LOCUS       NM_001037987            5358 bp    mRNA    linear   ROD 12-DEC-2023
DEFINITION  Mus musculus EGF-like repeats and discoidin I-like domains 3
            (Edil3), transcript variant 1, mRNA.
ACCESSION   NM_001037987
VERSION     NM_001037987.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5358)
  AUTHORS   Zhao M, Zheng Z, Yin Z, Zhang J, Peng S, Liu J, Pan W, Wei C, Xu Y,
            Qin JJ, Wan J and Wang M.
  TITLE     DEL-1 deficiency aggravates pressure overload-induced heart failure
            by promoting neutrophil infiltration and neutrophil extracellular
            traps formation
  JOURNAL   Biochem Pharmacol 218, 115912 (2023)
   PUBMED   37956894
  REMARK    GeneRIF: DEL-1 deficiency aggravates pressure overload-induced
            heart failure by promoting neutrophil infiltration and neutrophil
            extracellular traps formation.
REFERENCE   2  (bases 1 to 5358)
  AUTHORS   Wu SR and Zoghbi HY.
  TITLE     The Atoh1-Cre Knock-In Allele Ectopically Labels a Subpopulation of
            Amacrine Cells and Bipolar Cells in Mouse Retina
  JOURNAL   eNeuro 10 (11) (2023)
   PUBMED   37923392
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5358)
  AUTHORS   Agudo-Rios C, Rogers A, King I, Bhagat V, Nguyen LMT,
            Cordova-Fletes C, Krapf D, Strauss JF 3rd, Arevalo L, Merges GE,
            Schorle H, Roldan ERS and Teves ME.
  TITLE     SPAG17 mediates nuclear translocation of protamines during
            spermiogenesis
  JOURNAL   Front Cell Dev Biol 11, 1125096 (2023)
   PUBMED   37766963
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5358)
  AUTHORS   Sun Y, Boyko T, Marecic O, Struck D, Mann RK, Andrew TW, Lopez M,
            Tong X, Goodman SB, Yang F, Longaker MT, Chan CKF and Yang GP.
  TITLE     Del1 Is a Growth Factor for Skeletal Progenitor Cells in the
            Fracture Callus
  JOURNAL   Biomolecules 13 (8), 1214 (2023)
   PUBMED   37627279
  REMARK    GeneRIF: Del1 Is a Growth Factor for Skeletal Progenitor Cells in
            the Fracture Callus.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5358)
  AUTHORS   Hua X, Blosch CD, Dorsey H, Ficaro MK, Wallace NL, Hsung RP and Dai
            J.
  TITLE     Epidermal Loss of RORalpha Enhances Skin Inflammation in a
            MC903-Induced Mouse Model of Atopic Dermatitis
  JOURNAL   Int J Mol Sci 24 (12), 10241 (2023)
   PUBMED   37373387
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5358)
  AUTHORS   Vincent SD, Dunn NR, Hayashi S, Norris DP and Robertson EJ.
  TITLE     Cell fate decisions within the mouse organizer are governed by
            graded Nodal signals
  JOURNAL   Genes Dev 17 (13), 1646-1662 (2003)
   PUBMED   12842913
REFERENCE   7  (bases 1 to 5358)
  AUTHORS   Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R,
            Varner JA and Quertermous T.
  TITLE     The embryonic angiogenic factor Del1 accelerates tumor growth by
            enhancing vascular formation
  JOURNAL   Microvasc Res 64 (1), 148-161 (2002)
   PUBMED   12074641
  REMARK    GeneRIF: acts as an angiogenic factor in the context of solid tumor
            formation; the increase in vascularization accelerates tumor growth
            through decreased apoptosis
REFERENCE   8  (bases 1 to 5358)
  AUTHORS   Rezaee M, Penta K and Quertermous T.
  TITLE     Del1 mediates VSMC adhesion, migration, and proliferation through
            interaction with integrin alpha(v)beta(3)
  JOURNAL   Am J Physiol Heart Circ Physiol 282 (5), H1924-H1932 (2002)
   PUBMED   11959660
  REMARK    GeneRIF: mediates vascular smooth muscle cells adhesion, migration,
            and proliferation through interaction with integrin alpha(v)beta(3)
REFERENCE   9  (bases 1 to 5358)
  AUTHORS   Lakkis MM and Epstein JA.
  TITLE     Neurofibromin modulation of ras activity is required for normal
            endocardial-mesenchymal transformation in the developing heart
  JOURNAL   Development 125 (22), 4359-4367 (1998)
   PUBMED   9778496
REFERENCE   10 (bases 1 to 5358)
  AUTHORS   Hidai C, Zupancic T, Penta K, Mikhail A, Kawana M, Quertermous EE,
            Aoka Y, Fukagawa M, Matsui Y, Platika D, Auerbach R, Hogan BL,
            Snodgrass R and Quertermous T.
  TITLE     Cloning and characterization of developmental endothelial locus-1:
            an embryonic endothelial cell protein that binds the alphavbeta3
            integrin receptor
  JOURNAL   Genes Dev 12 (1), 21-33 (1998)
   PUBMED   9420328
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046885.1, AK036117.1, AK139093.1 and BY701378.1.
            
            [WARNING] On Jan 24, 2024 this sequence was replaced by
            NM_001037987.4.
            
            On Jan 12, 2008 this sequence version replaced NM_001037987.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139093.1, SRR1660817.48145.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               AK046885.1         2-283
            283-2682            AK036117.1         244-2643
            2683-5356           AK139093.1         2645-5318
            5357-5358           BY701378.1         387-388
FEATURES             Location/Qualifiers
     source          1..5358
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 45.3 cM"
     gene            1..5358
                     /gene="Edil3"
                     /gene_synonym="Del-1; Del1; Sox2-cre; Sox2Cre;
                     Tg(Sox2-cre)1Amc"
                     /note="EGF-like repeats and discoidin I-like domains 3"
                     /db_xref="GeneID:13612"
                     /db_xref="MGI:MGI:1329025"
     exon            1..577
                     /gene="Edil3"
                     /gene_synonym="Del-1; Del1; Sox2-cre; Sox2Cre;
                     Tg(Sox2-cre)1Amc"
                     /inference="alignment:Splign:2.1.0"
     CDS             511..1953
                     /gene="Edil3"
                     /gene_synonym="Del-1; Del1; Sox2-cre; Sox2Cre;
                     Tg(Sox2-cre)1Amc"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; developmental endothelial locus-1; EGF-like
                     repeat and discoidin I-like domain-containing protein 3;
                     integrin-binding protein DEL1; developmentally-regulated
                     endothelial cell locus 1 protein"
                     /codon_start=1
                     /product="EGF-like repeat and discoidin I-like
                     domain-containing protein 3 isoform a precursor"
                     /protein_id="NP_001033076.1"
                     /db_xref="CCDS:CCDS26669.1"
                     /db_xref="GeneID:13612"
                     /db_xref="MGI:MGI:1329025"
                     /translation="MKHLVAAWLLVGLSLGVPQFGKGDICNPNPCENGGICLSGLADD
                     SFSCECPEGFAGPNCSSVVEVASDEEKPTSAGPCIPNPCHNGGTCEISEAYRGDTFIG
                     YVCKCPRGFNGIHCQHNINECEAEPCRNGGICTDLVANYSCECPGEFMGRNCQYKCSG
                     PLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQI
                     NLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEEMVFRGNVD
                     NNTPYANSFTPPIKAQYVRLYPQICRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQ
                     ITASSVFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGII
                     TQGAKDFGHVQFVGSYKLAYSNDGEHWMVHQDEKQRKDKVFQGNFDNDTHRKNVIDPP
                     IYARFIRILPWSWYGRITLRSELLGCAEEE"
     exon            578..706
                     /gene="Edil3"
                     /gene_synonym="Del-1; Del1; Sox2-cre; Sox2Cre;
                     Tg(Sox2-cre)1Amc"
                     /inference="alignment:Splign:2.1.0"
     exon            707..736
                     /gene="Edil3"
                     /gene_synonym="Del-1; Del1; Sox2-cre; Sox2Cre;
                     Tg(Sox2-cre)1Amc"
                     /inference="alignment:Splign:2.1.0"
     exon            737..865
                     /gene="Edil3"
                     /gene_synonym="Del-1; Del1; Sox2-cre; Sox2Cre;
                     Tg(Sox2-cre)1Amc"
                     /inference="alignment:Splign:2.1.0"
     exon            866..979
                     /gene="Edil3"
                     /gene_synonym="Del-1; Del1; Sox2-cre; Sox2Cre;
                     Tg(Sox2-cre)1Amc"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1161
                     /gene="Edil3"
                     /gene_synonym="Del-1; Del1; Sox2-cre; Sox2Cre;
                     Tg(Sox2-cre)1Amc"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1317
                     /gene="Edil3"
                     /gene_synonym="Del-1; Del1; Sox2-cre; Sox2Cre;
                     Tg(Sox2-cre)1Amc"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1462
                     /gene="Edil3"
                     /gene_synonym="Del-1; Del1; Sox2-cre; Sox2Cre;
                     Tg(Sox2-cre)1Amc"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1647
                     /gene="Edil3"
                     /gene_synonym="Del-1; Del1; Sox2-cre; Sox2Cre;
                     Tg(Sox2-cre)1Amc"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1803
                     /gene="Edil3"
                     /gene_synonym="Del-1; Del1; Sox2-cre; Sox2Cre;
                     Tg(Sox2-cre)1Amc"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..5358
                     /gene="Edil3"
                     /gene_synonym="Del-1; Del1; Sox2-cre; Sox2Cre;
                     Tg(Sox2-cre)1Amc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctaggctc agtctcacac gcgcgccgcc actgtttgta cacagtgcgc tcctggcctc
       61 aggctcgctc ccctccagct ctcgcttcat tgttctccaa gtcagaagcc cccgcagccg
      121 ccgcggcagc agcgtgagcc gtagtcactg ctggccgctt cgcctgcggt gcgcgcacgg
      181 aaatcgggga gccaggaacc caaggagccc gcgctccgcc cgctgtgcct ctgctaggac
      241 ccactcgcag ccccagcctc tctcaagcgc acccacctcc gcgcacccca gctcaggcga
      301 agctggagtg aggggtgaat caccctttct ctagggccac cactctttta tcgcccttcc
      361 caagaatttg aggaagcgct gcgggaggaa agacgtcctc ttgaatctct gacagggcgg
      421 ggtttactgc tgtcctgcag ggccgcctcg cctactgtgc cctccgctac gaccccggac
      481 cagcccaggt cacgtccgtg agaagggatc atgaagcact tggtagcagc ctggcttttg
      541 gttggactca gcctcggggt gccccagttc ggcaaaggtg acatttgcaa cccgaacccc
      601 tgtgaaaatg gtggcatctg tctgtcagga ctggctgatg attccttttc ctgtgagtgt
      661 ccagaaggct tcgcaggtcc gaactgctct agtgttgtgg aggttgcatc agatgaagaa
      721 aagcctactt cagcaggtcc ctgcatccct aacccatgcc ataacggagg aacctgtgag
      781 ataagcgaag cctatcgagg agacacattc ataggctatg tttgtaaatg tcctcgggga
      841 tttaatggga ttcactgtca gcacaatata aatgaatgtg aagctgagcc ttgcagaaat
      901 ggcggaatat gtaccgacct tgttgctaac tactcttgtg aatgcccagg agaatttatg
      961 ggacgaaatt gtcaatataa atgctctggg ccattgggaa tcgaaggtgg gatcatatct
     1021 aatcagcaaa tcacagcttc atctactcac cgagctcttt ttggactcca gaagtggtat
     1081 ccctactatg ctcgacttaa taagaagggc cttataaatg cctggacagc tgctgaaaat
     1141 gacagatggc catggattca gataaatttg caaagaaaaa tgagagtcac tggtgttatt
     1201 acccaaggag caaaaaggat tggaagccca gagtacataa aatcctacaa aattgcctac
     1261 agcaatgacg ggaagacctg ggcaatgtac aaagtaaaag gcaccaatga agagatggtc
     1321 tttcgtggaa atgttgataa caacacacca tatgctaatt ctttcacacc cccaatcaaa
     1381 gctcagtatg taagactcta cccccaaatt tgtcgaaggc attgtacttt aagaatggaa
     1441 cttcttggct gtgagctctc aggctgttca gaacctttgg ggatgaaatc agggcatata
     1501 caagactacc agatcactgc ctccagcgtc ttcagaacac tcaacatgga catgtttact
     1561 tgggaaccaa ggaaagccag gctggacaag caaggcaaag taaatgcctg gacttccggc
     1621 cataacgacc agtcacaatg gttacaggtt gatcttcttg tccctactaa ggtgacaggc
     1681 atcattacac aaggagctaa agattttggt cacgtgcagt ttgttgggtc atacaaacta
     1741 gcttacagca atgatggaga acactggatg gtgcaccagg atgaaaaaca gagaaaagac
     1801 aaggtttttc aaggcaattt tgacaatgac actcacagga aaaatgtcat cgaccctccc
     1861 atctatgcac gattcataag aatccttcct tggtcctggt atggaaggat cactctgcgg
     1921 tcagagctgc tgggctgcgc agaggaggaa tgaagtgcgg ggccgcacat cccacaatgc
     1981 ttttctttat tttcctataa gtatctccac gaaatgaact gtgtgaagct gatggaaact
     2041 gcatttgttt ttttcaaagt gttcaaatta tggtaggcta ctgactgtct ttttaggagt
     2101 tctaagcttg cctttttaat aatttaattt ggtttccttt gctcaactct cttatgtaat
     2161 atcacactgt ctgtgagtta ctcttcttgt tctctgaatt ctatagattg gttgaagtat
     2221 agtaggcaaa gcaagtcttc tttttacagc aaaacttaaa aacaatctca cagtcatcag
     2281 atggaagggt taagggagaa ctttggtcac tattcaatta actcttataa aatgttacaa
     2341 tgttagcaat acagtttttt gttatgaatt tgatcatctt gattgtttcc ctgtgtctaa
     2401 tgctgttagt atgtattaca gagacttggt gaaaattatt tgatatgcag gaccattaat
     2461 atgacaattc tagttttatt tttttcactt acaataaaat actaagttct ttatgtttaa
     2521 ttttatatta tttatatgct acataaacag gccaatattc tttgtcattg cattttctcc
     2581 ctttatttac cttaaagtcc tgtttttatt tatagacaca gaacatatat taatatacgt
     2641 tgaacatgat tggatatcag taaatgcttc tatattaaac attaatacat tgaatctgaa
     2701 ttttcatttt tgaagaaagc tatatgcatt tcatttccaa aggctatctg agattccctt
     2761 gttacagttt agtgaaaaag aacagaaaaa cactatggcc cttgaattta aatcttcatt
     2821 tctttgagat aacagaatca ctatctgtgt gtttaataca ctagcaaatg tatgtgagcc
     2881 tactgctgca cagctgggct aagtgcactc aacaattctt tgcaaatttc cacatttcct
     2941 gtgaaatgaa aattccaatg ctgtttaaaa ccagtggtag tttctgaaga aagcacattg
     3001 taaaattatt tgtgagaagc gacgtattta caaatgacaa agtcataaaa catcttcagg
     3061 atgaaaattg atttttattt cttttgcttc aaaggtctta gaaaaactaa gcaattatca
     3121 taacagtttg ttattgataa tggaggcatc attgacatat gtctcaaatt aaagctcaca
     3181 ctgcctccat aaatgtccta catacctaat ttataagctt aacacatatt tattttataa
     3241 ggctttgaca cagaattatt ggagttttaa attgaagatc caggaaagga aagggtggat
     3301 gtggatgaaa tgctaaagaa ctacacaaca ctgctatatt ttattttatt tttgtcttta
     3361 atatgtgtgc tgtataagca aagccactac tgttatgtcc tgtctgttca cgtgttcaca
     3421 gcatctctca atgatgtaaa tatgaagcag tcttcaatca cagtgaagaa ttgaaagtga
     3481 aagtcaatca cattactgtt ttaaatgaca gcaaattcat tgttctatgg taactgtcag
     3541 gccaaatgtt tctccttgcc cacctgctta ctgcaacaga tttgttaaaa atctgttgat
     3601 tttcagcata taaaatgctg aataattttt aacattttcc caaaagaaaa ctgatatgcc
     3661 ctcaatatta ttgtcctaga aaatgtttta aattattaat atagaatatt taaaatagta
     3721 tttttaatta aaatagttat acatagaatc acttatgccc taaaggtaca ttttctgtct
     3781 tgccatggtc cttgtttcta tcagtgataa ccatactact gaatttgtag ctgtttttcc
     3841 ttgcagattc tttatcctta atataaaatt ccagaaatta tgaataatac gctgtgctga
     3901 aatacttttc aaaactgttc ttgatttcat gtggcactgc tggtacatgt ttaaaatttg
     3961 ttctccaaag gagttgttag taatggtatc tgctactatt tacaaggctg gtgagaggct
     4021 ttctcttgct tgtcctcttc ctctcagctt catgcgctac ctacagcata gcttacgcaa
     4081 tggatatgcg tttgtccaca agggtgcttg cacaaaaatt aatgacatgt attagggagt
     4141 agcttgtatc agtggcttca agtcgaaaca tggaattttc atttagtttt atttgcaagt
     4201 aaaattttac aaacacacaa cctggaattc cctactcttc actatactac ataattatta
     4261 tgagataatt tcattgtata gaagattatg aattaattag ctttaaaaat atcaatttca
     4321 tgtattttat tctaatcatt tgtcacagac actaattcca actttagggt tgactttctc
     4381 tctgtgaatg tcttcagaaa gataagaatg gatcttgaag accaggcatt aatgactata
     4441 tctttgctag acatcaaatt atgaaatata acattgaatg ttgtagtctg gtgtgtctgt
     4501 aaggacagaa ataactaaga tacacataac ttttgcaaac tttcaagctg tgtaatattc
     4561 caatgttgtt gttttttttt ttgtagatat acttaaatca tgtaggatgt tgtaaactca
     4621 gtatgatcct gtctagtctt caaacttaaa ataaactttt gaaaaactgt gctacttttg
     4681 aagttgtgtt ttaaacatct gtgtaagaat gtacaaattg tctgtggctg cccttaacct
     4741 tcaacatatg attagcttaa tttgtattta tatagattaa ctaaatgcac aaagaaaaag
     4801 agattataat tgtataatta ttttaaaata taagactgca aaagtggttt tgccaagatt
     4861 ataaaaatgt ataaatttat ccataccttt ttatttgcag agattttgca aaatattaat
     4921 aatccaattg ttttctccaa atatatattt agagtagtat actataagac tgataaatct
     4981 attattattc atacaacatt tctattgctt ctattgttct ttcaaattta tcatgctcag
     5041 gagtatattg aaggaagctg gttggtaata agctacaatg tgacatgaat aatacatatt
     5101 agcctctaac tccagctatt gcttaatgaa agtctgaaca tgtggcttct ttaagaacag
     5161 tcttttctgg ttctgtagaa gccacgagta aaaaggggat gtgtaactct aacacttcaa
     5221 tattttctta ggattaaaaa tttagagtaa aactaaagat attaaaagtt gttttcttca
     5281 agcagatctc tggtagatca agtttcatgg ttttgtatac caacatgttc ctatcaaagt
     5341 aaattttaat atgaatgc
//
