LOCUS       NM_010108               2337 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus ephrin A3 (Efna3), transcript variant 1, mRNA.
ACCESSION   NM_010108 XM_892839 XM_910035 XM_988846
VERSION     NM_010108.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2337)
  AUTHORS   Ballester Roig,M.N., Roy,P.G., Hannou,L., Delignat-Lavaud,B., Sully
            Guerrier,T.A., Belanger-Nelson,E., Dufort-Gervais,J. and
            Mongrain,V.
  TITLE     Transcriptional regulation of the mouse EphA4, Ephrin-B2 and
            Ephrin-A3 genes by the circadian clock machinery
  JOURNAL   Chronobiol Int 40 (8), 983-1003 (2023)
   PUBMED   37551686
  REMARK    GeneRIF: Transcriptional regulation of the mouse EphA4, Ephrin-B2
            and Ephrin-A3 genes by the circadian clock machinery.
REFERENCE   2  (bases 1 to 2337)
  AUTHORS   Arpke,R.W., Moritz,T.C., Hahn,K.L., Stark,D.A., Villalon,E.,
            Lorson,C.L. and Cornelison,D.
  TITLE     Normal muscle fiber type distribution is recapitulated in aged
            ephrin-A3-/- mice that previously lacked most slow myofibers
  JOURNAL   Am J Physiol Cell Physiol 324 (3), C718-C727 (2023)
   PUBMED   36717102
REFERENCE   3  (bases 1 to 2337)
  AUTHORS   Yan,K., Bormuth,I., Bormuth,O., Tutukova,S., Renner,A., Bessa,P.,
            Schaub,T., Rosario,M. and Tarabykin,V.
  TITLE     TrkB-dependent EphrinA reverse signaling regulates callosal axon
            fasciculate growth downstream of Neurod2/6
  JOURNAL   Cereb Cortex 33 (5), 1752-1767 (2023)
   PUBMED   35462405
REFERENCE   4  (bases 1 to 2337)
  AUTHORS   Hoshino,N., Altarshan,Y., Alzein,A., Fernando,A.M., Nguyen,H.T.,
            Majewski,E.F., Chen,V.C., Rochlin,M.W. and Yu,W.M.
  TITLE     Ephrin-A3 is required for tonotopic map precision and auditory
            functions in the mouse auditory brainstem
  JOURNAL   J Comp Neurol 529 (16), 3633-3654 (2021)
   PUBMED   34235739
  REMARK    GeneRIF: Ephrin-A3 is required for tonotopic map precision and
            auditory functions in the mouse auditory brainstem.
REFERENCE   5  (bases 1 to 2337)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2337)
  AUTHORS   .
  TITLE     Unified nomenclature for Eph family receptors and their ligands,
            the ephrins. Eph Nomenclature Committee
  JOURNAL   Cell 90 (3), 403-404 (1997)
   PUBMED   9267020
REFERENCE   7  (bases 1 to 2337)
  AUTHORS   Park,S. and Sanchez,M.P.
  TITLE     The Eek receptor, a member of the Eph family of tyrosine protein
            kinases, can be activated by three different Eph family ligands
  JOURNAL   Oncogene 14 (5), 533-542 (1997)
   PUBMED   9053851
REFERENCE   8  (bases 1 to 2337)
  AUTHORS   Marcus,R.C., Gale,N.W., Morrison,M.E., Mason,C.A. and
            Yancopoulos,G.D.
  TITLE     Eph family receptors and their ligands distribute in opposing
            gradients in the developing mouse retina
  JOURNAL   Dev Biol 180 (2), 786-789 (1996)
   PUBMED   8954746
REFERENCE   9  (bases 1 to 2337)
  AUTHORS   Flenniken,A.M., Gale,N.W., Yancopoulos,G.D. and Wilkinson,D.G.
  TITLE     Distinct and overlapping expression patterns of ligands for
            Eph-related receptor tyrosine kinases during mouse embryogenesis
  JOURNAL   Dev Biol 179 (2), 382-401 (1996)
   PUBMED   8903354
REFERENCE   10 (bases 1 to 2337)
  AUTHORS   Cerretti,D.P., Lyman,S.D., Kozlosky,C.J., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Valentine,V., Kirstein,M.N.,
            Shapiro,D.N. and Morris,S.W.
  TITLE     The genes encoding the eph-related receptor tyrosine kinase ligands
            LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4,
            Epl4) are clustered on human chromosome 1 and mouse chromosome 3
  JOURNAL   Genomics 33 (2), 277-282 (1996)
   PUBMED   8660976
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171273.1 and AC132327.3.
            
            On Dec 13, 2019 this sequence version replaced NM_010108.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.658780.1, BC107002.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC171273.1         219234-219467
            235-524             AC132327.3         173862-174151       c
            525-590             AC132327.3         173469-173534       c
            591-668             AC132327.3         173207-173284       c
            669-2337            AC132327.3         171298-172966       c
FEATURES             Location/Qualifiers
     source          1..2337
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.06 cM"
     gene            1..2337
                     /gene="Efna3"
                     /gene_synonym="EFL-2; Ehk1-L; Epl3; LERK-3"
                     /note="ephrin A3"
                     /db_xref="GeneID:13638"
                     /db_xref="MGI:MGI:106644"
     exon            1..234
                     /gene="Efna3"
                     /gene_synonym="EFL-2; Ehk1-L; Epl3; LERK-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..799
                     /gene="Efna3"
                     /gene_synonym="EFL-2; Ehk1-L; Epl3; LERK-3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; EHK1 ligand; EPH-related receptor tyrosine
                     kinase ligand 3"
                     /codon_start=1
                     /product="ephrin-A3 isoform a precursor"
                     /protein_id="NP_034238.1"
                     /db_xref="CCDS:CCDS38488.1"
                     /db_xref="GeneID:13638"
                     /db_xref="MGI:MGI:106644"
                     /translation="MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHL
                     RREGYTVQVNVNDYLDIYCPHYNSSGPGGGAEQYVLYMVNLSGYRTCNASQGSKRWEC
                     NRQHASHSPIKFSEKFQRYSAFSLGYEFHAGQEYYYISTPTHNLHWKCLRMKVFVCCA
                     STSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAV
                     GIAFFLMTLLAS"
     exon            235..524
                     /gene="Efna3"
                     /gene_synonym="EFL-2; Ehk1-L; Epl3; LERK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            525..590
                     /gene="Efna3"
                     /gene_synonym="EFL-2; Ehk1-L; Epl3; LERK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            591..668
                     /gene="Efna3"
                     /gene_synonym="EFL-2; Ehk1-L; Epl3; LERK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..2337
                     /gene="Efna3"
                     /gene_synonym="EFL-2; Ehk1-L; Epl3; LERK-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1736..1741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efna3"
                     /gene_synonym="EFL-2; Ehk1-L; Epl3; LERK-3"
                     /note="hexamer: AATAAA"
     polyA_site      1756
                     /gene="Efna3"
                     /gene_synonym="EFL-2; Ehk1-L; Epl3; LERK-3"
                     /note="major polyA site"
     regulatory      2310..2315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efna3"
                     /gene_synonym="EFL-2; Ehk1-L; Epl3; LERK-3"
                     /note="hexamer: AAGAAA"
     polyA_site      2337
                     /gene="Efna3"
                     /gene_synonym="EFL-2; Ehk1-L; Epl3; LERK-3"
ORIGIN      
        1 gtgactaaga ttgggggctg gcagcggcgg cagcagggag ctgggaagct gagaagccgg
       61 gagtgcgggg ctcagtcggg gggcggcggc ggcggcggct ccggggatgg cggcggctcc
      121 gctgctgctg ctgctgctgc tcgtgcccgt gccgctgctg ccgctgctgg cccaggggcc
      181 tgggggcgca ctgggaaacc ggcatgcggt atactggaac agctccaatc agcacctgcg
      241 gcgagagggc tacaccgtgc aggtgaacgt gaacgactat ctggatattt actgtccgca
      301 ctacaacagc tcagggcctg gcggcggggc ggagcagtac gtgctgtaca tggtgaacct
      361 gagcggctac cgcacctgca acgccagcca aggctccaag cgctgggaat gcaaccggca
      421 gcacgcctcg cacagcccca tcaagttctc cgagaagttc cagcgttaca gcgccttctc
      481 gctgggctat gaattccatg ccggccaaga atactactac atctccacgc ccactcacaa
      541 cctgcactgg aagtgtctga ggatgaaggt gttcgtctgc tgcgcctcca catcgcactc
      601 cggggagaag ccggtcccca ctctccccca gttcaccatg ggccccaatg tgaagatcaa
      661 cgtgttggaa gactttgagg gagagaatcc ccaggtgccc aagcttgaga agagcatcag
      721 tgggaccagc cccaagcggg aacacctgcc tctggccgtg ggcatcgcct tcttcctcat
      781 gacgctcttg gcctcctagc tctgcccctt cctatgacag agagaggtgg gaagggctga
      841 gaaggagcag ggagcttgct gtggggccta catccttctt cccatggttg ggagcggggt
      901 ctgcactgta catctctctg ggcctgccct ctttgcccac acactctcta ggacaggcac
      961 cgtagtggat caggcacagg gacagccaca ggtcccaggt ggcctgtggc tttggtaatg
     1021 tttggtacca aacctggggg ctataaaggc agtgctcagg actccctggc ccctggtacc
     1081 tttccctgac ccttggtgcc ctccctcttt gtcccccaag aggcaaatat gccccagaga
     1141 gaacaaacga agcatgggag gtgccccctg tcctctcctc tggggcagaa catggggagg
     1201 ggactaggtg ggtgaggggt ggagcctcag gctgcccctc cccctgttta cagcaataag
     1261 catgtcctct ccctccactc ccacatagag gactgtggtt tggattgaat ccaagtttac
     1321 aaatagacac ccctgggggg gagcaggcag tggacagggg tgggcatcgg ggtgccagac
     1381 aggcatgtac agactctata tctctatata taatgtacag acagacagag tcccttcccc
     1441 ttcttaacct tgacctttct cgacttcccc ttccagactc agaccccttc ccctaccagg
     1501 ttaggccccc cttgggaccc ccctggcccc tcttttgtct tctgtgaaga caggacctat
     1561 gcaacgcaca gacacttttg gagaccgtaa caacaatgcc ccctcccttc cagccctgag
     1621 ccgggaacca actcccagga ccttgccctg cccaccctaa gtggtcccca cccatcctgg
     1681 gcctttttca agtgctttgg ctgtgacttt catactctgc tcttagtcta aaaaaaataa
     1741 actggagata aaaatacctg agtgtgtgtg gtttcaaggg gccacgtccc tctgtttcac
     1801 tggctgaacc aatcctgtgg ggctcaaggc ccgggtgagc aggcattcta ggttagaggc
     1861 cacagagtgg agagagggac agagcttcaa gttgagcccg ggtgactttg ggcaggttcc
     1921 ttaacctttc taggctccgg cttcccacag ggaaagtggt gtgagtaccc gcttcccagg
     1981 ccctgtgtac ccgagttaag gctcaggctg gtgcgctcta tgctgtagtc agaagctttt
     2041 ggctgggtcc agggatttca ggggatttgt gatcctagat aggaaaaaaa aagttacatg
     2101 gttattttca ctcacctgtg acaagtttaa cattcccttt ctgtacttgg gcaacaggcc
     2161 acagcagcat aaagagtacg tgtgactttg tagccaacag aaatcccaga tgttttcaga
     2221 cctgctttat atctcagaat atcatttatg tgtcactact ttgaaatgat catagttgtt
     2281 agactttact tgtttttaac atgttaataa agaaacatat atattacata ccaaaaa
//
