LOCUS       NM_007907               3126 bp    mRNA    linear   ROD 20-FEB-2024
DEFINITION  Mus musculus eukaryotic translation elongation factor 2 (Eef2),
            mRNA.
ACCESSION   NM_007907
VERSION     NM_007907.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3126)
  AUTHORS   Hu,K., Wang,C., Xu,Y., Li,F., Han,X., Song,C. and Liang,M.
  TITLE     Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis
            in ovarian follicular granulosa cells
  JOURNAL   J Ovarian Res 16 (1), 171 (2023)
   PUBMED   37612724
  REMARK    GeneRIF: Interaction of lncRNA Gm2044 and EEF2 promotes estradiol
            synthesis in ovarian follicular granulosa cells.
            Erratum:[J Ovarian Res. 2023 Oct 6;16(1):199. PMID: 37798763]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3126)
  AUTHORS   Bai,Y., Yu,G., Zhou,H.M., Amarasinghe,O., Zhou,Y., Zhu,P., Li,Q.,
            Zhang,L., Nguele Meke,F., Miao,Y., Chapman,E., Tao,W.A. and
            Zhang,Z.Y.
  TITLE     PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805
  JOURNAL   Autophagy 19 (5), 1562-1581 (2023)
   PUBMED   36300783
REFERENCE   3  (bases 1 to 3126)
  AUTHORS   Ma,X., Li,L., Li,Z., Huang,Z., Yang,Y., Liu,P., Guo,D., Li,Y.,
            Wu,T., Luo,R., Xu,J., Ye,W.C., Jiang,B. and Shi,L.
  TITLE     eEF2 in the prefrontal cortex promotes excitatory synaptic
            transmission and social novelty behavior
  JOURNAL   EMBO Rep 23 (10), e54543 (2022)
   PUBMED   35993189
  REMARK    GeneRIF: eEF2 in the prefrontal cortex promotes excitatory synaptic
            transmission and social novelty behavior.
REFERENCE   4  (bases 1 to 3126)
  AUTHORS   Lizarazo,S., Yook,Y. and Tsai,N.P.
  TITLE     Amyloid beta induces Fmr1-dependent translational suppression and
            hyposynchrony of neural activity via phosphorylation of eIF2alpha
            and eEF2
  JOURNAL   J Cell Physiol 237 (7), 2929-2942 (2022)
   PUBMED   35434801
  REMARK    GeneRIF: Amyloid beta induces Fmr1-dependent translational
            suppression and hyposynchrony of neural activity via
            phosphorylation of eIF2alpha and eEF2.
REFERENCE   5  (bases 1 to 3126)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3126)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 3126)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
REFERENCE   8  (bases 1 to 3126)
  AUTHORS   Satyamoorthy,K. and Howe,C.C.
  TITLE     The mouse elongation factor-2 gene: isolation and characterization
            of the promoter
  JOURNAL   DNA Cell Biol 16 (4), 401-412 (1997)
   PUBMED   9150427
REFERENCE   9  (bases 1 to 3126)
  AUTHORS   Brown,T.L., Fischer,W.C., Collins,M.D., De,B.K. and Scott,W.J. Jr.
  TITLE     Identification of a 100-kDa phosphoprotein in developing murine
            embryos as elongation factor 2
  JOURNAL   Arch Biochem Biophys 309 (1), 105-110 (1994)
   PUBMED   8117099
REFERENCE   10 (bases 1 to 3126)
  AUTHORS   Ishiura,M., Ohashi,H., Hazumi,N., Uchida,T. and Okada,Y.
  TITLE     Simplified cosmid vectors for gene transfer to cultured mammalian
            cells: isolation of the gene for elongation factor 2 from the mouse
  JOURNAL   Gene 85 (2), 427-433 (1989)
   PUBMED   2628177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ170931.1, AK168794.1 and CJ316208.1.
            
            [WARNING] On Mar 18, 2024 this sequence was replaced by
            NM_007907.3.
            
            On May 21, 2009 this sequence version replaced NM_007907.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007152.1, AK159421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CJ170931.1         2-16
            16-3086             AK168794.1         2-3072
            3087-3126           CJ316208.1         400-439
FEATURES             Location/Qualifiers
     source          1..3126
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3126
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /note="eukaryotic translation elongation factor 2"
                     /db_xref="GeneID:13629"
                     /db_xref="MGI:MGI:95288"
     exon            1..99
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2673
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /codon_start=1
                     /product="elongation factor 2"
                     /protein_id="NP_031933.1"
                     /db_xref="CCDS:CCDS35993.1"
                     /db_xref="GeneID:13629"
                     /db_xref="MGI:MGI:95288"
                     /translation="MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAG
                     IIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGSGFLINL
                     IDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKM
                     DRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGL
                     HGWAFTLKQFAEMYVAKFAAKGEGQLSAAERAKKVEDMMKKLWGDRYFDPANGKFSKS
                     ANSPDGKKLPRTFCQLILDPIFKVFDAIMNFRKEETAKLIEKLDIKLDSEDKDKEGKP
                     LLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDPKG
                     PLMMYISKMVPTSDKGRFYAFGRVFSGVVSTGLKVRIMGPNYTPGKKEDLYLKPIQRT
                     ILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMKFSVSPVVRVA
                     VEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHA
                     CIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSA
                     RQELKARARYLAEKYEWDVAEARKIWCFGPDGTGPNILTDITKGVQYLNEIKDSVVAG
                     FQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQIIPTARRCLYASVLTAQPRL
                     MEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTA
                     DLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKRKGLKEGIPALDNFLD
                     KL"
     exon            100..314
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            315..496
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..708
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..887
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            888..993
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1246
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1442
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1701
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1809
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2163
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2346
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2479
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..3100
                     /gene="Eef2"
                     /gene_synonym="Ef-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgacgtca gcggtctctt ccgccgcagc cgccgccatc gtcggcgcgc ttccctgttc
       61 acctctgact ctgagaatcc gtcgccatcc gccaccatgg tgaacttcac agtagatcag
      121 atccgtgcca tcatggacaa gaaagccaac atccggaaca tgtcagtcat cgcccatgtg
      181 gaccacggca agtccacgct gaccgactcc cttgtgtgca aggctggcat cattgcctct
      241 gcccgagctg gggagacgcg cttcactgac actcgcaagg atgagcagga gcgctgcatc
      301 acaatcaaat ccaccgccat ctccctcttc tacgagctct ctgagaacga cctgaacttc
      361 attaagcaga gcaaggatgg ctcgggcttc ctcatcaacc tcatcgactc tccaggccat
      421 gtggacttct cttcagaggt gacagctgcc ttgcgtgtca ccgatggagc tctggtggtg
      481 gtggactgtg tgtctggcgt gtgtgtgcag acagaaactg tgctgcgcca ggccatcgct
      541 gaacgcatca agcccgtcct gatgatgaac aagatggacc gggccctgct ggagctgcag
      601 ctggagcccg aggagctcta ccagaccttc cagcgcatcg tggagaacgt caacgtcatc
      661 atctctacct acggcgaggg cgagagtggg cccatgggca atatcatgat tgaccccgtc
      721 ctgggcaccg taggctttgg ttctggcctg catggctggg ccttcaccct gaagcagttt
      781 gcggagatgt atgtggccaa gtttgcagcc aagggtgagg gccagctgag cgcagccgag
      841 cgtgccaaga aagtagagga catgatgaag aagctgtggg gagaccggta ctttgatccg
      901 gccaatggca agttcagtaa gtcagccaat agcccagatg ggaaaaaact tccccgcacc
      961 ttctgccagc tcatcctgga ccccatcttc aaggtgttcg acgccatcat gaacttcagg
     1021 aaggaggaga cagccaagct gatcgagaag ctggacatca agctggacag cgaggacaaa
     1081 gacaaggagg gcaagccatt gctcaaggct gtgatgcgcc gctggctgcc tgcaggggac
     1141 gccctcctgc agatgatcac catccactta ccatcccccg tcactgcaca gaagtaccgt
     1201 tgtgagctgc tatacgaggg gcctcccgac gatgaggccg ccatgggtat taagagctgc
     1261 gaccccaaag gcccacttat gatgtacatt tccaagatgg tgccaacctc tgacaaaggc
     1321 cgcttctatg cctttggtag agtgttctct ggggtggtgt ccacgggcct gaaggtccgg
     1381 atcatgggcc ccaactacac gcctgggaag aaagaggacc tatacctgaa gcctatccag
     1441 agaaccattc tgatgatggg ccgctacgtg gagccgattg aggacgtgcc atgtggaaac
     1501 attgtggggc tggtcggagt ggaccagttc cttgtgaaga cggggaccat cactaccttt
     1561 gagcacgctc acaacatgcg cgtgatgaag ttcagcgtca gccctgtcgt ccgtgtggca
     1621 gtggaggcca agaacccagc tgacctgccc aagctggtgg aggggctgaa gcggctggct
     1681 aagtctgacc ctatggtgca gtgcatcatt gaggagtctg gagaacatat tattgctggc
     1741 gccggtgagc tgcacctgga gatctgcctt aaggacctgg aggaggacca tgcctgcatc
     1801 cccatcaaga aatctgaccc tgttgtgtca tatcgggaga cagtcagtga ggaatccaac
     1861 gtgctgtgtc tgtccaagtc ccccaataag cacaaccggc tgtacatgaa ggccaggccc
     1921 ttccctgatg gcctggcaga ggacatcgat aagggtgagg tgtctgcccg ccaggagctc
     1981 aaggcacgtg cccgctacct ggccgaaaag tatgagtggg acgttgctga agcccgcaag
     2041 atctggtgct ttggccctga tggcactggc cccaacattc tcaccgacat caccaagggt
     2101 gtgcagtacc tgaatgagat caaggacagt gtggtggctg gcttccagtg ggctactaag
     2161 gagggcgctc tctgtgagga aaacatgcgt ggtgtgcggt ttgatgttca tgatgtgacc
     2221 ctgcatgctg atgccattca ccggggaggt ggccagatca tccccacagc acgccgctgc
     2281 ctgtatgcca gtgtgctgac cgcacagccc cgcctcatgg agcctatcta tctggtggag
     2341 atccagtgtc ctgagcaagt ggtgggtggc atctacggtg tcctgaacag gaagcgtggc
     2401 catgtgtttg aggagtccca ggtggctggt acccccatgt ttgtggtcaa ggcatacctg
     2461 cctgtcaatg agtcctttgg cttcaccgct gatctgcgat ccaacaccgg cggccaggcc
     2521 ttcccccagt gcgtgtttga ccactggcag atcctgcctg gggatccttt tgacaacagc
     2581 agccgcccca gccaagtggt agctgagacg cgcaagcgca agggcctgaa agagggcatc
     2641 ccagcgctgg acaacttcct ggacaaactg taggcagcct gatactgcca catgctgcac
     2701 agtgcccacc catcagaaga caccttgaga ctgtcccaca gtgctcctct agaggctgct
     2761 ggggccaccc tgacatcact cagcactcac ttgctaccaa ttctatttat ttcggaatta
     2821 caagatagcg ggaatctctc tgcaggctgg actggcaggc tgtggggtgg gcgggacacg
     2881 gctcttaaca ttttcagagg gaaacgcgca gatgtccaaa agtctaaata aatgcattca
     2941 gaggtttttg gggtccatgg ccaagtggag ttcccccaga gggggaggtg gggtaagtgc
     3001 ctccaggaag gcaggcagcc tgccttagac ttgcagcccg gctgtgggaa tgaatcattg
     3061 gagtaataaa ctacagtggt tgatccacat gtgctcgcaa aaaaaaaaaa aaaaaaaaaa
     3121 aaaaaa
//
