LOCUS       NM_172497               2661 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus EF hand domain family, member B (Efhb), mRNA.
ACCESSION   NM_172497
VERSION     NM_172497.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2661)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2661)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2661)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   4  (bases 1 to 2661)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   5  (bases 1 to 2661)
  AUTHORS   Chang,S.Y., Yong,T.F., Yu,C.Y., Liang,M.C., Pletnikova,O.,
            Troncoso,J., Burgunder,J.M. and Soong,T.W.
  TITLE     Age and gender-dependent alternative splicing of P/Q-type calcium
            channel EF-hand
  JOURNAL   Neuroscience 145 (3), 1026-1036 (2007)
   PUBMED   17291689
REFERENCE   6  (bases 1 to 2661)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (bases 1 to 2661)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029550.1 and BC132103.1.
            
            On Aug 1, 2009 this sequence version replaced NM_172497.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029550.1, BC137880.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AK029550.1         2-10
            10-2641             BC132103.1         1-2632
            2642-2661           AK029550.1         2643-2662
FEATURES             Location/Qualifiers
     source          1..2661
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 27.78 cM"
     gene            1..2661
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /note="EF hand domain family, member B"
                     /db_xref="GeneID:211482"
                     /db_xref="MGI:MGI:3045296"
     exon            1..891
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2604
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /note="cilia- and flagella-associated protein 21"
                     /codon_start=1
                     /product="EF-hand domain-containing family member B"
                     /protein_id="NP_766085.2"
                     /db_xref="CCDS:CCDS37652.1"
                     /db_xref="GeneID:211482"
                     /db_xref="MGI:MGI:3045296"
                     /translation="MCSFVRVGSPKPLQTSASPLEMSSLRRTRAPEISELGLTPEQKD
                     DIRDRVLRGSKSPTELGFDLRLEQDRKWRERMGSSEAKSPPCHALGVGLERHTISGTP
                     TEMGNLGLHKGSAFQGSKPLGVLPGRVGPENKGLPPRLRYGGTLHPPFSTVHASPLAA
                     ESRRRPLAWGSAWTDAVVEKQPVVGLELRKEPEKEPTCVVMNPYPEMPPKEVDIGLPQ
                     TQESDEAKNTEPLIGLVREPSECPFAQQPEEKKEPGSTEPGVEPPGNIRPIYSGKFFD
                     RVPCWPSAGKVKPVGYRVATCLTEKLPRLMTPPEAKKYFNFRYPPAGAERVFYGRAND
                     PQIAPYLTHGLRSKISIPMGSLINPQPITTFQQKIKDKKESIYFSHQRAPLGKSHDQT
                     PGLPKGMDVINTTLGTPTIRELSVRDTVNPSKSFEDVLKEGQEGHDLYTVSHNDYFAG
                     EAKNRKYNPASFHRFNLYGIPTPHFNDGRTMAKALHWLHELQMERGAKIVSKRVDDFK
                     EKFQHKLGKVLDPIAETMNVPPGHTFGSCLHPEEYGAGDLIHYRSPDEYLRGKDHQRA
                     VVAAARHHLKKFNHQNFDTLQVAFRHYDKKGDGVIDRAELHEACVQANLHLDKMLLDH
                     LFDYCDVDQDGLINYLEFANFLNWKDRIPLKEHEKRVVVKGKKPDCENVTDTSMGEAE
                     PSLLINPEDIVPKEPGSSEETLRTIQRPGDKVSHQYKTTSSEINAVVGAVPSMCHPIF
                     GVPTIRSDISAPRIRRVSDMNNYGDEGNAYSLLHPSIFSQKGVFERDFFKTRSKEEIS
                     DILTNIGVKLSKEEFENVWNLASKKHQRGEVCVETIRNVLDELLHADLVKCKTAM"
     exon            892..954
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1098
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1279
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1390
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1520
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1604
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1672
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1827
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2035
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2248
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2430
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2661
                     /gene="Efhb"
                     /gene_synonym="4921525D22Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtcctag gcaggaagta gtctgcacgg agtactggga gtatgtgttc gtttgtgaga
       61 gtggggtccc ccaaaccttt gcaaacttca gcttctccgt tagagatgag ttccctgaga
      121 aggacgagag cacctgaaat ctcggaactt ggactcaccc cagagcaaaa ggacgatata
      181 agagacaggg tacttagggg gtcaaaatct cccacggagc tggggtttga cttgagacta
      241 gaacaagatc gaaaatggag agagaggatg ggatcatcag aagcaaaatc gccaccttgc
      301 catgctcttg gagtaggatt agaaagacat actatttctg ggacacccac agagatgggt
      361 aatttaggac ttcacaaagg ctctgccttc cagggatcaa aacctctggg tgtgttacca
      421 ggaagagtgg ggccagaaaa caagggcctt ccgcctcgcc ttcgctacgg agggacacta
      481 caccctcctt tcagcacagt acatgcaagt ccgctggcgg cagagagcag aaggaggcct
      541 ttagcctggg gttctgcttg gacggatgct gtagtggaaa agcaacctgt tgtaggtttg
      601 gaactgagaa aagaaccgga aaaagaaccc acctgtgtcg tgatgaaccc ctacccagag
      661 atgcccccta aggaggtaga catcgggttg ccacaaactc aggaatcaga tgaagccaag
      721 aatacagagc ctctaatagg tttagtaaga gaaccttctg aatgtccatt tgcccaacaa
      781 ccggaagaga aaaaggagcc cggcagcacc gaacccggag tggagcctcc agggaacatc
      841 aggcccatat actcagggaa gttctttgat cgggtgcctt gctggccaag tgcaggaaaa
      901 gttaagccag ttggatacag agttgcaacc tgtttgactg agaagcttcc caggctaatg
      961 actcccccag aggcaaagaa gtatttcaac ttcagatatc cacctgctgg agcagaaaga
     1021 gtattttatg gcagagcaaa tgacccccaa attgcacctt atttgacaca tggactaaga
     1081 tctaaaatct caataccgat gggatcattg ataaacccac agcccattac cacgtttcaa
     1141 cagaaaatta aagacaaaaa agaatctata tattttagcc atcaacgagc accattggga
     1201 aaatctcatg atcaaacacc aggattgcca aaaggaatgg atgtgatcaa cacaacatta
     1261 gggacaccga ctatcagaga actgtctgtt cgtgacactg tgaatccatc gaaatccttc
     1321 gaagatgtgc ttaaagaagg acaggaagga catgatttgt acactgtctc tcacaatgat
     1381 tattttgcag gagaagcaaa gaatcgaaaa tataacccgg caagcttcca taggtttaac
     1441 ttgtatggaa tcccaacacc tcactttaat gatgggcgca ccatggctaa agctttacat
     1501 tggctccatg aactacaaat ggaaagagga gcgaaaattg tatccaaaag agttgatgac
     1561 ttcaaagaga aatttcaaca caaacttgga aaagttttag accccattgc agaaactatg
     1621 aatgttcccc caggtcacac atttggaagt tgcctccatc ctgaggaata tggagctggc
     1681 gatctcatcc attatagaag cccagatgaa tatcttcgtg ggaaggacca ccagagagcc
     1741 gtggttgcag ctgctcgcca ccacttgaag aaatttaatc accagaactt tgacactttg
     1801 caggtggctt tcaggcacta tgacaagaag ggagatgggg tgattgacag agcagaactt
     1861 catgaagctt gtgtccaagc caacctgcat ctagacaaga tgctcctgga ccatctgttt
     1921 gactactgtg acgtggacca ggatggcttg atcaactacc tggaatttgc caatttcctt
     1981 aactggaaag acagaatacc tctcaaagag catgagaaga gggtcgttgt taaaggtaaa
     2041 aaaccagact gtgaaaacgt tactgatact agcatgggag aagctgaacc aagtctcctg
     2101 ataaatcctg aagacattgt ccccaaagaa ccaggaagtt cagaagagac tctccggaca
     2161 atccagagac caggtgacaa agtttctcac cagtataaga caacgtcttc tgagatcaac
     2221 gctgtggttg gagctgtccc ctccatgtgt caccccatat tcggtgttcc aaccattcga
     2281 tctgacatct ctgctccccg gattcgtcga gtcagtgaca tgaataacta cggtgacgaa
     2341 ggcaatgctt actctctgct gcacccctcc atcttctccc agaaaggtgt atttgagaga
     2401 gacttcttca agacaaggtc aaaggaagag atttcagata tattaactaa cattggagtc
     2461 aagctttcta aggaagaatt cgaaaatgtg tggaatcttg cttcaaaaaa acaccagcga
     2521 ggagaagttt gtgttgaaac tatcaggaac gttctagatg agctactgca tgcagacctc
     2581 gtcaagtgta aaacggccat gtgattgata tttttgggaa cttacacatt taagcaaagc
     2641 agattaaatc tatattcatc t
//
