrane protein, in mouse
            hair follicle morphogenesis
  JOURNAL   Exp Cell Res 303 (1), 148-159 (2005)
   PUBMED   15572035
  REMARK    GeneRIF: MAEG may play a role as a mediator regulating
            epithelial-mesenchymal interaction through binding to RGD-binding
            integrins including alpha8beta1 during hair follicle development.
REFERENCE   9  (residues 1 to 550)
  AUTHORS   Buchner,G., Broccoli,V., Bulfone,A., Orfanelli,U., Gattuso,C.,
            Ballabio,A. and Franco,B.
  TITLE     MAEG, an EGF-repeat containing gene, is a new marker associated
            with dermatome specification and morphogenesis of its derivatives
  JOURNAL   Mech Dev 98 (1-2), 179-182 (2000)
   PUBMED   11044626
REFERENCE   10 (residues 1 to 550)
  AUTHORS   Buchner,G., Orfanelli,U., Quaderi,N., Bassi,M.T., Andolfi,G.,
            Ballabio,A. and Franco,B.
  TITLE     Identification of a new EGF-repeat-containing gene from human Xp22:
            a candidate for developmental disorders
  JOURNAL   Genomics 65 (1), 16-23 (2000)
   PUBMED   10777661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672174.8.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ245672.1, AK078534.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..550
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 77.66 cM"
     Protein         1..550
                     /product="epidermal growth factor-like protein 6
                     precursor"
                     /note="epidermal growth factor-like protein 6; EGF-like
                     protein 6; MAM and EGF domains-containing gene protein"
                     /calculated_mol_wt=59549
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1989
     mat_peptide     19..550
                     /product="Epidermal growth factor-like protein 6.
                     /id=PRO_0000295812"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJZ5.1)"
                     /calculated_mol_wt=59549
     Region          92..123
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(92,95,109)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          172..200
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF domain; pfam07645"
                     /db_xref="CDD:429571"
     Site            order(172,175,191)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          221..256
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          295..354
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJZ5.1)"
     Site            394
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JJZ5.1)"
     Region          399..541
                     /region_name="MAM"
                     /note="Meprin, A5 protein, and protein tyrosine
                     phosphatase Mu (MAM) domain. MAM is an extracellular
                     domain which mediates protein-protein interactions and is
                     found in a diverse set of proteins, many of which are
                     known to function in cell adhesion. Members...; cd06263"
                     /db_xref="CDD:99706"
     CDS             1..550
                     /gene="Egfl6"
                     /gene_synonym="Maeg"
                     /coded_by="NM_019397.3:194..1846"
                     /db_xref="CCDS:CCDS30528.1"
                     /db_xref="GeneID:54156"
                     /db_xref="MGI:MGI:1858599"
ORIGIN      
        1 mqppwglalp lllpwvtggv gtspwdygls alahqpgvcq ygtkmaccyg wkrnnkgvce
       61 amceprckfg ecvgpnkcrc fpgytgktct qdvnecgvkp rpcqhrcvnt hgsykcfcls
      121 ghmllpdatc snsrtcarln cqygcedtee gprcvcpssg lrlgpngrvc ldidecassk
      181 avcpsnrrcv ntfgsyyckc higfelkyig rrydcvdine calnthpcsp hanclntrgs
      241 fkckckqgyr gnglqcsvip ehsvkeilta pgtikdrikk llahkrtmkk kvklkmvtpr
      301 pastrvpkvn lpysseegvs rgrnydgeqk kkeegkrerl eeekgektlr neveqertlr
      361 gdvfspkvne aedldlvyvq rkelnsklkh kdlnisvdcs fdlgvcdwkq dreddfdwhp
      421 adrdndvgyy mavpalaghk knigrlklll pnltpqsnfc llfdyrlagd kvgklrvfvk
      481 nsnnalawee tknedgrwrt gkiqlyqgid ttksvifeae rgkgktgeia vdgvllvsgl
      541 cpddflsveg
//
