LOCUS       NM_007911               3231 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus ephrin B3 (Efnb3), mRNA.
ACCESSION   NM_007911 XM_992702
VERSION     NM_007911.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3231)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3231)
  AUTHORS   Qiao,Z., Liao,M., Xiao,M., Luo,S., Wang,K., Niu,M., Jiang,H.,
            Sun,S., Xu,G., Xu,N., Xu,Q. and Liu,Y.
  TITLE     Ephrin B3 exacerbates colitis and colitis-associated colorectal
            cancer
  JOURNAL   Biochem Pharmacol 220, 116004 (2024)
   PUBMED   38142837
  REMARK    GeneRIF: Ephrin B3 exacerbates colitis and colitis-associated
            colorectal cancer.
REFERENCE   3  (bases 1 to 3231)
  AUTHORS   Yan,K., Bormuth,I., Bormuth,O., Tutukova,S., Renner,A., Bessa,P.,
            Schaub,T., Rosario,M. and Tarabykin,V.
  TITLE     TrkB-dependent EphrinA reverse signaling regulates callosal axon
            fasciculate growth downstream of Neurod2/6
  JOURNAL   Cereb Cortex 33 (5), 1752-1767 (2023)
   PUBMED   35462405
REFERENCE   4  (bases 1 to 3231)
  AUTHORS   Yang,K.Y., Zhao,S., Feng,H., Shen,J., Chen,Y., Wang,S.T.,
            Wang,S.J., Zhang,Y.X., Wang,Y., Guo,C., Liu,H. and Tang,T.S.
  TITLE     Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum
            development via ERK signaling
  JOURNAL   Cell Death Dis 13 (8), 674 (2022)
   PUBMED   35927240
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3231)
  AUTHORS   Bernhardt,N., Memic,F., Velica,A., Tran,M.A., Vieillard,J.,
            Sayyab,S., Chersa,T., Andersson,L., Whelan,P.J., Boije,H. and
            Kullander,K.
  TITLE     Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally
            Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26
  JOURNAL   eNeuro 9 (2) (2022)
   PUBMED   35210288
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3231)
  AUTHORS   Wang,H.U., Chen,Z.F. and Anderson,D.J.
  TITLE     Molecular distinction and angiogenic interaction between embryonic
            arteries and veins revealed by ephrin-B2 and its receptor Eph-B4
  JOURNAL   Cell 93 (5), 741-753 (1998)
   PUBMED   9630219
REFERENCE   7  (bases 1 to 3231)
  AUTHORS   Bergemann,A.D., Zhang,L., Chiang,M.K., Brambilla,R., Klein,R. and
            Flanagan,J.G.
  TITLE     Ephrin-B3, a ligand for the receptor EphB3, expressed at the
            midline of the developing neural tube
  JOURNAL   Oncogene 16 (4), 471-480 (1998)
   PUBMED   9484836
REFERENCE   8  (bases 1 to 3231)
  AUTHORS   .
  TITLE     Unified nomenclature for Eph family receptors and their ligands,
            the ephrins. Eph Nomenclature Committee
  JOURNAL   Cell 90 (3), 403-404 (1997)
   PUBMED   9267020
REFERENCE   9  (bases 1 to 3231)
  AUTHORS   Gale,N.W., Flenniken,A., Compton,D.C., Jenkins,N., Copeland,N.G.,
            Gilbert,D.J., Davis,S., Wilkinson,D.G. and Yancopoulos,G.D.
  TITLE     Elk-L3, a novel transmembrane ligand for the Eph family of receptor
            tyrosine kinases, expressed in embryonic floor plate, roof plate
            and hindbrain segments
  JOURNAL   Oncogene 13 (6), 1343-1352 (1996)
   PUBMED   8808709
REFERENCE   10 (bases 1 to 3231)
  AUTHORS   Brambilla,R., Bruckner,K., Orioli,D., Bergemann,A.D., Flanagan,J.G.
            and Klein,R.
  TITLE     Similarities and differences in the way transmembrane-type ligands
            interact with the Elk subclass of Eph receptors
  JOURNAL   Mol Cell Neurosci 8 (2-3), 199-209 (1996)
   PUBMED   8918835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ065252.1, BC058617.1 and BE955272.1.
            
            On Apr 15, 2009 this sequence version replaced NM_007911.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058617.1, AK048305.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                CJ065252.1         2-68
            68-3179             BC058617.1         1-3112
            3180-3231           BE955272.1         1-52                c
FEATURES             Location/Qualifiers
     source          1..3231
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.8 cM"
     gene            1..3231
                     /gene="Efnb3"
                     /gene_synonym="EFL-6; ELF-3; Elk-L3; Epl8; LERK-8;
                     NLERK-2"
                     /note="ephrin B3"
                     /db_xref="GeneID:13643"
                     /db_xref="MGI:MGI:109196"
     exon            1..546
                     /gene="Efnb3"
                     /gene_synonym="EFL-6; ELF-3; Elk-L3; Epl8; LERK-8;
                     NLERK-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1447
                     /gene="Efnb3"
                     /gene_synonym="EFL-6; ELF-3; Elk-L3; Epl8; LERK-8;
                     NLERK-2"
                     /codon_start=1
                     /product="ephrin-B3 precursor"
                     /protein_id="NP_031937.1"
                     /db_xref="CCDS:CCDS24896.1"
                     /db_xref="GeneID:13643"
                     /db_xref="MGI:MGI:109196"
                     /translation="MGAPHFGPGGVQVGALLLLGFAGLVSGLSLEPVYWNSANKRFQA
                     EGGYVLYPQIGDRLDLLCPRARPPGPHSSPSYEFYKLYLVEGAQGRRCEAPPAPNLLL
                     TCDRPDLDLRFTIKFQEYSPNLWGHEFRSHHDYYIIATSDGTREGLESLQGGVCLTRG
                     MKVLLRVGQSPRGGAVPRKPVSEMPMERDRGAAHSAEPGRDTIPGDPSSNATSRGAEG
                     PLPPPSMPAVAGAAGGMALLLLGVAGAGGAMCWRRRRAKPSESRHPGPGSFGRGGSLG
                     LGGGGGMGPREAEPGELGIALRGGGTADPPFCPHYEKVSGDYGHPVYIVQDGPPQSPP
                     NIYYKV"
     exon            547..839
                     /gene="Efnb3"
                     /gene_synonym="EFL-6; ELF-3; Elk-L3; Epl8; LERK-8;
                     NLERK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            840..932
                     /gene="Efnb3"
                     /gene_synonym="EFL-6; ELF-3; Elk-L3; Epl8; LERK-8;
                     NLERK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1037
                     /gene="Efnb3"
                     /gene_synonym="EFL-6; ELF-3; Elk-L3; Epl8; LERK-8;
                     NLERK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..3215
                     /gene="Efnb3"
                     /gene_synonym="EFL-6; ELF-3; Elk-L3; Epl8; LERK-8;
                     NLERK-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3189..3194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efnb3"
                     /gene_synonym="EFL-6; ELF-3; Elk-L3; Epl8; LERK-8;
                     NLERK-2"
                     /note="hexamer: AATAAA"
     polyA_site      3215
                     /gene="Efnb3"
                     /gene_synonym="EFL-6; ELF-3; Elk-L3; Epl8; LERK-8;
                     NLERK-2"
                     /note="major polyA site"
ORIGIN      
        1 tcctttaact cccccctcct gggctcggga ctggtttcct cccttagccc gctgccctca
       61 atcccggcga ggctggggct ccagctcggt gtctccttct tcgctccctt gcccggcgcc
      121 tcatgttgcc cccgcccggc cctcggctcc ccatgtcccc cacgtagcgg ggcgcacaaa
      181 tcccgaggtg cggcgcgtgg gccgggggcg cgtaaggcgc ctgcagacgg cccctgcaag
      241 ggttcttgtg gggctgagcg ctctggagcc ggggagcaag catcgcagaa aagagggtcc
      301 ttgtgggagc tgggggtgac tagccaccca ccagggtgac tggggttcca cagcgtggta
      361 gccacccctg ggggtgagag actttggggg agttggtgcc ccgcccccag gccttggtag
      421 ggtcatgggg gccccccatt ttgggccagg gggtgtgcaa gtcggggccc tgctgctgtt
      481 aggttttgcg gggctggtat ctggactcag cctggagcct gtctactgga actcggcgaa
      541 taagaggttc caggcagagg gcggttacgt gctttatcct cagatcgggg accggctaga
      601 tctactttgt ccccgggctc ggcctcctgg cccccactcc tctcctagtt atgagttcta
      661 caaactgtac ctggtagagg gtgcccaggg tcggcgttgt gaggcacccc ctgccccaaa
      721 ccttcttctc acatgtgacc ggccagacct ggacctccgc ttcaccatca agttccagga
      781 atacagccct aacctctggg gccacgagtt ccgatcccac cacgattact acataattgc
      841 cacatcagac gggacccggg aaggccttga gagcttgcaa ggaggcgtgt gcctaaccag
      901 aggcatgaag gtgcttctgc gagtgggaca aagtccccga ggaggagctg taccccgaaa
      961 acctgtgtct gaaatgccca tggagagaga cagaggggca gctcacagcg cggaacctgg
     1021 gagggacacc ataccaggtg accccagcag caatgcaacc tcccggggtg ctgaaggccc
     1081 cctgccccct cccagcatgc ccgcagtggc tggggcagca ggggggatgg cgctgctctt
     1141 gctgggcgtg gcaggggctg ggggtgccat gtgttggcgg agacggcggg ccaagccttc
     1201 ggagagtcgc caccctggtc ctggctcctt tgggagggga gggtctctgg gcctgggtgg
     1261 tggaggaggg atggggcctc gggaagctga gcctggggag ctaggaatag ccctgcgggg
     1321 tggtgggact gcagaccccc ccttctgccc tcactacgag aaggtgagcg gtgactatgg
     1381 gcaccctgtg tacattgtgc aggatgggcc cccccagagc cctccgaaca tctattacaa
     1441 ggtatgaggg ctcctcccac ctggctctcc tcaatctagc cgtccatggg gtgctcctcc
     1501 agtgtaattc atggtatgag ggacacctgc gccatgactt tggccccctt tgccctacca
     1561 gctctttggc tcctcctggc tatagccctc atctccaatt ttaggatccc ttaagacttg
     1621 actacacctt ttcctgacct ccccgactga ccctcatttg actgtgggca ctcctctgtt
     1681 tctgcctctt aggggagggg ggtcacaggc tcagcctccc ttaatcacta cccaggtgtc
     1741 ctttctccct cacccaccca gagtgggggt ggggacagtc tgtcttttgg ttggcacctc
     1801 tttctgcctc tcaccatttt tctcttctct ctatttctta ttctctctct ctcctgtgtc
     1861 taggtctgtt ctcttcctcc tccctagcct cctccttaca tctcctttta ccctctcggc
     1921 ttcttgtcct tcctgtgcct ctcacgtgtc tcctgggttg gggcatcaaa gcatctctcc
     1981 tctttgctct tggccctttc caacctttca taccaactgc tcccctctgt ccgccaaaaa
     2041 cgggggcttg cggggggtgg gggggagatt ctggaactct acccccccag ctccaggcat
     2101 gggcacaggg cctctttccc tgcctttctg tgtacttact ccagccattt ggggtggtta
     2161 ttgggccaca actactacca tgagaagaag tgtcctgttg tggccagtgg ctgataggaa
     2221 gacatgaagc agtgtggaca tgatggactg tgtctgatgc cgaatgggca tcagatagga
     2281 agtgactcgt tccagacaag aagtgaccag gcctggacag aaatggcctg ggaagtgtcc
     2341 gcagcaggaa ctggaagtgc cttcatccag aacaggaagt cgcacttctg aaataggaag
     2401 tggtctggct ggaattccaa gtggcttagt ctggggaggt ggcctgggtg ggggtggggg
     2461 catgggaagt ggatggttct taccctgtgg agaaaggggc aggaggaact ccctgcttta
     2521 ggaggaagct ggaacttacc actgtgagag gacagatgtg gactgagagt tttcttagtg
     2581 ttcagtggca cttcccaagg accccttccc ttgtgctctg tgcagttttt aggacagcta
     2641 agatgactgc cacttgctgt ggcaggccca atttgtcttg ttctcccctt actgtacccc
     2701 agtataatct ctgttgatca acagaactac cccaagaacc cacatgttct ccccacctaa
     2761 ccagacggct gtctggctga tgccttcctc ccttcaagcc caacacagcg cccttgtcag
     2821 tgaagaggtg gtccatggac tggtctagct gatggcagtt attagcactg gttgctgttt
     2881 ccatagtgac aagcctatac ctcttcccgc tctttagtgt gcagtgggct gctgcctcgg
     2941 tgttctcccg cctcagtttt attagatcaa agctgccctt ggccatcatg ttggccacct
     3001 caatcaccag ccaaaatggt tgctttgtcc accagaggtc aagccatctc tctggcgctg
     3061 tagttcccag ctccttctag ggaacaggaa gttgatattg ccattgggga ggtggcgggg
     3121 tatggccgtc acctcgatag ttttattgta aaagggaaat ttgaacaaca acaaaaaaac
     3181 tggaaaaaaa taaaaaaaaa aactttaaaa gttgaaaaaa aaaaaaaaaa a
//
