LOCUS       NM_025994               2381 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus EF hand domain containing 2 (Efhd2), mRNA.
ACCESSION   NM_025994 XM_917278 XM_924848 XM_924850 XM_924854
VERSION     NM_025994.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2381)
  AUTHORS   Zhang,W., Chen,L., Lu,X., Dong,X., Feng,M., Tu,Y. and Wang,Z.
  TITLE     EFHD2 regulates T cell receptor signaling and modulates T helper
            cell activation in early sepsis
  JOURNAL   Int Immunopharmacol 133, 112087 (2024)
   PUBMED   38669951
  REMARK    GeneRIF: EFHD2 regulates T cell receptor signaling and modulates T
            helper cell activation in early sepsis.
REFERENCE   2  (bases 1 to 2381)
  AUTHORS   Wu,J., Xu,X., Duan,J., Chai,Y., Song,J., Gong,D., Wang,B., Hu,Y.,
            Han,T., Ding,Y., Liu,Y., Li,J. and Cao,X.
  TITLE     EFHD2 suppresses intestinal inflammation by blocking intestinal
            epithelial cell TNFR1 internalization and cell death
  JOURNAL   Nat Commun 15 (1), 1282 (2024)
   PUBMED   38346956
  REMARK    GeneRIF: EFHD2 suppresses intestinal inflammation by blocking
            intestinal epithelial cell TNFR1 internalization and cell death.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2381)
  AUTHORS   Bo,X., Xie,F., Zhang,J., Gu,R., Li,X., Li,S., Yuan,Z. and Cheng,J.
  TITLE     Deletion of Calhm2 alleviates MPTP-induced Parkinson's disease
            pathology by inhibiting EFHD2-STAT3 signaling in microglia
  JOURNAL   Theranostics 13 (6), 1809-1822 (2023)
   PUBMED   37064868
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2381)
  AUTHORS   Xue,B., Qu,Y., Zhang,X. and Xu,X.F.
  TITLE     miRNA-126a-3p participates in hippocampal memory via alzheimer's
            disease-related proteins
  JOURNAL   Cereb Cortex 32 (21), 4763-4781 (2022)
   PUBMED   35059720
  REMARK    GeneRIF: miRNA-126a-3p participates in hippocampal memory via
            alzheimer's disease-related proteins.
REFERENCE   5  (bases 1 to 2381)
  AUTHORS   Lehne,F., Pokrant,T., Parbin,S., Salinas,G., Grosshans,J., Rust,K.,
            Faix,J. and Bogdan,S.
  TITLE     Calcium bursts allow rapid reorganization of EFhD2/Swip-1
            cross-linked actin networks in epithelial wound closure
  JOURNAL   Nat Commun 13 (1), 2492 (2022)
   PUBMED   35524157
  REMARK    GeneRIF: Calcium bursts allow rapid reorganization of EFhD2/Swip-1
            cross-linked actin networks in epithelial wound closure.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2381)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2381)
  AUTHORS   Vega,I.E., Traverso,E.E., Ferrer-Acosta,Y., Matos,E., Colon,M.,
            Gonzalez,J., Dickson,D., Hutton,M., Lewis,J. and Yen,S.H.
  TITLE     A novel calcium-binding protein is associated with tau proteins in
            tauopathy
  JOURNAL   J Neurochem 106 (1), 96-106 (2008)
   PUBMED   18346207
  REMARK    GeneRIF: The identification of a novel calcium-binding protein
            associated with tau protein in terminally ill tauopathy mouse model
            suggests that this association may play an important physiological
            and/or pathological role.
REFERENCE   8  (bases 1 to 2381)
  AUTHORS   Avramidou,A., Kroczek,C., Lang,C., Schuh,W., Jack,H.M. and
            Mielenz,D.
  TITLE     The novel adaptor protein Swiprosin-1 enhances BCR signals and
            contributes to BCR-induced apoptosis
  JOURNAL   Cell Death Differ 14 (11), 1936-1947 (2007)
   PUBMED   17673920
  REMARK    GeneRIF: study shows that swiprosin-1 may regulate lifespan and BCR
            signaling thresholds in immature B cells
REFERENCE   9  (bases 1 to 2381)
  AUTHORS   Mielenz,D., Vettermann,C., Hampel,M., Lang,C., Avramidou,A.,
            Karas,M. and Jack,H.M.
  TITLE     Lipid rafts associate with intracellular B cell receptors and
            exhibit a B cell stage-specific protein composition
  JOURNAL   J Immunol 174 (6), 3508-3517 (2005)
   PUBMED   15749887
REFERENCE   10 (bases 1 to 2381)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK048475.1.
            
            On Apr 5, 2007 this sequence version replaced NM_025994.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048475.1, AK159367.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2381              AK048475.1         2-2382
FEATURES             Location/Qualifiers
     source          1..2381
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 74.75 cM"
     gene            1..2381
                     /gene="Efhd2"
                     /gene_synonym="2600015J22Rik; D4Wsu27e"
                     /note="EF hand domain containing 2"
                     /db_xref="GeneID:27984"
                     /db_xref="MGI:MGI:106504"
     exon            1..361
                     /gene="Efhd2"
                     /gene_synonym="2600015J22Rik; D4Wsu27e"
                     /inference="alignment:Splign:2.1.0"
     exon            362..509
                     /gene="Efhd2"
                     /gene_synonym="2600015J22Rik; D4Wsu27e"
                     /inference="alignment:Splign:2.1.0"
     exon            510..644
                     /gene="Efhd2"
                     /gene_synonym="2600015J22Rik; D4Wsu27e"
                     /inference="alignment:Splign:2.1.0"
     exon            645..2381
                     /gene="Efhd2"
                     /gene_synonym="2600015J22Rik; D4Wsu27e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      892..897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efhd2"
                     /gene_synonym="2600015J22Rik; D4Wsu27e"
                     /note="hexamer: ACTAAA"
     polyA_site      911
                     /gene="Efhd2"
                     /gene_synonym="2600015J22Rik; D4Wsu27e"
     regulatory      2172..2177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efhd2"
                     /gene_synonym="2600015J22Rik; D4Wsu27e"
                     /note="hexamer: GATAAA"
     polyA_site      2191
                     /gene="Efhd2"
                     /gene_synonym="2600015J22Rik; D4Wsu27e"
                     /note="major polyA site"
     regulatory      2357..2362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efhd2"
                     /gene_synonym="2600015J22Rik; D4Wsu27e"
                     /note="hexamer: ATTAAA"
     polyA_site      2379
                     /gene="Efhd2"
                     /gene_synonym="2600015J22Rik; D4Wsu27e"
ORIGIN      
        1 gggagcgcgg cgcagagcag gggcccggcc gaggcagcgc tgcgcgggcc accatggcca
       61 cggacgagtt ggccagcaag ctgagccgga ggctgcagat ggagggcgaa ggcggcgagg
      121 cgacggagca gccggggctc aacggggcgg cggcggcggc ggcggccgag gctcccgacg
      181 agactgccca ggcgttgggc agcgcggacg acgagctgag cgccaagctg ctgcggcgcg
      241 cggacctcaa ccagggcatc ggcgagccac agtcgcccag ccgccgcgtc ttcaacccct
      301 acaccgagtt caaggagttc tccaggaagc agatcaaaga catggagaag atgttcaagc
      361 agtatgatgc cggcagggat ggcttcatcg acctgatgga gctgaaactc atgatggaga
      421 agctgggggc cccccagaca cacttgggcc tcaagagtat gatccaggag gtggacgagg
      481 atttcgacag caaactcagc ttccgggagt tccttctgat cttccgcaag gcagcagcag
      541 gggagttgca ggaagacagc ggcttgcacg tcctggcccg cctgtccgag atcgatgtct
      601 ccacagaggg cgttaagggt gccaagaact tcttcgaggc caaggtacag gccatcaacg
      661 tgtccagccg ctttgaggaa gagatcaaag ctgagcaaga ggaaaggaag aagcaggctg
      721 aggaggtgaa gcagcggaaa gcggccttta aggagctgca gtccacgttc aagtagccag
      781 agccaaggcc gagacctggc cctgccccgt gtgcggtctg ggggcacggg tgggtacagg
      841 ggatctgtgg gagactagct cccaggtcct gctctctgtg cccggaccac tactaaaaac
      901 cgcaaacgat atgtgacccg atctcattca ggagtctcct cggtggttgg tccctgccct
      961 gccctctcct gcggttcatg cggctgtgat gccagccagc agcatcctct ctggccatcc
     1021 ctacgtgtct tgttctctgg ccaccttgct gcctgctcta gcccaacttc agcccattca
     1081 cgcccctgcc tttggtacca gctactttct ccacccaccc aactcccctt aactataggc
     1141 cgccctgcca tggtccagca gagagtgaga ccctccccag gacgcttcct ttcagatcag
     1201 gccccatctc tgatggaagt ggagagactc ttctattagt gaggagatcc ggggactcct
     1261 acattagtga ggagatccag gccctagcac tctaagctga tttcaatggg gcccagccag
     1321 gcagggtgaa ggccactgtg cgaatctacc tcacaggcta cactctgcca ggcatgcctt
     1381 ggggatgtga gtgatagggt tccgagggga ggggcagaaa tgtcaccctc tgacagccta
     1441 cccccgcagc aagctgaggg tcccaagggg ctgtggagag aggggtgggg tccctaaggg
     1501 attggccttt tcagggtgga cctcagcact ctgccttgac tccccaagga gtgcctgacg
     1561 tgtttatgtt cactggcagt aggactcggg gccggcaccc ctttcacact ctccttcctt
     1621 gggtttgtca cccgtgatgg caccagcctg tcgtgcccac ccgtagactc gcatggggac
     1681 tccccaggcc acagtgaaac ccgtgccgtt cctctatagc tccatgtgct tgctcacgtg
     1741 tgtgtatgtg cgtgtccgtt gctgtgttgt gaaactgtga cgtcacccag tctaagtgaa
     1801 tggccaccgg ggccaccgtt atgcaatgtt cagcgtgtca ctgcttgtga agctcgataa
     1861 ctctttattt tactacaatg tccccagagt ccctgggacc cctgtgggac ttgcaaaggt
     1921 tttatttttt cggtcttaga acctatgaga atcggagggg ccgagccaag cccagcccag
     1981 cccagctgcc gtggccttgg cttgcgtttg cctcagcgga tatgtttata cagatgaata
     2041 taaattctct ttacttttgg ctgtttgcat tttatttttg gttccccctc tcagtacctc
     2101 ccaaaaaaag aaaaaaagaa aaaaactact tcttcattcg gtggtacgat tatttttttt
     2161 aactaaaatg agataaaatt ctatattctt atgtgtgtgt ggtttttgat gactaactag
     2221 aaacaaaggt ggacaggatc aggatgaggt cgctggatct gggccgtcac atcaggagcc
     2281 tggggaggaa ggcactcctg ctggagagct ctgtccctta gcatctacaa acactcctga
     2341 tctaagcact acctgtatta aactcatttc atccttaaag g
//
