LOCUS       NM_029412               2706 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus EGF-like and EMI domain containing 1 (Egfem1),
            transcript variant 1, mRNA.
ACCESSION   NM_029412
VERSION     NM_029412.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2706)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2706)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   3  (bases 1 to 2706)
  AUTHORS   Herlan,L., Schulz,A., Schulte,L., Schulz,H., Hubner,N. and
            Kreutz,R.
  TITLE     Novel candidate genes for impaired nephron development in a rat
            model with inherited nephron deficit and albuminuria
  JOURNAL   Clin Exp Pharmacol Physiol 42 (10), 1051-1058 (2015)
   PUBMED   26192016
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110222.9, AC113454.8, AC119240.11 and AL691427.15.
            
            On Dec 20, 2022 this sequence version replaced NM_029412.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-376               AC110222.9         98339-98714         c
            377-511             AC110222.9         32796-32930         c
            512-621             AC110222.9         29328-29437         c
            622-726             AC110222.9         27676-27780         c
            727-777             AC113454.8         27895-27945
            778-900             AC119240.11        138659-138781
            901-1020            AL691427.15        123118-123237       c
            1021-1143           AL691427.15        120563-120685       c
            1144-1281           AL691427.15        114187-114324       c
            1282-1404           AL691427.15        108955-109077       c
            1405-1602           AL691427.15        103016-103213       c
            1603-1776           AL691427.15        100715-100888       c
            1777-1905           AL691427.15        84658-84786         c
            1906-2040           AL691427.15        81259-81393         c
            2041-2706           AL691427.15        80396-81061         c
FEATURES             Location/Qualifiers
     source          1..2706
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 12.57 cM"
     gene            1..2706
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /note="EGF-like and EMI domain containing 1"
                     /db_xref="GeneID:75740"
                     /db_xref="MGI:MGI:1922990"
     exon            1..376
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..2060
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; EGF-like and EMI domain-containing protein 1;
                     EF-hand calcium binding domain 11"
                     /codon_start=1
                     /product="EGF-like and EMI domain-containing protein 1
                     isoform a precursor"
                     /protein_id="NP_083688.1"
                     /db_xref="CCDS:CCDS50881.1"
                     /db_xref="GeneID:75740"
                     /db_xref="MGI:MGI:1922990"
                     /translation="MTSPLCFWCFCVWAAANWPPGSALQLQPGMPNVCREEQLTLVRL
                     SRPCAQAFIDTIQFWKQGCSGPRWCVGYERRIRYYIIYRHVYATEHQTVFRCCPGWIQ
                     WDDEPGCFSSLSSLGTHFSGRECSYQDTRQCLCSQGFHGPHCQYEKNKHLESELTPGF
                     LQKNVDECAVVNGGCQQRCINTLGTFHCECDTGYRRHADERTCIKTDPCAGANGCAHL
                     CQTENGMARCACHAGYQLSEDKKACEDINECAEELAPCAHHCVNSKGSFTCTCHPGFE
                     LGADRKHCYRIELEIVNICEKNNGGCSHHCEPAIGGAHCSCNHGHQLDTDGKTCIDFD
                     ECESGEACCAQLCINYLGGYECSCEEGFQISSDGCGCDALDEQLEEEEEEIDILRFPG
                     RLAQNPPQPFPYLDPSLTASYEDEDNDDADSEAEGEVQGLTALYRVVCLDGTFGLDCS
                     LSCEDCMNGGRCQEGKSGCLCPAEWTGLICNESSVLRTGEDQQAPAGCLKGFFGKNCK
                     RKCHCANNVHCHRVYGACMCDLGRYGRFCHLSCPRGAYGASCSLECQCVEENTLECSA
                     KNGSCTCKSGYQGNRCQEELPLPA"
     exon            377..511
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     exon            512..621
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     exon            622..726
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     exon            727..777
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     exon            778..900
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1020
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1143
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1281
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1404
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1602
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1776
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1905
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2040
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2706
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2685..2690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /note="hexamer: AGTAAA"
     polyA_site      2706
                     /gene="Egfem1"
                     /gene_synonym="6130401L20Rik; Efcab11"
                     /note="major polyA site"
ORIGIN      
        1 agtcgccgcc ggcagtgcag ggctgtgcag ctcttgggct acagtgcccg gggttggttt
       61 ggccggccac tgctagcacg ggcgctgttg cgggtgtcgt ctgctggggt cgagctgctg
      121 cggtgccctc cgcagcaaga cgcacgtcgc ggtcctcgag agcgagcccg gcactagcaa
      181 cttctgcttg gcgagcctaa cttctgagcg ggcttcggac ttgaggatcc caagctgcgc
      241 accgcgcgca gttggggcgg tggccccacc ggctcaccat caccgagatg acctccccac
      301 tgtgcttctg gtgtttctgc gtctgggccg ctgccaactg gccgccagga agcgccctac
      361 agctccagcc cggcatgcca aatgtttgca gagaggagca gctgaccttg gtaagactgt
      421 cacgcccatg tgcccaagcc ttcatagaca ccatccagtt ctggaaacaa ggctgctcag
      481 gcccacggtg gtgtgtggga tacgagagaa ggattcgcta ctacatcatc tacagacatg
      541 tatatgccac agagcaccag acagtcttca ggtgctgccc tggttggatc caatgggatg
      601 atgaaccagg ctgcttctcc tctctctctt ccttgggaac tcatttcagt ggaagggagt
      661 gctcgtatca ggacactcgg cagtgccttt gttcacaagg atttcatgga ccccactgtc
      721 aatatgagaa gaacaaacac ctagaaagcg aactgacacc tggattccta cagaaaaatg
      781 tggatgagtg tgccgtggtg aacggaggct gccagcagcg ctgtattaac actctgggca
      841 ccttccactg tgagtgtgac acaggataca gacgccatgc tgacgaacgt acctgcataa
      901 agacagaccc ctgtgcaggt gcaaatggat gtgctcacct atgtcaaact gaaaatggca
      961 tggccaggtg tgcctgccac gctgggtacc agctgtctga agacaaaaag gcctgcgaag
     1021 atataaatga gtgtgctgaa gaactcgctc cctgtgctca tcactgtgtg aactcaaagg
     1081 ggtccttcac atgtacctgc caccctggct ttgagctagg agctgacaga aaacattgtt
     1141 acagaattga attagaaatt gtcaatatct gtgagaagaa caatggcggc tgttctcatc
     1201 actgcgagcc tgcaattggt ggagcccact gttcctgtaa ccacggacat caactggata
     1261 ccgatgggaa aacatgtata gactttgatg aatgtgagag cggagaagcc tgctgtgccc
     1321 aactctgcat caactactta ggaggctatg agtgcagctg tgaggaaggc tttcagatca
     1381 gttcggatgg ttgtggatgt gatgctttag atgagcagtt agaggaagaa gaagaggaaa
     1441 tagacattct gaggtttcca ggccgtctgg ctcagaaccc acctcagcca ttcccttatc
     1501 ttgatccttc tctgactgct tcatatgaag atgaagacaa tgatgatgct gactctgaag
     1561 cagaaggaga ggtccaaggg ctgacagcct tgtacagagt tgtctgttta gatggcacct
     1621 ttggcctgga ctgcagcttg agctgtgaag attgtatgaa tggaggaaga tgccaagaag
     1681 gaaagagtgg gtgcttgtgc ccagcagaat ggactggtct tatatgcaat gaaagcagtg
     1741 tcctaagaac tggggaagat cagcaagctc ctgcgggatg cctgaaaggg ttctttggga
     1801 agaactgcaa aagaaaatgt cattgtgcta acaatgttca ttgccacagg gtatatggtg
     1861 cctgcatgtg tgacctaggg cgctatggaa gattctgcca cctaagctgt cccaggggag
     1921 cctatggagc tagctgttct ttggaatgtc agtgtgtgga agagaacacc ctggaatgca
     1981 gtgccaaaaa tggtagttgc acctgcaaat ctggttacca aggcaacaga tgccaggaag
     2041 aattgccctt gccagcctga gcagaggaag aagatggcac atctttaaat tatatctgga
     2101 aacaattaca gctcaataac attgactcat caatcaaaga cacgctctcc tccagcatga
     2161 aggacattcc tttttctgtc taaaactcaa tcatccaaac aaatttattt atggtttctt
     2221 aataccaaga acttaaggat ggatacccgt actgtcactt ttcaagtacc tagatatcac
     2281 gtaattttag ataaatctcc aagcagaaaa ctatggtccc agtagtaaga aacacgtaga
     2341 gatacatgtg cagctgtgtg tggaatttgg ggaaatggta tttcaacctg tcagcaagcc
     2401 atccctggct tgtaaagccc ttgagtactt gtttatggtt ttggtgtctt gttaccatgt
     2461 cactgacttc ttttgatgcc atttcttaag aaggcagtga gcagctttcc tggagttcct
     2521 tttgttgact atagcatgcc ttgtcttcta atctagcaca ttcacccatt actgtgtgtt
     2581 actatcgact gcctgttctc ttgcttgaat ccaaggccca tgtaggcagt atatttgttt
     2641 gtttcttcct gtatttcctc actcatgcaa taaagacagt catcagtaaa tctcttctta
     2701 aatcaa
//
