LOCUS       NM_010111               4793 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus ephrin B2 (Efnb2), transcript variant 1, mRNA.
ACCESSION   NM_010111
VERSION     NM_010111.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4793)
  AUTHORS   Trinh,L.T., Finnel,R.R., Osipovich,A.B., Musselman,J.R.,
            Sampson,L.L., Wright,C.V.E. and Magnuson,M.A.
  TITLE     Positive autoregulation of Sox17 is necessary for gallbladder and
            extrahepatic bile duct formation
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39745200
REFERENCE   2  (bases 1 to 4793)
  AUTHORS   Nord,C., Jones,I., Garcia-Maestre,M., Hagglund,A.C. and Carlsson,L.
  TITLE     Reduced mTORC1-signaling in progenitor cells leads to retinal
            lamination deficits
  JOURNAL   Dev Dyn 253 (10), 922-939 (2024)
   PUBMED   38546215
REFERENCE   3  (bases 1 to 4793)
  AUTHORS   Tu,L., Cheng,W., Wang,X., Li,Z. and Li,X.
  TITLE     Circular RNA circEfnb2 promotes cell injury after cerebral
            infarction by sponging miR-202-5p and regulating TRAF3 expression
  JOURNAL   Transpl Immunol 84, 102042 (2024)
   PUBMED   38527707
  REMARK    GeneRIF: Circular RNA circEfnb2 promotes cell injury after cerebral
            infarction by sponging miR-202-5p and regulating TRAF3 expression.
REFERENCE   4  (bases 1 to 4793)
  AUTHORS   Fowler,J.L., Zheng,S.L., Nguyen,A., Chen,A., Xiong,X., Chai,T.,
            Chen,J.Y., Karigane,D., Banuelos,A.M., Niizuma,K., Kayamori,K.,
            Nishimura,T., Cromer,M.K., Gonzalez-Perez,D., Mason,C., Liu,D.D.,
            Yilmaz,L., Miquerol,L., Porteus,M.H., Luca,V.C., Majeti,R.,
            Nakauchi,H., Red-Horse,K., Weissman,I.L., Ang,L.T. and Loh,K.M.
  TITLE     Lineage-tracing hematopoietic stem cell origins in vivo to
            efficiently make human HLF+ HOXA+ hematopoietic progenitors from
            pluripotent stem cells
  JOURNAL   Dev Cell 59 (9), 1110-1131 (2024)
   PUBMED   38569552
REFERENCE   5  (bases 1 to 4793)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4793)
  AUTHORS   Ronchi,A., Berry,M., Raguz,S., Imam,A., Yannoutsos,N.,
            Ottolenghi,S., Grosveld,F. and Dillon,N.
  TITLE     Role of the duplicated CCAAT box region in gamma-globin gene
            regulation and hereditary persistence of fetal haemoglobin
  JOURNAL   EMBO J 15 (1), 143-149 (1996)
   PUBMED   8598197
REFERENCE   7  (bases 1 to 4793)
  AUTHORS   Cerretti,D.P., Vanden Bos,T., Nelson,N., Kozlosky,C.J., Reddy,P.,
            Maraskovsky,E., Park,L.S., Lyman,S.D., Copeland,N.G., Gilbert,D.J.
            et al.
  TITLE     Isolation of LERK-5: a ligand of the eph-related receptor tyrosine
            kinases
  JOURNAL   Mol Immunol 32 (16), 1197-1205 (1995)
   PUBMED   8559144
REFERENCE   8  (bases 1 to 4793)
  AUTHORS   Bergemann,A.D., Cheng,H.J., Brambilla,R., Klein,R. and
            Flanagan,J.G.
  TITLE     ELF-2, a new member of the Eph ligand family, is segmentally
            expressed in mouse embryos in the region of the hindbrain and newly
            forming somites
  JOURNAL   Mol Cell Biol 15 (9), 4921-4929 (1995)
   PUBMED   7651410
REFERENCE   9  (bases 1 to 4793)
  AUTHORS   Bennett,B.D., Zeigler,F.C., Gu,Q., Fendly,B., Goddard,A.D.,
            Gillett,N. and Matthews,W.
  TITLE     Molecular cloning of a ligand for the EPH-related receptor
            protein-tyrosine kinase Htk
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 1866-1870 (1995)
   PUBMED   7534404
REFERENCE   10 (bases 1 to 4793)
  AUTHORS   Bonaldo,M.F., Yu,M.T., Jelenc,P., Brown,S., Su,L., Lawton,L.,
            Deaven,L., Efstratiadis,A., Warburton,D. and Soares,M.B.
  TITLE     Selection of cDNAs using chromosome-specific genomic clones:
            application to human chromosome 13
  JOURNAL   Hum Mol Genet 3 (9), 1663-1673 (1994)
   PUBMED   7833926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138368.8 and AC161867.6.
            
            On Feb 5, 2019 this sequence version replaced NM_010111.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L38847.1, AK142283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-759               AC138368.8         86090-86848
            760-1043            AC138368.8         107843-108126
            1044-1136           AC161867.6         165822-165914       c
            1137-1250           AC161867.6         165005-165118       c
            1251-4793           AC161867.6         160108-163650       c
FEATURES             Location/Qualifiers
     source          1..4793
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 3.42 cM"
     gene            1..4793
                     /gene="Efnb2"
                     /gene_synonym="ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5;
                     NLERK-1"
                     /note="ephrin B2"
                     /db_xref="GeneID:13642"
                     /db_xref="MGI:MGI:105097"
     exon            1..759
                     /gene="Efnb2"
                     /gene_synonym="ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5;
                     NLERK-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             629..1639
                     /gene="Efnb2"
                     /gene_synonym="ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5;
                     NLERK-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; HTK ligand; EPH-related receptor tyrosine
                     kinase ligand 5"
                     /codon_start=1
                     /product="ephrin-B2 isoform 1 precursor"
                     /protein_id="NP_034241.2"
                     /db_xref="CCDS:CCDS22090.1"
                     /db_xref="GeneID:13642"
                     /db_xref="MGI:MGI:105097"
                     /translation="MAMARSRRDSVWKYCWGLLMVLCRTAISRSIVLEPIYWNSSNSK
                     FLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKENTPLL
                     NCARPDQDVKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRA
                     MKILMKVGQDASSAGSARNHGPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGH
                     SGNNLLGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLA
                     TPKRGGNNNGSEPSDVIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYY
                     KV"
     exon            760..1043
                     /gene="Efnb2"
                     /gene_synonym="ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5;
                     NLERK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1136
                     /gene="Efnb2"
                     /gene_synonym="ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5;
                     NLERK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1250
                     /gene="Efnb2"
                     /gene_synonym="ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5;
                     NLERK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..4793
                     /gene="Efnb2"
                     /gene_synonym="ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5;
                     NLERK-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4317..4322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efnb2"
                     /gene_synonym="ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5;
                     NLERK-1"
                     /note="hexamer: AATAAA"
     polyA_site      4339
                     /gene="Efnb2"
                     /gene_synonym="ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5;
                     NLERK-1"
                     /note="major polyA site"
     regulatory      4766..4771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efnb2"
                     /gene_synonym="ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5;
                     NLERK-1"
                     /note="hexamer: AATAAA"
     polyA_site      4793
                     /gene="Efnb2"
                     /gene_synonym="ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5;
                     NLERK-1"
                     /note="major polyA site"
ORIGIN      
        1 gctgactctc cgcggcgggg acagaggcac cggtcggatc gcggagctgc gcgcagagcg
       61 ggtcctggcg ccctccccgc acacaaaggc ccgcgcgcgt cagacgcctg cgggggttcc
      121 agtgctctcc tgactgctta gtggccgcga gttgcgagga ttcaggaggc gccctttatc
      181 tctgcgctcc aggacatgga accgcgccga cgcggcgctc gcttgcccgg gccactgccc
      241 gctgtcctgg atctatagtc aggcggcccc tctcggggag cagcacccgc cgcctcacac
      301 cgactcgtct ctccgctgcg ggcctttgtc ccggcccagt gccctcgccg cgcccgccct
      361 ccgcggctgg cccggcaccc tggagccgca cgggagccga ctgtcccagc tgcgtccggc
      421 gcagcgcccc ggagccccga gtccgccgag ccgccgcgcc ccgcgcgttc gaccccaccc
      481 cgcgcgctga gggacgcgca gggtgagcgc acctggcctc ggcgaccgcg ggagcggcgc
      541 ggcgtgtccg ccccggagga ttgggggtcg ctgcccgcgg ccggtcccaa cgcgtcccgg
      601 agtgcgcaga actgggagcg gcttgggcat ggccatggcc cggtccagga gggactctgt
      661 gtggaagtac tgttggggac ttttgatggt tttgtgcaga actgcgatct ccagatcgat
      721 agttttagag cctatctact ggaattcctc gaactccaaa tttctacccg gacaaggcct
      781 ggtactatac ccacagatag gagacaaatt ggatattatt tgccccaaag tggactctaa
      841 aactgttggc cagtatgaat attataaagt ttatatggtt gataaagacc aagcagacag
      901 atgcacaatt aagaaggaga ataccccgct gctcaactgt gccagaccag accaagatgt
      961 gaaattcacc atcaagtttc aagaattcag ccctaacctc tggggtctag aatttcagaa
     1021 gaacaaagat tactacatta tatctacatc aaatgggtct ttggagggcc tggataacca
     1081 ggagggaggg gtgtgccaga caagagccat gaagatcctc atgaaagttg gacaagatgc
     1141 aagttctgct ggatcagcca ggaatcacgg tccaacaaga cgtccagagc tagaagctgg
     1201 tacaaatggg agaagttcaa caacaagtcc ctttgtgaag ccaaatccag gttctagcac
     1261 cgatggcaac agcgcggggc attccgggaa caatctcctg ggttccgaag tggccttatt
     1321 cgcagggatc gcatcaggat gcatcatctt catcgtcatc atcatcactt tggtggtgct
     1381 gctgctcaag taccgcagga gacaccgcaa acactctcca cagcacacga ccacgctgtc
     1441 tctcagcaca ctggccacgc ccaagcgagg tggcaacaac aatggctcgg agcccagtga
     1501 cgttatcata ccactaagga ctgcagacag cgtcttctgc ccgcactacg agaaggtcag
     1561 cggggactat gggcacccgg tgtacatcgt gcaggagatg cccccacaga gtcctgccaa
     1621 catttactac aaggtctgag gcctgagacc tgcgcctccc aagggaactc gcaccttgtt
     1681 cttgggcacg cagggactgc ctgagcctgg ctgtgggggc aggatgcctc ctggaagagc
     1741 ctggatctgg acagttttgt agtctgtagc ttttccgacc ctggggacca cagaccctcc
     1801 ccggaagctg gaagactgct aggagatccc cacttggact gccgcggccc cacgcggacc
     1861 tccaagccat gcacccagcc actcaggcct ctgcagagcc cggggaggac acggtaggct
     1921 atggatggcg cagcagcatc ttaggagaag gttgcgcacc aggccggccc ctgcctccac
     1981 gtttcctgcc gtgcacactg gacttatcac ttggacctcg ggttcagtaa ggttttcaaa
     2041 gatctctagt gtttagtcct cactcactca ctcactcact cactccttct cttgccaggg
     2101 ctctgcagca aactccctag acccctcact ccacgtactg catcattacg ggacactcac
     2161 cacagagtcc cagctccacc ctttacacca agatcaaatt agatgggtat taggtacaga
     2221 agaaccctgc ttgcctggag gccgggtcag ccgggaagcg cagatgtgtg gaggagtgag
     2281 gaggtgctgg ctgccacggc aggtcaaggc tgcttgctgc ccctggagca tagtagggat
     2341 gcaggaagga aatagataat gctttggttt ttctgagagg acagagacag gtgggaggtg
     2401 actgactggt gagtggtggg gagcctttca ctaccacaca gctatgcagc agggaatcaa
     2461 aagtccctct cctgcgggga acaaaggggc cattgttgtg aaaggaccag ctagagcaca
     2521 gagggagagg gcaggcctcc ggtgaagtgc tggggcagaa ctgcagaggt actggaaata
     2581 aaaagcgcag cgcagagctg tgggagagtc cgtctgcttt gggagatgtt ttaagcagac
     2641 tcagctgcta tattaccacg tttttattaa aaacacaggg aaagcattta ggagaagagc
     2701 agagagccaa atctgaccta gaagttgaaa agccaaaggt caaacaggct gtaagtccat
     2761 caccactgag gttattggag aattctcatt aggaaaggca ggtcagattc cccaggcccc
     2821 ataagtgccc cttccccctc cctgattgag ccttacacgt tggtttttgg tttatggccg
     2881 tgctgtccgg gctccaaggc agtacccggg ctccatgtca aagcaaagca cacatggccc
     2941 acctcttaga gtccttgaga tggaagtaag ttatgccgcg gaaggaaagg cgaagatagg
     3001 acatatttat aataggtgta tagaacacaa gggatataaa atgaaagatt tttactaata
     3061 tatattttaa gattacacac aatacacacc agaagacgtg gagttcggtg gtggtggtgg
     3121 tcgtggtggt ggtgattaaa gtgaccccag cgcttagtgc tttaaaaagt gaaagattgg
     3181 gtagctactc cccgaaacgt accaatagca agaaaagtat ccataatgag agcaaatggc
     3241 aaaaataaca cggtcctgcg ggaatctcgc agaaccgtag actaggaatg ccagcccccc
     3301 aaattgatgt gaccctgccc cgggttagac aatgataaaa tgcgctggcc tttattttct
     3361 gtgttgggtt ttcccttgcc ttatgggctg aagtgttctc tagaatttag caggtcacac
     3421 tgaggggatt ccagtttaac tgtgggtccc tcctcctctc ctaccccatc cctgcccttc
     3481 cagagaataa caggaagcct tccttttttt ttttttttaa gtgctatgca aaagagacat
     3541 ctttaacaga gtcctgttac tatggtaaca ttttgctttc tgaattggga ggaaataaaa
     3601 attgtaatga cagcatttga aggttctcag acctccagtg agtacctgca aaaatgagtt
     3661 gtcacagaga ttattcccta cttctcaaac ctgaaaatga tgttggttcg atgtgtgtgt
     3721 gtgtgtatga gtgggtgtgt ggtacatgtg tgtacatata tgtataatat atatctccag
     3781 tatatattat atatatctat atcatatttc tgtggagggt tgccatggca atcaactgca
     3841 gtacatatgt agttctttcc atcaccctaa cctctcctgc gcattcacac aagagtttct
     3901 tgtaagccat caaaagttaa ttctaggggg agagggatga ggcggggaga catgggaaac
     3961 cgtctgattt taatgaaatc aaatgtctgt gtcatcggtt ggctacgttt tggttctatg
     4021 ctaaactgtg aagaatcgga tgaattgatg aagagttgag ttacctgcaa cccattgaga
     4081 agtgtcctgt gcgtctgttt tgtgtctggt gcagaaaatg acaatctacc aactgtcccc
     4141 ttatttggag ttggttcagc tttggaaagt tactgtaaat gccttgcttg tattatcatc
     4201 cctagtcacc tgacttcgga gcttgcacca tcgtgtttta agtgaagacg ctgtaaatag
     4261 gttcagatct taccgtctat ggattcgggt gttacagtag ccttattcac ctttttaata
     4321 aaaatacaca tgaaaacgag acagtaatgg cttttcttac ccagattgtg tacatagagc
     4381 aatgttggtt ttttataaag tctaagcaag atgttttgta taaaatctga attttgcaat
     4441 gtatttagct acagcttgtt taacggcagt gtcatcccct ttgcactgta atgaggaaaa
     4501 aaaaaaggta taaaaggttg ccaaattgct gcatatttgt gccgtaatta tgtaccatga
     4561 atatttattt aatttcgttg tccaatttgt aagtaacaca gtattatgct tgagttataa
     4621 atattttttc tttgttttat tttaatagcc tgtcataggt ttttttttta atctgcttta
     4681 gttccacatg acagttaagc cccagaaatg agatccgagc agccacattc cacgtctgtt
     4741 tcaaaatgaa tttgttctta aaaaaaataa aatatttttt tcctatggaa aaa
//
