LOCUS       NM_010110               3375 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ephrin B1 (Efnb1), mRNA.
ACCESSION   NM_010110
VERSION     NM_010110.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3375)
  AUTHORS   Sutley-Koury,S.N., Taitano-Johnson,C., Kulinich,A.O., Farooq,N.,
            Wagner,V.A., Robles,M., Hickmott,P.W., Santhakumar,V., Mimche,P.N.
            and Ethell,I.M.
  TITLE     EphB2 Signaling Is Implicated in Astrocyte-Mediated Parvalbumin
            Inhibitory Synapse Development
  JOURNAL   J Neurosci 44 (45), e0154242024 (2024)
   PUBMED   39327008
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3375)
  AUTHORS   Thowfeequ,S., Fiorentino,J., Hu,D., Solovey,M., Ruane,S.,
            Whitehead,M., Zhou,F., Godwin,J., Mateo-Otero,Y.,
            Vanhaesebroeck,B., Scialdone,A. and Srinivas,S.
  TITLE     An integrated approach identifies the molecular underpinnings of
            murine anterior visceral endoderm migration
  JOURNAL   Dev Cell 59 (17), 2347-2363 (2024)
   PUBMED   38843837
REFERENCE   3  (bases 1 to 3375)
  AUTHORS   Sutley-Koury,S.N., Anderson,A., Taitano-Johnson,C., Ajayi,M.,
            Kulinich,A.O., Contreras,K., Regalado,J., Tiwari-Woodruff,S.K. and
            Ethell,I.M.
  TITLE     Astrocytic Ephrin-B1 Regulates Oligodendrocyte Development and
            Myelination
  JOURNAL   ASN Neuro 16 (1), 2401753 (2024)
   PUBMED   39437409
  REMARK    GeneRIF: Astrocytic Ephrin-B1 Regulates Oligodendrocyte Development
            and Myelination.
REFERENCE   4  (bases 1 to 3375)
  AUTHORS   Gao,G., Li,X., Jiang,Z., Osorio,L., Tang,Y.L., Yu,X., Jin,G. and
            Zhou,Z.
  TITLE     Isthmin-1 (Ism1) modulates renal branching morphogenesis and
            mesenchyme condensation during early kidney development
  JOURNAL   Nat Commun 14 (1), 2378 (2023)
   PUBMED   37185772
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3375)
  AUTHORS   Karsenty,C., Guilbeau-Frugier,C., Genet,G., Seguelas,M.H.,
            Alzieu,P., Cazorla,O., Montagner,A., Blum,Y., Dubroca,C.,
            Maupoint,J., Tramunt,B., Cauquil,M., Sulpice,T., Richard,S.,
            Arcucci,S., Flores-Flores,R., Pataluch,N., Montoriol,R., Sicard,P.,
            Deney,A., Couffinhal,T., Senard,J.M. and Gales,C.
  TITLE     Ephrin-B1 regulates the adult diastolic function through a late
            postnatal maturation of cardiomyocyte surface crests
  JOURNAL   Elife 12, e80904 (2023)
   PUBMED   36649053
  REMARK    GeneRIF: Ephrin-B1 regulates the adult diastolic function through a
            late postnatal maturation of cardiomyocyte surface crests.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3375)
  AUTHORS   Henkemeyer,M., Orioli,D., Henderson,J.T., Saxton,T.M., Roder,J.,
            Pawson,T. and Klein,R.
  TITLE     Nuk controls pathfinding of commissural axons in the mammalian
            central nervous system
  JOURNAL   Cell 86 (1), 35-46 (1996)
   PUBMED   8689685
REFERENCE   7  (bases 1 to 3375)
  AUTHORS   Bergemann,A.D., Cheng,H.J., Brambilla,R., Klein,R. and
            Flanagan,J.G.
  TITLE     ELF-2, a new member of the Eph ligand family, is segmentally
            expressed in mouse embryos in the region of the hindbrain and newly
            forming somites
  JOURNAL   Mol Cell Biol 15 (9), 4921-4929 (1995)
   PUBMED   7651410
REFERENCE   8  (bases 1 to 3375)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
REFERENCE   9  (bases 1 to 3375)
  AUTHORS   Fletcher,F.A., Renshaw,B., Hollingsworth,T., Baum,P., Lyman,S.D.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Davison,B.L.
  TITLE     Genomic organization and chromosomal localization of mouse Eplg2, a
            gene encoding a binding protein for the receptor tyrosine kinase
            elk
  JOURNAL   Genomics 24 (1), 127-132 (1994)
   PUBMED   7896266
REFERENCE   10 (bases 1 to 3375)
  AUTHORS   Shao,H., Lou,L., Pandey,A., Pasquale,E.B. and Dixit,V.M.
  TITLE     cDNA cloning and characterization of a ligand for the Cek5 receptor
            protein-tyrosine kinase
  JOURNAL   J Biol Chem 269 (43), 26606-26609 (1994)
   PUBMED   7929389
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL671478.9, AK034996.1,
            BQ177892.1 and BI988800.1.
            
            On May 7, 2015 this sequence version replaced NM_010110.4.
            
            Summary: This gene encodes a membrane protein that acts as a ligand
            for Eph family receptors. Signalling occurs bidirectionally in both
            the cell containing the receptor and the cell expressing this
            protein. Activity of this protein is important in neuronal axon
            growth and other developmental processes. [provided by RefSeq, May
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018572.1, AK034996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AL671478.9         26516-26584
            70-2155             AK034996.1         2-2087
            2156-2300           BQ177892.1         252-396
            2301-3020           AK034996.1         2233-2952
            3021-3375           BI988800.1         77-431
FEATURES             Location/Qualifiers
     source          1..3375
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.22 cM"
     gene            1..3375
                     /gene="Efnb1"
                     /gene_synonym="Cek5-L; EFL-3; Elk-L; Epl2; Eplg2; LERK-2;
                     Lerk2; Stra1"
                     /note="ephrin B1"
                     /db_xref="GeneID:13641"
                     /db_xref="MGI:MGI:102708"
     exon            1..953
                     /gene="Efnb1"
                     /gene_synonym="Cek5-L; EFL-3; Elk-L; Epl2; Eplg2; LERK-2;
                     Lerk2; Stra1"
                     /inference="alignment:Splign:2.1.0"
     CDS             826..1863
                     /gene="Efnb1"
                     /gene_synonym="Cek5-L; EFL-3; Elk-L; Epl2; Eplg2; LERK-2;
                     Lerk2; Stra1"
                     /note="ELK ligand; CEK5 receptor ligand; stimulated by
                     retinoic acid gene 1 protein; EPH-related receptor
                     tyrosine kinase ligand 2; Cek ligand"
                     /codon_start=1
                     /product="ephrin-B1 precursor"
                     /protein_id="NP_034240.1"
                     /db_xref="CCDS:CCDS30298.1"
                     /db_xref="GeneID:13641"
                     /db_xref="MGI:MGI:102708"
                     /translation="MARPGQRWLSKWLVAMVVLTLCRLATPLAKNLEPVSWSSLNPKF
                     LSGKGLVIYPKIGDKLDIICPRAEAGRPYEYYKLYLVRPEQAAACSTVLDPNVLVTCN
                     KPHQEIRFTIKFQEFSPNYMGLEFKKYHDYYITSTSNGSLEGLENREGGVCRTRTMKI
                     VMKVGQDPNAVTPEQLTTSRPSKESDNTVKTATQAPGRGSQGDSDGKHETVNQEEKSG
                     PGAGGGGSGDSDSFFNSKVALFAAVGAGCVIFLLIIIFLTVLLLKLRKRHRKHTQQRA
                     AALSLSTLASPKGGSGTAGTEPSDIIIPLRTTENNYCPHYEKVSGDYGHPVYIVQEMP
                     PQSPANIYYKV"
     exon            954..1231
                     /gene="Efnb1"
                     /gene_synonym="Cek5-L; EFL-3; Elk-L; Epl2; Eplg2; LERK-2;
                     Lerk2; Stra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1324
                     /gene="Efnb1"
                     /gene_synonym="Cek5-L; EFL-3; Elk-L; Epl2; Eplg2; LERK-2;
                     Lerk2; Stra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1450
                     /gene="Efnb1"
                     /gene_synonym="Cek5-L; EFL-3; Elk-L; Epl2; Eplg2; LERK-2;
                     Lerk2; Stra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..3358
                     /gene="Efnb1"
                     /gene_synonym="Cek5-L; EFL-3; Elk-L; Epl2; Eplg2; LERK-2;
                     Lerk2; Stra1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3274..3279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efnb1"
                     /gene_synonym="Cek5-L; EFL-3; Elk-L; Epl2; Eplg2; LERK-2;
                     Lerk2; Stra1"
                     /note="hexamer: TATAAA"
     polyA_site      3291
                     /gene="Efnb1"
                     /gene_synonym="Cek5-L; EFL-3; Elk-L; Epl2; Eplg2; LERK-2;
                     Lerk2; Stra1"
                     /note="major polyA site"
     regulatory      3326..3331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efnb1"
                     /gene_synonym="Cek5-L; EFL-3; Elk-L; Epl2; Eplg2; LERK-2;
                     Lerk2; Stra1"
                     /note="hexamer: ACTAAA"
     polyA_site      3358
                     /gene="Efnb1"
                     /gene_synonym="Cek5-L; EFL-3; Elk-L; Epl2; Eplg2; LERK-2;
                     Lerk2; Stra1"
ORIGIN      
        1 aggagcaggg ttggccttgt gctcgcctga gcaggagagt agaaagctca gcggcagcgg
       61 agggagtcta tgcgcgctgg acagcagtgg ggggtgtgtg tgattcgcac tgactgcaga
      121 cactcgggct caatcgccgg ggattaagga cttggcgacc gggctgccgg gctacccggc
      181 cgaggcttca gaggtgcaaa tcgacgggac tgatttgctc ggcagggccg tactagcctt
      241 ttaagtatac tgagaagggc cggtgctaaa gtagaagctg tcgtgggacg cgccggcgcg
      301 gagtcccact gtggcccgga ggaacggagt ccgtgttagg gggacccagt cgggagcctg
      361 gggaccgagc tcgcattgtt gggagacaac ccgcctcttc ttcccagagg cgtcaatccc
      421 aggacggtcg aggcgtcggg gcagccactg agcgctcttc agggagaccc gatcggggag
      481 aggacttgca gtctcaaaca atctgggaga gccgagcgga atccggcggg atcactcggg
      541 ggcggcgagc ccccgtcgcg cctcgtgcgg cggagaggcc agggaagaaa gtcctcggag
      601 gccgcagccc atgcgcgggt tggggacgcc tgcccagtga gtcctcctgg ccagccgggc
      661 gaaggagagc gaccccgagg ccagcgggag gggagtgctt caaggccggc ggctgcggag
      721 gatgggcgcc tgagtggctc cgagcgctgc gcggcacggg caggcgaggc gagctttgct
      781 gaggaggcgc taggggatcc tgaagtgcat tctgccccgg ggaaaatggc ccggcctggg
      841 cagcgttggc tcagcaagtg gcttgtggct atggtcgtgc tgacgctgtg ccggcttgcc
      901 acgccgttgg ccaagaacct ggagcccgtg tcctggagct ctcttaaccc taagttccta
      961 agtgggaagg gcttggtgat ctacccgaag attggagaca agctggacat catctgcccc
     1021 cgagcagaag cagggcggcc ctacgagtac tacaagctgt acctggtgcg gccagagcag
     1081 gcggctgctt gcagcactgt gcttgatccc aatgtactgg tcacttgcaa caagccacac
     1141 caggaaatcc gcttcaccat caagttccaa gagttcagcc ccaactacat gggcctggaa
     1201 ttcaaaaagt accacgatta ctacattaca tcaacgtcca atgggagctt ggagggactg
     1261 gagaaccggg agggaggtgt gtgtcgcacc cgcactatga agatcgttat gaaggttggg
     1321 caagatccaa atgctgtgac acccgagcag ttgactacca gccggccaag caaggagtca
     1381 gacaacactg tcaagacagc cacacaggct cctggtcggg gatcccaggg tgactctgac
     1441 ggcaagcatg agactgtgaa ccaggaagag aagagtggcc caggtgcagg tggcggtggc
     1501 agcggggact ctgacagctt cttcaactcc aaggtagcat tgttcgcagc cgtcggcgcc
     1561 ggctgtgtca tcttcctgct catcatcatc ttcttgacag tcctactact caagctccgc
     1621 aagcgccatc gcaagcatac acagcagcgg gcggctgccc tctcgctcag taccctagcc
     1681 agccccaaag ggggtagtgg tacagcgggc accgagccca gcgacatcat catcccctta
     1741 cggactacag agaacaacta ctgcccccac tatgagaagg tgagtgggga ctacgggcat
     1801 cctgtctaca tcgtccagga gatgccccct cagagcccgg cgaacatcta ctacaaggtt
     1861 tgaaggccca gcatggcctc aggccccaca ggacacatgg cctggatcgg ccgctctctt
     1921 ctcccccaca cccctgccct tgccagctgt gcccaccttt gtatttagtt ttgtagtttc
     1981 ttggctttta taatcccctt tttcttgccc cctgggcttc ggaggggggt gcttgtgccc
     2041 ccaatcccca tgctcttgtg ccttccccct ctggccaggc ctctgggctc cgtgggggtg
     2101 ccctttctag gagggcaggg ttggacactg acggactgca ggcagggagg tagccccctg
     2161 gccctgcccc ctcctcatcc cttcacccat ccccaggact gctcgtccac tatcatcact
     2221 gtttttaatg cttttgtgtt gatttttttt aaagctgtca actcattttc atctgttttt
     2281 ttttttttga gaaaaaaaaa tgggaaaatg tacaaggcag ccccttccca ggctttctga
     2341 gcctggcctg acccagtcta agagggcctg gggcaggatg tggccagcca ggaaacatag
     2401 gatggcattt cttttataga ctccttagta gttcagggga gtgggggagg gtaggccagg
     2461 gctatttctg cccaccgagg agagaagagc gccaccctcc tttttggacc ctcatgagac
     2521 aatgctgttc ctagcagtgg ggtagtgact accacccttc taccaaaaaa aaaaaaaaat
     2581 cccttccttg tgggattctt gggcatctcc tgcctccttc actctcacgg taattaatgt
     2641 cttaattggc tgttgcctgg ggaacaggag agctgctgca ggcagatgac ctcatggggg
     2701 gtggagggag gtgaggtgcc caggtggcta tttgccctgc agagctggga gttcccccca
     2761 ccaccaccac cctgttctct ccttatcttt ggcatctttg gttcaaggtg gagatcttaa
     2821 gcgggtgtaa ggccaggcgg cctgctcctt ccctgggttc tagtacaaag cacacacacc
     2881 ccccactcac tcaatatggc tcccactgtc cccccacccc accccccgcc ccgagtttgg
     2941 agctggggcc tggaaagagg aagaggctgc ttggggctgg gccagcctgc agtgcacttt
     3001 gaccccagct ccttggcagc acggctgcta acagactgcc actcaactgt gcctcgcagg
     3061 cactcccagg gctgccatgg aaggagctgg gccttacacc acccacctcc acactgcctc
     3121 ctggccagct gcccaccccg gtgccaggtg ggagagggag caaaacagcc agccccttcc
     3181 aggtggcagt cggaagggat ttttgttttt gattctgttg ccatttgtgt aaatactagt
     3241 cttttttgga agaaataatg taaagatgtt ttgtataaac tctgaattat tttcttgttg
     3301 cttttttctt agaaaaaaaa tgagaactaa aaaaaaaaaa aaaaattaac cacatggaaa
     3361 aaaaaaaaaa aaaaa
//
