LOCUS       NM_007909               2153 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ephrin A2 (Efna2), mRNA.
ACCESSION   NM_007909
VERSION     NM_007909.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2153)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2153)
  AUTHORS   Yan,K., Bormuth,I., Bormuth,O., Tutukova,S., Renner,A., Bessa,P.,
            Schaub,T., Rosario,M. and Tarabykin,V.
  TITLE     TrkB-dependent EphrinA reverse signaling regulates callosal axon
            fasciculate growth downstream of Neurod2/6
  JOURNAL   Cereb Cortex 33 (5), 1752-1767 (2023)
   PUBMED   35462405
REFERENCE   3  (bases 1 to 2153)
  AUTHORS   Ting,M.C., Farmer,D.T., Teng,C.S., He,J., Chai,Y., Crump,J.G. and
            Maxson,R.E.
  TITLE     Embryonic requirements for Tcf12 in the development of the mouse
            coronal suture
  JOURNAL   Development 149 (1) (2022)
   PUBMED   34878091
REFERENCE   4  (bases 1 to 2153)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2153)
  AUTHORS   Ciossek,T. and Ullrich,A.
  TITLE     Identification of Elf-1 and B61 as high affinity ligands for the
            receptor tyrosine kinase MDK1
  JOURNAL   Oncogene 14 (1), 35-43 (1997)
   PUBMED   9010230
REFERENCE   6  (bases 1 to 2153)
  AUTHORS   Flenniken,A.M., Gale,N.W., Yancopoulos,G.D. and Wilkinson,D.G.
  TITLE     Distinct and overlapping expression patterns of ligands for
            Eph-related receptor tyrosine kinases during mouse embryogenesis
  JOURNAL   Dev Biol 179 (2), 382-401 (1996)
   PUBMED   8903354
REFERENCE   7  (bases 1 to 2153)
  AUTHORS   Gale,N.W., Holland,S.J., Valenzuela,D.M., Flenniken,A., Pan,L.,
            Ryan,T.E., Henkemeyer,M., Strebhardt,K., Hirai,H., Wilkinson,D.G.,
            Pawson,T., Davis,S. and Yancopoulos,G.D.
  TITLE     Eph receptors and ligands comprise two major specificity subclasses
            and are reciprocally compartmentalized during embryogenesis
  JOURNAL   Neuron 17 (1), 9-19 (1996)
   PUBMED   8755474
REFERENCE   8  (bases 1 to 2153)
  AUTHORS   Shao,H., Lou,L., Pandey,A., Verderame,M.F., Siever,D.A. and
            Dixit,V.M.
  TITLE     cDNA cloning and characterization of a Cek7 receptor
            protein-tyrosine kinase ligand that is identical to the ligand
            (ELF-1) for the Mek-4 and Sek receptor protein-tyrosine kinases
  JOURNAL   J Biol Chem 270 (8), 3467-3470 (1995)
   PUBMED   7876076
REFERENCE   9  (bases 1 to 2153)
  AUTHORS   Shao,H., Lou,L., Pandey,A., Pasquale,E.B. and Dixit,V.M.
  TITLE     cDNA cloning and characterization of a ligand for the Cek5 receptor
            protein-tyrosine kinase
  JOURNAL   J Biol Chem 269 (43), 26606-26609 (1994)
   PUBMED   7929389
REFERENCE   10 (bases 1 to 2153)
  AUTHORS   Cheng,H.J. and Flanagan,J.G.
  TITLE     Identification and cloning of ELF-1, a developmentally expressed
            ligand for the Mek4 and Sek receptor tyrosine kinases
  JOURNAL   Cell 79 (1), 157-168 (1994)
   PUBMED   7522971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140544.1, AC159999.6 and CF740879.1.
            
            On Jul 2, 2009 this sequence version replaced NM_007909.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140544.1, BC048697.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-759               AK140544.1         1-759
            760-760             AC159999.6         188486-188486
            761-1766            AK140544.1         761-1766
            1767-2153           CF740879.1         141-527
FEATURES             Location/Qualifiers
     source          1..2153
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2153
                     /gene="Efna2"
                     /gene_synonym="CEK7L; Elf1; Epl6; Eplg6; Lerk6"
                     /note="ephrin A2"
                     /db_xref="GeneID:13637"
                     /db_xref="MGI:MGI:102707"
     exon            1..409
                     /gene="Efna2"
                     /gene_synonym="CEK7L; Elf1; Epl6; Eplg6; Lerk6"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..911
                     /gene="Efna2"
                     /gene_synonym="CEK7L; Elf1; Epl6; Eplg6; Lerk6"
                     /note="CEK7-ligand; EPH related receptor tyrosine kinase
                     ligand 6; ephrin A6"
                     /codon_start=1
                     /product="ephrin-A2 precursor"
                     /protein_id="NP_031935.3"
                     /db_xref="CCDS:CCDS24013.1"
                     /db_xref="GeneID:13637"
                     /db_xref="MGI:MGI:102707"
                     /translation="MAPAQRPLLPLLLLLLPLRARNEDPARANADRYAVYWNRSNPRF
                     QVSAVGDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMERYILYMVNGEGHASCDHRQ
                     RGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNLVDRPCL
                     RLKVYVRPTNETLYEAPEPIFTSNSSCSGLGGCHLFLTTVPVLWSLLGS"
     exon            410..723
                     /gene="Efna2"
                     /gene_synonym="CEK7L; Elf1; Epl6; Eplg6; Lerk6"
                     /inference="alignment:Splign:2.1.0"
     exon            724..789
                     /gene="Efna2"
                     /gene_synonym="CEK7L; Elf1; Epl6; Eplg6; Lerk6"
                     /inference="alignment:Splign:2.1.0"
     exon            790..2131
                     /gene="Efna2"
                     /gene_synonym="CEK7L; Elf1; Epl6; Eplg6; Lerk6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2110..2115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efna2"
                     /gene_synonym="CEK7L; Elf1; Epl6; Eplg6; Lerk6"
                     /note="hexamer: AATAAA"
     polyA_site      2131
                     /gene="Efna2"
                     /gene_synonym="CEK7L; Elf1; Epl6; Eplg6; Lerk6"
                     /note="major polyA site"
ORIGIN      
        1 ggggagcccc cgcgcccggg gaacccggga gagcgccttg cgcagtgcac cgctcgggcc
       61 tctgccccgc gccgccgtcg ccgccgccgc cgccgccgcc gccgccgcct ggtttctcgg
      121 cgcccgcggt ctacggcggg ggccgcgcgc agaggcgggg cggcagatct ccaagcgcgc
      181 gcggcgctcc gcccgctcgg cggcggaggc ggaggcggag acggcggggc caggcggcgg
      241 ctggagagcg agggagcgag cgcggcggca gcaccggggc catggcgccc gcgcagcgcc
      301 cgctgctgcc gctgctgctg ctgctgctgc cgctgcgtgc gcgcaacgag gacccggccc
      361 gggccaacgc tgaccgatac gcagtctact ggaaccgtag caaccccagg tttcaggtga
      421 gcgctgtggg tgatggcggc ggctataccg tggaggtgag catcaacgac tacctggata
      481 tctactgccc acactacggg gcgccgctgc ccccggctga gcgcatggag cggtacatcc
      541 tgtacatggt gaatggtgag ggccacgcct cctgtgacca ccggcagcga ggcttcaagc
      601 gctgggaatg caaccggccc gcagcgcccg ggggacccct caagttctca gagaagttcc
      661 aactcttcac ccccttttcc ctgggctttg agttccggcc tggccacgaa tactactaca
      721 tctctgccac acctcccaac ctcgtggacc gaccctgcct gcgactcaag gtttatgtgc
      781 gtccaaccaa tgagaccctg tatgaggctc cagagcccat cttcaccagt aacagctcct
      841 gcagcggcct gggtggctgc cacctcttcc tcaccaccgt ccctgtgctg tggtcccttc
      901 tgggctccta gtgtcaggcc ggagaacacc agccccacct ggaccccgtg acctttgccc
      961 tctgacctgc cacggccacc tccgagacaa aatccttgct gcttctcttt catggtgctg
     1021 tcccgccgga ggaggccatc catccgtccc tgggatgcaa catggggtcc caatgcctga
     1081 ggagaagacc cccccccaag gctgactcgc tttcaccagg gccaccaggg ccatccagtg
     1141 ttgtttaatt acagtcggaa agacttaagg tttttctttt aatttaattt attccctgac
     1201 attgctggtg acactgggaa gggaacaagc cacagggatg aggtgaagcc atctctgtcc
     1261 ttcctggaat accggagatc caggggcctc cagctgctcc tttcttctgt gtcctgttat
     1321 ttgggtccca gatggagccc accgcggact tgccttgcat tcctcaggcc aggcaagcct
     1381 gagccagaaa gggcgcacgg tgccagcccc tctcggggac tctgggggtg ccatccccca
     1441 ctcttcttcc agccactctc gggccccact cccacatcat ctcagaaacc cttcagccct
     1501 cgcaactcgc ccctccgggc ccccccacca ggcacaacca tccccggggc cagccgggac
     1561 gttgtcggtt tatttctgta aatagaaacc agcaagtgta tactgtgatt tattttaatg
     1621 tattcttaag gacagaatgg aaattcttta aaaaaaattt tttttccgac cttcaattca
     1681 aggggtcatt tattttggtg gggggagtgg ggtggacttt ttaggataga agcaacactt
     1741 tgcaataaac tcattttttt ttgttccgtt ggagccctcc cccttgatca tgtgacctag
     1801 taatgtttat aacaaaaaaa attaaaaaaa aaaaaagaag aaggaaaaaa aatacaggac
     1861 tggaaaggaa ggggagctac ctaccaaaaa tacagcaggc aaaggactga gtgaagctgg
     1921 ccacaccaca cgtttatacg gatttcggat ttctacccac gtttcctcac tctgttttct
     1981 atatattcta tataaatata tattgtggat ggccgccatg gcgagtggtg gctggggctt
     2041 ttctaggggc gggggacggg tggcccggcc ccctcatcac aatcagcttt gaagtctgta
     2101 tttttttata ataaaatgga caaactgtta aaaaaaaaaa aaaaaaaaaa aaa
//
