LOCUS       NM_021876               2060 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus embryonic ectoderm development (Eed), mRNA.
ACCESSION   NM_021876
VERSION     NM_021876.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2060)
  AUTHORS   Guerreiro,I., Rang,F.J., Kawamura,Y.K., Kroon-Veenboer,C.,
            Korving,J., Groenveld,F.C., van Beek,R.E., Lochs,S.J.A., Boele,E.,
            Peters,A.H.M.F. and Kind,J.
  TITLE     Antagonism between H3K27me3 and genome-lamina association drives
            atypical spatial genome organization in the totipotent embryo
  JOURNAL   Nat Genet 56 (10), 2228-2237 (2024)
   PUBMED   39284976
REFERENCE   2  (bases 1 to 2060)
  AUTHORS   Du,Z., Hu,L., Zou,Z., Liu,M., Li,Z., Lu,X., Harris,C., Xiang,Y.,
            Chen,F., Yu,G., Xu,K., Kong,F., Xu,Q., Huang,B., Liu,L., Fan,Q.,
            Wang,H., Kalantry,S. and Xie,W.
  TITLE     Stepwise de novo establishment of inactive X chromosome
            architecture in early development
  JOURNAL   Nat Genet 56 (10), 2185-2198 (2024)
   PUBMED   39256583
REFERENCE   3  (bases 1 to 2060)
  AUTHORS   Oberin,R., Petautschnig,S., Jarred,E.G., Qu,Z., Tsai,T.,
            Youngson,N.A., Pulsoni,G., Truong,T.T., Fernando,D., Bildsoe,H.,
            Blucher,R.O., van den Buuse,M., Gardner,D.K., Sims,N.A.,
            Adelson,D.L. and Western,P.S.
  TITLE     Fetal growth delay caused by loss of non-canonical imprinting is
            resolved late in pregnancy and culminates in offspring overgrowth
  JOURNAL   Elife 13, e81875 (2024)
   PUBMED   38813868
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2060)
  AUTHORS   Guo,P., Lim,R.C., Rajawasam,K., Trinh,T., Sun,H. and Zhang,H.
  TITLE     A methylation-phosphorylation switch controls EZH2 stability and
            hematopoiesis
  JOURNAL   Elife 13, e86168 (2024)
   PUBMED   38346162
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2060)
  AUTHORS   Ko,T., Choi,R., Issa,K., Gupta,R., Llinas,E., Morey,L., Finlay,J.B.
            and Goldstein,B.J.
  TITLE     Polycomb repressive complex 2 regulates basal cell fate during
            adult olfactory neurogenesis
  JOURNAL   Stem Cell Reports 18 (11), 2283-2296 (2023)
   PUBMED   37832538
REFERENCE   6  (bases 1 to 2060)
  AUTHORS   Holdener,B.C., Rinchik,E.M. and Magnuson,T.
  TITLE     Phenotypic and physical analysis of a chemically induced mutation
            disrupting anterior axial development in the mouse
  JOURNAL   Mamm Genome 6 (7), 474-475 (1995)
   PUBMED   7579891
REFERENCE   7  (bases 1 to 2060)
  AUTHORS   Holdener,B.C., Thomas,J.W., Schumacher,A., Potter,M.D.,
            Rinchik,E.M., Sharan,S.K. and Magnuson,T.
  TITLE     Physical localization of eed: a region of mouse chromosome 7
            required for gastrulation
  JOURNAL   Genomics 27 (3), 447-456 (1995)
   PUBMED   7558026
REFERENCE   8  (bases 1 to 2060)
  AUTHORS   Potter,M.D., Klebig,M.L., Carpenter,D.A. and Rinchik,E.M.
  TITLE     Genetic and physical mapping of the fitness 1 (fit1) locus within
            the Fes-Hbb region of mouse chromosome 7
  JOURNAL   Mamm Genome 6 (2), 70-75 (1995)
   PUBMED   7767008
REFERENCE   9  (bases 1 to 2060)
  AUTHORS   Sharan,S.K., Holdener-Kenny,B., Threadgill,D.W. and Magnuson,T.
  TITLE     Genomic mapping within the albino-deletion complex using individual
            early postimplantation mouse embryos
  JOURNAL   Mamm Genome 3 (2), 79-83 (1992)
   PUBMED   1617218
REFERENCE   10 (bases 1 to 2060)
  AUTHORS   Sharan,S.K., Holdener-Kenny,B., Ruppert,S., Schedl,A., Kelsey,G.,
            Rinchik,E.M. and Magnuson,T.
  TITLE     The albino-deletion complex of the mouse: molecular mapping of
            deletion breakpoints that define regions necessary for development
            of the embryonic and extraembryonic ectoderm
  JOURNAL   Genetics 129 (3), 825-832 (1991)
   PUBMED   1684331
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U97675.1, BQ899891.1, AK131976.1 and CJ200028.1.
            
            On Apr 17, 2008 this sequence version replaced NM_021876.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U78103.1, U97675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                U97675.1           8-33
            27-433              BQ899891.1         1-407
            434-2041            AK131976.1         1-1608
            2042-2060           CJ200028.1         376-394
FEATURES             Location/Qualifiers
     source          1..2060
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 50.42 cM"
     gene            1..2060
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /note="embryonic ectoderm development"
                     /db_xref="GeneID:13626"
                     /db_xref="MGI:MGI:95286"
     exon            1..565
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /inference="alignment:Splign:2.1.0"
     CDS             452..1777
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /note="lethal, Chr 7, Rinchik 5"
                     /codon_start=1
                     /product="polycomb protein EED"
                     /protein_id="NP_068676.1"
                     /db_xref="CCDS:CCDS40016.1"
                     /db_xref="GeneID:13626"
                     /db_xref="MGI:MGI:95286"
                     /translation="MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSI
                     ESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFN
                     WHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSH
                     PLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLW
                     NIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE
                     SYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPG
                     KMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLE
                     VEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR"
     exon            566..718
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /inference="alignment:Splign:2.1.0"
     exon            719..811
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /inference="alignment:Splign:2.1.0"
     exon            812..877
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1003
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1085
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1177
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1311
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1417
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1576
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1650
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..2060
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1962..1967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /note="hexamer: AATAAA"
     polyA_site      1983
                     /gene="Eed"
                     /gene_synonym="l(7)5Rn; l7Rn5; lusk"
                     /note="major polyA site"
ORIGIN      
        1 gcgggtcgga gatcgaagga ttgagccaat tgcggatgaa acgtcttggc caggaagggg
       61 gtgagggagc agccctttga gttccgcctc gtctctaggc gctggtgggg aagggggacg
      121 taggaaaccc ctgccctctg agccagcaga tccgacgcct cggtgcaaag tgtcgagagg
      181 gcggcgggaa aaccgcccgc ccggaccaag ggacgggaag cagccgggaa gccgtgcggg
      241 agggcgcgcg cgtgcgcgcc cctttttcag cagtgtggcg gggtcgcacg cacgcccgcc
      301 tcggcggctg ggcgcgattt gcgacagtgg ggggggcggc ggcggtggcg gcgccggcag
      361 ctttgcggca ggctcgggcc gggcgtgctt gacggcggtg tggcggaggc cccgcccgag
      421 gcggcaagaa cctggaggga ggcggaggaa catgtccgag agggaagtgt cgactgcgcc
      481 ggcgggaaca gacatgcccg cggccaagaa gcagaagttg agcagcgacg agaacagcaa
      541 cccggacctc tcgggagacg aaaatgacga tgctgtcagt attgagagtg gcacaaacac
      601 agaacgcccg gacacgccca caaatacgcc aaatgcacca ggaaggaaaa gctggggaaa
      661 gggaaaatgg aagtcaaaga aatgcaaata ttctttcaaa tgtgtgaaca gcctcaagga
      721 agatcataac cagccattgt ttggagttca gtttaactgg cacagtaaag aaggagaccc
      781 tctggtgttt gcaactgtgg gaagcaacag agtaacctta tacgaatgcc attcacaggg
      841 ggagatacgg ttattgcagt cctatgtaga tgctgatgca gatgaaaact tttacacttg
      901 tgcatggacc tatgatagca acaccagcca ccctctatta gcagttgctg gatctagagg
      961 cattataaga ataattaatc ctataacaat gcagtgtata aagcactatg ttggccatgg
     1021 aaatgctatc aatgagctga aattccaccc acgagaccca aaccttctcc tgtcagtaag
     1081 taaagatcat gctttacggt tatggaatat ccaaacagac actcttgtgg caatattcgg
     1141 aggtgtggaa gggcacagag atgaagttct gagtgctgat tatgatcttt tgggtgaaaa
     1201 aataatgtcc tgtggtatgg atcactctct taaactgtgg agaatcaact caaagaggat
     1261 gatgaatgca attaaggagt cttatgatta taacccaaac aaaactaaca ggccatttat
     1321 ttcccagaaa atccactttc ctgacttttc taccagagac atacatagga attatgttga
     1381 ttgtgtgcga tggttaggcg atttgatact ttccaagtct tgtgaaaatg ccattgtatg
     1441 ctggaaacct ggcaaaatgg aggatgatat agataaaatt aaacctagtg agtctaatgt
     1501 gactattctt gggcgatttg attacagcca gtgtgacatt tggtacatga ggttttctat
     1561 ggatttctgg caaaagatgc ttgcattggg caatcaggtt ggcaaactgt atgtttggga
     1621 tttagaagta gaagatcctc ataaagccaa atgcacaaca ctgacccatc ataaatgtgg
     1681 cgcggctatt cgacaaacca gtttcagtag ggatagcagc atcctcatag ctgtctgcga
     1741 tgatgccagc atttggcgat gggatcgact tcgataaact attttttcct agtaaaaatt
     1801 agtctgttgt ctgtaaaata gaagtaatgt atcttgctag taagggcaca tagagcattt
     1861 agacttgttt ttcagcattc gatcaggctg agctgaatgt agtgatgttc acattgttta
     1921 cattctttgt actgtcttcc tgctcggact ttactgcttt taataaaaat ttatttttgt
     1981 aaagctgtgt tatttttatt gtgatggaaa caaactggaa gaaataaagt tgtaccatat
     2041 ctttttgtaa tgtttacttt
//
