LOCUS       NM_021519                742 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus endothelial differentiation-related factor 1 (Edf1),
            mRNA.
ACCESSION   NM_021519
VERSION     NM_021519.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 742)
  AUTHORS   Lopez-Victorio,C.J., Velez-delValle,C., Beltran-Langarica,A. and
            Kuri-Harcuch,W.
  TITLE     EDF-1 downregulates the CaM/Cn/NFAT signaling pathway during
            adipogenesis
  JOURNAL   Biochem Biophys Res Commun 432 (1), 146-151 (2013)
   PUBMED   23376715
  REMARK    GeneRIF: these results showed that EDF-1 inactivates the
            calmodulin/calcineurin/NFAT pathway via sequestration of
            calmodulin, during early adipogenesis.
REFERENCE   2  (bases 1 to 742)
  AUTHORS   Leidi,M., Mariotti,M. and Maier,J.A.
  TITLE     Transcriptional coactivator EDF-1 is required for
            PPARgamma-stimulated adipogenesis
  JOURNAL   Cell Mol Life Sci 66 (16), 2733-2742 (2009)
   PUBMED   19554257
  REMARK    GeneRIF: EDF-1 is required for PPARgamma transcriptional activation
            during preadipocyte differentiation.
REFERENCE   3  (bases 1 to 742)
  AUTHORS   Rogers,M.S., Rohan,R.M., Birsner,A.E. and D'Amato,R.J.
  TITLE     Genetic loci that control vascular endothelial growth
            factor-induced angiogenesis
  JOURNAL   FASEB J 17 (14), 2112-2114 (2003)
   PUBMED   12958152
REFERENCE   4  (bases 1 to 742)
  AUTHORS   De Benedictis,L., Mariotti,M., Dragoni,I. and Maier,J.A.
  TITLE     Cloning and characterization of murine EDF-1
  JOURNAL   Gene 275 (2), 299-304 (2001)
   PUBMED   11587857
REFERENCE   5  (bases 1 to 742)
  AUTHORS   Inoue,S., Sano,H. and Ohta,M.
  TITLE     Growth suppression of Escherichia coli by induction of expression
            of mammalian genes with transmembrane or ATPase domains
  JOURNAL   Biochem Biophys Res Commun 268 (2), 553-561 (2000)
   PUBMED   10679242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856073.1, AB030185.1 and CF740336.1.
            
            On Apr 25, 2018 this sequence version replaced NM_021519.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK030881.1, BI147266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BB856073.1         1-53
            54-722              AB030185.1         1-669
            723-742             CF740336.1         493-512
FEATURES             Location/Qualifiers
     source          1..742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.39 cM"
     gene            1..742
                     /gene="Edf1"
                     /gene_synonym="0610008L11Rik; MBF1"
                     /note="endothelial differentiation-related factor 1"
                     /db_xref="GeneID:59022"
                     /db_xref="MGI:MGI:1891227"
     exon            1..183
                     /gene="Edf1"
                     /gene_synonym="0610008L11Rik; MBF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..552
                     /gene="Edf1"
                     /gene_synonym="0610008L11Rik; MBF1"
                     /note="multiprotein-bridging factor 1; hypothetical
                     protein 1-9"
                     /codon_start=1
                     /product="endothelial differentiation-related factor 1"
                     /protein_id="NP_067494.1"
                     /db_xref="CCDS:CCDS15780.1"
                     /db_xref="GeneID:59022"
                     /db_xref="MGI:MGI:1891227"
                     /translation="MAESDWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKW
                     AAGQNKQHSITKNTAKLDRETEELHHDRVTLEVGKVIQRGRQSKGLTQKDLATKINEK
                     PQVIADYESGRAIPNNQVLGKIERAIGLKLRGKDIGKPIEKGPKAK"
     exon            184..235
                     /gene="Edf1"
                     /gene_synonym="0610008L11Rik; MBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..396
                     /gene="Edf1"
                     /gene_synonym="0610008L11Rik; MBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            397..490
                     /gene="Edf1"
                     /gene_synonym="0610008L11Rik; MBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..724
                     /gene="Edf1"
                     /gene_synonym="0610008L11Rik; MBF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      699..704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Edf1"
                     /gene_synonym="0610008L11Rik; MBF1"
                     /note="hexamer: AACAAA"
     polyA_site      722
                     /gene="Edf1"
                     /gene_synonym="0610008L11Rik; MBF1"
                     /note="major polyA site"
ORIGIN      
        1 gcgctggcgc cggaagcggg gaggcgacga agggacgtcg cgtcgccgcg ccgggtctcg
       61 agcagctgcc agagccgccg gacggatcgc tgcccccgcc gcgccatggc cgagagtgac
      121 tgggacaccg tgacggtgct gcgcaagaag ggccccacgg ccgcacaggc caagtctaag
      181 caggccatct tagcggctca gcgacgagga gaagatgtgg agacatccaa gaaatgggct
      241 gctggccaga acaagcagca ttccattact aaaaacacag ccaagctcga ccgggagacc
      301 gaggagctgc atcacgacag ggtgaccctg gaggtgggca aagtgatcca gcggggccgg
      361 cagagcaaag gcctgaccca gaaggacctg gccacgaaaa tcaatgagaa gccgcaagtc
      421 atcgcagact atgaaagtgg acgggccatt ccgaataacc aggttttggg caaaattgag
      481 agagccatcg gcctcaagct ccgggggaag gacatcggga agcctatcga gaaggggccg
      541 aaggcgaaat gaacacaaag cctcgaagcc agtggttccg gctgagctct cctggctggt
      601 cccccaggac caccagcact gccgtgggtc tcctcacatg gtcaaacgga acacgggggg
      661 ttaggcctgt gtgccccctc aacccataac tgctgtcaaa caaagcaaac cttgtaaagt
      721 gataaaaaaa aaaaaaaaaa aa
//
