LOCUS       NM_026189               2689 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus endonuclease/exonuclease/phosphatase family domain
            containing 1 (Eepd1), mRNA.
ACCESSION   NM_026189
VERSION     NM_026189.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2689)
  AUTHORS   Xiong,J., Xu,Y., Wang,N., Wang,S., Zhang,Y., Lu,S., Zhang,X.,
            Liang,X., Liu,C., Jiang,Q., Xu,J., Qian,Q., Zhou,P., Yin,L.,
            Liu,F., Chen,S., Yin,S. and Liu,J.
  TITLE     Obstructive Sleep Apnea Syndrome Exacerbates NASH Progression via
            Selective Autophagy-Mediated Eepd1 Degradation
  JOURNAL   Adv Sci (Weinh) 11 (35), e2405955 (2024)
   PUBMED   38924647
  REMARK    GeneRIF: Obstructive Sleep Apnea Syndrome Exacerbates NASH
            Progression via Selective Autophagy-Mediated Eepd1 Degradation.
REFERENCE   2  (bases 1 to 2689)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2689)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2689)
  AUTHORS   Heng,X., Guo,Q., Leung,A.W. and Li,J.Y.
  TITLE     Analogous mechanism regulating formation of neocortical basal
            radial glia and cerebellar Bergmann glia
  JOURNAL   Elife 6, e23253 (2017)
   PUBMED   28489004
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2689)
  AUTHORS   Nelson,J.K., Koenis,D.S., Scheij,S., Cook,E.C., Moeton,M.,
            Santos,A., Lobaccaro,J.A., Baron,S. and Zelcer,N.
  TITLE     EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates
            ABCA1 Abundance and Cholesterol Efflux
  JOURNAL   Arterioscler Thromb Vasc Biol 37 (3), 423-432 (2017)
   PUBMED   28082258
  REMARK    GeneRIF: EEPD1 is a novel LXR-regulated gene in macrophages and
            that it promotes cellular cholesterol efflux by controlling
            cellular levels and activity of ABCA1.
REFERENCE   6  (bases 1 to 2689)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY127756.1, AK009180.2, AA543616.1, CK619108.1 and AW050261.1.
            
            On Jul 21, 2005 this sequence version replaced NM_026189.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168564.1, AK173239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BY127756.1         2-7
            7-550               AK009180.2         2-545
            551-727             AA543616.1         295-471
            728-1609            AK009180.2         723-1604
            1610-1855           CK619108.1         338-583
            1856-2634           AK009180.2         1851-2629
            2635-2689           AW050261.1         1-55                c
FEATURES             Location/Qualifiers
     source          1..2689
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 10.25 cM"
     gene            1..2689
                     /gene="Eepd1"
                     /gene_synonym="2310005P05Rik"
                     /note="endonuclease/exonuclease/phosphatase family domain
                     containing 1"
                     /db_xref="GeneID:67484"
                     /db_xref="MGI:MGI:1914734"
     exon            1..300
                     /gene="Eepd1"
                     /gene_synonym="2310005P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            301..1339
                     /gene="Eepd1"
                     /gene_synonym="2310005P05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             462..2171
                     /gene="Eepd1"
                     /gene_synonym="2310005P05Rik"
                     /codon_start=1
                     /product="endonuclease/exonuclease/phosphatase family
                     domain-containing protein 1"
                     /protein_id="NP_080465.3"
                     /db_xref="CCDS:CCDS22935.1"
                     /db_xref="GeneID:67484"
                     /db_xref="MGI:MGI:1914734"
                     /translation="MGSTLGCHRSIPRDPSDLSHNRKFSAACNFSNILVNQERLNINT
                     ATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSS
                     KGNSAQHSPSSLRRDLLAEQQPHHLTTTVPLTPRVNINTATLAQLMSVRGLSEKMALS
                     IVDYRREHGPFRSVEDLVRMDGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPH
                     PSPTSLSLQSEDLDLPPGGPTQIISMRPSVEAFGGMRDGRPVFRLATWNLQGCSVEKA
                     NNPGVREVVCMTLLENSIKLLAVQELLDKEALEKFCTELNQPILPNIRKWKGSRGCWR
                     SIVAEKPSNQLQKGPCYSGFLWDTAANVELRDIPGRESSPSNGHAKAVGPSPFLARFK
                     VGSNDLTLVNLQLTALALPGAENSSKNHSDGHRLLNFALTLQETLKGEKDVVILGDFG
                     QGPDSNDYDILRREKFHHLVPAHTFTNISTRNPQGSKSVDNIWISKSLKKVFTGHWAV
                     VREGLTNPWIPDNWSWGGVASEHCPVLAELYMEKDWSKKEVPRNGNGVTLEPSEANIK
                     HER"
     exon            1340..1391
                     /gene="Eepd1"
                     /gene_synonym="2310005P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1502
                     /gene="Eepd1"
                     /gene_synonym="2310005P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1637
                     /gene="Eepd1"
                     /gene_synonym="2310005P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1776
                     /gene="Eepd1"
                     /gene_synonym="2310005P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1971
                     /gene="Eepd1"
                     /gene_synonym="2310005P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2673
                     /gene="Eepd1"
                     /gene_synonym="2310005P05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2646..2651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eepd1"
                     /gene_synonym="2310005P05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2673
                     /gene="Eepd1"
                     /gene_synonym="2310005P05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gacttcagct gtgacaccca cggcgagcgg ccgtggtggc gcgcggcgcg aggttcagga
       61 cgcgctccgc cgcctctcgc acccgagtta ggcgccgggc tttgcctgga ttcaagcagc
      121 tacgacgcgg ctagtcctgg tgcagcatcg ggggccgaat ttcgccgcgg ctactgtcgc
      181 tcaggagcaa ttctgcctgc tccgggaaag cggcactgag agtttccctg ggagaaagaa
      241 ccgggacgcg cgcgtagagc cacaggggac cgggaaccga tccgaccgag cggcggagag
      301 gtggcccagc aaaaggtaat tttggacact agccatggaa gatttgatgt ttgtctgcag
      361 caacttcctc gacccttaag tcctgtaacc tcccgttctt ttgtgcctat caaggctccc
      421 gggtttcttc tctatccaga gttattctgt tgtggttggc catggggagc acactgggct
      481 gccatcgctc tatccccaga gatccctcgg acctgtcaca taaccgcaag ttcagcgctg
      541 cctgcaactt cagcaacatc ctggtgaatc aggagcggct aaatatcaac actgccactg
      601 aggaggaact gatgactctg cctggggtga cacgtgcagt ggcccgaagc atcgtggaat
      661 accgagaata tatcggcggc ttcaaaaagg tggaagatct ggcacttgtc agtggtgtag
      721 gggccaccaa actggaacag gtcaagtttg agatctgtgt gagcagcaag ggtaactctg
      781 cacagcactc tcccagttcc ctgaggcggg atcttctggc tgagcagcag cctcatcacc
      841 tgaccaccac tgtgcccctc actcctcgag tcaatatcaa cacagccacc cttgctcagc
      901 tcatgagtgt ccggggcctc agcgagaaga tggccctcag catcgtggac taccgcaggg
      961 aacacggtcc ttttcgaagt gttgaggact tggtgagaat ggatggaatc aatgcagcct
     1021 tcctggacag aataagacac caggtgttcg cagagaggtc caggccccca tcaacccaca
     1081 ccaatggggg tcttaccttc actgccaagc ctcatcccag tcccacatct ctgagcctgc
     1141 agagtgagga cttggacctg ccaccagggg ggcccacgca gattatctcc atgaggccct
     1201 cggtggaggc ctttggaggt atgagggatg ggcgacctgt gtttaggttg gccacgtgga
     1261 acttacaggg ctgctctgtg gagaaggcca ataacccggg ggttcgagag gtggtgtgca
     1321 tgacgcttct ggaaaacagc atcaaacttc tagctgtgca agagctgctt gacaaagagg
     1381 ccctggaaaa gttctgtaca gagctgaacc agccgatcct gcccaacatc cgcaagtgga
     1441 aggggtcccg aggatgctgg aggtccattg ttgctgagaa gccttccaat cagctccaga
     1501 agggcccctg ctactctgga ttcctatggg acacagcagc caacgtggag ctgagagaca
     1561 tccccgggcg ggagagctca cccagcaacg gtcatgctaa ggctgtgggc cccagccctt
     1621 tcctcgccag attcaaggtg ggaagtaatg acttaaccct ggttaacctc cagctgacag
     1681 ccctggccct cccaggagct gagaattcaa gcaagaatca cagtgatggc caccgattat
     1741 tgaactttgc actaaccctc caggaaaccc tgaaaggaga aaaggatgtt gttattttag
     1801 gggattttgg ccaagggcca gatagcaatg actacgatat cctaaggaga gaaaaatttc
     1861 accacctagt cccggctcac actttcacca acatcagcac caggaatcct caaggctcca
     1921 agtctgtgga caacatctgg atcagcaaaa gcttaaagaa agtgttcaca ggtcactggg
     1981 ctgttgtgag agaagggctc acaaaccctt ggattccaga taactggtcc tggggtggag
     2041 tcgcttctga acattgccct gtgcttgctg aattgtacat ggaaaaggac tggagcaaga
     2101 aggaagtccc caggaatggc aatggagtca ccttagagcc aagtgaagcc aacattaaac
     2161 atgagcgatg atgacatcac tctttcccgc ctctgacttg ggagagcata ggatggagat
     2221 ggcactacag ggtgagaaga tccagggcct gtgaatcatc attctgagga ccttagtctt
     2281 ggtccctgga ccactgtcca ctttgtgaac actttagaac ctggcctgag gggagcctgt
     2341 caggcactgg ctatggtggg catcatggcg gagctggctg gaactgcgac gtcttgacgc
     2401 tatgtagctg agttcgggct tgggatgggg gctgcactgc tggctgattg tttagcagca
     2461 tgagaacagt aacagaggag tgaagtgcag atgggaacag tggctcaggc tgacaagcag
     2521 tgccacagct ctcgtttctg cctcaccagg atgtcatgtt ctaccgacaa atttcaggaa
     2581 gcttttaact gtgatgaatg cacttctcaa agatttttag ttttgttttg aaaaaagaaa
     2641 agaataataa acagattaat ctgcctggct tcaaaaaaaa aaaaaaaaa
//
