LOCUS       NM_007910               1596 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus ephrin A4 (Efna4), mRNA.
ACCESSION   NM_007910
VERSION     NM_007910.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1596)
  AUTHORS   Zhou,B., Feng,C., Sun,S., Chen,X., Zhuansun,D., Wang,D., Yu,X.,
            Meng,X., Xiao,J., Wu,L., Wang,J., Wang,J., Chen,K., Li,Z., You,J.,
            Mao,H., Yang,S., Zhang,J., Jiao,C., Li,Z., Yu,D., Wu,X., Zhu,T.,
            Yang,J., Xiang,L., Liu,J., Chai,T., Shen,J., Mao,C.X., Hu,J.,
            Hao,X., Xiong,B., Zheng,S., Liu,Z. and Feng,J.
  TITLE     Identification of signaling pathways that specify a subset of
            migrating enteric neural crest cells at the wavefront in mouse
            embryos
  JOURNAL   Dev Cell 59 (13), 1689-1706 (2024)
   PUBMED   38636517
REFERENCE   2  (bases 1 to 1596)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1596)
  AUTHORS   Yan,K., Bormuth,I., Bormuth,O., Tutukova,S., Renner,A., Bessa,P.,
            Schaub,T., Rosario,M. and Tarabykin,V.
  TITLE     TrkB-dependent EphrinA reverse signaling regulates callosal axon
            fasciculate growth downstream of Neurod2/6
  JOURNAL   Cereb Cortex 33 (5), 1752-1767 (2023)
   PUBMED   35462405
REFERENCE   4  (bases 1 to 1596)
  AUTHORS   Hoshino,N., Altarshan,Y., Alzein,A., Fernando,A.M., Nguyen,H.T.,
            Majewski,E.F., Chen,V.C., Rochlin,M.W. and Yu,W.M.
  TITLE     Ephrin-A3 is required for tonotopic map precision and auditory
            functions in the mouse auditory brainstem
  JOURNAL   J Comp Neurol 529 (16), 3633-3654 (2021)
   PUBMED   34235739
REFERENCE   5  (bases 1 to 1596)
  AUTHORS   Wurmser,M., Chaverot,N., Madani,R., Sakai,H., Negroni,E.,
            Demignon,J., Saint-Pierre,B., Mouly,V., Amthor,H., Tapscott,S.,
            Birchmeier,C., Tajbakhsh,S., Le Grand,F., Sotiropoulos,A. and
            Maire,P.
  TITLE     SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell
            properties during fetal epaxial myogenesis
  JOURNAL   Development 147 (19) (2020)
   PUBMED   32591430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1596)
  AUTHORS   Cerretti,D.P. and Nelson,N.
  TITLE     Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3),
            mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6):
            conservation of intron/exon structure
  JOURNAL   Genomics 47 (1), 131-135 (1998)
   PUBMED   9465306
REFERENCE   7  (bases 1 to 1596)
  AUTHORS   .
  TITLE     Unified nomenclature for Eph family receptors and their ligands,
            the ephrins. Eph Nomenclature Committee
  JOURNAL   Cell 90 (3), 403-404 (1997)
   PUBMED   9267020
REFERENCE   8  (bases 1 to 1596)
  AUTHORS   Marcus,R.C., Gale,N.W., Morrison,M.E., Mason,C.A. and
            Yancopoulos,G.D.
  TITLE     Eph family receptors and their ligands distribute in opposing
            gradients in the developing mouse retina
  JOURNAL   Dev Biol 180 (2), 786-789 (1996)
   PUBMED   8954746
REFERENCE   9  (bases 1 to 1596)
  AUTHORS   Flenniken,A.M., Gale,N.W., Yancopoulos,G.D. and Wilkinson,D.G.
  TITLE     Distinct and overlapping expression patterns of ligands for
            Eph-related receptor tyrosine kinases during mouse embryogenesis
  JOURNAL   Dev Biol 179 (2), 382-401 (1996)
   PUBMED   8903354
REFERENCE   10 (bases 1 to 1596)
  AUTHORS   Cerretti,D.P., Lyman,S.D., Kozlosky,C.J., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Valentine,V., Kirstein,M.N.,
            Shapiro,D.N. and Morris,S.W.
  TITLE     The genes encoding the eph-related receptor tyrosine kinase ligands
            LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4,
            Epl4) are clustered on human chromosome 1 and mouse chromosome 3
  JOURNAL   Genomics 33 (2), 277-282 (1996)
   PUBMED   8660976
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142604.1, AK012195.1, AA764182.1 and BB472066.1.
            
            On Jul 29, 2006 this sequence version replaced NM_007910.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142604.1, AK012195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1109              AK142604.1         2-1110
            1110-1251           AK012195.1         1114-1255
            1252-1324           AK142604.1         1253-1325
            1325-1559           AA764182.1         15-249
            1560-1596           BB472066.1         167-203
FEATURES             Location/Qualifiers
     source          1..1596
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.07 cM"
     gene            1..1596
                     /gene="Efna4"
                     /gene_synonym="EFL-4; Epl4; LERK-4"
                     /note="ephrin A4"
                     /db_xref="GeneID:13639"
                     /db_xref="MGI:MGI:106643"
     exon            1..191
                     /gene="Efna4"
                     /gene_synonym="EFL-4; Epl4; LERK-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..699
                     /gene="Efna4"
                     /gene_synonym="EFL-4; Epl4; LERK-4"
                     /note="EPH-related receptor tyrosine kinase ligand 4"
                     /codon_start=1
                     /product="ephrin-A4 precursor"
                     /protein_id="NP_031936.2"
                     /db_xref="CCDS:CCDS38489.1"
                     /db_xref="GeneID:13639"
                     /db_xref="MGI:MGI:106643"
                     /translation="MRLLPLLRTVLWAALLGSRLPGCSSLRHPIYWNSSNPRLLRGDA
                     VVELGFNDYLDIFCPHYESPGPPEGPETFALYMVDWSGYEACTAEGANAFQRWNCSMP
                     FAPFSPVRFSEKIQRYTPFPLGFEFLPGETYYYISVPTPESPGRCLRLQVSVCCKESG
                     SSHESAHPVGSPGESGTSGWRGGHAPSPLCLLLLLLLPILRLLRVL"
     exon            192..487
                     /gene="Efna4"
                     /gene_synonym="EFL-4; Epl4; LERK-4"
                     /inference="alignment:Splign:2.1.0"
     exon            488..556
                     /gene="Efna4"
                     /gene_synonym="EFL-4; Epl4; LERK-4"
                     /inference="alignment:Splign:2.1.0"
     exon            557..1596
                     /gene="Efna4"
                     /gene_synonym="EFL-4; Epl4; LERK-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1227..1232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efna4"
                     /gene_synonym="EFL-4; Epl4; LERK-4"
                     /note="hexamer: AATAAA"
     polyA_site      1250
                     /gene="Efna4"
                     /gene_synonym="EFL-4; Epl4; LERK-4"
ORIGIN      
        1 cacttttgta cctttctcgc cgggacagag aagtgggccg ggaccagccg ggccagacca
       61 gactggaccc caggggcgat gcggctgctg cccctgctgc ggactgtgct ctgggccgcg
      121 ctgctcggct cgcgcctgcc ggggtgctcc agcctccgcc acccaatcta ctggaactcc
      181 tctaacccca ggttgctccg aggagatgcc gtggtggagc tgggcttcaa cgattaccta
      241 gacatcttct gcccacatta tgaaagccca gggcccccag aaggcccgga aacctttgca
      301 ttatacatgg tggactggtc aggctacgag gcctgcacgg cagagggggc aaatgccttc
      361 cagcgctgga attgctcgat gccttttgcc cctttcagcc ctgttcgatt ctcagaaaag
      421 attcagcgct acacaccctt cccgctgggc tttgagttct tgcctggaga gacttactac
      481 tacatctcgg tgccgactcc ggagagtcct ggccggtgcc tgagactcca ggtgtctgtc
      541 tgctgcaagg agagcgggtc atcacatgag tcagctcatc ctgttgggag tcctggagaa
      601 agcggtacgt ccgggtggcg gggaggacac gcgcccagcc ccctgtgtct cttgctgctg
      661 ctgctgctcc caatcctccg tctcctgaga gttctgtgag ccaagcacac cttccaagtc
      721 accccaagga accgcagccc ttgtcaagag cctctgtgga aggggttcct gccaccatac
      781 aggcgatgcc aaaccaggca gacaggatga aactttgatg tgcaaagtcg gaggatctga
      841 ggtgaccctt gtaggtgact gccccctcac cacaggctga agagggacct gtaaggcagc
      901 tgccgacagt ccgacagtcc gggggcgccc aggaacatag catagctgct ttgatggtct
      961 tgtctcctcc ccctggaaga ctgggattcc aggggatcaa ctccttgaga cactgagggc
     1021 ccaagccaaa gacctgggaa caggtgggtt cctggccaag aagcaaagga gaagccatgg
     1081 cgcctgtgcc ctccaggcct cttcccagga gcaattgttg ccccttcctg ggggccactc
     1141 gcttgtcttc tgtgaagacg gacttgccat gaggttgaat ttcatgctgg tttgtatttt
     1201 ttataaagtg tttggaccaa accttcaata aatcacccgt tctagtgggg catggtggct
     1261 cacacctgta attccagcac tgggagggtg agggtgggga gagtgagcag gaggtcagat
     1321 gggtatggga gaccctgtct caaaaaaaaa aaaaaacaag aacaaagcaa accaccacct
     1381 tggagagcag tgagcaggct cagcaggtga aagtgtgagc tcaccacaga gccttgacca
     1441 cctgagcgag gtcaatccct ggaacccaca ctgtgaagag agagaacaca ccccaaaaag
     1501 ttgtccttcg aacatgctac acggcgtgtc aatggatatg ccacacacat gcgcgggcac
     1561 gcgtgcacac acactcaaat aataaactta ggttaa
//
