LOCUS       NM_001001932            7836 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus early endosome antigen 1 (Eea1), mRNA.
ACCESSION   NM_001001932 XM_125851
VERSION     NM_001001932.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7836)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7836)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7836)
  AUTHORS   Carpentieri,J.A., Di Cicco,A., Lampic,M., Andreau,D., Del
            Maestro,L., El Marjou,F., Coquand,L., Bahi-Buisson,N., Brault,J.B.
            and Baffet,A.D.
  TITLE     Endosomal trafficking defects alter neural progenitor proliferation
            and cause microcephaly
  JOURNAL   Nat Commun 13 (1), 16 (2022)
   PUBMED   35013230
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7836)
  AUTHORS   Oueslati Morales,C.O., Ignacz,A., Bencsik,N., Sziber,Z.,
            Ratkai,A.E., Lieb,W.S., Eisler,S.A., Szucs,A., Schlett,K. and
            Hausser,A.
  TITLE     Protein kinase D promotes activity-dependent AMPA receptor
            endocytosis in hippocampal neurons
  JOURNAL   Traffic 22 (12), 454-470 (2021)
   PUBMED   34564930
REFERENCE   5  (bases 1 to 7836)
  AUTHORS   Perea-Gomez,A., Cases,O., Lelievre,V., Pulina,M.V., Collignon,J.,
            Hadjantonakis,A.K. and Kozyraki,R.
  TITLE     Loss of Cubilin, the intrinsic factor-vitamin B12 receptor, impairs
            visceral endoderm endocytosis and endodermal patterning in the
            mouse
  JOURNAL   Sci Rep 9 (1), 10168 (2019)
   PUBMED   31308417
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7836)
  AUTHORS   Jones,C., Hammer,R.E., Li,W.P., Cohen,J.C., Hobbs,H.H. and Herz,J.
  TITLE     Normal sorting but defective endocytosis of the low density
            lipoprotein receptor in mice with autosomal recessive
            hypercholesterolemia
  JOURNAL   J Biol Chem 278 (31), 29024-29030 (2003)
   PUBMED   12746448
REFERENCE   7  (bases 1 to 7836)
  AUTHORS   Cataldo,A.M., Petanceska,S., Peterhoff,C.M., Terio,N.B.,
            Epstein,C.J., Villar,A., Carlson,E.J., Staufenbiel,M. and
            Nixon,R.A.
  TITLE     App gene dosage modulates endosomal abnormalities of Alzheimer's
            disease in a segmental trisomy 16 mouse model of down syndrome
  JOURNAL   J Neurosci 23 (17), 6788-6792 (2003)
   PUBMED   12890772
REFERENCE   8  (bases 1 to 7836)
  AUTHORS   Gurung,R., Tan,A., Ooms,L.M., McGrath,M.J., Huysmans,R.D.,
            Munday,A.D., Prescott,M., Whisstock,J.C. and Mitchell,C.A.
  TITLE     Identification of a novel domain in two mammalian
            inositol-polyphosphate 5-phosphatases that mediates membrane ruffle
            localization. The inositol 5-phosphatase skip localizes to the
            endoplasmic reticulum and translocates to membrane ruffles
            following epidermal growth factor stimulation
  JOURNAL   J Biol Chem 278 (13), 11376-11385 (2003)
   PUBMED   12536145
REFERENCE   9  (bases 1 to 7836)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 7836)
  AUTHORS   Leem,J.Y., Vijayan,S., Han,P., Cai,D., Machura,M., Lopes,K.O.,
            Veselits,M.L., Xu,H. and Thinakaran,G.
  TITLE     Presenilin 1 is required for maturation and cell surface
            accumulation of nicastrin
  JOURNAL   J Biol Chem 277 (21), 19236-19240 (2002)
   PUBMED   11943765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB638838.1, BC075637.1 and AC115970.8.
            
            On Apr 19, 2006 this sequence version replaced NM_001001932.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075637.1, SRR10223971.10509.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                BB638838.1         1-87
            88-5380             BC075637.1         1-5293
            5381-7836           AC115970.8         108661-111116       c
FEATURES             Location/Qualifiers
     source          1..7836
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 49.59 cM"
     gene            1..7836
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /note="early endosome antigen 1"
                     /db_xref="GeneID:216238"
                     /db_xref="MGI:MGI:2442192"
     exon            1..310
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..4522
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /codon_start=1
                     /product="early endosome antigen 1"
                     /protein_id="NP_001001932.1"
                     /db_xref="CCDS:CCDS36042.1"
                     /db_xref="GeneID:216238"
                     /db_xref="MGI:MGI:2442192"
                     /translation="MFRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICP
                     QCMKSLGSADELFKHYQAVHDAGNDSGHGGEAGLALTRDDITLLRQEVQDLQASLKEE
                     KWYSEELKKELEKYQGLQQQEAKSDGLVTDSSAELQALEQQLEEAQTENFNIKQMKDL
                     FEQKAAQLATEIADIKSKYDEEKSLRAAAEQKVTHLTEDLNKQTTVIQDLKTELLQRP
                     GIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSEHAHLEATINQLRSEL
                     AKGPQEVAVYVQEIQKLKGSINELTQKNQNLTEKLQKKDLDYTHLEEKHNEESASRKT
                     LQASLHQRDLDCQQLQARLTASESSLQRAQGELSEKAEAAQKLREELREVESTRQHLK
                     VEVKQLQQQREEKEQHGLQLQGEVSQLHCKLLETERQLGEAHGRLKEQRQLSSEKLME
                     KEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLEKSKQQHQEQQALQQSATAKLREAQ
                     NDLEQVLRQIGDKDQKIQNLEALLQKGKESVSLLEKEREDLYAKIQAGEGETAVLNQL
                     QEKNHALQQQLTQLTEKLKNQSESHKQAEENLHDQVQEQKAHLRAAQDRVLSLETSVS
                     ELSSQLNESKEKVSQLDIQIKAKTELLLSAEAAKAAQRADLQNHLDTAQHALQDKQQE
                     LNKVSVQLDQLTAKFQEKQEHCIQLESHLKDHKEKHLSLEQKVEDLEGHIKKLEADAL
                     EVKASKEQALQSLQQQRQLSTDLELRNAELSRELQEQEEVVSCTKLDLQNKSEILENI
                     KQTLTKKEEENVVLKQEFEKLSQDSKTQHKELGDRMQAAVTELTAVKAQKDALLAELS
                     TTKEKLSKVSDSLKNSKSEFEKENQKGKAAVLDLEKACKELKHQLQVQAESALKEQED
                     LKKSLEKEKETSQQLKIELNSVKGEVSQAQNTLKQKEKDEQQLQGTINQLKQSAEQKK
                     KQIEALQGEVKNAVSQKTVLENKLQQQSSQAAQELAAEKGKLSALQSNYEKCQADLKQ
                     LQSDLYGKESELLATRQDLKSVEEKLTLAQEDLISNRNQIGNQNKSIQELQAAKASLE
                     QDSAKKEALLKEQSKALEDAQREKSVKEKELVAEKSKLAEMEEIKCRQEKEITKLNEE
                     LKSHKQESIKEITNLKDAKQLLIQQKLELQGRVDSLKAALEQEKESQQLMREQVKKEE
                     EKRKEEFSEKEAKLHSEIKEKEAGMKKHEENEAKLTMQVTTLNENLGTVKKEWQSSQR
                     RVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKALELQRKL
                     DNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMSCGKCFSVTVRRHHCRQCG
                     NIFCAECSTKNALTPSSKKPVRVCDACFNDLQG"
     exon            311..403
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..531
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..586
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..652
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..692
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..806
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            807..928
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1084
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1201
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1540
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1690
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1810
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..2014
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2215
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2329
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2485
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2625
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2956
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3058
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3253
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3436
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..3622
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3754
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            3755..3940
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            3941..4179
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            4180..4300
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            4301..4399
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            4400..7836
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7423..7428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /note="hexamer: AAGAAA"
     polyA_site      7450
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /note="major polyA site"
     regulatory      7806..7811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /note="hexamer: ATTAAA"
     polyA_site      7829
                     /gene="Eea1"
                     /gene_synonym="A430109M19Rik; B230358H09Rik; ZFYVE2"
                     /note="major polyA site"
ORIGIN      
        1 ggccccgggc gggcgggccc gcccagctgt cagttacggg ggcggcccgg caggcgggcg
       61 ctcgctggct ccctcctcgc tggctcgtgc tcgtgagcct ctcgccgcct gtggggaagt
      121 cggggccgcc aaagccgcgt ccaccgccgc ctcttccccg ccctcctccc tcccggctcg
      181 gctgccggcc cctcgcgccc tccagtcgtg agtaacccgc ataagggcgc ggagagtccc
      241 cgcggcggcg gcggcggtga cggcggcggc ggcggccggc caaaccatgt ttcgaaggat
      301 cttgcagagg actcctgggc gagttggctc tcaaggttct gatttagatt catcagcaac
      361 tcctataaat acggtggatg tcaataatga aagttcttca gagggtttca tatgtcccca
      421 gtgtatgaaa tcccttggct ctgctgatga gcttttcaag cactatcagg ccgttcatga
      481 tgctggtaat gactcgggtc atggtggaga ggccggtctt gctttgacac gagatgacat
      541 aacactactc agacaagagg tccaagacct acaggcctca cttaaggaag aaaaatggta
      601 ctcagaagaa ttaaagaaag aattagaaaa atatcaaggg ctacagcagc aagaggctaa
      661 atctgatgga ttggtgactg attcgtcagc agagctacag gctttagagc aacaattaga
      721 agaagcacaa acagagaatt ttaatattaa gcaaatgaaa gatctgtttg aacagaaagc
      781 agcccaactt gctactgaaa ttgcagatat aaagtcaaaa tatgatgaag aaaagagtct
      841 ccgagcagct gctgaacaaa aagtgacaca tttgacagaa gacttaaaca aacagacaac
      901 tgtaattcaa gatctgaaaa ctgaactgct tcagagacct ggtatagaag atgttgctgt
      961 actaaagaaa gaactggtcc aagttcaaac actaatggat aacatgactt tggaacgtga
     1021 gagagaatct gaaaaactta aagatgaatg caaaaagtta caatcagagc atgctcattt
     1081 ggaggctaca ataaaccagc taaggagtga acttgccaaa ggcccccaag aagttgcagt
     1141 atatgtgcag gaaatacaaa aacttaaagg ttcaattaat gaattaacac aaaaaaacca
     1201 gaacttgact gaaaaattgc agaagaaaga cctagactac acccacttag aggagaagca
     1261 caatgaagag tcagcaagtc ggaagactct ccaggcatcc ctccaccagc gggacctgga
     1321 ttgccagcag cttcaggcaa ggctaactgc atctgaaagc tcactccaga gggcccaggg
     1381 agaactcagt gaaaaggcag aggctgctca gaagctcaga gaagaactgc gggaagtaga
     1441 gagcacgcgc cagcatctca aggtggaggt gaagcagctg cagcagcagc gggaagagaa
     1501 ggaacagcac gggctgcagc tgcaggggga agtcagccag ttacactgca aacttctgga
     1561 gaccgagcgc caactggggg aagctcacgg caggctgaag gaacagcggc agctttccag
     1621 cgagaagctg atggaaaagg agcagcaggt ggctgaccta cagctcaagc tctctcgtct
     1681 ggaggagcag ttgaaggaaa aggtaacaaa ttccactgaa ttacaacatc agttagaaaa
     1741 atcaaagcaa cagcatcaag aacagcaagc tctacagcaa agtgctacag ccaaactccg
     1801 agaagctcag aatgatttgg agcaagtgtt acgtcagatt ggagataagg accaaaagat
     1861 ccagaacctt gaagccttgc tgcagaaggg taaagaaagc gtttccttac tagaaaagga
     1921 aagagaagat ctttatgcaa aaatccaggc cggtgaagga gagactgctg ttcttaacca
     1981 gttacaagag aaaaatcatg cactgcagca gcagctaact caactgacgg agaagctgaa
     2041 gaatcagtcg gaaagccata aacaagccga ggagaacttg catgaccagg tacaggaaca
     2101 gaaggcacat cttcgagctg cacaagaccg tgttctttct ctggaaacca gtgtcagtga
     2161 actaagcagt cagttaaatg aaagcaagga gaaggtctcg cagcttgaca tacagattaa
     2221 agccaaaact gaattattac tatcagcaga agcagcaaaa gctgctcaga gagctgatct
     2281 tcagaatcac ttggacacag ctcaacatgc gttacaggat aaacaacagg agttaaataa
     2341 ggtcagtgtg cagttggatc agctcactgc aaagtttcag gagaagcagg agcattgcat
     2401 tcagctggaa agccacctta aggatcacaa ggagaagcac ctctctttag aacaaaaagt
     2461 tgaagactta gaaggccaca ttaagaaact agaagctgat gctcttgaag ttaaagccag
     2521 caaggaacag gctttgcaga gtctacagca gcagaggcag ctgagcacag acctggagtt
     2581 gagaaatgca gagctgagta gagagctcca ggagcaggag gaagtagtat cttgtacaaa
     2641 actggatcta cagaataaat ctgaaatcct tgaaaatatc aaacaaaccc tcaccaagaa
     2701 agaagaagaa aatgtcgtct tgaaacaaga atttgaaaag ttaagtcaag attcaaagac
     2761 acagcacaag gagctggggg acaggatgca agctgcggtc acagagctga cagcagtgaa
     2821 ggcacagaag gacgcactcc tggccgagct ttctacaaca aaagaaaaac tgtcaaaagt
     2881 ttcggattct ttaaaaaact ccaaaagtga atttgagaaa gaaaatcaga aaggaaaagc
     2941 tgctgtatta gatttggaaa aagcttgtaa agaattaaag catcagcttc aagtacaggc
     3001 agagagtgcc ctgaaggagc aggaggacct gaaaaagtca ctcgagaaag agaaagagac
     3061 ttctcagcag ttgaagatag aactcaattc agtcaaggga gaagtctcac aggctcaaaa
     3121 tacattaaag caaaaggaga aagacgaaca acagcttcag gggaccataa atcagctaaa
     3181 gcaatcagct gaacaaaaga aaaaacaaat tgaagcgctt caaggagagg ttaaaaatgc
     3241 tgtttcacaa aagacagtgc tggagaataa gctgcagcag cagtcatcac aggcagccca
     3301 ggagcttgca gcagagaaag gaaaactgtc agcgctgcag agcaactacg agaagtgcca
     3361 ggcggacctg aaacagctgc agtccgacct ctatggcaaa gagtctgaac ttctagccac
     3421 gaggcaagac cttaagtctg tagaagagaa gctcactctg gcacaagaag acttgatttc
     3481 aaacagaaat caaattggaa accaaaataa atcaattcaa gaattgcaag ccgccaaagc
     3541 tagtttggag caggactcag caaagaaaga ggcgctgcta aaggagcaga gtaaggcact
     3601 tgaggatgct cagagagaaa agtcagtgaa ggaaaaagaa ctagtagctg aaaagtctaa
     3661 attggcagag atggaggaaa ttaaatgtag acaagaaaaa gaaatcacaa aactcaatga
     3721 ggagctcaag tcgcacaaac aagaaagcat aaaggaaata acaaatctca aggatgccaa
     3781 gcaacttttg attcaacaga aattagaact tcaaggcaga gtggactcac tgaaggcagc
     3841 tcttgagcag gagaaggaga gtcagcagct gatgcgagag caggtgaaga aggaggaaga
     3901 gaagcggaag gaagagtttt ctgagaagga agcgaagctg cattctgaaa taaaagaaaa
     3961 ggaagcggga atgaagaaac acgaagaaaa cgaggctaag cttactatgc aggtcacaac
     4021 attaaatgaa aacttgggta ctgtgaagaa ggagtggcag tctagtcaac ggagagtcag
     4081 tgagcttgag aagcaaacgg atgacttacg gggagaaatt gctgtcttag aagcaactgt
     4141 tcagaataat caagacgaaa gaagagcact cctagagagg tgtcttaaag gcgaaggtga
     4201 aatagaaaag cttcagacca aagccctaga gctgcagaga aagctggata acacaactgc
     4261 ggccgtgcag gagctgggca gggagaacca gtctctccag atcaaacaca cacaagcatt
     4321 gaacagaaag tgggcggaag acaacgaagt gcagaactgc atgtcctgtg ggaagtgctt
     4381 ctccgtcacc gtgcggcggc atcactgccg acagtgtggg aatatcttct gtgccgagtg
     4441 ctcaaccaaa aatgccttaa ctccttcttc gaagaagcct gttcgtgtct gtgatgcatg
     4501 cttcaatgat ttgcaaggat aacgggttat cacaacttca gagtagtatc acactaacgt
     4561 tagactttta ataaattgat ttggactctg gttgcatact aggccaaatt ggaattcgta
     4621 tattttggaa tgttaccagt atcaagtaaa actcttctat ttttgtgaga cttgggttca
     4681 tctttaatta ctttttccat taaaccccta aaacagcttt catgccaagg tcagaattag
     4741 ccaatgaaat gtaaataatc tttggacaga aaatagcaat gtattttttt aaatataatt
     4801 taattattca caaatgatga ctacaattcc ttagcttctt cctctcagag taaatgtaca
     4861 gaatgtctgg acggctccta tcatttgttg cggttttgtt gcacaacgac acagtgattc
     4921 tattctcttg gtggagtcat gcacaggaat gtaacacttt ctgttttttc ctctataggt
     4981 ctgtagctca attatgttgt tgtgttatac atattacttg agtgttctaa atgcagtgta
     5041 tgctaaatga tgtgttaacc atgagtttgc gtgtgggttt tgtttgggca gtattgatta
     5101 aattctcaag tagatttgat aaactcctat gtaaaattta tggtacttct gggattgtat
     5161 ttatgaaatg agttaatttg catttctcta tcttatttct gacacccaca cactgtcccc
     5221 taaaacattg tatgtaactt ccctttctga gctggagggt gagtagtaga gccgtgtggt
     5281 ggcttggtct tggtttttgc tggtggaaag ttttctgaag tgatctcaca gcgcagcctc
     5341 actccctcaa tttcagcatc tttaggaagt ttgctttcca gccttcataa atgtagctca
     5401 gcctcagtgc agttgtgctt gcagtagggc ctttgtaaag ataggaacgg acactgctaa
     5461 tgtcgcatct gtacctgtga agactaagtc aagtggtaag gaaatagtag ccttcttctc
     5521 ggtacttcct ctaaccaaac aggaaagact aaatacagcg acagaaagct ggcgccatgt
     5581 ctctgatgag gggcccatat taacttggga tcttttaact ttgaaaaaat agtgctatga
     5641 gattacacaa ccgctacaga gcagagtccg tacagcccca cctccatata cctaggagct
     5701 cctaaatgat gataaaaagg aaaacactgg ctgctgctcg accccttaaa agtcatttgt
     5761 ctaccaacca ataaacttgt tcttagaaag catcagaaga ctgaacttgc cacatactag
     5821 tttttaaatt atctttctgt agaagaaata taaagttaca catcgaatca ttacagtcat
     5881 ttagtgataa tagcagagaa agataagagc taatatttca tttgcaagaa agaatttata
     5941 ttacacactg ctgtcaggag tatgctggag tcttcatgtt tttatgacat acttacaaca
     6001 ttacacaaac aagagactga catgtaattt ttaatcattt agcaaagtta agccctgctt
     6061 tcagtaatga ctaaggacac tgattacatc ccaggacttg gataagtata tccttgagct
     6121 tatatactga agtgatacaa tggctctata ttaaaaataa tagttgggta atatagactg
     6181 agctgtttat gctttttata taattgtgaa tcctttccgg tagtcctaat tctacctttt
     6241 tggtttttgc atataaacac tttgactatg ttaaaaatgc agatattcac agcactactt
     6301 tgtgaaaatt ctggattaaa atatttgttc atttcatcct ttaattgaag acactggaga
     6361 ctttcttttt gtgcatcctc acttcacaaa aaaatagaag tggctacaaa gaaaacccgt
     6421 atgtgtttat ggtaggtttc ctgttccccc aataatctta tgccacaggt cccaaataat
     6481 gtccctatca cacgccactt tactgatgac acaatgaagc caaacaaacc accgttcctc
     6541 ttaactatta ccaattcaga atggactgga cacagaaatg taagattttt tttttctcgt
     6601 ttaatgaaaa agtcttgtga attctttttg gctgtacact tagctgtttg ctagtagtat
     6661 tgtactgtca gtgggctgga gctgccgcat acagagtccc aggtcttggc tatcatgcac
     6721 agttggcatc aggtgttggc aaactgcaca ccccagcaca gaaatgggag ctgaaatgag
     6781 gttgtgctgg gttgtgcaca gtaaactgta tgtagagagt gtctgtagta ggcagcaggg
     6841 gaagctgctg atacaggact tacttgtttt gaagaaagga aagaaggaga caaacacaca
     6901 aacctcagtg cagtgtacaa ataaacattt tgttcaacta cctcttaaag tggagttagc
     6961 tagtgtaatg gtttccttat agtaatagtc aatagcaact gccaaattta cgttcccatg
     7021 cctcttaaaa ggtcttcatg attactttct atagctttga ggtccttcct tgtggctact
     7081 tttttactct tgcatttgca taagatatta ccctctaagt ggaaggcaaa tgacagccgt
     7141 atattttgat atttgtgacc tgtttaatta tagcagtttt tttaatgcac tttggctata
     7201 aaaactatgg gtaacttgat ctataagatt taaatgtgcc atcaatttag tattcctaga
     7261 cataagcttg atgaatgatc ttctataatt ataatgtgcc acatttttct gtgtcttaat
     7321 tgccctttgc ctgaatttca atgatcaaaa tgttattgtt gcacatgtga atactgtgta
     7381 taaaacttcc taaatttatg taaagttgta taatatagaa taaagaaatc ccactgtgtt
     7441 ctctctgtaa gaagtaatga acttactgta acatggtcca gccacaagtc tgacatttta
     7501 tgctctctga agtggatcat atatccatag cctctgtaca tacttttgca tgagtatttt
     7561 ctctgttagt ttttgggttc attatttata ttgtgtttac tacttgtgat catgtagttg
     7621 tgccttattt ttgtgaaaga gtttagctca gtaaatactg taatttctaa tcccagtgat
     7681 tagaaagtta ccgattataa ataaataact gataaattat aagacagcat ttaaatctgt
     7741 ataaagaaca atggaaggat ccttactgaa ttgccacttc tgttttttaa tatgttaaag
     7801 atgatattaa agaccatttc tttctagtag atgtta
//
