LOCUS       NM_029663               2819 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus eukaryotic translation elongation factor 1 delta
            (Eef1d), transcript variant 1, mRNA.
ACCESSION   NM_029663
VERSION     NM_029663.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2819)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2819)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2819)
  AUTHORS   Kaitsuka,T., Kiyonari,H., Shiraishi,A., Tomizawa,K. and
            Matsushita,M.
  TITLE     Deletion of Long Isoform of Eukaryotic Elongation Factor 1Bdelta
            Leads to Audiogenic Seizures and Aversive Stimulus-Induced
            Long-Lasting Activity Suppression in Mice
  JOURNAL   Front Mol Neurosci 11, 358 (2018)
   PUBMED   30333725
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2819)
  AUTHORS   Kaitsuka,T., Tomizawa,K. and Matsushita,M.
  TITLE     Transformation of eEF1Bdelta into heat-shock response transcription
            factor by alternative splicing
  JOURNAL   EMBO Rep 12 (7), 673-681 (2011)
   PUBMED   21597468
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2819)
  AUTHORS   Kohr,M.J., Aponte,A.M., Sun,J., Wang,G., Murphy,E., Gucek,M. and
            Steenbergen,C.
  TITLE     Characterization of potential S-nitrosylation sites in the
            myocardium
  JOURNAL   Am J Physiol Heart Circ Physiol 300 (4), H1327-H1335 (2011)
   PUBMED   21278135
REFERENCE   6  (bases 1 to 2819)
  AUTHORS   Trinidad,J.C., Thalhammer,A., Specht,C.G., Lynn,A.J., Baker,P.R.,
            Schoepfer,R. and Burlingame,A.L.
  TITLE     Quantitative analysis of synaptic phosphorylation and protein
            expression
  JOURNAL   Mol Cell Proteomics 7 (4), 684-696 (2008)
   PUBMED   18056256
REFERENCE   7  (bases 1 to 2819)
  AUTHORS   Miyamoto-Sato,E., Ishizaka,M., Horisawa,K., Tateyama,S.,
            Takashima,H., Fuse,S., Sue,K., Hirai,N., Masuoka,K. and Yanagawa,H.
  TITLE     Cell-free cotranslation and selection using in vitro virus for
            high-throughput analysis of protein-protein interactions and
            complexes
  JOURNAL   Genome Res 15 (5), 710-717 (2005)
   PUBMED   15867431
REFERENCE   8  (bases 1 to 2819)
  AUTHORS   Joseph,P., Lei,Y.X. and Ong,T.M.
  TITLE     Up-regulation of expression of translation factors--a novel
            molecular mechanism for cadmium carcinogenesis
  JOURNAL   Mol Cell Biochem 255 (1-2), 93-101 (2004)
   PUBMED   14971650
  REMARK    GeneRIF: the up-regulation of expression of TEF-1delta is a novel
            molecular mechanism responsible, at least in part, for cadmium
            carcinogenesis
REFERENCE   9  (bases 1 to 2819)
  AUTHORS   Joseph,P., Lei,Y.X., Whong,W.Z. and Ong,T.M.
  TITLE     Oncogenic potential of mouse translation elongation factor-1 delta,
            a novel cadmium-responsive proto-oncogene
  JOURNAL   J Biol Chem 277 (8), 6131-6136 (2002)
   PUBMED   11711542
REFERENCE   10 (bases 1 to 2819)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116520.14.
            
            On Sep 13, 2022 this sequence version replaced NM_029663.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079855.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC116520.14        98090-98151         c
            63-77               AC116520.14        94731-94745         c
            78-1207             AC116520.14        91524-92653         c
            1208-1331           AC116520.14        89977-90100         c
            1332-1403           AC116520.14        89536-89607         c
            1404-1503           AC116520.14        85665-85764         c
            1504-1604           AC116520.14        85485-85585         c
            1605-1826           AC116520.14        85088-85309         c
            1827-2021           AC116520.14        84577-84771         c
            2022-2819           AC116520.14        83639-84436         c
FEATURES             Location/Qualifiers
     source          1..2819
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.05 cM"
     gene            1..2819
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /note="eukaryotic translation elongation factor 1 delta"
                     /db_xref="GeneID:66656"
                     /db_xref="MGI:MGI:1913906"
     exon            1..62
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            63..77
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2060
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /note="isoform a is encoded by transcript variant 1;
                     eukaryotic translation elongation factor 1 delta (guanine
                     nucleotide exchange protein)"
                     /codon_start=1
                     /product="elongation factor 1-delta isoform a"
                     /protein_id="NP_083939.1"
                     /db_xref="CCDS:CCDS27553.1"
                     /db_xref="GeneID:66656"
                     /db_xref="MGI:MGI:1913906"
                     /translation="MRSGKASCALETVWEDRHKYEGAERRFHEQEATQVVAAAATAAA
                     TASASVQQLLDEVPAVNGPSQEDTEDTEEAEAPNTSSRSDPGKSHECKKPIQKKRKRS
                     PKSWLGQADLALVGLSADHVWLDKPLFDQAESSYRQRLADVAAQAAQPPALAPRGPCT
                     HGSHVACHHVTWGIWVNKSCFDQAERAFVEWSQSLLLAAEGSHRQGTPDTGQQAVTPD
                     LALACQPCPPANGQPPLGSLQALVREVWLEKPRYDAAERGFYEALFDGHPPGKVRLQE
                     RASQAEGTRRGRRDHRSCNNVGNKRAGSKRANGEAPPAFPYWYFLHKDAEAPWLSKPT
                     YDSAECRHHAVEALRIAWRLEAASLAHRPTPRSGPSMSSLRPNRKMATNFLAHEKIWF
                     DKFKYDDAERRFYEQMNGPVTSGSRQENGASVILRDIARARENIQKSLAGSSGPGASS
                     GPGGDHSELIVRITSLEVENQNLRGVVQDLQQAISKLEARLSSLEKSSPTPRATAPQT
                     QHVSPMRQVEPPTKKGATPAEDDEDKDIDLFGSDEEEEDKEAARLREERLRQYAEKKA
                     KKPTLVAKSSILLDVKPWDDETDMAQLETCVRSIQLDGLVWGASKLVPVGYGIRKLQI
                     QCVVEDDKVGTDLLEEEITKFEEHVQSVDIAAFNKI"
     exon            78..1207
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1331
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1403
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1503
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1604
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1826
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2021
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2819
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2105..2110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /note="hexamer: ATTAAA"
     polyA_site      2125
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /note="major polyA site"
     polyA_site      2206
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
     regulatory      2783..2788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
                     /note="hexamer: AATAAA"
     polyA_site      2819
                     /gene="Eef1d"
                     /gene_synonym="EF-1-delta"
ORIGIN      
        1 ctctcctttg cagtcctgag ctcgcagttc caggttttgg ttgctgcgtc cttggctggc
       61 gtgaggccaa agcaaaaatg aggagtggga aggcctcttg tgcactggag accgtctggg
      121 aggacaggca caagtatgag ggagccgagc ggcgcttcca cgagcaggag gccacacaag
      181 tcgtcgccgc cgccgccact gccgccgcca ctgcctccgc ctctgtccag cagctcctgg
      241 acgaagtgcc agctgtgaac gggcccagcc aggaggacac agaggacact gaggaggcag
      301 aggccccaaa caccagcagc aggagtgatc ccgggaagag ccacgagtgc aagaagccga
      361 tacagaaaaa gaggaagcgc tccccgaaaa gttggctggg ccaggcagac ctggcccttg
      421 tgggcctctc ggctgaccac gtatggttag acaagccact cttcgaccag gcagaaagct
      481 cctaccgtca gaggctggca gatgtagctg cccaggcagc ccagccgcct gctctggccc
      541 ctcgggggcc ctgtacacat ggaagccatg tggcatgcca ccatgtaacc tgggggatct
      601 gggtcaacaa gtcttgcttt gatcaagccg agcgggcttt tgtggagtgg tctcagtcct
      661 tgctgctggc tgcagagggg agccataggc aggggactcc tgacacaggc cagcaggctg
      721 tcactcctga cctggccttg gcctgccagc cttgcccacc agccaatggc cagcctcctc
      781 tgggcagcct gcaggcactg gtgcgggagg tatggctgga gaagccccgg tacgatgccg
      841 ctgagagggg cttctatgag gccctgtttg atggtcatcc cccagggaaa gtgcgcctgc
      901 aggagcgagc cagtcaggca gagggtaccc ggaggggccg cagagaccat cggagctgca
      961 ataacgtagg aaacaagaga gctgggtcaa aacgggccaa cggggaggct cctcctgctt
     1021 ttccctactg gtacttccta cacaaggacg cagaggcccc ctggctcagc aagcctacct
     1081 acgacagcgc tgagtgccgc caccatgccg ttgaggccct gcgcatagcc tggcgcctag
     1141 aagctgcctc cctggctcac cgacccacac cccgttctgg cccatccatg tccagcctga
     1201 gacccaacag aaaaatggct acaaactttc tagcgcatga gaagatctgg tttgacaagt
     1261 ttaaatatga tgatgcagaa aggagattct atgagcagat gaacgggcct gtgacctccg
     1321 gctcccgcca ggagaatggt gccagcgtga tcctccgaga cattgcaaga gccagagaga
     1381 acatccagaa atccttggct ggaagctcag gccctggagc ctccagtgga cctggtggag
     1441 accacagtga gctcattgtg aggattacca gtctggaagt ggagaaccag aaccttcgag
     1501 gcgtggtgca agatttgcag caggccattt ccaagttgga ggcccggctg agctctctag
     1561 agaagagttc acctactccc cgagccacgg ccccacagac ccaacatgtc tctcctatgc
     1621 gtcaagtgga gcccccaacc aagaaaggag ccacaccagc agaggacgat gaggacaagg
     1681 acattgacct gttcggcagt gacgaggagg aagaagataa ggaggctgcc cgactacggg
     1741 aggagaggct acgccagtac gcagagaaga aggccaagaa gcccacactg gtggccaaat
     1801 cctccatcct tttggatgtt aaaccttggg atgatgagac tgacatggcc cagctagaga
     1861 cttgtgtgcg ttccatccaa ttggacgggc tggtttgggg ggcctccaag cttgtgcctg
     1921 ttggctatgg catccggaag ctgcagatcc agtgtgtggt ggaggatgac aaagtgggca
     1981 ccgacttgct cgaggaggag atcaccaaat ttgaggagca tgtgcagagt gtcgacatcg
     2041 cagctttcaa caagatctga atgtccgaga gagtgtggtt tcatgtgtgt gaggacctgc
     2101 tgagattaaa gactgagact ctgcactccg cctcttgtgt tacttggtgt acagcgctct
     2161 gtgggctctg gctcatactt gtcccagaaa caatctatta ggtccacatt tgtccaccgt
     2221 gtctctcctg tccctgctgt tgtcaccgtg tacacctaga cccagtctaa cactcctctt
     2281 cacactcctt acctctggag ggatacatcc tctttatata ttctgggatg gttagaatat
     2341 ggacagccag ctgtactgta tggaattttg tctgcccgct cccctaaaac cccttgtcag
     2401 tgcttgggta ttggtggtat tgggacgata gtgctcgtga aatcctgcga acatctaagt
     2461 tgagaaagtg taccaagtgt ggctgattcc tgtcagtgtt gttcatcatg gcccctagtc
     2521 accaggaaac aatgtagccc tccccctcaa aagttttaga cttttcctgt gggacctgaa
     2581 caaaaaactg tcacctgggc aaggatgact tcgcagttaa gaacactatt ctggaagatg
     2641 gggctcattc ccagcaacca catggaaact tacaaaccag ctgtaactcc agttcctgga
     2701 tacctgatac cctcttctgg cctctgggca tgcatatctg cctgcagtac aaaaacacct
     2761 acactttttt tttttttttg agaataaatt ttgctgtata tccttgtcag tttagagaa
//
