LOCUS       NM_007902               1514 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus endothelin 2 (Edn2), mRNA.
ACCESSION   NM_007902
VERSION     NM_007902.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Musthafa,A., Ryanto,G.R.T., Suraya,R., Nagano,T., Suzuki,Y.,
            Hara,T., Hirata,K.I. and Emoto,N.
  TITLE     Acute Amelioration of Inflammatory Activity Caused by Endothelin-2
            Deficiency during Acute Lung Injury
  JOURNAL   Kobe J Med Sci 69 (3), E96-E105 (2023)
   PUBMED   37941117
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Iwagawa,T., Aihara,Y., Umutoni,D., Baba,Y., Murakami,A., Miyado,K.
            and Watanabe,S.
  TITLE     Cd9 Protects Photoreceptors from Injury and Potentiates Edn2
            Expression
  JOURNAL   Invest Ophthalmol Vis Sci 61 (3), 7 (2020)
   PUBMED   32150249
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Pontes,R.B., Lisboa,M.R.P., Pereira,A.F., Lino,J.A., de
            Oliveira,F.F.B., de Mesquita,A.K.V., de Freitas Alves,B.W.,
            Lima-Junior,R.C.P. and Vale,M.L.
  TITLE     Involvement of Endothelin Receptors in Peripheral Sensory
            Neuropathy Induced by Oxaliplatin in Mice
  JOURNAL   Neurotox Res 36 (4), 688-699 (2019)
   PUBMED   31228092
  REMARK    GeneRIF: Endothelin ETA and ETB receptors seem to be involved in
            the oxaliplatin-induced peripheral sensory neuropathy in mice and
            they should be considered possible targets for the management of
            this clinical feature.
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   Reid,K., Turnley,A.M., Maxwell,G.D., Kurihara,Y., Kurihara,H.,
            Bartlett,P.F. and Murphy,M.
  TITLE     Multiple roles for endothelin in melanocyte development: regulation
            of progenitor number and stimulation of differentiation
  JOURNAL   Development 122 (12), 3911-3919 (1996)
   PUBMED   9012511
REFERENCE   7  (bases 1 to 1514)
  AUTHORS   Maemura,K., Kurihara,H., Kurihara,Y., Kuwaki,T., Kumada,M. and
            Yazaki,Y.
  TITLE     Gene expression of endothelin isoforms and receptors in
            endothelin-1 knockout mice
  JOURNAL   J Cardiovasc Pharmacol 26 Suppl 3, S17-S21 (1995)
   PUBMED   8587354
REFERENCE   8  (bases 1 to 1514)
  AUTHORS   Saida,K. and Mitsui,Y.
  TITLE     cDNA cloning, sequence analysis and tissue distribution of a
            precursor for vasoactive intestinal contractor (VIC)
  JOURNAL   Biochim Biophys Acta 1089 (3), 404-406 (1991)
   PUBMED   1859843
REFERENCE   9  (bases 1 to 1514)
  AUTHORS   Bloch,K.D., Hong,C.C., Eddy,R.L., Shows,T.B. and Quertermous,T.
  TITLE     cDNA cloning and chromosomal assignment of the endothelin 2 gene:
            vasoactive intestinal contractor peptide is rat endothelin 2
  JOURNAL   Genomics 10 (1), 236-242 (1991)
   PUBMED   1840558
REFERENCE   10 (bases 1 to 1514)
  AUTHORS   Saida,K., Mitsui,Y. and Ishida,N.
  TITLE     A novel peptide, vasoactive intestinal contractor, of a new
            (endothelin) peptide family. Molecular cloning, expression, and
            biological activity
  JOURNAL   J Biol Chem 264 (25), 14613-14616 (1989)
   PUBMED   2768235
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC037042.1.
            
            On Feb 4, 2016 this sequence version replaced NM_007902.2.
            
            Summary: This gene encodes a member of the endothelin family of
            peptides. The encoded preproprotein undergoes proteolytic
            processing to generate a potent vasoconstrictive peptide. This gene
            is abundantly expressed in the gastrointestinal tract, strongly
            induced in photorecepteror cells in retinal diseases and injury,
            and produced by microglia and macrophages in the early stages of
            glaucoma. Mice lacking the encoded protein exhibit severe growth
            retardation, hypothermia and juvenile lethality. [provided by
            RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037042.1, X59556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1514              BC037042.1         12-1525
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 55.77 cM"
     gene            1..1514
                     /gene="Edn2"
                     /gene_synonym="ET-2; PPET2; VIC"
                     /note="endothelin 2"
                     /db_xref="GeneID:13615"
                     /db_xref="MGI:MGI:95284"
     exon            1..359
                     /gene="Edn2"
                     /gene_synonym="ET-2; PPET2; VIC"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..832
                     /gene="Edn2"
                     /gene_synonym="ET-2; PPET2; VIC"
                     /note="preproendothelin-2; vasoactive intestinal
                     contractor peptide"
                     /codon_start=1
                     /product="endothelin-2 preproprotein"
                     /protein_id="NP_031928.2"
                     /db_xref="CCDS:CCDS38864.1"
                     /db_xref="GeneID:13615"
                     /db_xref="MGI:MGI:95284"
                     /translation="MVSAWCSIALALLLALHEGKGQAAATLEQPASAPKGRGPHLRFR
                     RCSCNSWLDKECVYFCHLDIIWVNTAGQTAPYGLGNPPRRRRRSLPKRCECSTAGDSA
                     CATFCHRRHWPEAVVAPSSQAPAAVLKTGKMWTAEGDLLRKLRDISATKLRFARLQPE
                     VTRKAIPAYSRWRKR"
     exon            360..516
                     /gene="Edn2"
                     /gene_synonym="ET-2; PPET2; VIC"
                     /inference="alignment:Splign:2.1.0"
     exon            517..639
                     /gene="Edn2"
                     /gene_synonym="ET-2; PPET2; VIC"
                     /inference="alignment:Splign:2.1.0"
     exon            640..738
                     /gene="Edn2"
                     /gene_synonym="ET-2; PPET2; VIC"
                     /inference="alignment:Splign:2.1.0"
     exon            739..1462
                     /gene="Edn2"
                     /gene_synonym="ET-2; PPET2; VIC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1445..1450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Edn2"
                     /gene_synonym="ET-2; PPET2; VIC"
                     /note="hexamer: AATAAA"
     polyA_site      1462
                     /gene="Edn2"
                     /gene_synonym="ET-2; PPET2; VIC"
                     /note="major polyA site"
ORIGIN      
        1 ctgaaggtgt tgcagagaag cgcagagggt ggagcccagc cttccacctc cctctccccc
       61 tcaccgggag gccagggcgg gccaggcacc cagggaggag gcggtgtccc tggctctctg
      121 cccaaggtgc agcagctaag caggcggggc tgcaccagta ggggcgggcg ggcgccctgc
      181 ctggtattat aagaggcggc cagggcacct cagcaatgag ctctcagctc ggcttagcag
      241 gaggacactg gcgacctgct ctcccggctc ccttggccca gccaagcact ctgccgctgc
      301 tgctatggtc tccgcctggt gttccatcgc tctggccctg cttttggccc tgcatgaagg
      361 gaagggccag gcagctgcca ccctggagca gccggcctcg gcacccaagg gccgaggccc
      421 ccacctgcgt tttcgtcgat gctcctgcaa ctcctggctt gacaaggaat gtgtgtactt
      481 ctgccacctg gacatcatct gggtgaacac tgcgggacag acagctccct acggcctggg
      541 aaacccgcca aggcgccggc gccgctccct gccaaagcgt tgtgagtgct ctactgcggg
      601 ggactctgcc tgtgctacct tctgccatcg aagacactgg cctgaagctg tggtcgcccc
      661 aagcagccag gctcctgctg ctgtgttaaa gactggcaag atgtggactg ctgagggaga
      721 cctcctccga aagctgaggg atatctcagc caccaagctc cgctttgcca ggctacagcc
      781 agaggtgaca agaaaggcca tccctgcata ctctagatgg aggaagagat aacaccatga
      841 gctgcaggac cattgaaaaa gaagctcacg tggagacagg aggaaacggg cagctgctgg
      901 gagaccccta tgcctatctc ctgggccaag gcctcggatc ccggctagtc ggacccgtct
      961 gatgggttca gcacaagctc tggctgctct tacagcagct ctgtgcctta acactgccag
     1021 agccaccatc agcccctgga cagcagtgca gcctgccagt gctggttgct agctactgta
     1081 cctgcttgga ggagctatgt gaggacaaat gaacatgctg actgtatctt acggaatgtc
     1141 ctgtttgctg gactgaaatc caggagcaat cccacagcag gacacaatta cctaagccac
     1201 acctggagac tgaacagtca tcctaatgac tgacatcatg gctggcccct atggtcccct
     1261 ctggttcccc ttccctagag gtcttacaaa ctgttctctt gggacacttt tgggagcaca
     1321 gaacctgctg tacttcgctc atctgtatat aacttatttg cttcgagaac ttttgagatt
     1381 cttattattt attttaatgt atttttttag agcctcaatt gtttacttat gaactcatgt
     1441 ttgtaataaa ggatgaaatg ataaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1501 aaaaaaaaaa aaaa
//
