LOCUS       NM_010107               1483 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus ephrin A1 (Efna1), transcript variant 1, mRNA.
ACCESSION   NM_010107
VERSION     NM_010107.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1483)
  AUTHORS   Yan,K., Bormuth,I., Bormuth,O., Tutukova,S., Renner,A., Bessa,P.,
            Schaub,T., Rosario,M. and Tarabykin,V.
  TITLE     TrkB-dependent EphrinA reverse signaling regulates callosal axon
            fasciculate growth downstream of Neurod2/6
  JOURNAL   Cereb Cortex 33 (5), 1752-1767 (2023)
   PUBMED   35462405
REFERENCE   3  (bases 1 to 1483)
  AUTHORS   de Lemos,L., Dias,A., Novoa,A. and Mallo,M.
  TITLE     Epha1 is a cell-surface marker for the neuromesodermal competent
            population
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35299237
REFERENCE   4  (bases 1 to 1483)
  AUTHORS   Lewis,A.E., Kuwahara,A., Franzosi,J. and Bush,J.O.
  TITLE     Tracheal separation is driven by NKX2-1-mediated repression of
            Efnb2 and regulation of endodermal cell sorting
  JOURNAL   Cell Rep 38 (11), 110510 (2022)
   PUBMED   35294885
REFERENCE   5  (bases 1 to 1483)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1483)
  AUTHORS   Takahashi,H. and Ikeda,T.
  TITLE     Molecular cloning and expression of rat and mouse B61 gene:
            implications on organogenesis
  JOURNAL   Oncogene 11 (5), 879-883 (1995)
   PUBMED   7675446
REFERENCE   7  (bases 1 to 1483)
  AUTHORS   Brown,A., Bernier,G., Mathieu,M., Rossant,J. and Kothary,R.
  TITLE     The mouse dystonia musculorum gene is a neural isoform of bullous
            pemphigoid antigen 1
  JOURNAL   Nat Genet 10 (3), 301-306 (1995)
   PUBMED   7670468
REFERENCE   8  (bases 1 to 1483)
  AUTHORS   Shao,H., Pandey,A., O'Shea,K.S., Seldin,M. and Dixit,V.M.
  TITLE     Characterization of B61, the ligand for the Eck receptor
            protein-tyrosine kinase
  JOURNAL   J Biol Chem 270 (10), 5636-5641 (1995)
   PUBMED   7890684
REFERENCE   9  (bases 1 to 1483)
  AUTHORS   Beckmann,M.P., Cerretti,D.P., Baum,P., Vanden Bos,T., James,L.,
            Farrah,T., Kozlosky,C., Hollingsworth,T., Shilling,H.,
            Maraskovsky,E. et al.
  TITLE     Molecular characterization of a family of ligands for eph-related
            tyrosine kinase receptors
  JOURNAL   EMBO J 13 (16), 3757-3762 (1994)
   PUBMED   8070404
REFERENCE   10 (bases 1 to 1483)
  AUTHORS   Holzman,L.B., Marks,R.M. and Dixit,V.M.
  TITLE     A novel immediate-early response gene of endothelium is induced by
            cytokines and encodes a secreted protein
  JOURNAL   Mol Cell Biol 10 (11), 5830-5838 (1990)
   PUBMED   2233719
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN696019.1, AK009144.1 and AC132327.3.
            
            On Jul 2, 2009 this sequence version replaced NM_010107.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002046.1, AK009144.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-612               CN696019.1         1-612
            613-1477            AK009144.1         610-1474
            1478-1483           AC132327.3         129129-129134       c
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.04 cM"
     gene            1..1483
                     /gene="Efna1"
                     /gene_synonym="B61; Efl1; Epl1; Eplg1; Lerk1"
                     /note="ephrin A1"
                     /db_xref="GeneID:13636"
                     /db_xref="MGI:MGI:103236"
     exon            1..195
                     /gene="Efna1"
                     /gene_synonym="B61; Efl1; Epl1; Eplg1; Lerk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..721
                     /gene="Efna1"
                     /gene_synonym="B61; Efl1; Epl1; Eplg1; Lerk1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; immediate early response protein B61;
                     EPH-related receptor tyrosine kinase ligand 1"
                     /codon_start=1
                     /product="ephrin-A1 isoform 1 precursor"
                     /protein_id="NP_034237.3"
                     /db_xref="CCDS:CCDS17501.1"
                     /db_xref="GeneID:13636"
                     /db_xref="MGI:MGI:103236"
                     /translation="MEFLWAPLLGLCCSLAAADRHIVFWNSSNPKFREEDYTVHVQLN
                     DYLDIICPHYEDDSVADAAMERYTLYMVEHQEYVACQPQSKDQVRWNCNRPSAKHGPE
                     KLSEKFQRFTPFILGKEFKEGHSYYYISKPIYHQESQCLKLKVTVNGKITHNPQAHVN
                     PQEKRLQADDPEVQVLHSIGYSAAPRLFPLVWAVLLLPLLLLQSQ"
     exon            196..491
                     /gene="Efna1"
                     /gene_synonym="B61; Efl1; Epl1; Eplg1; Lerk1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..557
                     /gene="Efna1"
                     /gene_synonym="B61; Efl1; Epl1; Eplg1; Lerk1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..608
                     /gene="Efna1"
                     /gene_synonym="B61; Efl1; Epl1; Eplg1; Lerk1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..1483
                     /gene="Efna1"
                     /gene_synonym="B61; Efl1; Epl1; Eplg1; Lerk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1455..1460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efna1"
                     /gene_synonym="B61; Efl1; Epl1; Eplg1; Lerk1"
                     /note="hexamer: AATAAA"
     polyA_site      1478
                     /gene="Efna1"
                     /gene_synonym="B61; Efl1; Epl1; Eplg1; Lerk1"
                     /note="major polyA site"
ORIGIN      
        1 ggccagattt gtgatcgtgg tgcctactgt accgtggaga agcctgtggg aaccttacac
       61 tgcagagctc tcgtcctggc ctggctcggc ccggccccgc gctatggagt tcctttgggc
      121 ccctctcttg ggtctgtgct gcagtctggc cgctgctgac cgccacatcg tcttctggaa
      181 cagttcaaat cccaagttcc gtgaggagga ctacacggtg cacgtgcagc tgaatgacta
      241 cctagacatc atctgcccac attacgagga cgactctgtg gcagatgcag ccatggagcg
      301 atacacactg tacatggtgg aacaccagga gtatgtggca tgccaacccc agtccaagga
      361 ccaggtccgt tggaattgca accggcccag tgccaagcat ggcccggaga agctgtctga
      421 gaaattccag cgcttcacgc cttttatctt gggcaaggag ttcaaggaag gacacagcta
      481 ctactacatc tccaaaccta tctaccatca ggaatcccag tgcttgaagc tgaaggtgac
      541 tgtcaatggc aaaatcactc ataatcccca ggcccatgtc aacccacagg agaagagact
      601 ccaagcagat gacccggaag tacaggtttt gcacagcatt ggttacagtg ccgccccccg
      661 cctcttccca ctggtctggg cagtattgct cctaccactg ctgctgctgc aatctcagtg
      721 agggtgtacg cttgccctgg cttatggatt ggaatgggac taaggggcag ccccagccct
      781 gggaacctct cccactacac ccacaagacg ccaccatgaa gcctcaaaag gttcagtatt
      841 aagggtttta accgaaaaga gtttaaccag cccaactgtg ccatccctgc ctccacttca
      901 gagggatgga gaaagaagtg gagaaggtcc ttaacctgca gtttctgcct ttaagccaaa
      961 gaaacaagct gtgcggacct ggcccattaa gaggcctcag tgggagaagg gctaaaaaga
     1021 gcctgaggtc atgcggttgg acactgaact tggtaaagac gtccttcccc aaggaagcca
     1081 taatgtgcag atgaactgac cgaaggaaaa gcttgagaca gcttcctgcg ggggagccag
     1141 gtacagaaga ggcagcttgg gctgacccag catctctgca agatttccac ctgctgggct
     1201 gccagagagg tttgtagccc ggccctgact gcatcctccc catccctggg gcaacattcc
     1261 ctggagctgt gccaacagga ggactgaagc agcctggttt tagagtgtag ctgtaagggc
     1321 agtgcccgtg tgtacagtct gtggagttta gcttaacggg cagggcccac atgtacagtg
     1381 tctgtatata aatgtgctgt atctgttcat ttctatgact gcagggtttt tttatacagt
     1441 gtttttggat tcataataaa ttgatggttt tttatggaca tgc
//
