LOCUS       NM_207654               5381 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus ephrin A5 (Efna5), transcript variant 1, mRNA.
ACCESSION   NM_207654
VERSION     NM_207654.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5381)
  AUTHORS   Horner,J.L., Vu,M.P., Clark,J.T., Innis,I.J. and Cheng,C.
  TITLE     Canonical ligand-dependent and non-canonical ligand-independent
            EphA2 signaling in the eye lens of wild-type, knockout, and aging
            mice
  JOURNAL   Aging (Albany NY) 16 (20), 13039-13075 (2024)
   PUBMED   39466050
REFERENCE   2  (bases 1 to 5381)
  AUTHORS   Nord,C., Jones,I., Garcia-Maestre,M., Hagglund,A.C. and Carlsson,L.
  TITLE     Reduced mTORC1-signaling in progenitor cells leads to retinal
            lamination deficits
  JOURNAL   Dev Dyn 253 (10), 922-939 (2024)
   PUBMED   38546215
REFERENCE   3  (bases 1 to 5381)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   4  (bases 1 to 5381)
  AUTHORS   Thowfeequ,S., Fiorentino,J., Hu,D., Solovey,M., Ruane,S.,
            Whitehead,M., Zhou,F., Godwin,J., Mateo-Otero,Y.,
            Vanhaesebroeck,B., Scialdone,A. and Srinivas,S.
  TITLE     An integrated approach identifies the molecular underpinnings of
            murine anterior visceral endoderm migration
  JOURNAL   Dev Cell 59 (17), 2347-2363 (2024)
   PUBMED   38843837
REFERENCE   5  (bases 1 to 5381)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 5381)
  AUTHORS   Park,S. and Sanchez,M.P.
  TITLE     The Eek receptor, a member of the Eph family of tyrosine protein
            kinases, can be activated by three different Eph family ligands
  JOURNAL   Oncogene 14 (5), 533-542 (1997)
   PUBMED   9053851
REFERENCE   7  (bases 1 to 5381)
  AUTHORS   Marcus,R.C., Gale,N.W., Morrison,M.E., Mason,C.A. and
            Yancopoulos,G.D.
  TITLE     Eph family receptors and their ligands distribute in opposing
            gradients in the developing mouse retina
  JOURNAL   Dev Biol 180 (2), 786-789 (1996)
   PUBMED   8954746
REFERENCE   8  (bases 1 to 5381)
  AUTHORS   Flenniken,A.M., Gale,N.W., Yancopoulos,G.D. and Wilkinson,D.G.
  TITLE     Distinct and overlapping expression patterns of ligands for
            Eph-related receptor tyrosine kinases during mouse embryogenesis
  JOURNAL   Dev Biol 179 (2), 382-401 (1996)
   PUBMED   8903354
REFERENCE   9  (bases 1 to 5381)
  AUTHORS   Cerretti,D.P., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Kuefer,M.U., Valentine,V., Shapiro,D.N., Cui,X. and Morris,S.W.
  TITLE     The gene encoding LERK-7 (EPLG7, Epl7), a ligand for the
            Eph-related receptor tyrosine kinases, maps to human chromosome 5
            at band q21 and to mouse chromosome 17
  JOURNAL   Genomics 35 (2), 376-379 (1996)
   PUBMED   8661153
REFERENCE   10 (bases 1 to 5381)
  AUTHORS   Gale,N.W., Holland,S.J., Valenzuela,D.M., Flenniken,A., Pan,L.,
            Ryan,T.E., Henkemeyer,M., Strebhardt,K., Hirai,H., Wilkinson,D.G.,
            Pawson,T., Davis,S. and Yancopoulos,G.D.
  TITLE     Eph receptors and ligands comprise two major specificity subclasses
            and are reciprocally compartmentalized during embryogenesis
  JOURNAL   Neuron 17 (1), 9-19 (1996)
   PUBMED   8755474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154385.2 and AC134243.3.
            
            On Oct 27, 2022 this sequence version replaced NM_207654.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040218.1, SRR13948564.855041.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-431               AC154385.2         214527-214957       c
            432-724             AC134243.3         98501-98793         c
            725-790             AC134243.3         61496-61561         c
            791-871             AC134243.3         60975-61055         c
            872-5381            AC134243.3         50613-55122         c
FEATURES             Location/Qualifiers
     source          1..5381
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 32.57 cM"
     gene            1..5381
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /note="ephrin A5"
                     /db_xref="GeneID:13640"
                     /db_xref="MGI:MGI:107444"
     exon            1..431
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..993
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; EPH-related receptor tyrosine kinase ligand 7"
                     /codon_start=1
                     /product="ephrin-A5 isoform 1 precursor"
                     /protein_id="NP_997537.1"
                     /db_xref="CCDS:CCDS28935.1"
                     /db_xref="GeneID:13640"
                     /db_xref="MGI:MGI:107444"
                     /translation="MLHVEMLTLLFLVLWMCVFSQDPGSKVVADRYAVYWNSSNPRFQ
                     RGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWEC
                     NRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRP
                     TNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAIL
                     LFLLAMLLTL"
     exon            432..724
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /inference="alignment:Splign:2.1.0"
     exon            725..790
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /inference="alignment:Splign:2.1.0"
     exon            791..871
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /inference="alignment:Splign:2.1.0"
     exon            872..5381
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1268..1273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /note="hexamer: GATAAA"
     polyA_site      1299
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /note="major polyA site"
     regulatory      4136..4141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /note="hexamer: AATAAA"
     polyA_site      4153
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /note="major polyA site"
     regulatory      5347..5352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /note="hexamer: AATAAA"
     regulatory      5354..5359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /note="hexamer: ATTAAA"
     polyA_site      5370
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
     polyA_site      5381
                     /gene="Efna5"
                     /gene_synonym="AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS"
                     /note="major polyA site"
ORIGIN      
        1 ctacccccgc cctcgccgcc gccaccgcac acacgcacgc gtctctccgt cttgtgattc
       61 ttctcccctc ccgagccctt cagtgggggt gcgagtttgt ccccccgccc cagccactgc
      121 ctccttcttc tctctctcct cttcctcttc ctcccgcgct cgccgcgcgc ctctcgcccc
      181 ttcatcgtat ttattcctat ttatttggcg tccgctctct tcgtctgccc ctctccctcc
      241 ctccccctgg atccccgatc tctccccgga gtggcgcgtc gggggctccg ccgctggcta
      301 ggcgtgatgt tgcacgtgga gatgttgacg ctgctctttc tggtgctctg gatgtgtgtg
      361 ttcagccagg acccgggctc caaagtcgtc gccgaccgct acgccgtcta ctggaacagc
      421 agcaacccca gattccagag gggtgactac cacattgatg tctgtatcaa tgactacctg
      481 gatgttttct gccctcacta tgaggactct gtcccagaag acaagactga gcgctacgtc
      541 ctgtacatgg tgaattttga tgggtacagt gcctgcgacc acacgtccaa agggttcaag
      601 agatgggaat gtaaccggcc tcactcccca aacggaccgc tgaagttctc ggaaaaattc
      661 cagctcttca ctcccttttc tttaggattt gaattcaggc caggccgaga gtatttctac
      721 atctcctctg caatcccaga caacggaaga aggtcctgtc taaagctcaa agtctttgtg
      781 agaccaacaa atagctgtat gaaaactata ggtgttcatg atcgtgtttt cgatgttaac
      841 gacaaagtag aaaattcatt agaaccagca gatgacaccg tacatgagtc agccgagcca
      901 tcccgcggtg agaacgcggc gcagacacca aggataccca gccgcctttt ggcaatccta
      961 ctgttcctcc tggcgatgct tttgacatta tagcacagtc tcctcccgtc gcctgtcaca
     1021 gaaaatgtca gggtcttgga acaccagaga tccacctaac tgctcatccc aagaagggac
     1081 ttgttattgg tttttggcag atgtcagatt tttgttttct ttccttcagc ctgatttcta
     1141 agcaacaact tggggttgtt gggtgggtgg ggggggggta aaccagttgc tgcctccttc
     1201 accccaccct acccctaagc ccttgccctt gactcctctc atccccttcc caatcaaacg
     1261 gagtccagat aaaaatgcca gattgtcaga gtgacagcag caggtcttgg cctcctgtgc
     1321 gttttctaga gctcacctcc ttaggttcag ggtatccacc atatgcacac aagaaagaat
     1381 ggcggcagat gctgcctgca atgtccaggc ctgagagggg tgccctctcc tatacaatac
     1441 ttatgccttc acggtcagga cagtaaggtg attgtgtgga gcttggtgtt ggcctgtcga
     1501 gtccagaggg ggcggagtta agaataggcc taatactatc ccacatcctc taggagtgtg
     1561 gaagtgagca ggctttgcaa aggttcagat actagttttt atttcatcaa atgggactgt
     1621 cttaaagcat tttttttttt tttttttttt tttgccagca aaacttgggc tgtgttgaag
     1681 aagccttttc tcccaggagg aaggttggat gatgcaggga tgctaataag aggaagtgtg
     1741 gatattgaga aaatgatctg ttgctggagg tgtgagtgcc tctaactttt taggaccggg
     1801 cagtgcacac ctgagggttt cttttctttt cttttttttt ttaaatcttt gaatacagtt
     1861 caccatggtg ctacaacttt ttttttcttt ttaggacttc aaagaggcat ttttatgaat
     1921 aaagtgacct tccccaaggc tgccaagcca gggttgatga gtagagagtg gaatagcttt
     1981 ggctactcct ctggggacaa tatgtacaag gaaagagagt ctgaccagag gagatgcaat
     2041 ttggctttgc tggagctcca gtgtgctgtg gcctttcccc aattcccacc ccgataccca
     2101 cgttctgctc cttgctccgt gaccacaggg gactcagaca cagaccccta tcaccaggag
     2161 agtcagtcag cactacttgg gagggctaaa gggaaatttg gaatacaaat tccaaatttt
     2221 ggaataagaa attcaagtgt tgatgttcta tcctttccct ttctgacaca gcctaaagcg
     2281 tagggggaaa cgcgtgttta tctgtgggag ataaacaaga tggagtccca aagactttga
     2341 caaaatattt ttttaaaaat ccactagaat agaaaataca ttatttagat atactttatg
     2401 ctgagagtga gtatatatgc ttgtcctatt taaacttgtg agaaaaagtg gtatcccttg
     2461 gtacatttag aaacacaggg ggttatcttg tttcatagtg gggtttgggg cagaagaatg
     2521 aacatgggat gaccctgttg aaagaaactt agcatggccg aggggttggt tccagctgat
     2581 tgccaggaaa cacaagcagt gggggtctcc ttgtggggtg tcgggagctt taaaccccaa
     2641 agccaagcga gacagggaat agtgtcagac caatggaaaa gtgatctagc ctatttttgc
     2701 tattgcacga catcaataga aaccatgcct ttgtaaacaa gcaagtcagt aaatgcaatg
     2761 atcatgtaat gtggaaaatt gaaagcattc cagtttaaaa aatatggaat tttttatata
     2821 ttcgttttta agatgtatat gtaaaaaaaa gagttcacat tatagatgga cttcatggat
     2881 cggaaattgc ttagaatttc gagtggtttc aaattagaaa aatatgtgag tggaaggcag
     2941 ctgtgaacga actgcaccct agagagttgt acgcacgttg gaatgtaagc tgggcttact
     3001 tacctggtcc ctttggagtg gaggcaactg gagtctgctc tcacctgaac catgtgaccg
     3061 gagtcgccag cctcaaagat atagttagtc ctctcccctc ttctcccaac atctgagact
     3121 tctctggagt agcagagtct catcacagaa ggcacccaac atttccactg aaacagaact
     3181 tcaaagcatt ggatttcttt gcctttattt atgcgctcga cactctcagt gatatccaga
     3241 tgtattcttt ttattaatag ttacaggttt gtgggttagt gggatttcag taaagggaca
     3301 aaaaaaaaaa tcccttctaa gatggatcga tagaaccaag ataatactgc atgtactaca
     3361 gtcaaggaca ccaagtgatc ctatggtgat tccagttagt cctaacgaca ttagtggttc
     3421 taatgtcatt gtagaaatgg tgagtcctgt gattctagca tttgtctcta accaatgatg
     3481 aaacaattcc tcatggccct ctctgccatt gtctttcatt tcccactgtg caattagacc
     3541 cttttacttc actgccatgc caccaattat taagtttaaa aaaaaaagaa aaagaaaaaa
     3601 gaaaaactat ccacgccagt agacaatatg ctttttacct gtgacataat cttagctaat
     3661 acgcttgtgc agagttttca agatgattgg tgtcagacag tttttatctt gtccaaaaaa
     3721 tgcgctggtg gctttttgtg gtggtgttac aatcctctgt gggcttagga tgtggtgcaa
     3781 ctcggtagtt ggtttcattt taaaagcaat ggaaaaacag gaagggcagc ccttgaagcc
     3841 cctcagcccc agttggtcaa accccagcga cctttgcccc tggttgccaa gggctttgca
     3901 acatgaagca gggaataaag atctgtctgt ttagtggata ctgtgtatcc tttaatagac
     3961 caggtaacag ttcgtgttag ttttagacta ttgttttgta ctgtactttc ttgggtggca
     4021 gaggaaagaa aagttaaaat gttaaaaaaa caaaacaaaa aaaaaacaaa caaaaaaaca
     4081 actgcgttct ttaattctgt attattagcg acctctgttg tatatagtgt ttgataataa
     4141 agtattaatt tgattcttat gtcttttgta agtgaaaaca gactttcagg atacaaaaca
     4201 tgcattgagg ctttgaaaca tccaacgtat ccatggctaa gaagccacaa gtggctggaa
     4261 ctccatcctg gaccattcca tcttacagct ccaccggaaa caacaggact gctttgattg
     4321 acatttttgt cctcggtgtt ttcaaggtct gatgtcggag ctctgtggtc cttcccctca
     4381 ccccaagcat gtggtttgaa aaggtttaga taacttagaa atggttctgt actttggttt
     4441 ggttttctgt tttgtcattc tcccccagga agtcttgtga gtatcaagtg cggctcagac
     4501 tcaggatgca gaccagtccc tttaggaagg ctcagtgggg ctgtttccct ctctgcgtct
     4561 ttgtgaaagg aagagtcaca gtacctgtgg gctttcaggg actctgtttt tctcctgtgc
     4621 cttagcaacg gctgcagcca ttttattagt ttcacaaaat tagaaaaaca gtttgaaact
     4681 cctccttacc attcattgtt ctcagagttg tggtcacaag atttttcttt tgaaaatcgc
     4741 ctccaccacc aacacccacc cgtttgcctc tcccctccag ccccgcctct ctctctctct
     4801 ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct ctctcgtttt
     4861 ctctctcgct ctctcacccc cacccccacc cccacattct gttttccctc agagccgtga
     4921 atgggcaggt ctgtctctgg tttggcatcg ctgagttctt cccacgcatt tgccccagag
     4981 ctgctcggat gcgagacgaa atctccctac aatgggctca ctcccattgt ttgtacagtt
     5041 taatagatgc tgccatgttg gaggttaccc atgagtccaa aatctgtttt ccatgcttct
     5101 tcttgacacc gcattgaagc cactcacctg tgtgcgtctg ggtatgaagt ccagctcctt
     5161 ccgtgcagcc ctgtgcttgg actccccgcc ttgctgtcct ttgcacctcc tcatcgagtg
     5221 ccgttttgaa atgctgacat tatataaacg taaaagaaaa tgtaaaaaaa aaaaaaatta
     5281 aaacacacac acgcaaatcc atacgatctg tatttgtata tacacgtgtc cgtacaagta
     5341 tacctaaata aaaattaaag attttcatca ttttaattgg a
//
