LOCUS       NM_028095               1097 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus EEF1A lysine methyltransferase 2 (Eef1akmt2),
            transcript variant 1, mRNA.
ACCESSION   NM_028095 XM_133902
VERSION     NM_028095.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1097)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1097)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 1097)
  AUTHORS   Somma,G., Alger,H.M., McGuire,R.M., Kretlow,J.D., Ruiz,F.R.,
            Yatsenko,S.A., Stankiewicz,P., Harrison,W., Funk,E.,
            Bergamaschi,A., Oghalai,J.S., Mikos,A.G., Overbeek,P.A. and
            Pereira,F.A.
  TITLE     Head bobber: an insertional mutation causes inner ear defects,
            hyperactive circling, and deafness
  JOURNAL   J Assoc Res Otolaryngol 13 (3), 335-349 (2012)
   PUBMED   22383091
REFERENCE   4  (bases 1 to 1097)
  AUTHORS   Hackney,J.A., Charbord,P., Brunk,B.P., Stoeckert,C.J.,
            Lemischka,I.R. and Moore,K.A.
  TITLE     A molecular profile of a hematopoietic stem cell niche
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13061-13066 (2002)
   PUBMED   12226475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ830246.1, AK008476.1 and BC038323.1.
            
            On Aug 30, 2004 this sequence version replaced XM_133902.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038323.1, BC096622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BQ830246.1         27-42
            17-778              AK008476.1         2-763
            779-1097            BC038323.1         734-1052
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 76.31 cM"
     gene            1..1097
                     /gene="Eef1akmt2"
                     /gene_synonym="2010208K18Rik; Mettl10"
                     /note="EEF1A lysine methyltransferase 2"
                     /db_xref="GeneID:72096"
                     /db_xref="MGI:MGI:1919346"
     exon            1..149
                     /gene="Eef1akmt2"
                     /gene_synonym="2010208K18Rik; Mettl10"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..774
                     /gene="Eef1akmt2"
                     /gene_synonym="2010208K18Rik; Mettl10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     methyltransferase-like protein 10; protein-lysine
                     N-methyltransferase Mettl10; methyltransferase like 10"
                     /codon_start=1
                     /product="EEF1A lysine methyltransferase 2 isoform 1"
                     /protein_id="NP_082371.1"
                     /db_xref="CCDS:CCDS21927.1"
                     /db_xref="GeneID:72096"
                     /db_xref="MGI:MGI:1919346"
                     /translation="MNADAEGHSGAVVPAQSPEGSSAADDFVPSALGTREHWDAVYER
                     ELRTFQEYGDTGEIWFGEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELVKHGF
                     SNITGIDYSPSAIKLSASILEKEGLSNINLKVEDFLNPSTKLSGFHVCVDKGTYDAIS
                     LNPDNAIEKRKQYVMSLSRVLEVKGFFLITSCNWTKAELLDAFSEGFELFEELPTPKF
                     SFGGRSGNTVAALVFQKRGTSLDKIS"
     exon            150..215
                     /gene="Eef1akmt2"
                     /gene_synonym="2010208K18Rik; Mettl10"
                     /inference="alignment:Splign:2.1.0"
     exon            216..330
                     /gene="Eef1akmt2"
                     /gene_synonym="2010208K18Rik; Mettl10"
                     /inference="alignment:Splign:2.1.0"
     exon            331..438
                     /gene="Eef1akmt2"
                     /gene_synonym="2010208K18Rik; Mettl10"
                     /inference="alignment:Splign:2.1.0"
     exon            439..655
                     /gene="Eef1akmt2"
                     /gene_synonym="2010208K18Rik; Mettl10"
                     /inference="alignment:Splign:2.1.0"
     exon            656..1078
                     /gene="Eef1akmt2"
                     /gene_synonym="2010208K18Rik; Mettl10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      993..998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eef1akmt2"
                     /gene_synonym="2010208K18Rik; Mettl10"
                     /note="hexamer: TATAAA"
     polyA_site      1015
                     /gene="Eef1akmt2"
                     /gene_synonym="2010208K18Rik; Mettl10"
                     /note="major polyA site"
     regulatory      1059..1064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eef1akmt2"
                     /gene_synonym="2010208K18Rik; Mettl10"
                     /note="hexamer: AGTAAA"
     polyA_site      1078
                     /gene="Eef1akmt2"
                     /gene_synonym="2010208K18Rik; Mettl10"
ORIGIN      
        1 caaatcgcgt ctctatggcg gcttcgagcg cagagcgaca tgaacgcgga tgctgagggc
       61 cacagcggtg ctgtggtccc cgcgcaatct ccagagggca gttccgcggc ggatgacttc
      121 gtcccgtccg cgctggggac acgagagcat tgggatgctg tttatgagag agaactgaga
      181 acattccaag aatatgggga tacaggagaa atctggtttg gggaagagag tatgaaccga
      241 ctaatacggt ggatgcagaa acacaagatc ccattggatg cctcagtgct tgatattgga
      301 actggaaatg gtgttttcct ggttgaactt gtgaaacatg gtttctctaa tataactggg
      361 attgattatt ctccttctgc aattaagctt tctgcaagta ttttagagaa agaagggcta
      421 tctaacatta acttgaaggt agaagacttt ttgaatccct ctacaaagct ttctggattt
      481 catgtttgtg ttgacaaagg gacttacgat gccataagtc ttaatcctga caatgcaatt
      541 gagaagagga agcagtatgt gatgtctctc tccagggtgt tggaagtaaa aggctttttt
      601 ctaataacct catgtaattg gaccaaggca gagttgctag atgcattcag tgaaggattt
      661 gaactttttg aagagctgcc aacacccaag ttcagctttg gaggtagatc tggaaacact
      721 gtagcagctt tggtttttca aaaaaggggg acttccttgg acaaaatcag ttagctttct
      781 agaagaaact gcaaagtcaa cctgatacag aagaaggaag tgcaaatagt gcttagtaag
      841 tacccaggct tagtaagtgc aaatagtact tagtaagtac ccaggctaca cagactgaat
      901 aggaataatg ggttgatggg aagccacacg catgggaatc agtacttaga tatcaactaa
      961 gaataattta agattttctt ttgtatttaa aatataaatt ttttattgtg atttatgaca
     1021 gttttctgta gctgttaatc agttgagaac ttcaaagcag taaatgaatt tatagaaaaa
     1081 aaaaaaaaaa aaaaaaa
//
