LOCUS       NM_021474               1561 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus epidermal growth factor-containing fibulin-like
            extracellular matrix protein 2 (Efemp2), transcript variant 1,
            mRNA.
ACCESSION   NM_021474 XM_979992
VERSION     NM_021474.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1561)
  AUTHORS   Crandall,C.L., Wu,Y., Kailash,K.A., Bersi,M.R., Halabi,C.M. and
            Wagenseil,J.E.
  TITLE     Changes in transmural mass transport correlate with ascending
            thoracic aortic aneurysm diameter in a fibulin-4 E57K knockin mouse
            model
  JOURNAL   Am J Physiol Heart Circ Physiol 325 (1), H113-H124 (2023)
   PUBMED   37267118
  REMARK    GeneRIF: Changes in transmural mass transport correlate with
            ascending thoracic aortic aneurysm diameter in a fibulin-4 E57K
            knockin mouse model.
REFERENCE   2  (bases 1 to 1561)
  AUTHORS   Nguyen,T.A.V., Lino,C.A., Hang,H.T., Alves,J.V., Thang,B.Q.,
            Shin,S.J., Sugiyama,K., Matsunaga,H., Takeyama,H., Yamashiro,Y. and
            Yanagisawa,H.
  TITLE     Protective Role of Endothelial Fibulin-4 in Valvulo-Arterial
            Integrity
  JOURNAL   J Am Heart Assoc 12 (1), e026942 (2023)
   PUBMED   36565192
  REMARK    GeneRIF: Protective Role of Endothelial Fibulin-4 in
            Valvulo-Arterial Integrity.
REFERENCE   3  (bases 1 to 1561)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1561)
  AUTHORS   Noda,K., Kitagawa,K., Miki,T., Horiguchi,M., Akama,T.O.,
            Taniguchi,T., Taniguchi,H., Takahashi,K., Ogra,Y., Mecham,R.P.,
            Terajima,M., Yamauchi,M. and Nakamura,T.
  TITLE     A matricellular protein fibulin-4 is essential for the activation
            of lysyl oxidase
  JOURNAL   Sci Adv 6 (48) (2020)
   PUBMED   33239290
  REMARK    GeneRIF: A matricellular protein fibulin-4 is essential for the
            activation of lysyl oxidase.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1561)
  AUTHORS   Lu,T., Lin,X., Pan,Y.H., Yang,N., Ye,S., Zhang,Q., Wang,C., Zhu,R.,
            Zhang,T., Wisniewski,T.M., Cao,Z., Ding,B.S., Dang,S. and Zhang,W.
  TITLE     ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial
            Microfibril Accumulation
  JOURNAL   iScience 23 (9), 101472 (2020)
   PUBMED   32882513
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1561)
  AUTHORS   McLaughlin,P.J., Chen,Q., Horiguchi,M., Starcher,B.C.,
            Stanton,J.B., Broekelmann,T.J., Marmorstein,A.D., McKay,B.,
            Mecham,R., Nakamura,T. and Marmorstein,L.Y.
  TITLE     Targeted disruption of fibulin-4 abolishes elastogenesis and causes
            perinatal lethality in mice
  JOURNAL   Mol Cell Biol 26 (5), 1700-1709 (2006)
   PUBMED   16478991
  REMARK    GeneRIF: fibulin-4 plays an irreplaceable role in elastogenesis.
REFERENCE   7  (bases 1 to 1561)
  AUTHORS   Gallagher,W.M., Greene,L.M., Ryan,M.P., Sierra,V., Berger,A.,
            Laurent-Puig,P. and Conseiller,E.
  TITLE     Human fibulin-4: analysis of its biosynthetic processing and mRNA
            expression in normal and tumour tissues
  JOURNAL   FEBS Lett 489 (1), 59-66 (2001)
   PUBMED   11231014
REFERENCE   8  (bases 1 to 1561)
  AUTHORS   Katsanis,N., Venable,S., Smith,J.R. and Lupski,J.R.
  TITLE     Isolation of a paralog of the Doyne honeycomb retinal dystrophy
            gene from the multiple retinopathy critical region on 11q13
  JOURNAL   Hum Genet 106 (1), 66-72 (2000)
   PUBMED   10982184
REFERENCE   9  (bases 1 to 1561)
  AUTHORS   Gallagher,W.M., Argentini,M., Sierra,V., Bracco,L., Debussche,L.
            and Conseiller,E.
  TITLE     MBP1: a novel mutant p53-specific protein partner with oncogenic
            properties
  JOURNAL   Oncogene 18 (24), 3608-3616 (1999)
   PUBMED   10380882
REFERENCE   10 (bases 1 to 1561)
  AUTHORS   Ohno,M., Komiyama,A., Martin,P.M. and Suzuki,K.
  TITLE     MHC class II antigen expression and T-cell infiltration in the
            demyelinating CNS and PNS of the twitcher mouse
  JOURNAL   Brain Res 625 (2), 186-196 (1993)
   PUBMED   8275302
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY234446.1, AK075585.1 and AI327154.1.
            
            On Aug 21, 2009 this sequence version replaced NM_021474.2.
            
            Transcript Variant: This variant (1) represents the more frequently
            occurring transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075585.1, SRR11927935.3096901.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY234446.1         1-11
            12-1544             AK075585.1         1-1533
            1545-1561           AI327154.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1561
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.33 cM"
     gene            1..1561
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /note="epidermal growth factor-containing fibulin-like
                     extracellular matrix protein 2"
                     /db_xref="GeneID:58859"
                     /db_xref="MGI:MGI:1891209"
     exon            1..85
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            86..203
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1424
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; EGF-containing fibulin-like extracellular
                     matrix protein 2 (Efemp2); FIBL-4; mutant p53-binding
                     protein 1; fibulin-4"
                     /codon_start=1
                     /product="EGF-containing fibulin-like extracellular matrix
                     protein 2 isoform 1 precursor"
                     /protein_id="NP_067449.3"
                     /db_xref="CCDS:CCDS29466.1"
                     /db_xref="GeneID:58859"
                     /db_xref="MGI:MGI:1891209"
                     /translation="MLPFASCLPGSLLLWAFLLLLLGAASPQDPEEPDSYTECTDGYE
                     WDADSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVISDLHGEGPPPPAAH
                     AQQPNPCPQGYEPDEQESCVDVDECTQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGP
                     ECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCF
                     NSYGTFLCRCNQGYELHRDGFSCSDIDECGYSSYLCQYRCVNEPGRFSCHCPQGYQLL
                     ATRLCQDIDECETGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYVQVSDNRCLCPASNP
                     LCREQPSSIVHRYMSITSERSVPADVFQIQATSVYPGAYNAFQIRSGNTQGDFYIRQI
                     NNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF"
     exon            204..252
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..459
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..582
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..699
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..819
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..939
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1066
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1262
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1556
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1536..1541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /note="hexamer: AATAAA"
     polyA_site      1555
                     /gene="Efemp2"
                     /gene_synonym="0610011K11Rik; Fbln4; MBP1"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcttcc tggggccgcg cgtccagtga gctgcgcggt ccgtccgtcc gtccgcccgc
       61 ccgcaggcac tgctggagtc gacgccctca ggatgctccc ttttgcctcc tgcctccccg
      121 ggtctttgct gctctgggcg tttctgctgt tgctcttggg agcagcgtcc ccacaggatc
      181 ccgaggagcc ggacagctac acggaatgca cagatggcta tgagtgggat gcagacagcc
      241 agcactgccg ggatgtcaac gagtgcctga ccatcccgga ggcttgcaag ggtgagatga
      301 aatgcatcaa ccactacggg ggttatttgt gtctgcctcg ctctgctgcc gtcatcagtg
      361 atctccatgg tgaaggacct ccaccgccag cggcccatgc tcaacaacca aacccttgcc
      421 cgcagggcta cgagcctgat gaacaggaga gctgtgtgga tgtggacgag tgtacccagg
      481 ctttgcatga ctgtcgccct agtcaggact gccataacct tcctggctcc taccagtgca
      541 cctgccctga tggttaccga aaaattggac ccgaatgtgt ggacatagat gagtgtcgtt
      601 accgctattg ccagcatcga tgtgtgaacc tgccgggctc ttttcgatgc cagtgtgagc
      661 caggcttcca gttgggacct aacaaccgct cttgtgtgga tgtgaatgag tgtgacatgg
      721 gagccccatg tgagcagcgc tgcttcaact cctatgggac cttcctgtgt cgctgtaacc
      781 agggctatga gctgcaccgg gatggcttct cctgcagcga tatcgatgag tgcggctact
      841 ccagttacct ctgccagtac cgctgtgtca acgagccagg ccgattctcc tgtcactgcc
      901 cacaaggcta ccagctgctg gctacaaggc tctgccaaga tattgacgag tgtgaaacag
      961 gtgcacacca atgttctgag gcccaaacct gtgtcaactt ccatgggggt taccgctgtg
     1021 tggacaccaa ccgttgtgtg gagccctatg tccaagtgtc agacaaccgc tgcctctgcc
     1081 ctgcctccaa tcccctttgt cgagagcagc cttcatccat tgtgcaccgc tacatgagca
     1141 tcacctcaga gcgaagtgtg cctgctgacg tgtttcagat ccaggcaacc tctgtctacc
     1201 ctggtgccta caatgccttt cagatccgtt ctggaaacac acagggggac ttctacatta
     1261 ggcaaatcaa caatgtcagc gccatgctgg tcctcgccag gccagtgacg ggaccccggg
     1321 agtacgtgct ggacctggag atggtcacca tgaattccct tatgagctac cgggccagct
     1381 ctgtactgag actcacggtc tttgtgggag cctatacctt ctgaagaccc tcagggaagg
     1441 gccatgtggg ggcccccttc cccctcccat agcttaagca gccccggggg cctagggatg
     1501 accgttctgc ttaaaggaac tatgatgtga aggacaataa agggagaaag aaggagaaaa
     1561 a
//
