LOCUS       NM_176965               5990 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus EF-hand calcium binding domain 5 (Efcab5), mRNA.
ACCESSION   NM_176965 XM_017314592
VERSION     NM_176965.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5990)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5990)
  AUTHORS   Pritsker,M., Doniger,T.T., Kramer,L.C., Westcot,S.E. and
            Lemischka,I.R.
  TITLE     Diversification of stem cell molecular repertoire by alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14290-14295 (2005)
   PUBMED   16183747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663066.12, BX321897.4 and AL603842.9.
            
            On or before Mar 9, 2023 this sequence version replaced
            XM_017314592.3, NM_176965.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AL663066.12        99447-99658         c
            213-458             AL663066.12        98584-98829         c
            459-543             AL663066.12        97650-97734         c
            544-1084            AL663066.12        87392-87932         c
            1085-1241           AL663066.12        70981-71137         c
            1242-1397           AL663066.12        50494-50649         c
            1398-1497           AL663066.12        39515-39614         c
            1498-2787           AL663066.12        35682-36971         c
            2788-2865           AL663066.12        33692-33769         c
            2866-2958           AL663066.12        33495-33587         c
            2959-3173           AL663066.12        30678-30892         c
            3174-3330           AL663066.12        28529-28685         c
            3331-3620           AL663066.12        19772-20061         c
            3621-3790           AL663066.12        16466-16635         c
            3791-4019           AL663066.12        14743-14971         c
            4020-4172           AL663066.12        12284-12436         c
            4173-4273           AL663066.12        4018-4118           c
            4274-4527           AL663066.12        2774-3027           c
            4528-4716           AL663066.12        2001-2189           c
            4717-4811           BX321897.4         3900-3994           c
            4812-4908           BX321897.4         3464-3560           c
            4909-5990           AL603842.9         10840-11921
FEATURES             Location/Qualifiers
     source          1..5990
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.25 cM"
     gene            1..5990
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /note="EF-hand calcium binding domain 5"
                     /db_xref="GeneID:319634"
                     /db_xref="MGI:MGI:2442440"
     exon            1..212
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..5102
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /codon_start=1
                     /product="EF-hand calcium-binding domain-containing
                     protein 5"
                     /protein_id="NP_795939.3"
                     /db_xref="CCDS:CCDS36232.1"
                     /db_xref="GeneID:319634"
                     /db_xref="MGI:MGI:2442440"
                     /translation="MSESTSQDQSKPDQDNGKEDREQQQDSSKDRKDEKNEKDLKETK
                     EEKDKKEEKNKKDKKKEKDKQDKKEEEDKKEEEDKKEEEDTKEEEDKEDEKEPSTNPP
                     SDVDSETSNQVTEKATVDMKFQAGSTKDSPAVSRNVMLKKPAKVILGIDESDLRFKVQ
                     LPWKKNLNLRIEERAQAKQQKILENDKLKKEQEKKVTKKLPRDDLAKEWFNPESMTLN
                     TRAYLLDKLLPTLVPGVEQMLMQVEKKKLLSQADIPTKFDPINYLGEYLMRHNTHYIK
                     DPGVSGYQRVMKEITEELKTHVPDTINNRISKMKEKVKEKREQREYISTVKVKVAGMR
                     KQALEEQFNEWVLNPKGMIPIVVYISSYITDLKSEVFEEFLKHLCHSAEEFREIILTD
                     MRRQMFAELFLQCDSGKVMALDRQRTLALLEAFYDQCSSTTRSLLRNPRQWPFVEFEE
                     IELIEFWGDMDIKKHIYEDFDALLLKMNMLVAEKLAGKLAENKDLPQQQRDQELSSDS
                     TTEPETATQLTSQQRSRRVSLTGQGQGKGPRKTSASKQGASRGSVAEQGSRRSSGVNQ
                     TQQRGSVAEQGSRRSSAVEQTQQRGSVAEQGSRRSSTVEQTRQRGSVAEQGSRRSSTV
                     EQTQRRGSVAEQGSRRSSGVNQTQQRGSVAEQGSRRSSAVEQTQQRGSVAEQGSRRSS
                     AMEQEPQTAQDPNSDSLPEQESHRGSITEGSHRGSISEPGQRRASVTGQRRKSSVDDS
                     GSAGSRRGSGTDQGQHRGSVGQRKGSGERKMSASEYGPHQESITEEPLTASEPGPQID
                     TIQELDEDSTPQLEDDSALKESKTSELTKIETQEEKPLLLINEEQVPRDSKQPEVPTS
                     SKKERPSGSPKKGRLSGTSKRDSQKDKACEPKPQHVEGKKWSGEFLICDWKIKHVKSE
                     EEEQAKLICDDTRFTDLHATIRNFQTYKGIKGRSAFNGVSLDLLQFVQLLETFVGEDT
                     SFSLSKDLASFFQKNYSETKQEKIKALEQARQNSSRIRRRILLQAIFEKWDNDGSGFL
                     DLNEVDDLLYTYKEGMERESMKKAKLHINFPEPSPGHEVKLSSKQFQRYIELVVSELR
                     GNEDEVLESVVEFLMGSLERSHVEGLRNCARRKWLHQIQYAAETSGVSLEPVYTETFR
                     VLTQDAEAHGNKKISAHISLLEENVFLPERGHVLLRNVACTLDDAPFVLNKVLYRDMK
                     GISFTVVDEGKPIHVPQVQHHGNIFFWNSFRSKNEYNGSFLALPLQDAYMRIFGVLAV
                     DTLRDPHEINIFLPHEIKFYQGVANAFSTAYHHVHSREHVLHSVMTGIRWLFSVTSGI
                     TTITTCFIEPSSEQEDYVLRNMMVTDCLGLAEIHTDPPTITRNACIFRDFLFKCTDTS
                     EVILASSGGETHIAIPLRQRTKEAMGILDVNIGRSRMLLYQEYKDLQKMVKMIQNVSY
                     EILGEFSGEIEKTMVIEMESAGEVKRAGILFFRTMLQELQECLCLLDSMDFVSLLLYE
                     HKYHVDSILQDITLQEVEANVALVHDVLKGVILFSQREKDSLSDLEEWEKWKFHINKY
                     LVEEICVLDPTASNVEVNVELVTSYIQAHSRTEVWNFRNIVIELLYHWINICLTLIEL
                     NMRQDVSIIPPLPKKSATSIYAISSERSIREKL"
     exon            213..458
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            459..543
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1084
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1241
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1397
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1497
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..2787
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2865
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..2958
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3173
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3330
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3620
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3621..3790
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3791..4019
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4172
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4173..4273
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4274..4527
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4528..4811
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4812..4908
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4909..5990
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5468..5473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5489
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /note="major polyA site"
     regulatory      5971..5976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5990
                     /gene="Efcab5"
                     /gene_synonym="4930563A03Rik"
ORIGIN      
        1 attcagtaga atgccagggt gtggtggggc aggaaatgac agaggttatc accattcagc
       61 gtatctctgc tgcttgttaa catttgattt ctctcttttg gttgttaata ttgtaaggtt
      121 tacttctcag tatcatttgg tggccttttt tttttttttt ttgtggtcaa atgagtgaat
      181 caacatctca agatcagtcc aagcctgacc aggacaatgg aaaagaagac agggaacagc
      241 agcaggactc ctcaaaggac agaaaggacg aaaagaatga aaaggactta aaggaaacaa
      301 aggaggaaaa ggacaaaaag gaagaaaaga acaaaaagga caaaaagaag gaaaaggaca
      361 aacaggacaa aaaggaggaa gaggacaaaa aggaggaaga ggacaaaaag gaggaagagg
      421 acacaaagga ggaagaggac aaagaggacg aaaaggagcc atcaacaaat ccaccaagtg
      481 atgttgattc agaaactagc aaccaagtga cagaaaaggc aacggtggat atgaaattcc
      541 aagctggttc aacaaaggac tcccctgcag tttccaggaa tgttatgctt aaaaagcctg
      601 caaaagtgat tcttggtata gacgaaagtg atctgaggtt caaagtacag ctgccgtgga
      661 agaaaaatct taatttgagg atagaggaaa gagcccaggc caagcaacag aaaatattag
      721 agaacgataa actgaagaag gaacaggaaa agaaggttac aaaaaagctc cctagggatg
      781 acttggctaa agagtggttc aatcctgaaa gcatgacact gaatacccgg gcgtacctgc
      841 tggacaagct tctacccacc ttggttcccg gagtggagca aatgctgatg caggtggaga
      901 agaagaagct tttgagccaa gctgacatcc caaccaagtt tgatccaatt aattatttgg
      961 gggaatattt aatgagacac aacactcatt atatcaaaga cccaggagtg tctggctacc
     1021 agagggtgat gaaagagatc actgaagaac tgaagactca tgtccctgat acgatcaaca
     1081 acagaatatc caagatgaag gagaaagtga aagagaagag agaacaaaga gagtacataa
     1141 gcacagtcaa agtcaaggtg gccggcatga gaaagcaggc tctggaagag cagttcaatg
     1201 aatgggttct caaccccaaa gggatgattc caatagtcgt gtacatttct tcatacatca
     1261 cagacttgaa aagcgaagtc tttgaggaat tccttaaaca cctgtgccac agcgcagaag
     1321 aattccggga gatcatactg actgacatgc ggaggcagat gtttgcagaa ctcttcctac
     1381 agtgcgacag tgggaaggtg atggccttgg atcggcagag gacactggcc ctgctggaag
     1441 cgttctatga tcaatgctct tccaccacta ggagtttact ccgaaaccca cgacaatggc
     1501 cctttgttga atttgaagag atagagttga ttgagttctg gggagacatg gatattaaga
     1561 agcacattta tgaagacttt gatgcactgc tcttaaagat gaatatgtta gttgctgaaa
     1621 aacttgcagg caaactcgca gaaaacaaag atctcccaca gcagcagaga gatcaagaac
     1681 tttcatctga ctcaacaacg gagccagaaa ctgccacaca actgacctca caacagagat
     1741 cccgcagagt atcacttaca ggacaaggac agggcaaagg gcctcgcaaa acatctgctt
     1801 caaaacaagg agcaagcaga gggtcagtgg cagagcaagg gtcccgaaga agctcgggag
     1861 tgaaccaaac ccagcagaga gggtcggtgg cagaacaagg atcccgaaga agctcagcag
     1921 tagaacaaac ccagcagaga gggtcggtgg cagagcaagg gtcccgaaga agctctacag
     1981 tagaacaaac tcggcagaga gggtcagtgg cagagcaagg gtcccgaaga agctctacag
     2041 tagaacaaac ccagcggaga gggtcggtgg cagagcaagg gtcccgaaga agctcgggag
     2101 tgaaccaaac ccagcagaga gggtcggtgg cagaacaagg atcccgaaga agctcggcag
     2161 tagaacaaac tcagcagaga gggtcggtgg cagagcaagg gtcccgaaga agttcagcca
     2221 tggaacaaga gccacaaaca gcacaagatc caaacagcga ttcattgcca gaacaagaat
     2281 cacacagagg gtccatcaca gaaggatcac acagagggtc aatttcagaa cctgggcaac
     2341 gcagagcatc agtaacagga caacgcagaa agtcgtctgt agatgactcc ggtagtgcag
     2401 ggtcacgcag aggatcaggg acagatcaag gacagcacag aggatccgta gggcagcgca
     2461 aagggtcagg agaacgcaaa atgtcagctt cagagtatgg accacatcaa gagtccataa
     2521 cagaagagcc cctcactgcg tcagaaccag gaccgcaaat agacactatt caagaactgg
     2581 atgaagactc aactccacaa ttagaagacg atagtgccct aaaagaaagt aaaacctcgg
     2641 aactcactaa aatagaaact caagaagaaa agcctttgct gctcatcaac gaagagcaag
     2701 tccccagaga ttccaaacag ccagaagttc ccacatccag caaaaaggaa cgtccatcag
     2761 gcagccccaa aaaagggcgc ctttcaggaa cttcaaaaag ggattctcag aaagacaaag
     2821 cctgtgaacc aaagccgcaa catgtagaag gaaaaaaatg gtcaggagaa tttttgatct
     2881 gtgactggaa gataaagcat gtcaaatctg aagaggagga acaggccaag ttaatctgtg
     2941 atgacaccag attcacagac ctacatgcga ctattaggaa ttttcagact tacaagggga
     3001 tcaaagggag gagtgccttc aatggagtct ccctcgattt gctgcagttt gtacagctcc
     3061 tggagacatt tgttggtgaa gacacctcct tcagtctcag caaggacctc gcctcctttt
     3121 ttcagaagaa ctattctgaa acaaagcaag agaaaattaa agccttagaa caggccagac
     3181 aaaattcctc ccgcatccga cggagaattc tcctccaagc catctttgag aagtgggaca
     3241 atgatggctc aggctttctg gatctgaatg aagttgatga tctcctgtat acatataagg
     3301 agggaatgga aagagaatct atgaagaaag ctaaactgca cataaatttt ccagagccaa
     3361 gtcccggtca cgaagttaaa ctgtcttcaa agcaatttca gaggtacata gaactggtcg
     3421 tatctgaact caggggcaat gaagacgaag ttctggaaag tgttgtggaa ttcctgatgg
     3481 gttctttaga gaggagccac gttgagggtc taaggaactg tgcaaggcgg aaatggctcc
     3541 atcagattca gtacgctgca gagacaagtg gggtgtccct ggagccggtg tacactgaga
     3601 ccttcagggt cctcacccag gacgctgagg ctcacggaaa taagaagatc agtgctcaca
     3661 tctccctcct agaggaaaac gtgttcctgc ctgagagagg gcacgttctc ttgaggaacg
     3721 tggcttgtac tctagatgac gctccgttcg tcctgaacaa agtgctctac agggacatga
     3781 agggaatcag ctttacagta gtggatgaag gaaagccaat ccatgtcccc caagttcagc
     3841 accatggaaa tatcttcttc tggaacagtt tccgaagtaa gaatgagtat aacgggtcgt
     3901 tcctggcttt gcctcttcag gatgcataca tgaggatctt tggggtcctg gcagttgaca
     3961 cgcttcgaga tcctcatgaa ataaacatct tcttacctca tgagatcaaa ttctatcagg
     4021 gggtcgccaa tgccttcagc acagcttacc accatgttca cagcagggaa cacgtgctgc
     4081 actccgtgat gactggcatc cggtggctct tcagtgtcac atctggcatc accaccatca
     4141 ctacatgctt catcgaaccc agctcagaac aggaagacta tgttttgcgc aatatgatgg
     4201 ttacagattg tctcggtcta gcagaaatcc acacagatcc cccgaccatc acgaggaacg
     4261 catgcatctt tagggacttc ctctttaaat gcacagacac ttcagaagtt attttggctt
     4321 cttccggtgg agaaacccac attgccattc cacttcgcca gagaaccaaa gaggctatgg
     4381 gcatcctcga tgttaacatt ggccggagca ggatgctgct gtaccaagag tataaagatc
     4441 tacagaaaat ggtgaagatg atccaaaacg tctcctatga aatactgggc gaattctctg
     4501 gcgaaatcga gaaaactatg gttatagaga tggaatcggc aggagaggtg aagcgggctg
     4561 ggatcctttt cttccgaacc atgctgcagg agctgcagga atgcctctgc ctcctcgatt
     4621 ccatggactt tgtgtcgctg cttctctatg agcacaaata tcatgtcgac tccatccttc
     4681 aggacatcac tctccaggag gtggaagcca atgtggccct ggtgcacgac gtcctgaaag
     4741 gagttattct gttctctcag cgggagaaag actctttaag cgacttggaa gagtgggaaa
     4801 aatggaagtt tcatattaac aagtacttag tggaggagat ttgtgtgctt gatccgactg
     4861 ctagcaacgt ggaggttaat gtagagctcg ttacaagcta tatccaagct cattctcgga
     4921 ctgaagtctg gaatttcagg aacattgtca ttgaactcct gtatcactgg ataaacatct
     4981 gtctgactct catagagcta aacatgcgac aagatgtttc cattatcccg ccattgccca
     5041 agaagagtgc cacctctatt tatgcaatat cctcagaaag atcaatccga gagaaacttt
     5101 aaggactggt actgtgtcgg gacatgttga ttgtgtccaa tgctgttaac catgaaatat
     5161 tttcaactgg aaagagtacc ccatagatat attctgctcc cagatactca ccccagtact
     5221 ctctaaagcc aaaagtgcta cctacctaag ggaaaaattt tatctaaaga gcatgcattg
     5281 atgatgacca taaccagaag caccagcgga atacgtaata gaatgtattt cagtttgagc
     5341 ttcctgtatg acagactagt atagctgttt gggaagttgc tttccattaa tttaaatagc
     5401 ataataaaga gtactggggg tctggacagt gagaaatggc agcttttaca tcaaaagagt
     5461 accaaacaat aaagagttta agaagtggac ttgtaactgg tttttggttt gggttttttt
     5521 tttttttttt agaatttttt catagattat ccaaacacta cttctccatc tcttcttcat
     5581 ctcttctttc cttaacaatt taaaagtcac ttttatattt ctggttggtt ggttggttgg
     5641 ttggttgaaa cagtatctcc atatatttct gagactagcc tggaactggc tatgtagccc
     5701 aggctggctt tgaactcctg atattcctgc ctcagcacct tgagggctgt gagaataatt
     5761 atgtaccctg ccataaatat catttcaatg aacaggaaat gtttgtccat ggctcacaga
     5821 ataaagaaaa cagcaatttt tattaacaaa aacttctcaa gtttgtaact acaaaagaat
     5881 ggatatttgc tcagagcttg ttattacagc aaactttact gctgtgttgt aagatttcat
     5941 ctttgtaaga aaatatctta ccccattttt aataaaattg ggaaattaaa
//
