LOCUS       NP_067494                148 aa            linear   ROD 05-JUN-2024
DEFINITION  endothelial differentiation-related factor 1 [Mus musculus].
ACCESSION   NP_067494
VERSION     NP_067494.1
DBSOURCE    REFSEQ: accession NM_021519.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 148)
  AUTHORS   Lopez-Victorio,C.J., Velez-delValle,C., Beltran-Langarica,A. and
            Kuri-Harcuch,W.
  TITLE     EDF-1 downregulates the CaM/Cn/NFAT signaling pathway during
            adipogenesis
  JOURNAL   Biochem Biophys Res Commun 432 (1), 146-151 (2013)
   PUBMED   23376715
  REMARK    GeneRIF: these results showed that EDF-1 inactivates the
            calmodulin/calcineurin/NFAT pathway via sequestration of
            calmodulin, during early adipogenesis.
REFERENCE   2  (residues 1 to 148)
  AUTHORS   Leidi,M., Mariotti,M. and Maier,J.A.
  TITLE     Transcriptional coactivator EDF-1 is required for
            PPARgamma-stimulated adipogenesis
  JOURNAL   Cell Mol Life Sci 66 (16), 2733-2742 (2009)
   PUBMED   19554257
  REMARK    GeneRIF: EDF-1 is required for PPARgamma transcriptional activation
            during preadipocyte differentiation.
REFERENCE   3  (residues 1 to 148)
  AUTHORS   Rogers,M.S., Rohan,R.M., Birsner,A.E. and D'Amato,R.J.
  TITLE     Genetic loci that control vascular endothelial growth
            factor-induced angiogenesis
  JOURNAL   FASEB J 17 (14), 2112-2114 (2003)
   PUBMED   12958152
REFERENCE   4  (residues 1 to 148)
  AUTHORS   De Benedictis,L., Mariotti,M., Dragoni,I. and Maier,J.A.
  TITLE     Cloning and characterization of murine EDF-1
  JOURNAL   Gene 275 (2), 299-304 (2001)
   PUBMED   11587857
REFERENCE   5  (residues 1 to 148)
  AUTHORS   Inoue,S., Sano,H. and Ohta,M.
  TITLE     Growth suppression of Escherichia coli by induction of expression
            of mammalian genes with transmembrane or ATPase domains
  JOURNAL   Biochem Biophys Res Commun 268 (2), 553-561 (2000)
   PUBMED   10679242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856073.1, AB030185.1 and CF740336.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK030881.1, BI147266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..148
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.39 cM"
     Protein         1..148
                     /product="endothelial differentiation-related factor 1"
                     /note="multiprotein-bridging factor 1; hypothetical
                     protein 1-9"
                     /calculated_mol_wt=16238
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:O60869; propagated from
                     UniProtKB/Swiss-Prot (Q9JMG1.1)"
     Site            4
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O60869; propagated from
                     UniProtKB/Swiss-Prot (Q9JMG1.1)"
     Region          5..71
                     /region_name="MBF1"
                     /note="Multiprotein bridging factor 1; pfam08523"
                     /db_xref="CDD:462508"
     Site            25
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:O60869; propagated from
                     UniProtKB/Swiss-Prot (Q9JMG1.1)"
     Region          34..67
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMG1.1)"
     Region          37..113
                     /region_name="Interaction with NR5A2, PPARG and NR1H3.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMG1.1)"
     Region          69..108
                     /region_name="Interaction with TBP and NR5A1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMG1.1)"
     Region          76..132
                     /region_name="aMBF1"
                     /note="Archaeal ribosome-binding protein aMBF1, putative
                     translation factor, contains Zn-ribbon and HTH domains
                     [Translation, ribosomal structure and biogenesis];
                     COG1813"
                     /db_xref="CDD:441418"
     Region          81..88
                     /region_name="IQ motif. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMG1.1)"
     CDS             1..148
                     /gene="Edf1"
                     /gene_synonym="0610008L11Rik; MBF1"
                     /coded_by="NM_021519.2:106..552"
                     /db_xref="CCDS:CCDS15780.1"
                     /db_xref="GeneID:59022"
                     /db_xref="MGI:MGI:1891227"
ORIGIN      
        1 maesdwdtvt vlrkkgptaa qakskqaila aqrrgedvet skkwaagqnk qhsitkntak
       61 ldreteelhh drvtlevgkv iqrgrqskgl tqkdlatkin ekpqviadye sgraipnnqv
      121 lgkieraigl klrgkdigkp iekgpkak
//
