LOCUS       NM_025380               1039 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus eukaryotic translation elongation factor 1 epsilon 1
            (Eef1e1), mRNA.
ACCESSION   NM_025380
VERSION     NM_025380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1039)
  AUTHORS   Kotov,D.I., Mitchell,J.S., Pengo,T., Ruedl,C., Way,S.S.,
            Langlois,R.A., Fife,B.T. and Jenkins,M.K.
  TITLE     TCR Affinity Biases Th Cell Differentiation by Regulating CD25,
            Eef1e1, and Gbp2
  JOURNAL   J Immunol 202 (9), 2535-2545 (2019)
   PUBMED   30858199
  REMARK    GeneRIF: high-affinity T cells sustained IL-2R expression longer
            and expressed two novel Th cell differentiation regulators, Eef1e1
            and Gbp2, to a higher level than low-affinity T cells.
REFERENCE   2  (bases 1 to 1039)
  AUTHORS   Kim,D., Kim,S., Oh,Y., Park,S., Jeon,Y., Kim,H., Lee,H. and Kim,S.
  TITLE     AIMP3 Deletion Induces Acute Radiation Syndrome-like Phenotype in
            Mice
  JOURNAL   Sci Rep 8 (1), 15025 (2018)
   PUBMED   30302025
  REMARK    GeneRIF: gamma-H2AX removal was delayed, and homologous DNA repair
            activity was significantly reduced. Reduction of RPA foci formation
            and subsequent Rad51 foci formation probably underlie the
            significant reduction in homologous recombination activity in the
            absence of AIMP3. Together, our data demonstrate that AIMP3 plays a
            role in genome stability through the DNA repair process
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1039)
  AUTHORS   Kim,S.M., Jeon,Y., Kim,D., Jang,H., Bae,J.S., Park,M.K., Kim,H.,
            Kim,S. and Lee,H.
  TITLE     AIMP3 depletion causes genome instability and loss of stemness in
            mouse embryonic stem cells
  JOURNAL   Cell Death Dis 9 (10), 972 (2018)
   PUBMED   30250065
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1039)
  AUTHORS   Oh,Y.S., Kim,D.G., Kim,G., Choi,E.C., Kennedy,B.K., Suh,Y.,
            Park,B.J. and Kim,S.
  TITLE     Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a
            progeroid phenotype in mice
  JOURNAL   Aging Cell 9 (5), 810-822 (2010)
   PUBMED   20726853
  REMARK    GeneRIF: AIMP3 is a specific regulator of mature lamin A and imply
            that enhanced expression of AIMP3 might be a factor driving
            cellular and/or organismal aging [AIMP3]
REFERENCE   5  (bases 1 to 1039)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   6  (bases 1 to 1039)
  AUTHORS   Tkatchenko,T.V., Moreno-Rodriguez,R.A., Conway,S.J.,
            Molkentin,J.D., Markwald,R.R. and Tkatchenko,A.V.
  TITLE     Lack of periostin leads to suppression of Notch1 signaling and
            calcific aortic valve disease
  JOURNAL   Physiol Genomics 39 (3), 160-168 (2009)
   PUBMED   19723774
REFERENCE   7  (bases 1 to 1039)
  AUTHORS   Park,B.J., Kang,J.W., Lee,S.W., Choi,S.J., Shin,Y.K., Ahn,Y.H.,
            Choi,Y.H., Choi,D., Lee,K.S. and Kim,S.
  TITLE     The haploinsufficient tumor suppressor p18 upregulates p53 via
            interactions with ATM/ATR
  JOURNAL   Cell 120 (2), 209-221 (2005)
   PUBMED   15680327
REFERENCE   8  (bases 1 to 1039)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1039)
  AUTHORS   Kim,J.Y., Kang,Y.S., Lee,J.W., Kim,H.J., Ahn,Y.H., Park,H., Ko,Y.G.
            and Kim,S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
REFERENCE   10 (bases 1 to 1039)
  AUTHORS   Quevillon,S. and Mirande,M.
  TITLE     The p18 component of the multisynthetase complex shares a protein
            motif with the beta and gamma subunits of eukaryotic elongation
            factor 1
  JOURNAL   FEBS Lett 395 (1), 63-67 (1996)
   PUBMED   8849690
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY197082.1, AK003335.1 and AK009889.1.
            
            On Apr 21, 2006 this sequence version replaced NM_025380.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009889.1, BC048466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY197082.1         5-22
            19-1030             AK003335.1         2-1013
            1031-1039           AK009889.1         1004-1012
FEATURES             Location/Qualifiers
     source          1..1039
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 18.38 cM"
     gene            1..1039
                     /gene="Eef1e1"
                     /gene_synonym="1110003A02Rik; AIMP3"
                     /note="eukaryotic translation elongation factor 1 epsilon
                     1"
                     /db_xref="GeneID:66143"
                     /db_xref="MGI:MGI:1913393"
     exon            1..122
                     /gene="Eef1e1"
                     /gene_synonym="1110003A02Rik; AIMP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..560
                     /gene="Eef1e1"
                     /gene_synonym="1110003A02Rik; AIMP3"
                     /note="elongation factor p18; multisynthetase complex
                     auxiliary component p18; multisynthase complex auxiliary
                     component p18"
                     /codon_start=1
                     /product="eukaryotic translation elongation factor 1
                     epsilon-1"
                     /protein_id="NP_079656.1"
                     /db_xref="CCDS:CCDS26465.1"
                     /db_xref="GeneID:66143"
                     /db_xref="MGI:MGI:1913393"
                     /translation="MAAAAELRLLEKSLGLKPGNKYSAQGERQIPVLQTNNGPSLMGL
                     STIATHLVKQASKEHLLGSTAEEKAMVQQWLEFRVTRVDGHSSKEDTQTLLKDLNSYL
                     EDKVYLAGHNITLADILLYYGLHRFIVDLTVQEKEKYLNVSRWFCHIQHYPDIRQHLS
                     SIVFIKNRLYANSH"
     exon            123..323
                     /gene="Eef1e1"
                     /gene_synonym="1110003A02Rik; AIMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            324..419
                     /gene="Eef1e1"
                     /gene_synonym="1110003A02Rik; AIMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            420..1039
                     /gene="Eef1e1"
                     /gene_synonym="1110003A02Rik; AIMP3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcaggcccc gcctccctag gagctgggcc agaagatggc ggcggccgcg gagttgaggc
       61 tgctggagaa gagtctggga ctgaagccgg ggaataagta cagtgctcag ggcgagcggc
      121 agattccagt tctacagaca aacaatggcc cgagtctaat gggattgagt accatcgcca
      181 cccatctagt caagcaggcc agtaaggagc acttgctggg gagcactgca gaagaaaagg
      241 caatggttca gcagtggtta gagttcaggg tcactcgagt agatggacac tccagtaaag
      301 aagacaccca gactctgctg aaggatctta attcctatct tgaagataaa gtctaccttg
      361 caggacataa catcaccctg gcggacatcc tgctgtacta cggcctccac cgctttatag
      421 ttgacctgac agttcaagaa aaggagaaat atcttaatgt gtctcgctgg ttttgtcaca
      481 ttcaacatta cccagacatc aggcaacatc tgtccagtat tgtcttcatc aagaacagac
      541 tctatgctaa ctcccactag aagccctcgc tgtgcagcag ccagaagtgt aatggaaaat
      601 gtatcttgga ccatggtact aatgtaaatt aatatggcat cattgtttct ttgttaatgt
      661 tggtagaatt tttaaagtgt aagctcaagt ctaaatgttt tatttgtcct gtagttgagg
      721 cttcgtaatt tttttaatgt aaaaatcagc tgttatccaa acaaatcagg atcaaattac
      781 agatcttgtt tttatgaaca aagttgattt tggtaacagt tgaaaatcag tggctcaact
      841 ttaaaaaaaa agcccctatt gatgtcacat ctggctgttt acttttttcg tgtttttaaa
      901 atttattttt ctcttagata tttattgtag tttatttact aaaacctatg acaaattatg
      961 ttgaggaatc agaaagggaa gttatatata tttgttctca aaatatttat gtgagctagt
     1021 aaatgtggtt ttaaaaatc
//
