LOCUS       NM_001136061            4191 bp    mRNA    linear   ROD 12-MAY-2023
DEFINITION  Mus musculus endothelin receptor type B (Ednrb), transcript variant
            2, mRNA.
ACCESSION   NM_001136061
VERSION     NM_001136061.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4191)
  AUTHORS   Xu G, Gong Y, Lu F, Wang B, Yang Z, Chen L, Min J, Cheng C and
            Jiang T.
  TITLE     Endothelin receptor B enhances liver injury and pro-inflammatory
            responses by increasing G-protein-coupled receptor kinase-2
            expression in primary biliary cholangitis
  JOURNAL   Sci Rep 12 (1), 19772 (2022)
   PUBMED   36396948
  REMARK    GeneRIF: Endothelin receptor B enhances liver injury and
            pro-inflammatory responses by increasing G-protein-coupled receptor
            kinase-2 expression in primary biliary cholangitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4191)
  AUTHORS   Szeto IYY, Chu DKH, Chen P, Chu KC, Au TYK, Leung KKH, Huang YH,
            Wynn SL, Mak ACY, Chan YS, Chan WY, Jauch R, Fritzsch B, Sham MH,
            Lovell-Badge R and Cheah KSE.
  TITLE     SOX9 and SOX10 control fluid homeostasis in the inner ear for
            hearing through independent and cooperative mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 119 (46), e2122121119 (2022)
   PUBMED   36343245
REFERENCE   3  (bases 1 to 4191)
  AUTHORS   Sahut-Barnola I, Lefrancois-Martinez AM, Dufour D, Botto JM,
            Kamilaris C, Faucz FR, Stratakis CA, Val P and Martinez A.
  TITLE     Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney
            Complex Syndrome
  JOURNAL   J Invest Dermatol 142 (11), 2949-2957 (2022)
   PUBMED   35568059
REFERENCE   4  (bases 1 to 4191)
  AUTHORS   Ye Q, Bhojwani A and Hu JK.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   5  (bases 1 to 4191)
  AUTHORS   Tabeling C, Gonzalez Calera CR, Lienau J, Hoppner J, Tschernig T,
            Kershaw O, Gutbier B, Naujoks J, Herbert J, Opitz B, Gruber AD,
            Hocher B, Suttorp N, Heidecke H, Burmester GR, Riemekasten G,
            Siegert E, Kuebler WM and Witzenrath M.
  TITLE     Endothelin B Receptor Immunodynamics in Pulmonary Arterial
            Hypertension
  JOURNAL   Front Immunol 13, 895501 (2022)
   PUBMED   35757687
  REMARK    GeneRIF: Endothelin B Receptor Immunodynamics in Pulmonary Arterial
            Hypertension.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4191)
  AUTHORS   Osada S, Mizuno K, Saido TC, Suzuki K, Kuroki T and Ohno S.
  TITLE     A new member of the protein kinase C family, nPKC theta,
            predominantly expressed in skeletal muscle
  JOURNAL   Mol Cell Biol 12 (9), 3930-3938 (1992)
   PUBMED   1508194
REFERENCE   7  (bases 1 to 4191)
  AUTHORS   Russell LB, Hunsicker PR, Cacheiro NL and Rinchik EM.
  TITLE     Genetic, cytogenetic, and molecular analyses of mutations induced
            by melphalan demonstrate high frequencies of heritable deletions
            and other rearrangements from exposure of postspermatogonial stages
            of the mouse
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 6182-6186 (1992)
   PUBMED   1352884
REFERENCE   8  (bases 1 to 4191)
  AUTHORS   Russell LB, Hunsicker PR and Shelby MD.
  TITLE     Melphalan, a second chemical for which specific-locus mutation
            induction in the mouse is maximum in early spermatids
  JOURNAL   Mutat Res 282 (3), 151-158 (1992)
   PUBMED   1378547
REFERENCE   9  (bases 1 to 4191)
  AUTHORS   Mayer,T.C.
  TITLE     Enhancement of melanocyte development from piebald neural crest by
            a favorable tissue environment
  JOURNAL   Dev Biol 56 (2), 255-262 (1977)
   PUBMED   849800
REFERENCE   10 (bases 1 to 4191)
  AUTHORS   Womack,J.E., Davisson,M.T., Eicher,E.M. and Kendall,D.A.
  TITLE     Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10)
            on mouse chromosome 14
  JOURNAL   Biochem Genet 15 (3-4), 347-355 (1977)
   PUBMED   405970
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC154670.2, AK083415.1 and
            BB003851.1.
            
            [WARNING] On Jun 2, 2023 this sequence was replaced by
            NM_001136061.3.
            
            On Jan 25, 2013 this sequence version replaced NM_001136061.1.
            
            Summary: This gene encodes a member of the G-protein coupled
            receptor family. It encodes a receptor for endothelins, peptides
            that are involved in vasocontriction. The encoded protein activates
            a phosphatidylinositol-calcium second messenger system and is
            required for the development of enteric neurons and melanocytes.
            Gene disruption causes pigmentation anomalies, deafness, and
            abnormal dilation of the colon due to defects of neural
            crest-derived cells. Mutations in this gene are found in the
            piebald mouse, and mouse models of Hirschsprung's disease and
            Waardenburg syndrome type 4. Renal collecting duct-specific gene
            deletion causes sodium retention and hypertension. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2013].
            
            Transcript Variant: This variant (2) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083415.1, AK082103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AC154670.2         99198-99500
            304-4181            AK083415.1         1-3878
            4182-4191           BB003851.1         279-288
FEATURES             Location/Qualifiers
     source          1..4191
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 53.05 cM"
     gene            1..4191
                     /gene="Ednrb"
                     /gene_synonym="ET-B; ET-BR; ETb; ETR-b; Sox10m1"
                     /note="endothelin receptor type B"
                     /db_xref="GeneID:13618"
                     /db_xref="MGI:MGI:102720"
     exon            1..350
                     /gene="Ednrb"
                     /gene_synonym="ET-B; ET-BR; ETb; ETR-b; Sox10m1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..894
                     /gene="Ednrb"
                     /gene_synonym="ET-B; ET-BR; ETb; ETR-b; Sox10m1"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..1740
                     /gene="Ednrb"
                     /gene_synonym="ET-B; ET-BR; ETb; ETR-b; Sox10m1"
                     /note="piebald; endothelin B receptor; endothelin receptor
                     non-selective type"
                     /codon_start=1
                     /product="endothelin receptor type B precursor"
                     /protein_id="NP_001129533.1"
                     /db_xref="CCDS:CCDS27317.1"
                     /db_xref="GeneID:13618"
                     /db_xref="MGI:MGI:102720"
                     /translation="MQSPASRCGRALVALLLACGFLGVWGEKRGFPPAQATLSLLGTK
                     EVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRGAGVPPRSFPPPCQRNIEISKTFKY
                     INTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINTY
                     KLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWT
                     AVEIVLIWVVSVVLAVPEAIGFDMITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWW
                     LFSFYFCLPLAITAVFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFAL
                     CWLPLHLSRILKLTLYDQSNPHRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKR
                     FKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS"
     exon            895..1007
                     /gene="Ednrb"
                     /gene_synonym="ET-B; ET-BR; ETb; ETR-b; Sox10m1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1212
                     /gene="Ednrb"
                     /gene_synonym="ET-B; ET-BR; ETb; ETR-b; Sox10m1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1362
                     /gene="Ednrb"
                     /gene_synonym="ET-B; ET-BR; ETb; ETR-b; Sox10m1"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1496
                     /gene="Ednrb"
                     /gene_synonym="ET-B; ET-BR; ETb; ETR-b; Sox10m1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1605
                     /gene="Ednrb"
                     /gene_synonym="ET-B; ET-BR; ETb; ETR-b; Sox10m1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..4191
                     /gene="Ednrb"
                     /gene_synonym="ET-B; ET-BR; ETb; ETR-b; Sox10m1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcggtcagc tggggctgat actgtccagg cgtcgcccaa gggaaaaggt tgtggcaagg
       61 tcgctcagaa aacgcgggag gagtctggcg ttgattgatg ctgggaaggg accgaatgaa
      121 taaaagtact tgtctgggga cagcaaagac cccgctcaag ctgctgagga tccgctgcct
      181 ggcattctct cggtcttttg tcagagccag agctgcattc agttgcgaga ggcctgttta
      241 ggagcagctg gacgcctgct gagagccgca agctccctag ggcagttgac aacctgggaa
      301 ggaggttccc tgctcgtggc gctgctcctg gtgcttccaa tccgcacgag ttggtctcca
      361 gactgaaaac agcagagcgg ctaccagact ctcacaggag caagctgtaa catgcaatcg
      421 cccgcaagcc ggtgcggacg cgccttggtg gcgctgctgc tggcctgtgg cttcttgggg
      481 gtatggggag agaaaagagg attcccacct gcccaagcca cgctgtcact tctcgggact
      541 aaagaggtaa tgacgccacc cactaagacc tcctggacca gaggttccaa ctccagtctg
      601 atgcgttcct ccgcacctgc ggaggtgacc aaaggaggga ggggggctgg agtcccgcca
      661 agatccttcc ctcctccgtg ccaacgaaat attgagatca gcaagacttt taaatacatc
      721 aacacgattg tgtcgtgcct cgtgttcgtg ctaggcatca tcgggaactc cacgctgcta
      781 agaatcatct acaagaacaa gtgcatgcgc aatggtccca atatcttgat cgccagtctg
      841 gctctgggag acctactgca catcatcata gacataccca ttaacaccta caagttgctc
      901 gcagaggact ggccatttgg agctgagatg tgtaagctgg tgcccttcat acagaaggct
      961 tctgtgggaa tcacagtgct gagtctttgt gctctaagta ttgacagata tcgagctgtt
     1021 gcttcttgga gtcgaattaa aggaattggg gttccaaaat ggacagcagt agaaattgtt
     1081 ttaatttggg tggtctctgt ggttctggct gtccccgaag ccataggttt tgatatgatt
     1141 acgtcggact acaaaggaaa gcccctaagg gtctgcatgc ttaatccctt tcagaaaaca
     1201 gccttcatgc agttttacaa gacagccaaa gattggtggc tgttcagttt ctacttctgc
     1261 ttgccgctag ccatcactgc agtcttttat accctgatga cctgcgaaat gctcaggaag
     1321 aagagcggta tgcagattgc tttgaatgat cacttaaagc agagacgaga agtggccaag
     1381 acagtcttct gcctggtcct cgtgtttgct ctctgttggc ttccccttca cctcagccgg
     1441 atcctgaagc tcaccctgta tgaccagagc aatccacaca ggtgtgagct tctgagcttt
     1501 ttgttggttt tggactacat tggtatcaac atggcttctt tgaactcctg catcaatcca
     1561 atcgctctgt atttggtgag caaaagattc aaaaactgct ttaagtcatg tttgtgctgc
     1621 tggtgccaaa cgtttgagga aaagcagtcc ttggaggaga agcagtcctg cctgaagttc
     1681 aaagccaacg atcacggata tgacaacttc cggtccagca ataaatacag ctcgtcttga
     1741 aggcaagaac actcgccgaa tctcactgtc ctcattgtgg acagatacca ttaaaacaaa
     1801 atgaaaccgt tgccaaatca aaatggaaaa aaccatgcta gcagaaaggt gtgcgcgcgt
     1861 gtgagaggga ttatttttaa ctgttctgac gctcaacacc ggatatattc acgggctgtt
     1921 tacaacctaa gaaagctgtg ggaaggaatg aagccctcct ccgtggggaa gcacttagat
     1981 tcttagtcag cacttcagca gagctcttaa aagcccctag tgcgttcaca tgccacttac
     2041 gtttaaaaaa acgagaactt cactgaagtt ctgttcagga gtttattatc cagtcctatg
     2101 aatctggatt caagaaagca tgacattgca aaacaattct taaaacgaag tttcaattgc
     2161 ttaatttgaa acttaaaaaa aaaaaaacta ataaattttt atgcatacta tcatacccac
     2221 taatctgatt gtaactatat gcaaaagaaa aggcaatatg gttggtaaac ttttttggtc
     2281 attaccaaca ttgaaatgat cagaattcgg gggaagaaaa gacagcctgc gaatgccaca
     2341 gagaaaacat gggaaagcgt gagctgctat gcctgagact tctgaaattc cctcacacat
     2401 actctgcaga aagacacaaa acagaacact acctatgatt tctttaaagt tctttcaaat
     2461 atcctttcat gattgaagtt taaattccat gtgttcaact tcatcatctg taaatactta
     2521 gctattagct ataagcacta cacgtagagg acttaacaaa gggcaggtcc cagcgttcgt
     2581 agctttctga caaagagatg ccagtaaccc ggttatagac agaatgtgaa ttgcccggtg
     2641 cagtgtccac atggcaaaga agcagggagc atcctttcag ccatgctgta gagaaaatgg
     2701 tccacagcac aatatgatag cgaaaatacc gtggtttaac gccatagaaa atagtcactg
     2761 taaccagctc tctcggaggc atactaccaa ctttttatgt tattcctgaa aatagccaat
     2821 agaaaggcgt tctggacatg gtgctttttc taaaacgtag aagccaaact gcttcggggt
     2881 ctgcaagatc ctcctctttg cgcattcttg tctaggtttt tttttttttt ttttaatctc
     2941 cttccacgac gtgccttagg ttcactccgg atgagcggtg tgtgaaagaa tgcccaagag
     3001 aaaactgaag agagaggaaa tgaggtgggg ccagaggaag cccgtgggga aatattccca
     3061 ttcttagccc tgtgttcgtc actgccacgt catgtcggtg tgaaaggtcc tggttcggct
     3121 ccagcaaaac aaagcgcagc gttctcagcg tgactcggga acaaaccaag cccgagagct
     3181 ttaaccttgt cttaaaatat aacagatttt ccttccttcc tttttctctt tcttctcttc
     3241 tcttctcttc tcttctcttc tcttctcttc tcttctcttc tcttcttttc ataacccagg
     3301 ccacatgttg aaaatgagct taacaatgca gttttctacc aaaatcattg tgacaataca
     3361 ataaacccaa acgggacaat gaggtaaaaa accaagaaca atactgaatc cacgtgacac
     3421 atgactctct ttaggagtca cccacagttc ttgtgtgtac agattgcttt ttaatcataa
     3481 aggacgcccc agatcttcaa ttttaagtta gttattggct ccccagtagt ttcacagcgt
     3541 ggatatattt ttaattttta ctaagtttta gattggtttt attgttgtgt tctaaattct
     3601 taagtcctaa catctttgtt taacccagat gttccttccc tcttcatggg caataatcgt
     3661 cctgccaaat tatgaaatgg cataagaata ctattcacat aatatataca ataaaactat
     3721 attaagtggc ttttttatta aaaattttag cacacagacc aagggtgata agaaaaaaaa
     3781 catgattccc ttgcataatt aaaaccaaga taagagaagg taccatctaa tttaaagcat
     3841 attttctaac atttaagtag cctaatatag caatgcataa aaatagtgtt aacaaggatg
     3901 ttagaggtca aacgatttgt aagtgacttc agcctatttt ctcccaaatt atttactgct
     3961 atttttggtc tgtgttcaaa cattttcagt attgataatg tgcaacagcc aaaggaacac
     4021 tgttttcatc caaatgcggg tgtgttgtac ctaacatgca cttgtaataa agccgtgtaa
     4081 aataactgtg ttttgttttg ctctggtcac ctaaagtggc agcttgtgtc gttgctaact
     4141 tcttgttgag taagcaaaac caataaacgt tcaaatggtt taaaagagca g
//
