LOCUS       NM_010104               2143 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus endothelin 1 (Edn1), mRNA.
ACCESSION   NM_010104
VERSION     NM_010104.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2143)
  AUTHORS   Waheed-Ullah,Q., Wilsdon,A., Abbad,A., Rochette,S., Bu'Lock,F.,
            Saed,A.A., Hitz,M.P., Brook,J.D. and Loughna,S.
  TITLE     Cyclin-dependent kinase 13 is indispensable for normal mouse heart
            development
  JOURNAL   J Anat (2024) In press
   PUBMED   39556044
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2143)
  AUTHORS   Lima,A.F.R., Rodrigues,D., Machado,M.R., Oliveira-Neto,J.T.,
            Bressan,A.F.M., Pedersoli,C.A., Alves,J.V., Silva-Neto,J.A.,
            Barros,P.R., Dias,T.B., Garcia,L.V., Bruder-Nascimento,A.,
            Bruder-Nascimento,T., Carneiro,F.S., Leiria,L.O.S., Tostes,R.C. and
            Costa,R.M.
  TITLE     Endothelin-1 down-regulates nuclear factor erythroid 2-related
            factor-2 and contributes to perivascular adipose tissue dysfunction
            in obesity
  JOURNAL   Clin Sci (Lond) 138 (17), 1071-1087 (2024)
   PUBMED   39136472
  REMARK    GeneRIF: Endothelin-1 down-regulates nuclear factor erythroid
            2-related factor-2 and contributes to perivascular adipose tissue
            dysfunction in obesity.
REFERENCE   3  (bases 1 to 2143)
  AUTHORS   Liu,S.Y., Chen,L.K., Jhong,Y.T., Chen,C.W., Hsiao,L.E., Ku,H.C.,
            Lee,P.H., Hwang,G.S. and Juan,C.C.
  TITLE     Endothelin-1 impairs skeletal muscle myogenesis and development via
            ETB receptors and p38 MAPK signaling pathway
  JOURNAL   Clin Sci (Lond) 138 (12), 711-723 (2024)
   PUBMED   38804865
  REMARK    GeneRIF: Endothelin-1 impairs skeletal muscle myogenesis and
            development via ETB receptors and p38 MAPK signaling pathway.
REFERENCE   4  (bases 1 to 2143)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   5  (bases 1 to 2143)
  AUTHORS   Quilez,S., Dumontier,E., Baim,C., Kam,J. and Cloutier,J.F.
  TITLE     Loss of Neogenin alters branchial arch development and leads to
            craniofacial skeletal defects
  JOURNAL   Front Cell Dev Biol 12, 1256465 (2024)
   PUBMED   38404688
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2143)
  AUTHORS   Kurihara,Y., Kurihara,H., Oda,H., Maemura,K., Nagai,R., Ishikawa,T.
            and Yazaki,Y.
  TITLE     Aortic arch malformations and ventricular septal defect in mice
            deficient in endothelin-1
  JOURNAL   J Clin Invest 96 (1), 293-300 (1995)
   PUBMED   7615798
REFERENCE   7  (bases 1 to 2143)
  AUTHORS   Harats,D., Kurihara,H., Belloni,P., Oakley,H., Ziober,A.,
            Ackley,D., Cain,G., Kurihara,Y., Lawn,R. and Sigal,E.
  TITLE     Targeting gene expression to the vascular wall in transgenic mice
            using the murine preproendothelin-1 promoter
  JOURNAL   J Clin Invest 95 (3), 1335-1344 (1995)
   PUBMED   7883980
REFERENCE   8  (bases 1 to 2143)
  AUTHORS   Saida,K., Mitsui,Y. and Ishida,N.
  TITLE     A novel peptide, vasoactive intestinal contractor, of a new
            (endothelin) peptide family. Molecular cloning, expression, and
            biological activity
  JOURNAL   J Biol Chem 264 (25), 14613-14616 (1989)
   PUBMED   2768235
REFERENCE   9  (bases 1 to 2143)
  AUTHORS   Takuwa,N., Takuwa,Y., Yanagisawa,M., Yamashita,K. and Masaki,T.
  TITLE     A novel vasoactive peptide endothelin stimulates mitogenesis
            through inositol lipid turnover in Swiss 3T3 fibroblasts
  JOURNAL   J Biol Chem 264 (14), 7856-7861 (1989)
   PUBMED   2542249
REFERENCE   10 (bases 1 to 2143)
  AUTHORS   Vierula,M., Alanko,M., Andersson,M. and Vanha-Perttula,T.
  TITLE     Tail stump sperm defect in Ayrshire bulls: morphogenesis of the
            defect
  JOURNAL   Andrologia 19 Spec No, 207-216 (1987)
   PUBMED   3631552
  REMARK    GeneRIF: Tail stump sperm defect in Ayrshire bulls: morphogenesis
            of the defect.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ135809.1, AK040778.1,
            AC154635.2 and BY618506.1.
            
            On Feb 4, 2016 this sequence version replaced NM_010104.3.
            
            Summary: This gene encodes a member of the endothelin family of
            peptides. The encoded preproprotein undergoes proteolytic
            processing to generate a peptide before secretion by the vascular
            endothelial cells. The mature peptide has various biological
            activities such as vasoconstriction, cell proliferation,
            stimulation of hormone release and modulation of central nervous
            activity. Mice lacking the encoded protein exhibit neonatal
            lethality accompanied with numerous craniofacial and cardiovascular
            defects due to disruption in cranial and cardiac neural crest cell
            patterning during early embryogenesis. [provided by RefSeq, Feb
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029547.1, AK040778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               CJ135809.1         208-345
            139-1522            AK040778.1         3-1386
            1523-1748           AK040778.1         1388-1613
            1749-1749           AC154635.2         105151-105151       c
            1750-2138           AK040778.1         1615-2003
            2139-2143           BY618506.1         369-373
FEATURES             Location/Qualifiers
     source          1..2143
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 20.82 cM"
     gene            1..2143
                     /gene="Edn1"
                     /gene_synonym="ET-1; PPET1; preproET"
                     /note="endothelin 1"
                     /db_xref="GeneID:13614"
                     /db_xref="MGI:MGI:95283"
     exon            1..483
                     /gene="Edn1"
                     /gene_synonym="ET-1; PPET1; preproET"
                     /inference="alignment:Splign:2.1.0"
     CDS             420..1028
                     /gene="Edn1"
                     /gene_synonym="ET-1; PPET1; preproET"
                     /note="preproendothelin-1"
                     /codon_start=1
                     /product="endothelin-1 preproprotein"
                     /protein_id="NP_034234.1"
                     /db_xref="CCDS:CCDS26474.1"
                     /db_xref="GeneID:13614"
                     /db_xref="MGI:MGI:95283"
                     /translation="MDYFPVIFSLLFVTFQGAPETAVLGAELSTGAENGVQSPPPSTP
                     WRPRRSKRCSCSSLMDKECVYFCHLDIIWVNTPERVVPYGLGGSSRSKRSLKDLLPNK
                     ATDQAVRCQCAHQKDKKCWNFCQAGKELRAQSTMQKSLKDSKKGKPCSKLGKKCIYQQ
                     LVEGRKLRRLEAISNSIKASFRVAKLKAELYRDQKLTHNRAH"
     exon            484..652
                     /gene="Edn1"
                     /gene_synonym="ET-1; PPET1; preproET"
                     /inference="alignment:Splign:2.1.0"
     exon            653..811
                     /gene="Edn1"
                     /gene_synonym="ET-1; PPET1; preproET"
                     /inference="alignment:Splign:2.1.0"
     exon            812..925
                     /gene="Edn1"
                     /gene_synonym="ET-1; PPET1; preproET"
                     /inference="alignment:Splign:2.1.0"
     exon            926..2139
                     /gene="Edn1"
                     /gene_synonym="ET-1; PPET1; preproET"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2117..2122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Edn1"
                     /gene_synonym="ET-1; PPET1; preproET"
                     /note="hexamer: AATAAA"
     polyA_site      2139
                     /gene="Edn1"
                     /gene_synonym="ET-1; PPET1; preproET"
                     /note="major polyA site"
ORIGIN      
        1 gccgggtctt atctctggct gcacgttgcc tgtgggtgac taatcacaca ataacattgt
       61 ttagggctgg aataaagtca gagctgttta cccccactct ataggggttc aatataaaaa
      121 ggcggcggag aactgtccga gtcagaagcg ttcctgcacc ggcgctgaga gcctgacccg
      181 gtctgctccg ctgtccttgc gcgctgcctc ccggctgccc gcgacgcttt cgccccagtg
      241 gaagggccac ttgctgagga ccgcgctgag atctaaaaaa aaaacaaaaa acaaaaaaca
      301 aaaaaaccca gaggcgatca gagcgaccag acaccgtcct cttcgttttg cattgagttc
      361 catttgcaac cgagttttct ttttttcctt tttccccact cttctgaccc ctttgcagaa
      421 tggattattt tcccgtgatc ttctctctgc tgttcgtgac tttccaagga gctccagaaa
      481 cagctgtctt gggagccgaa ctcagcaccg gagctgagaa tggagtgcag agcccccctc
      541 ccagcacacc ctggagaccc cgcaggtcca agcgctgttc ctgttcttcc ttgatggaca
      601 aggagtgtgt ctacttctgc cacctggaca tcatctgggt caacactccc gagcgcgtcg
      661 taccgtatgg actgggaggt tcttccaggt ccaagcgttc cttgaaagac ttacttccca
      721 ataaggccac agaccaggca gttagatgtc agtgcgctca ccaaaaagac aagaagtgct
      781 ggaatttctg ccaagcagga aaagaactca gggcccaaag taccatgcag aaaagcttaa
      841 aagactccaa gaaaggaaaa ccctgttcca agttgggaaa gaagtgtatc tatcagcagc
      901 tggtggaagg aaggaaacta cgaaggttgg aggccatcag caatagcatc aaggcatctt
      961 ttcgtgttgc aaagttgaaa gctgagctct atagagacca gaagttgacg cacaaccgag
     1021 cacattgact acagagctcc cccagtgttt tggaagtcat cccttatata gtgcgagccc
     1081 catggccagc tctgcactct ccatgctggc tgggatctta gcaagaccat ctgtgtggct
     1141 tctacagttt cttgttcaga cgggcagagg accagcatcc ttgatccaaa cattccaaga
     1201 aaggctgagg tgttccctag cctgtctgcg tccgctggga gcgagtgcct ttctgcctct
     1261 tcttgccggt tgggaatgac agaggacttc tcagagagca gagacacgat gccattctag
     1321 agtggcatca ctcagagagc caggagattc cacagcaggg cggggtttct gtagaaagtc
     1381 cttagggagt gttcgtgtct gactcaggcg cctggcacat ttcagggaga aactccaaag
     1441 tccatgcaaa aatttttctg aggaatgcac aaattgaaaa catactcgaa ggacaaacac
     1501 ttgagtttaa aaaaaaaaaa aagacaattt ttaagttgta aaatgcaaaa ctcaaagcaa
     1561 ctgttactac tgtacattgg gatgtatttc atgaatatga gtctacctca cctttctgca
     1621 ctgtcataca cattctcacc tttaattatt gcctccctgt attctctcct ctccgctatc
     1681 cgggttccca gtcccctata ctgaatcctt gcctcacaga aattgagtca gaagtagctg
     1741 aaacattgcc atgctaatct gctagctcta atctatgaga aaaaaggatg acagaatctg
     1801 gcccctgccc ttgaccttgg gaaacacaat ggtttagagt tgtttgtgta catgttgaaa
     1861 acctggtctg tgctttttag cagtaaaaat atgttcccgt atgtattgta actggctaat
     1921 ggaagaggtt agattgaatc ttgatgtact tattttttta tagatattta tattcaaaca
     1981 atttattcct tatatttacc atgttaaata tatgtctggg caggccatat tggtctatgt
     2041 attttttaaa aatatatatt tctgaatgaa attgagaaca tgctttgttt tgcctgtcaa
     2101 ggtaatgatt ttagaaaata aatatttttc cctactgtaa aaa
//
