LOCUS       NM_001412329            6391 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus eukaryotic elongation factor-2 kinase (Eef2k),
            transcript variant 5, mRNA.
ACCESSION   NM_001412329 XM_006507342
VERSION     NM_001412329.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6391)
  AUTHORS   Ruggiero,A., Heim,L.R., Susman,L., Hreaky,D., Shapira,I.,
            Katsenelson,M., Rosenblum,K. and Slutsky,I.
  TITLE     NMDA receptors regulate the firing rate set point of hippocampal
            circuits without altering single-cell dynamics
  JOURNAL   Neuron 113 (2), 244-259 (2025)
   PUBMED   39515323
REFERENCE   2  (bases 1 to 6391)
  AUTHORS   Xu,Y., Sun,F., Tian,Y., Zeng,G., Lei,G., Bai,Z., Wang,Y., Ge,X.,
            Wang,J., Xiao,C., Wang,Z., Hu,M., Song,J., Yang,P. and Liu,R.
  TITLE     Enhanced NK cell activation via eEF2K-mediated potentiation of the
            cGAS-STING pathway in hepatocellular carcinoma
  JOURNAL   Int Immunopharmacol 129, 111628 (2024)
   PUBMED   38320351
  REMARK    GeneRIF: Enhanced NK cell activation via eEF2K-mediated
            potentiation of the cGAS-STING pathway in hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 6391)
  AUTHORS   Iyyappan,R., Aleshkina,D., Ming,H., Dvoran,M., Kakavand,K.,
            Jansova,D., Del Llano,E., Gahurova,L., Bruce,A.W., Masek,T.,
            Pospisek,M., Horvat,F., Kubelka,M., Jiang,Z. and Susor,A.
  TITLE     The translational oscillation in oocyte and early embryo
            development
  JOURNAL   Nucleic Acids Res 51 (22), 12076-12091 (2023)
   PUBMED   37950888
REFERENCE   4  (bases 1 to 6391)
  AUTHORS   Peng,H.Y., Wang,L., Das,J.K., Kumar,A., Ballard,D.J., Ren,Y.,
            Xiong,X., de Figueiredo,P., Yang,J.M. and Song,J.
  TITLE     Control of CD4+ T cells to restrain inflammatory diseases via
            eukaryotic elongation factor 2 kinase
  JOURNAL   Signal Transduct Target Ther 8 (1), 415 (2023)
   PUBMED   37875468
  REMARK    GeneRIF: Control of CD4[+] T cells to restrain inflammatory
            diseases via eukaryotic elongation factor 2 kinase.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6391)
  AUTHORS   Knight,J.R.P., Proud,C.G., Mallucci,G., von der Haar,T.,
            Smales,C.M., Willis,A.E. and Sansom,O.J.
  TITLE     Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the
            Phenotypes of the Rpl24Bst Mouse
  JOURNAL   J Invest Dermatol 142 (12), 3346-3348 (2022)
   PUBMED   35850210
  REMARK    GeneRIF: Eukaryotic Elongation Factor 2 Kinase Activity Is Required
            for the Phenotypes of the Rpl24[Bst] Mouse.
REFERENCE   6  (bases 1 to 6391)
  AUTHORS   Boyce,M., Py,B.F., Ryazanov,A.G., Minden,J.S., Long,K., Ma,D. and
            Yuan,J.
  TITLE     A pharmacoproteomic approach implicates eukaryotic elongation
            factor 2 kinase in ER stress-induced cell death
  JOURNAL   Cell Death Differ 15 (3), 589-599 (2008)
   PUBMED   18188169
REFERENCE   7  (bases 1 to 6391)
  AUTHORS   Sakagami,H., Nishimura,H., Saito,R. and Kondo,H.
  TITLE     Transient up-regulation of elongation factor-2 kinase
            (Ca2+/calmodulin-dependent protein kinase III) messenger RNA in
            developing mouse brain
  JOURNAL   Neurosci Lett 330 (1), 41-44 (2002)
   PUBMED   12213630
  REMARK    GeneRIF: During late embryonic and early postnatal stages,
            elongation factor 2 kinase is up-regulated in the cerebral cortex
            and hippocampal pyramidal cell layer.
REFERENCE   8  (bases 1 to 6391)
  AUTHORS   Ryazanov,A.G., Pavur,K.S. and Dorovkov,M.V.
  TITLE     Alpha-kinases: a new class of protein kinases with a novel
            catalytic domain
  JOURNAL   Curr Biol 9 (2), R43-R45 (1999)
   PUBMED   10021370
REFERENCE   9  (bases 1 to 6391)
  AUTHORS   Ryazanov,A.G., Ward,M.D., Mendola,C.E., Pavur,K.S., Dorovkov,M.V.,
            Wiedmann,M., Erdjument-Bromage,H., Tempst,P., Parmer,T.G.,
            Prostko,C.R., Germino,F.J. and Hait,W.N.
  TITLE     Identification of a new class of protein kinases represented by
            eukaryotic elongation factor-2 kinase
  JOURNAL   Proc Natl Acad Sci U S A 94 (10), 4884-4889 (1997)
   PUBMED   9144159
REFERENCE   10 (bases 1 to 6391)
  AUTHORS   Gschwendt,M., Kittstein,W. and Marks,F.
  TITLE     Elongation factor-2 kinase: effective inhibition by the novel
            protein kinase inhibitor rottlerin and relative insensitivity
            towards staurosporine
  JOURNAL   FEBS Lett 338 (1), 85-88 (1994)
   PUBMED   8307162
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122214.4 and AC122248.5.
            
            On Sep 29, 2022 this sequence version replaced XM_006507342.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.1979248.1,
                                           SRR13422598.421786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AC122214.4         152603-152821
            220-313             AC122214.4         153732-153825
            314-632             AC122214.4         167380-167698
            633-733             AC122248.5         44680-44780
            734-794             AC122248.5         47803-47863
            795-832             AC122248.5         51185-51222
            833-1004            AC122248.5         51676-51847
            1005-1154           AC122248.5         56029-56178
            1155-1287           AC122248.5         56793-56925
            1288-1415           AC122248.5         57181-57308
            1416-1617           AC122248.5         57957-58158
            1618-1685           AC122248.5         59230-59297
            1686-1763           AC122248.5         60561-60638
            1764-1826           AC122248.5         61060-61122
            1827-1961           AC122248.5         62967-63101
            1962-2150           AC122248.5         63236-63424
            2151-2275           AC122248.5         66555-66679
            2276-2454           AC122248.5         70739-70917
            2455-6391           AC122248.5         74653-78589
FEATURES             Location/Qualifiers
     source          1..6391
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 64.95 cM"
     gene            1..6391
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /note="eukaryotic elongation factor-2 kinase"
                     /db_xref="GeneID:13631"
                     /db_xref="MGI:MGI:1195261"
     exon            1..219
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            220..313
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            314..632
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..2564
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /EC_number="2.7.11.20"
                     /note="isoform a is encoded by transcript variant 5;
                     eukaroytic elongation factor 2 kinase; eEF-2 kinase;
                     calcium/calmodulin-dependent eukaryotic elongation factor
                     2 kinase"
                     /codon_start=1
                     /product="eukaryotic elongation factor 2 kinase isoform a"
                     /protein_id="NP_001399258.1"
                     /db_xref="GeneID:13631"
                     /db_xref="MGI:MGI:1195261"
                     /translation="MADEDLIFCLEGVDGGRCSRAGHNADSDTDSDDDEGYFICPITD
                     DHMSNQNVSSKVQSYYSNLTKTECGSTGSPASSFHFKEAWKHAIEKAKHMPDPWAEFH
                     LEDIATEHATRHRYNAVTGEWLKDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQW
                     KGASNYVAKRYIEPVDRSVYFEDVQLQMEAKLWGEDYNRHKPPKQVDIMQMCIIELKD
                     RPGQPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQG
                     VGDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRICQSMGLTPFDLSPREQDA
                     VNQSTRLLQSAKTILRGTEEKCGSPRIRTLSSSRPPLLLRLSENSGDENMSDVTFDSL
                     PSSPSSATPHSQKLDHLHWPVFGDLDNMGPRDHDRMDNHRDSENSGDSGYPSEKRSDL
                     DDPEPREHGHSNGNRRHESDEDSLGSSGRVCVETWNLLNPSRLHLPRPSAVALEVQRL
                     NALDLGRKIGKSVLGKVHLAMVRYHEGGRFCEKDEEWDRESAIFHLEHAADLGELEAI
                     VGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRHSMILVARAFDTGLN
                     LSPDRCQDWSEALHWYNTALETTDCDEGGEYDGIQDEPQYALLAREAEMLLTGGFGLD
                     KNPQRSGDLYTQAAEAAMEAMKGRLANQYYEKAEEAWAQMEE"
     exon            633..733
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            734..794
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            795..832
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1004
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1154
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1287
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1415
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1617
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1685
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1763
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1826
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1961
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2150
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2275
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2454
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..6391
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3154..3159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /note="hexamer: AATATA"
     polyA_site      3174
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /note="major polyA site"
     regulatory      5609..5614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /note="hexamer: AATAAA"
     polyA_site      5628
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
     regulatory      6357..6362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
                     /note="hexamer: AATAAA"
     polyA_site      6391
                     /gene="Eef2k"
                     /gene_synonym="eEF-2K"
ORIGIN      
        1 agtgtcggct aaggggattg cgggaaacct gcccagctgc gccctgtgtg tgactgatcg
       61 cgtgcgtttc ggaagagtga gatctgactt gggaattctc cttgggggag tatttctgcg
      121 tcctccgcga tgaggcgctc cctggcttgg gaccactgaa cagatattac ggaggagaaa
      181 gccgaggtcc agagtggacc ccagatcctc agaggccagg gtctacaggt acagactaca
      241 aggcttcgga gaaagaaaag ggttgagtca gtcgctgcag tacggtaaca tttcacaggc
      301 tgaagagtca gaggaccatc cttgctgcac gtgcgcagta actctggctg cacagcggag
      361 cccccggata acacggtcgc ccccgcaaca tggcagacga agacctcatc ttctgcctgg
      421 aaggtgttga cggtggcagg tgctcccgag ctggccacaa tgcggactct gacacagaca
      481 gtgacgatga tgagggctat ttcatctgcc ccatcactga tgaccacatg tccaatcaga
      541 atgtcagctc caaagtccag agctactata gcaacctaac aaaaacagag tgcggctcca
      601 cagggtcacc agccagctcc ttccacttca aggaagcctg gaagcatgcg atcgagaaag
      661 ccaagcacat gcctgacccc tgggctgaat tccatctcga ggacatcgcc acagaacatg
      721 ctactcggca caggtacaac gctgtcaccg gggaatggct gaaagacgag gttctgatca
      781 agatggcgtc tcagcccttc ggccgtggag caatgaggga gtgcttcagg acgaagaaac
      841 tctccaactt cttgcacgcc cagcaatgga agggggcctc caactacgtg gccaagcgct
      901 acatcgagcc ggtggacagg agcgtgtact ttgaggatgt gcagctccag atggaggcga
      961 agctctgggg ggaggattac aatcggcaca agccccccaa gcaggtggat atcatgcaga
     1021 tgtgcatcat tgagctaaag gacagaccag gccagcccct cttccacttg gagcactaca
     1081 ttgagggcaa gtacatcaag tacaattcca actcaggctt tgtccgtgat gacaacatcc
     1141 gactaacccc acaggccttc agccatttca catttgagcg ttctggtcat cagctgattg
     1201 tagtggacat ccagggtgtg ggtgaccttt ataccgaccc acagatccac actgagaaag
     1261 gcactgactt tggagatggt aaccttggtg tccggggaat ggctctcttc ttctactctc
     1321 atgcctgcaa ccggatttgt cagagcatgg gccttacgcc ctttgacctc tccccacggg
     1381 aacaggatgc ggtgaatcag agcaccaggc tattgcaatc agccaagacc atcttgaggg
     1441 ggacagagga gaagtgtggg agtccccgca taaggacact ctctagcagc cggccccctt
     1501 tgctccttcg cctgtcagag aactccgggg atgagaacat gagtgacgtg acctttgact
     1561 ctctgccttc ctccccgtct tcagctacac cacacagcca gaaactggac cacctccatt
     1621 ggccagtgtt tggtgacctc gataacatgg gccctagaga ccatgaccgc atggacaatc
     1681 accgggactc tgagaatagt ggggacagtg ggtatccaag cgagaagcga agtgacctgg
     1741 atgatcctga gccccgagaa cacggccact ccaacggcaa ccgaaggcat gaatctgacg
     1801 aggatagcct gggcagctct ggacgggtct gtgtggagac gtggaacctg ctcaatccct
     1861 cccgcctgca cctgccgagg ccctcggccg tggccctaga agtgcagagg ctaaatgccc
     1921 tggaccttgg aaggaaaatc gggaagtctg ttttggggaa ggtccatttg gccatggtgc
     1981 gataccacga gggcgggcgc ttctgcgaga aggatgagga gtgggatcga gagtcagcca
     2041 tcttccatct ggagcatgca gctgacctgg gagaactgga ggccatcgtg ggcctaggcc
     2101 tcatgtactc tcagctgccc caccacatcc tggctgatgt ctctctgaag gagacagagg
     2161 agaacaagac aaaaggcttt gattacttac tgaaggcggc agaagctggt gacaggcatt
     2221 ccatgatttt agtggcccga gcttttgaca ctggcctgaa cctcagccca gacaggtgtc
     2281 aagactggtc ggaagccttg cactggtaca acacagccct ggagacaaca gactgcgatg
     2341 aaggcgggga gtacgatggg atacaggacg agccccagta cgcactgctg gccagggagg
     2401 cggagatgct gctcaccggg ggatttggac tggacaagaa cccccaaaga tcaggagatt
     2461 tgtacaccca ggcagctgag gcagcaatgg aagccatgaa gggccggcta gccaaccagt
     2521 actacgagaa ggcggaagag gcctgggccc agatggagga ataactgccc cacagaatca
     2581 ctgccaagga gaaaggctgg ggaagggagg atgggactca tttctaggga ggggagaagc
     2641 agttttatta tggtataaac tcacttttgt attccgtttt ctcactcttg atagcctttg
     2701 cagctggccg agacattata actgcccttt tagtggtggt actttggggg aagtgggggg
     2761 ttgaagatgc agcctaatga gtctctttcc cgtcctccac cccccggttt tccctttttc
     2821 atcctgagat gtaagcaagt atctttctgt ctggatgatc agacagtatc agggcttctc
     2881 tcgccagcct ttgcaggcag gactcacatc tcagggtctc caggccatgt gctgggaaac
     2941 ctttctattg gctttccaca atgggtcttt ctttcagttt tgagagcggt atgttgtttt
     3001 tttgtttgtt tcctccagtg gatgtgagat ggttcaatac ccaggctcct tcatgctggg
     3061 ggagatagtt gtataacttt cacttaatgc ccttccactg gacatgtgat tcctggcatc
     3121 cttctaaatt tttttttttt agacctgcta tgtaatatag atttttcaaa aacaggtttg
     3181 gcctttatac atgcgtattt actacctctg agtcttgcat tgggggtgtg gaagcagctg
     3241 tacctcaaag cattcacagt aagaccatgg cttaggagct gggcaacttt cctccaaaca
     3301 gaagtgccct ctgtacacca tggccacatc cactacgtga ctgaagcatc cttgtgcaga
     3361 attccatggc cgtttggccg tttcttaatg tgatgtttct tggactccgc cctcagcctg
     3421 ctgtccttgt cattttctgc ttgagactag gttttcctta cttaacacga ggtcatctgc
     3481 agcaagcggc ctccagctgc agccccttgg gatttgtcta agatgtttga gaatgagggg
     3541 acaagagtct aaacactgac tgggttagga catttcccca gggtcagtct gggactttga
     3601 tgagcttcct ctttaaaagg agttcagatt tcatgggagt gctattccag ccacagggaa
     3661 atggcccgct ttgatttgac cactgatatt agatctaccg cctctatctt tgcttaaaaa
     3721 acagaacagc agagtgggac atgcaagcca tcctcacctg ttggctaaaa caggcctttt
     3781 aaggatttca ctattgagtt tgcccaatca aaaacttgta gaagcagtag attgtaaagt
     3841 ctagggtgta tgttctttga gggaaaaatc agagtcagtt taaccttggg ggctggaggc
     3901 catggtatac atctgtaatc ccagcattca ggtggtagag gcagaaggat caaagtttga
     3961 gaccagccta ggctatgtaa tgagaccctg cccccaaaaa acaaacaagg aaaagagcca
     4021 gttagatggc tcatggatga agctcctgcc gaccctcacc tgacaatctg agttctgttc
     4081 ttgggaccca cgcgtggaag cagggaacaa actcctgcaa gttgtcttct gatcttcact
     4141 tgtgtgctgt gtcccgagag agcccccata cacacacaca cacacacaca cacacacaca
     4201 cacacacaca cacacacaca aacaacagta agagaaatga gatagcaaaa actacccttg
     4261 aaaattcctt tcatctacct gcaagttcca aaatccctgg atttgcattt gaagccataa
     4321 cttctgattc tctctgacag attggccctt gtccgttttt ttgtttttgt ttttgttttt
     4381 taattagtac cagaacagta gctggtttgc gttgtcctgt gggtgttcta acatagtgta
     4441 tatgttaaac ataagaagca gtttattgtg acataatctc tcagagtaac tgtcatataa
     4501 gttgtggtgt gtgtgtgtgt gtgtgctggt cagcagacaa cctcaatttt gttcctcagg
     4561 agctggccac ctttttccat tgagtctctc actggcctag aacttgccaa ataggctctg
     4621 ctggctgacc agtgaactcc agagatctgt ctgtcttatc ctttctaatt ctggaattgt
     4681 aaactcgaat ccttcactca ttgattagtc cttgtctgga tcacttaaag cctcaggcct
     4741 gcagttcccc caaccacgtg gccttcatgt ggagaagtgg tctctttctc ctccaagaga
     4801 ctgggatagc ctggtgcaca gctaagcaaa tgcctcttta aggacccttg cgaatgaaaa
     4861 gagagcttgg agagcctgct gggtaatatt gccacttgga ggctgaagca ggattgtgag
     4921 tttggagcca gcctgggcta tttactaaga ctgtgtctca aaaagaaaaa gccctggaaa
     4981 ctggagagat gcctcagtgg ttaagatcat tggctgctct tccagatgac ccaggttcaa
     5041 ttcccagcac ccacatggca gctcacacct gtctgtaatt ccagttttaa ggatccgatg
     5101 ctctcccaca accatgcagg ccaaacgccg atggacataa aaataaatca taaaaaaaaa
     5161 aaatagttca aacctgtaat ctcagcacag cacttgggag gctaaaatgg aagggtcact
     5221 gggagtttta tgccagattg ggctacatca tgacttccac ataagcctaa gttacagagt
     5281 gagattctgt ctttaaaatt aatggctgtt tctccttcca aacttagtct tagaccttca
     5341 aaagctggtc agggcatctt ctctttccat ataggctggg catgacaaga acaagccgac
     5401 aggattcagc tctggcaggg agacgccagt gcctggcact gatgatcagt tctgtcttcc
     5461 agtgctcaaa gcaggtaaca gcctcgatta acagagctga tatgcgtgct ttcatctcag
     5521 agacagaaac caggctacag tggtgctgtt ccttgaggct gagctggagc taggggccag
     5581 agagctgctg tttccagagc actctaggaa taaagacatt taactgtact gtgatggcgc
     5641 attccatttt gcaacaggta tcagggaaat ttcaatgaga caggattaga gtatgtgctt
     5701 agcatacagc caaggtcctg ggtctgggcc ccagcactgc aaggaaaata tacaagcttt
     5761 atgagtgtaa aaaagaaaca ttctccaact cactacttca gaagaatcct gctctctgca
     5821 cgctgggcca gccttggcta cttagtgatt tccccatctg tccttgctga ccgtcatccc
     5881 agcatctttg tatcagtaag tgtggtttgc agattcacaa acgtttgcac aggtctgtgc
     5941 agctcgagat ggaagtgaat cgggggcggg gggagggtac aaatttaccc attccctgct
     6001 tggatttgtg cctcttcctt aacgttttgt ctctgacctc aaggcaactg gctgaagtgt
     6061 ggctgcaatt gtgtgtgtat cagattttag cttctcttcc ccaacagttt gggttttttt
     6121 ctgaaatatc tcaaactcac acattccccc tccctatgaa aacatacaaa tcaagaaatg
     6181 agtatgtatc tacatggagg ctgaagtgag ccgcagcgtg catggatcga agagcggatg
     6241 tgctcacctt caacatgagc tccatcgccc acagtgtggg cccaacgtgg tcccatgctg
     6301 gcttttcaca gtagaaaaac ttcttaatat gatagccatt ggtttttaac atctgtaata
     6361 aattccaata aagaaagcct ttccgacctg g
//
