LOCUS       NM_010332               3643 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus endothelin receptor type A (Ednra), mRNA.
ACCESSION   NM_010332 XM_134499
VERSION     NM_010332.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3643)
  AUTHORS   Waheed-Ullah,Q., Wilsdon,A., Abbad,A., Rochette,S., Bu'Lock,F.,
            Saed,A.A., Hitz,M.P., Brook,J.D. and Loughna,S.
  TITLE     Cyclin-dependent kinase 13 is indispensable for normal mouse heart
            development
  JOURNAL   J Anat (2024) In press
   PUBMED   39556044
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3643)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3643)
  AUTHORS   Zou,R., Shi,W., Ceylan,A.F., Dong,M., Zhang,M., Zou,Z., Peng,B.,
            Dong,F., Turdi,S., Lin,J., Zhang,Y., Wang,G., Fan,X. and Ren,J.
  TITLE     Cardiomyocyte-specific deletion of endothelin receptor A (ETA)
            obliterates cardiac aging through regulation of mitophagy and
            ferroptosis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166958 (2024)
   PUBMED   37963542
REFERENCE   4  (bases 1 to 3643)
  AUTHORS   Kurihara,Y., Ekimoto,T., Gordon,C.T., Uchijima,Y., Sugiyama,R.,
            Kitazawa,T., Iwase,A., Kotani,R., Asai,R., Pingault,V.,
            Ikeguchi,M., Amiel,J. and Kurihara,H.
  TITLE     Mandibulofacial dysostosis with alopecia results from ETAR
            gain-of-function mutations via allosteric effects on ligand binding
  JOURNAL   J Clin Invest 133 (4), e151536 (2023)
   PUBMED   36637912
  REMARK    GeneRIF: Mandibulofacial dysostosis with alopecia results from ETAR
            gain-of-function mutations via allosteric effects on ligand
            binding.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3643)
  AUTHORS   Marola,O.J., Howell,G.R. and Libby,R.T.
  TITLE     Vascular derived endothelin receptor A controls endothelin-induced
            retinal ganglion cell death
  JOURNAL   Cell Death Discov 8 (1), 207 (2022)
   PUBMED   35429992
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3643)
  AUTHORS   Reid,K., Turnley,A.M., Maxwell,G.D., Kurihara,Y., Kurihara,H.,
            Bartlett,P.F. and Murphy,M.
  TITLE     Multiple roles for endothelin in melanocyte development: regulation
            of progenitor number and stimulation of differentiation
  JOURNAL   Development 122 (12), 3911-3919 (1996)
   PUBMED   9012511
REFERENCE   7  (bases 1 to 3643)
  AUTHORS   Hanania,E.G., Au,W.W., Ullrich,R.L. and Papaconstantinou,J.
  TITLE     Regulation of retinoblastoma gene expression in a mouse mammary
            tumor model
  JOURNAL   Cancer Gene Ther 2 (4), 251-261 (1995)
   PUBMED   8548579
REFERENCE   8  (bases 1 to 3643)
  AUTHORS   Maemura,K., Kurihara,H., Kurihara,Y., Kuwaki,T., Kumada,M. and
            Yazaki,Y.
  TITLE     Gene expression of endothelin isoforms and receptors in
            endothelin-1 knockout mice
  JOURNAL   J Cardiovasc Pharmacol 26 Suppl 3, S17-S21 (1995)
   PUBMED   8587354
REFERENCE   9  (bases 1 to 3643)
  AUTHORS   Wilkie,T.M., Chen,Y., Gilbert,D.J., Moore,K.J., Yu,L., Simon,M.I.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Identification, chromosomal location, and genome organization of
            mammalian G-protein-coupled receptors
  JOURNAL   Genomics 18 (2), 175-184 (1993)
   PUBMED   8288218
REFERENCE   10 (bases 1 to 3643)
  AUTHORS   Nakamura,T., Ebihara,I., Fukui,M., Osada,S., Tomino,Y., Masaki,T.,
            Goto,K., Furuichi,Y. and Koide,H.
  TITLE     Increased endothelin and endothelin receptor mRNA expression in
            polycystic kidneys of cpk mice
  JOURNAL   J Am Soc Nephrol 4 (4), 1064-1072 (1993)
   PUBMED   7904485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN669253.1, AK043210.1 and AV351599.1.
            
            On Apr 21, 2006 this sequence version replaced NM_010332.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.250527.1, AK043210.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               CN669253.1         1-104
            105-3641            AK043210.1         2-3538
            3642-3643           AV351599.1         245-246
FEATURES             Location/Qualifiers
     source          1..3643
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 36.63 cM"
     gene            1..3643
                     /gene="Ednra"
                     /gene_synonym="AEA001; ET-AR; ETa; Gpcr10; Mhdaaea1"
                     /note="endothelin receptor type A"
                     /db_xref="GeneID:13617"
                     /db_xref="MGI:MGI:105923"
     exon            1..357
                     /gene="Ednra"
                     /gene_synonym="AEA001; ET-AR; ETa; Gpcr10; Mhdaaea1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..832
                     /gene="Ednra"
                     /gene_synonym="AEA001; ET-AR; ETa; Gpcr10; Mhdaaea1"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..1696
                     /gene="Ednra"
                     /gene_synonym="AEA001; ET-AR; ETa; Gpcr10; Mhdaaea1"
                     /note="endothelin-1 receptor; ET-A; endothelin A receptor;
                     G-protein coupled receptor 10"
                     /codon_start=1
                     /product="endothelin-1 receptor precursor"
                     /protein_id="NP_034462.1"
                     /db_xref="CCDS:CCDS22427.1"
                     /db_xref="GeneID:13617"
                     /db_xref="MGI:MGI:105923"
                     /translation="MSIFCLAAYFWLTMVGGVMADNPERYSANLSSHMEDFTPFPGTE
                     INFLGTTHRPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLL
                     RIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKL
                     FPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAI
                     PEAIGFVMVPFEYKGELHRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYT
                     LMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYD
                     EMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSK
                     SLMTSVPMNGTSIQWKNQEQNNHNTERSSHKDSMN"
     exon            833..960
                     /gene="Ednra"
                     /gene_synonym="AEA001; ET-AR; ETa; Gpcr10; Mhdaaea1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1159
                     /gene="Ednra"
                     /gene_synonym="AEA001; ET-AR; ETa; Gpcr10; Mhdaaea1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1312
                     /gene="Ednra"
                     /gene_synonym="AEA001; ET-AR; ETa; Gpcr10; Mhdaaea1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1446
                     /gene="Ednra"
                     /gene_synonym="AEA001; ET-AR; ETa; Gpcr10; Mhdaaea1"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1555
                     /gene="Ednra"
                     /gene_synonym="AEA001; ET-AR; ETa; Gpcr10; Mhdaaea1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..3643
                     /gene="Ednra"
                     /gene_synonym="AEA001; ET-AR; ETa; Gpcr10; Mhdaaea1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagtagag aggaaggtct aggagcctgt ggagtctaag gaagatcgcg ggaggcgtgt
       61 tcctccggag tttgcttttc cttgggagcc tcgcgcgcac acccatccct tctagtctgg
      121 caactgtgtc taggaggtgg ggagcctctc tctgatccac cggaccatcg ctggagcttg
      181 caggctgagc aagatctccc cctagagaag cctggctgtc cggggaagtt tccccgagct
      241 gagactgtgc tgcagccctg gtcacccgcc accctgcgcg ccaccctcgt tctccagctc
      301 aggctccggc tggcccgtgc gcggacctgg agctgtctgc ttccgaggag ctctaaggtg
      361 aaaaaaagaa aggcgtgaga ccaacataag aagacttaaa atccaggtta agatgagtat
      421 cttttgcctt gcggcatact tttggctgac catggtggga ggcgtaatgg ctgacaatcc
      481 ggagagatac agcgctaatc taagcagcca catggaagac ttcacccctt ttccggggac
      541 ggagatcaac tttctgggca ccacccatcg accccctaat ttggccctgc ctagcaatgg
      601 ctcaatgcac ggctattgcc cacagcagac taaaatcacg acagctttca aatatattaa
      661 cactgtgata tcctgcacca ttttcatcgt gggaatggtg gggaacgcaa ctctactacg
      721 aatcatttac caaaacaagt gtatgaggaa cggccccaat gcgctcatag ccagcctggc
      781 ccttggagac cttatctacg tggtcattga cctccccatc aacgtgttta agctcttggc
      841 aggacgctgg cctttcgacc acaatgattt tggagtgttt ctctgcaagc tgttcccctt
      901 cctgcagaag tcctccgtgg gcatcaccgt cttgaacctc tgtgctctca gtgtggacag
      961 gtacagagca gtggcttcct ggagccgagt tcaaggaatc gggatcccct tgattaccgc
     1021 cattgaaatc gtctccatct ggattctttc cttcatcttg gccatcccgg aagcaatcgg
     1081 cttcgtcatg gtacccttcg aatacaaggg cgagctgcat aggacctgca tgctcaacgc
     1141 cacgtccaag ttcatggagt tttaccaaga tgtgaaggac tggtggctct ttgggttcta
     1201 cttctgcatg cccttggtgt gcacagcaat cttctacacc ctcatgacct gtgagatgct
     1261 caacaggagg aacggcagct tgcggatcgc ccttagtgag cacctcaaac agcgtcgaga
     1321 agtggcaaag actgtcttct gcttggttgt catcttcgcc ctgtgctggt tccctcttca
     1381 cttaagccgc attttgaaga aaactgtata tgatgagatg gataagaacc ggtgtgaact
     1441 gctcagcttc ttgctgctaa tggattacat cggcattaac ctggcaacca tgaattcttg
     1501 cataaaccca atagctctat attttgtgag caagaaattc aaaaattgtt ttcagtcctg
     1561 cctctgttgc tgttgtcacc agtccaaaag cctcatgacc tcggtcccca tgaatggaac
     1621 gagtatccag tggaagaacc aagagcagaa caaccacaac acggaacgga gcagccacaa
     1681 ggacagcatg aactaaccct ccgcagaaac accgagacgt gtgccttcaa gtcctaggat
     1741 ggaaacaacc attacgccac agatgcgctc ccaaaacctc ccaagtctct cccatgctcc
     1801 ttttctaagt ccatcctagg aaaagctctc ctgccctccc aacagcacgt ggtggaccgg
     1861 tcccagctat agccaatggg tctttcctga gtactgtata tgatttgcat accgcgcatg
     1921 tcatttccaa cacttgaaaa ttagagctgg gagaaaggag atgatggttc aaagaagcca
     1981 cctagctgcc gcctttgcat gaacacagag tttgcaagtt catgaccagc ttccgtgcag
     2041 ttctatggac cagctggtgg gaactgtcca tcctaagatt ctagagcagt gggtctcaac
     2101 cttcccaatg ctgcagcccc ttaatacagt tcttcatttt ccagtgaccc cccccaacca
     2161 caatattatt ttttgttgct acttcaatta ttttgaattg ttataattgt ctgatatttc
     2221 tgatagtctt agcctgcccc tgttaaaggg tcattagcaa cccacaagtt gagaaccact
     2281 gccctagaaa ttctgttgcg tttcatggcc catgactaca atcctaaaat tggagaggtg
     2341 agggaagatg gtcaggtgtt caaggttagc ctcatcaaca tagttcggaa aagccagggc
     2401 tacctgttct cacaagacac aaacagacaa aaagtgtttc aaagttatgg cagattcatt
     2461 attattaatt attattatct tatagccaaa cacattgtga ggttaaagta ctcttttgga
     2521 aatgtcaccg agtgttggta ctttataact gcatggtacc ctagaaatga tcgtttcatc
     2581 ttctttcaat gtactctgaa gaaaagaaag aggagaggaa gaggaggagg gaaggaagac
     2641 cgtctgatga ggagttagtt gtttctatgg tactgttttg tttggaaacc atgatttcca
     2701 cagctgctgc agacacagac acagaccagc agcacggcag cttagtagct gctagacaaa
     2761 gaatctttaa gaacctgtat tttcttttta tgttgttatt tggttggatt ttgcttgttt
     2821 acttggattt gtttttcaag acagagtttc tctttgtagc cctggctgtc ctgaaacttg
     2881 ttttataaat caggctggcc ttgaactcgc agagatcctc ctgcttctgc ctcccaaagt
     2941 actaataata cttgggcgag atagcactgt gcttccaact cggcatctgg aggctgaggc
     3001 agggacggtg agtgggagac tgcctgcact aactagagga actcgtctcc aaataataat
     3061 aattaatcat aataccatta ggtcaaatgg ttttctattt ttcataagcc tagtcttttt
     3121 taatgttttt tttttaatgt aaaaccttgt cctgcagatt aaatgtgtca ctgaagtatg
     3181 cctgagactt ccagccccac atctgaagca tacctaggaa aaaactgctg ggtggccttg
     3241 gagggcctgg gcattttcta caagtttcac aatagtagca catatataat gcatgtttcc
     3301 tttgactctc tcagtttctc ctacagtgat gactggctac caggctttcc tgctcattcc
     3361 tttttcctgg caggaaacaa tgtcaaagtg gccaaatgag ctgattgtgt taagtgagat
     3421 gtagttacac ttgccatgaa cctttaactc tttgctcctc tctgattgtg agacaaactt
     3481 aaatttccat cctgtcccca actcctcagt ggtcactatt tcaaagggcc ctggtaactc
     3541 tactgggcat tttcccagat gtttacagac tgtgagaatg acaaataact tttattttgt
     3601 atgtatataa atatataaat aattgtacat ttcttttagc caa
//
