LOCUS       NM_007903               3117 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus endothelin 3 (Edn3), mRNA.
ACCESSION   NM_007903
VERSION     NM_007903.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3117)
  AUTHORS   Tan,J., Duron,A., Sucov,H.M. and Makita,T.
  TITLE     Placode and neural crest origins of congenital deafness in mouse
            models of Waardenburg-Shah syndrome
  JOURNAL   iScience 28 (1), 111680 (2024)
   PUBMED   39868048
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3117)
  AUTHORS   Wang,C.H., Tsuji,T., Wu,L.H., Yang,C.Y., Huang,T.L., Sato,M.,
            Shamsi,F. and Tseng,Y.H.
  TITLE     Endothelin 3/EDNRB signaling induces thermogenic differentiation of
            white adipose tissue
  JOURNAL   Nat Commun 15 (1), 7215 (2024)
   PUBMED   39174539
  REMARK    GeneRIF: Endothelin 3/EDNRB signaling induces thermogenic
            differentiation of white adipose tissue.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3117)
  AUTHORS   Kurihara,Y., Ekimoto,T., Gordon,C.T., Uchijima,Y., Sugiyama,R.,
            Kitazawa,T., Iwase,A., Kotani,R., Asai,R., Pingault,V.,
            Ikeguchi,M., Amiel,J. and Kurihara,H.
  TITLE     Mandibulofacial dysostosis with alopecia results from ETAR
            gain-of-function mutations via allosteric effects on ligand binding
  JOURNAL   J Clin Invest 133 (4), e151536 (2023)
   PUBMED   36637912
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3117)
  AUTHORS   Sahut-Barnola,I., Lefrancois-Martinez,A.M., Dufour,D., Botto,J.M.,
            Kamilaris,C., Faucz,F.R., Stratakis,C.A., Val,P. and Martinez,A.
  TITLE     Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney
            Complex Syndrome
  JOURNAL   J Invest Dermatol 142 (11), 2949-2957 (2022)
   PUBMED   35568059
REFERENCE   5  (bases 1 to 3117)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3117)
  AUTHORS   Yanagisawa,M., Kurihara,H., Kimura,S., Tomobe,Y., Kobayashi,M.,
            Mitsui,Y., Yazaki,Y., Goto,K. and Masaki,T.
  TITLE     A novel potent vasoconstrictor peptide produced by vascular
            endothelial cells
  JOURNAL   Nature 332 (6163), 411-415 (1988)
   PUBMED   2451132
REFERENCE   7  (bases 1 to 3117)
  AUTHORS   Rothman,T.P. and Gershon,M.D.
  TITLE     Regionally defective colonization of the terminal bowel by the
            precursors of enteric neurons in lethal spotted mutant mice
  JOURNAL   Neuroscience 12 (4), 1293-1311 (1984)
   PUBMED   6207461
REFERENCE   8  (bases 1 to 3117)
  AUTHORS   Richardson,J.
  TITLE     Pharmacologic studies of Hirschsprung's disease on a murine model
  JOURNAL   J Pediatr Surg 10 (6), 875-884 (1975)
   PUBMED   1202171
REFERENCE   9  (bases 1 to 3117)
  AUTHORS   Bolande,R.P. and Towler,W.F.
  TITLE     Ultrastructural and histochemical studies of murine megacolon
  JOURNAL   Am J Pathol 69 (1), 139-162 (1972)
   PUBMED   5080702
REFERENCE   10 (bases 1 to 3117)
  AUTHORS   Lane,P.W.
  TITLE     Association of megacolon with two recessive spotting genes in the
            mouse
  JOURNAL   J Hered 57 (1), 29-31 (1966)
   PUBMED   5917257
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL844489.6, AK079150.1 and
            AK049775.1.
            
            On Feb 5, 2016 this sequence version replaced NM_007903.4.
            
            Summary: This gene is a member of the endothelin family whose
            members encode proteins that act on G protein-coupled receptors.
            Endothelins are produced as large prepropolypeptide precursors that
            undergo a first cleavage by a subtilisin serine protease to form an
            inactive intermediate, which in turn is cleaved again by
            endothelin-converting enzyme 1 (ECE-1) to yield the active 21 amino
            acid peptide. This gene encodes a protein which is expressed in
            neural crest cells (NCC), binds to endothelin receptor b (Ednrb)
            and plays an essential role in the development of NCC-derived cell
            lineages including melanocytes and enteric neurons. Mutations in
            this gene are associated with terminal aganglionosis and white
            spotted coat in mice and Hirschsprung's disease and Waardenburg
            syndrome in humans. [provided by RefSeq, Apr 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049775.1, BC137727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AL844489.6         30251-30390
            141-1693            AK079150.1         1-1553
            1694-3117           AK049775.1         1541-2964
FEATURES             Location/Qualifiers
     source          1..3117
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 98.1 cM"
     gene            1..3117
                     /gene="Edn3"
                     /gene_synonym="ET-3; ls; PPET3; tmgc48"
                     /note="endothelin 3"
                     /db_xref="GeneID:13616"
                     /db_xref="MGI:MGI:95285"
     exon            1..400
                     /gene="Edn3"
                     /gene_synonym="ET-3; ls; PPET3; tmgc48"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..993
                     /gene="Edn3"
                     /gene_synonym="ET-3; ls; PPET3; tmgc48"
                     /note="preproendothelin-3"
                     /codon_start=1
                     /product="endothelin-3 preproprotein"
                     /protein_id="NP_031929.1"
                     /db_xref="CCDS:CCDS17156.1"
                     /db_xref="GeneID:13616"
                     /db_xref="MGI:MGI:95285"
                     /translation="MEPGLWLLLGLTVTSAAGLVPCPQSGDSGRASVSQGPPEAGSER
                     GCEETVAGPGERIVSPTVALPAQPESAGQERAPGRSGKQEDKGLPAHHRPRRCTCFTY
                     KDKECVYYCHLDIIWINTPEQTVPYGLSNYRESLRGKRSLGPVPESSQPSPWTRLRCT
                     CMGADDKACAHFCARTRDVTSYSGRAERPAAEEMRETGGPRQRLMSRTDKAHRP"
     exon            401..713
                     /gene="Edn3"
                     /gene_synonym="ET-3; ls; PPET3; tmgc48"
                     /inference="alignment:Splign:2.1.0"
     exon            714..890
                     /gene="Edn3"
                     /gene_synonym="ET-3; ls; PPET3; tmgc48"
                     /inference="alignment:Splign:2.1.0"
     exon            891..956
                     /gene="Edn3"
                     /gene_synonym="ET-3; ls; PPET3; tmgc48"
                     /inference="alignment:Splign:2.1.0"
     exon            957..3117
                     /gene="Edn3"
                     /gene_synonym="ET-3; ls; PPET3; tmgc48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3090..3095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Edn3"
                     /gene_synonym="ET-3; ls; PPET3; tmgc48"
                     /note="hexamer: AATAAA"
     polyA_site      3108
                     /gene="Edn3"
                     /gene_synonym="ET-3; ls; PPET3; tmgc48"
                     /note="major polyA site"
ORIGIN      
        1 gcctggggcg aatgcgcctc tggtcagctc cccccctgcg cttgcaaagc gacccccgtg
       61 agccccgggt tcaaaggccc agcgcggcag ttccagcccc tcggaggggc ggggaggcga
      121 agggggtggt gcgggagcca gaaaagcctg agccacagcc ggccagccct gcgcagggat
      181 gggcagcgcg ctctgaaagt tcgtgaccgc ctcagccaag taactctgag ccgggacgcg
      241 cagctcaggc agcgacagga ctcgaaagct gtagccagtc tcactaccct tttgcggtca
      301 caagcggcca ccctccaggc ccggtgctcc cgcgcctgat cggggttcat ggagccgggg
      361 ctgtggctcc ttctcgggct cacagtgacc tccgctgcag gacttgtgcc ttgcccccag
      421 tctggggact ctggcagagc cagtgtgtcc cagggtcccc ctgaagctgg atcagagagg
      481 ggctgtgaag agactgtggc tggccctggt gagaggattg tgtccccaac agttgcactg
      541 cctgcacagc ctgaaagcgc tgggcaggaa cgggcaccag gcaggtctgg gaaacaagag
      601 gacaaggggc tgcctgcaca ccaccgccct cgccgctgca cgtgcttcac ttacaaggac
      661 aaggagtgtg tctactattg ccacctggac atcatctgga ttaacactcc tgaacagact
      721 gtgccctatg gactgtccaa ctacagagaa agccttcggg gaaagaggtc cttggggcca
      781 gttccagaaa gctcccagcc ttctccgtgg acacgcttgc gttgtacttg tatgggggcg
      841 gatgacaagg cctgtgcaca cttctgtgca cgcaccagag atgtcaccag ttattccggg
      901 agagcagaaa ggccagctgc agaagagatg cgggagactg gaggcccacg tcaaaggttg
      961 atgtcaagga cagataaagc ccaccggcct tagctggatc taacaggcca caactgatgc
     1021 ttcttgcttc ctgcagtgga cttcacctgc tctccctgcc tgcccactct tccaggaaag
     1081 agccttggag cttgtgcata cagagtttga atttccacct ctttagcgac aagttgggaa
     1141 ttggcctgag gcaaaaatga aagaatgacc catccaaaga gcccatgctt acctgtacac
     1201 ccttacccca agaatgccca agtccaaaag accccagttt ccctaatggg taaaatgatc
     1261 ccacatgtgc cctgggggcc ggatgcctga ggctccagtt tcacaaggaa attgtttgag
     1321 aggtatgtta agtcagaaag ctacttactg gccttggcat gactcctctt ggagagtaag
     1381 tggacaccag gctggctctt tacaaaagta aacacacatc catctcctag aagattcagg
     1441 acacccatgt ggccggagca ggccttcttc tgcagcctgc gtggcctgag caagttagcg
     1501 aggcatctgt gtgcttgaga cctggatcct agctgggcag tagtctatga aattgaattt
     1561 cataggactt agaaatcttc cactgtgctt aatactcatc agaagagcag ctctcaaaaa
     1621 caagaaggaa aagaaaacag gagatctaga tgttcatgag acaaaaagag aaataaacaa
     1681 caagactccc ccctccccca tattcttgat ggttttgaac tctggggcac tcggcaaaga
     1741 gctgggggtt ctgcgatggc ctctgtggca gagctcccaa ccctgccttg cagtaagctg
     1801 ccctgagggg cagcttcagc tcaaggctac tggtctggat atctgctttc atgaataaat
     1861 gtggatcctt ggggagtggc ttcaaaataa gcccaaaaac acaaactctt tgtacattat
     1921 gtaaatttct gtttgtctat ataattggca acaactggga attgtaacct ctgttcaaaa
     1981 tctcttttag ctgagctctt tcttctgtgt ccgtggtgag tatgggggtg ggggtgggat
     2041 cagactgtga gttcccatgt aaactctact ctgcaggccc agctgggaga gtctgcccac
     2101 ctccccacca ggcctcatag caatgagaac ctgtctttgg gcatgttcca agggcaccac
     2161 gtggagacac tttagctatt gtgtgaagtg gagccttaac cagatggtaa acttcagagg
     2221 accgtctcct aagttattac aggtgtgaac gtgcctgctt attgagggtg tgtgagagag
     2281 tgctggtttg ctggggggga atgtacagtt aagagaagta attatttatt ggggaactat
     2341 tttctacgta actcctttat gggatctatt aaaagtaaag gcactgtaga tagatagata
     2401 gacagacaga aaaatagatt ttaaattgtg ttcaaaaatc caaacccata tctcttagta
     2461 gctagaaatt gtttaaatct cataagcact atttggcaca gtggccagat tgtatttcaa
     2521 aaacaaatcc actcactgtg agaacactca ggagataagt caaatgcata ataaaagaaa
     2581 atctaaaagt ttgctctggc ttgcaggctt ttccttgcac acagttacac attcactctt
     2641 cacaggcctc tggagaggac aggacagagc cagagttctg gatgtaggat tcatctagag
     2701 aggaaagtat agaccaaggc gggtgggcag ctattgggag gagaggagtt tggggaccat
     2761 ttgagaagat aaacatcaaa gtgtctggaa aagaagaagg aggtttggat gaagttggtg
     2821 acttccttgg aatgcctgct cttctacaca accttttcag ggagacaacc atgggcctat
     2881 tgctcaaagc atctgagaat tatctccaga agtgatcaca gtagcaaggc cacacaggac
     2941 ataaaagcaa atggaaggga ggctgtttga taaaagaggg agaggggaca ggagggcaga
     3001 gggagggcag gagagggcaa ggggatgaac attgttaaag tattaatgca aatgccatta
     3061 taaaagcatc actttgtatg atccatgcta ataaactttt aaaaaagatt ctaaagc
//
