LOCUS       NM_138677               5858 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus ER degradation enhancer, mannosidase alpha-like 1
            (Edem1), mRNA.
ACCESSION   NM_138677
VERSION     NM_138677.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5858)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5858)
  AUTHORS   Jazwiec,P.A., Patterson,V.S., Ribeiro,T.A., Yeo,E., Kennedy,K.M.,
            Mathias,P.C.F., Petrik,J.J. and Sloboda,D.M.
  TITLE     Paternal obesity induces placental hypoxia and sex-specific
            impairments in placental vascularization and offspring
            metabolismdagger
  JOURNAL   Biol Reprod 107 (2), 574-589 (2022)
   PUBMED   35377412
REFERENCE   3  (bases 1 to 5858)
  AUTHORS   Yamaguchi,H., Meyer,M.D., He,L. and Komatsu,Y.
  TITLE     Disruption of Trip11 in cranial neural crest cells is associated
            with increased ER and Golgi stress contributing to skull defects in
            mice
  JOURNAL   Dev Dyn 251 (7), 1209-1222 (2022)
   PUBMED   35147267
REFERENCE   4  (bases 1 to 5858)
  AUTHORS   Pakarinen,E., Lindholm,P., Saarma,M. and Lindahl,M.
  TITLE     CDNF and MANF regulate ER stress in a tissue-specific manner
  JOURNAL   Cell Mol Life Sci 79 (2), 124 (2022)
   PUBMED   35129674
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5858)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   6  (bases 1 to 5858)
  AUTHORS   Gnann,A., Riordan,J.R. and Wolf,D.H.
  TITLE     Cystic fibrosis transmembrane conductance regulator degradation
            depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in
            yeast
  JOURNAL   Mol Biol Cell 15 (9), 4125-4135 (2004)
   PUBMED   15215312
  REMARK    GeneRIF: role of the lectins Htm1p/EDEM in the degradation process
            of CFTR
REFERENCE   7  (bases 1 to 5858)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 5858)
  AUTHORS   Molinari,M., Calanca,V., Galli,C., Lucca,P. and Paganetti,P.
  TITLE     Role of EDEM in the release of misfolded glycoproteins from the
            calnexin cycle
  JOURNAL   Science 299 (5611), 1397-1400 (2003)
   PUBMED   12610306
REFERENCE   9  (bases 1 to 5858)
  AUTHORS   Oda,Y., Hosokawa,N., Wada,I. and Nagata,K.
  TITLE     EDEM as an acceptor of terminally misfolded glycoproteins released
            from calnexin
  JOURNAL   Science 299 (5611), 1394-1397 (2003)
   PUBMED   12610305
REFERENCE   10 (bases 1 to 5858)
  AUTHORS   Hosokawa,N., Wada,I., Hasegawa,K., Yorihuzi,T., Tremblay,L.O.,
            Herscovics,A. and Nagata,K.
  TITLE     A novel ER alpha-mannosidase-like protein accelerates ER-associated
            degradation
  JOURNAL   EMBO Rep 2 (5), 415-422 (2001)
   PUBMED   11375934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB619976.1, AB042828.1 and AC132443.3.
            
            On Dec 21, 2006 this sequence version replaced NM_138677.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB042828.1, AK129090.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BB619976.1         2-12
            12-2288             AB042828.1         1-2277
            2289-5858           AC132443.3         154547-158116
FEATURES             Location/Qualifiers
     source          1..5858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 49.87 cM"
     gene            1..5858
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /note="ER degradation enhancer, mannosidase alpha-like 1"
                     /db_xref="GeneID:192193"
                     /db_xref="MGI:MGI:2180139"
     exon            1..593
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2058
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /note="ER degradation ER degradation enhancer, mannosidase
                     alpha-like 1; ER degradation-enhancing
                     alpha-mannosidase-like 1"
                     /codon_start=1
                     /product="ER degradation-enhancing alpha-mannosidase-like
                     protein 1"
                     /protein_id="NP_619618.1"
                     /db_xref="CCDS:CCDS20402.1"
                     /db_xref="GeneID:192193"
                     /db_xref="MGI:MGI:2180139"
                     /translation="MQWRALVLGLVLLRLGLHAVLWLVFGLGPSMGFYQRFPLSFGFQ
                     RLRDPDGSGPVGPPGGPAWLHRPRRGTEGRLETPPEPGPTPGPGVCGPAHWGYALGGG
                     GCGPDEYERRYSGAFPPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIYCRGRGP
                     DRGDPSNLNINDVLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQV
                     FEATIRVLGSLLSAHRIITDSKQPFGDMTIEDYDNELLYMAHDLAVRLLPAFENTKTG
                     IPYPRVNLKTGVPPDSNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNL
                     RSNDTGLLGNVVNIQTGHWVGKQSGLGAGLDSFYEYLLKSYILFGEKEDLEMFNAAYQ
                     SIQSYLRRGREACNEGEGDPPLYVNVNMFSGQLMNTWIDSLQAFFPGLQVLIGDVEDA
                     ICLHAFYYAIWKRYGALPERYNWQLQAPDVLFYPLRPELVESTYLLYQATKNPFYLHV
                     GMDILQSLEKYTKVKCGYATLHHVIDKSKEDRMESFFLSETCKYLYLLFDEENPVHKS
                     GTRYMFTTEGHIISVDKRLRELPWKEFFSEDGERDQEEKFVHRPKSQELRVINSSSNC
                     NRVPDERRYSLPLKSIYMRQIDQMVGLI"
     exon            594..666
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /inference="alignment:Splign:2.1.0"
     exon            667..770
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /inference="alignment:Splign:2.1.0"
     exon            771..942
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1126
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1301
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1422
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1593
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1667
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1764
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1968
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..5858
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2234..2239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /note="hexamer: AATAAA"
     polyA_site      2266
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /note="major polyA site"
     regulatory      5831..5836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /note="hexamer: ATTAAA"
     polyA_site      5858
                     /gene="Edem1"
                     /gene_synonym="A130059K23Rik; EDEM; mKIAA0212"
                     /note="major polyA site"
ORIGIN      
        1 aaaggggaag tgagcgggct cccggcggac gcgcggggag gcggtcggct ggggacgcgc
       61 ccggcgcttc aaaataatgc ccgcggcgga cgcgcgacca tgcaatggcg agcgcttgtc
      121 ctggggctgg tgctgctgcg cctcggcctc cacgcggtgc tctggttggt cttcgggctg
      181 gggcccagca tgggcttcta ccagcggttt ccgctcagct tcggcttcca gcgcttgagg
      241 gaccccgacg gctcggggcc agttggtccg cccggaggcc cggcctggct tcatcggcca
      301 aggcgcggaa cggaggggcg gcttgagacc ccgccagagc cgggaccgac gccgggaccg
      361 ggcgtgtgcg gcccggcgca ctggggctat gccctgggcg gcggtggctg cggcccggac
      421 gagtacgagc ggcgctacag cggcgccttc ccgccgcagc tgcgtgccca gatgcgcgac
      481 ctggcgcggg gcatgttcgt cttcggctat gacaactaca tggcgcacgc ctttccgcag
      541 gacgagctca accccatcta ctgccgcggc cgggggcctg accgcggaga cccttccaat
      601 ctgaacatca atgatgtcct agggaattac tctctgactc tggttgatgc cttggataca
      661 ttggcaataa tgggaaattc atccgagttc cagaaggcag tcaagttagt gatcaacact
      721 gtttcatttg acaaagattc cacagtccag gtcttcgaag ctacgataag ggttctggga
      781 agcctccttt ctgctcacag aataataact gattccaaac agccctttgg tgacatgaca
      841 attgaggatt atgataatga attgttgtac atggcccatg acttggctgt gcggctcctt
      901 ccagcctttg aaaacaccaa gacagggatc ccctatcctc gggtgaatct gaagacaggt
      961 gttcctcctg acagcaataa tgagacctgc acagcggggg ccggttctct cctggtggaa
     1021 tttgggattc tgagccgact gctgggggat tccacttttg agtgggttgc cagacgagct
     1081 gtgaaagccc tctggaactt gcggagcaac gatacaggat tattaggcaa tgttgtgaac
     1141 atccagacag gccattgggt tggaaagcag agtggcttgg gtgctgggct ggattccttc
     1201 tatgagtacc tcttgaaatc ttacattctt tttggagaaa aagaagatct agagatgttt
     1261 aatgctgcgt atcagagcat ccagagctac ctgcgaagag gccgggaagc ctgcaatgaa
     1321 ggagaaggag acccaccgct ctacgtcaac gtgaacatgt tcagtgggca gctcatgaac
     1381 acctggattg actcgctgca ggctttcttc cctggactgc aggttctgat aggggatgtg
     1441 gaagatgcca tctgcctaca cgccttctac tatgccatat ggaagcggta cggggccctc
     1501 cctgagcgct ataactggca actccaggcc cctgatgttc tcttctaccc tctgagacca
     1561 gagctagtgg agtccacata tctcctctac caggcaacca agaatccctt ctacctccat
     1621 gtaggaatgg acattctgca gagtcttgaa aaatacacaa aagtcaaatg tggatatgct
     1681 acgctgcatc acgtcataga caagtctaaa gaagaccgga tggaaagctt ctttctcagc
     1741 gagacttgca aatacttgta tctgctattt gatgaagaga atccagtaca caaatctgga
     1801 accagataca tgtttacaac tgagggccat atcatatctg tggacaaacg tcttcgggaa
     1861 ttgccttgga aggaattctt ctctgaagat ggggagcggg accaagagga aaagtttgta
     1921 cacagaccta agtctcagga gctcagagtc attaactcca gttctaattg taatcgtgtt
     1981 cctgatgaga ggagatactc cttgccctta aagagcatct acatgcgcca gatcgaccag
     2041 atggttggct tgatttgacc tgctcacctc aatgtggcca gaacttaaac caaacccaag
     2101 tgtaccaaaa tctcctctga ggtggaagcg gtggagcctg cccatctgtg atgctgtcga
     2161 agtttctgtc cagctcttac tcacctctgg ttgaatcttg cacttagtgc tttttagtgt
     2221 ttcccttctg tttaataaaa tactctattt tttctgaagg ataaaactag aaatgggaag
     2281 cttcgtggag agcttcttgc gctatgctga tgttgttaag cacaatggat attagcctct
     2341 ttggattctt cttccagctt cacacatagc acccagtctc cttgctttgc ccccgttgct
     2401 gtgctgaagt cttgctacct ctttgctaga ggatcaggaa tgcaattcct gtgcaaaggt
     2461 cctgaagttc acttggcatc actactgaaa tcaaagcgcc atcccttttc tctctgatgg
     2521 gatcattagg ctgtccccac gatagccagc tgtcagcgtg gatcacgtgg gggaaattca
     2581 cctggtttat ttgcatccta aagtaattta ttcactgtta cttgttttag tgtaatgtct
     2641 agccagaaat ctgacaggca acctttaaag ctaagttgaa atctaggaga ttaactaaca
     2701 gatcttttat actgtactta gcatatattt tgagcatcac cttacctgaa gaactcccat
     2761 ggttccagaa ccaggtgcct tctagggaga ggaaagccct aggattgtga gcttccaccc
     2821 tcctgcttca taaccaagga tgcacagtgc ccactgtcac tgggttagac ttctggtggg
     2881 ttttgttttt tgtttttttt gttttttctt gtttttgttt ttggcttatg tgtagtgcca
     2941 attagctaat cagggacaaa gaagtgatca gatgactttc tgacatcctt gagccatttc
     3001 tctgtgtgat atggacttta gattagtgcc ttatgggttt tgtttgggcc atgggctgtc
     3061 acaaccactg ctacagacag ctcgttttat attgccatat gatgggacca ataaggaaca
     3121 gggtgtatgt gaggaagatt ctggaaaact agtttgtcag tctttgcctt ttaacttatg
     3181 attttagcca ggcataaagg aggaaattat gagaaattgc ttttgttgtt ctgtaggtga
     3241 aatgggaagc tctgcacatg ggaagtttgc acaaactgtt cctaaaaggc agagctgggc
     3301 ctgccctggc ttggcctcct tgcactggga caggccaaat accaaaggca aagggtagaa
     3361 gtttatgaga aagctggttc aacctcacat atcttatgtc ttccctctac actgttaata
     3421 gacacttgag agtatttcat tccattctcc tatagccagg gaaaagcctc atctgaatcg
     3481 ttgcattttt agtcaaaagg gagaaattat aatcttcaat atgtagtact gtctggaaaa
     3541 taaatataat tcagttcctt ggcatgttta gaaagggggt ttcagtagta actatcatct
     3601 tttaaatact tactatgcaa ttggtcttat ttatttgtta agaatattga atgtttctgg
     3661 ttttctttct tttgatttca caagcattgt tctatgtatc cacagtgtct cgtctactgt
     3721 atagaaaact ttctttaagc agattatctg ttttacatat tttcgttaac tccgtaaaag
     3781 tattaaccac atgcatgcac aggcctgtgt gtgtaccccc ttttaccttt gttccaggca
     3841 cgttcacgtg caactgtgaa tgacccacta gggacagtaa agacctatca ggaaagaaag
     3901 catgcccctc aggcttctct ttaccatctt ccccatctct ccctctctct ctctctctct
     3961 ctggttttgg ttttggtttt gttttgtttt gttttttttt ggcaacagcg gtgtatgttg
     4021 gcacccagca gttctctctc atctgggttc tcatctgttg ctcttgatta agcttgggtt
     4081 gcttcttgct cctgtgctct tggaatggtg atctgtgtct ggaagtacca tggtgccttg
     4141 agtgctacca gtgggtctca ggggtacagg cagacatgca atgtatttta ttaagtctta
     4201 aaccctcttg acttttgggt accagatttt tcagctgttg acaaggctga gggtaaataa
     4261 gataatgcct gtaaatctta ccattgagtt tctagactgc tgagaccaaa gccagtgatt
     4321 tgtggggcta gatgaagaac actgtctact gccagacata taaagaacat tattagagac
     4381 aagttcgaag ctgtcttgct ttctgaatgt cagcaactgc aatgtatatc ttacaatata
     4441 tttgctgttc cttccaacct gtgtgctgaa atatgggtag aaaatttcta actcactgct
     4501 ttggtccagg aatgtgaaca gaagaatttc atggatgttt gtaaccatgc ttgtgttccc
     4561 aggagtagcc agtagtgtcc agtttggcca acatgtgaaa agttgcaaac tacgtagcag
     4621 gctgtcttat ggttaggtat ggtggagtcc cattctacaa ccaacaggct tgccttagct
     4681 gctctaaata ctgtgacagg gtaactccat tctcctggaa gaggaggtga ccaaggaatg
     4741 tttggtggct ttcggattgc tttggtagct gtggaaacca ggcttgtttc ccagagcctc
     4801 ccttgagttt cttcctgctc ttctactgga gcgtactttt tgtaattgga tttctagttc
     4861 tgatgtctgg actttccttg tcttggattg tagactctgc acatgacatt caaatacttt
     4921 tctgtgtgtt gaagtgaaag catgtgaggg tagtgcctgc ccagaggagt atctgagagc
     4981 ccatgtttta ctggtttcaa taaatgcagt cgtctctatc ctgtcttccc ttctctctca
     5041 aggaaaatat ccctcttagc atctccccac cagctcagtg aatgagtgtc cactgcagtt
     5101 cttcactttg gatcctgtag actctgcact ggacatccct tttcttctga gctctgagat
     5161 cttgttctct tgatgtggac aaacatagtg ctggtcagag ggtagggctg ggccacctca
     5221 ggcgcacgcg cagagtggcc gagcagggac ttgggaagaa ggtgctgatc tttgcctttc
     5281 tgttcctggc tgtccagcac ctgctctagt gcctcttccc tgcaaggcag ggaccccgtg
     5341 tgaatcagag ccggtgatgc gtgtgggcct tgtggccgct actcagcggg gctcagggtt
     5401 aaggtccctc ttgagtttgg atgtgaatat cctaaagcta tcaagtacct gtgaaactct
     5461 gcttcactgc tcttctcctt ctgagaggta aacaaatcat atttttaagg gtattttgtt
     5521 ttagtgttaa atagcatccc acgagctgca tttttattta ttacatacac aaaaagtaaa
     5581 tgtgtttcta taaaatacaa agtctagagt tggaaactct gggaaaactt gctgagatgc
     5641 acaaatgttt ctctctgtga tgtgcaatat gcttggccgc catagatggt acttcatgtt
     5701 taatctgtaa ataagaactg tatttaaatt aaatgggaaa tttttgtaaa aggaccaaat
     5761 gttcttttat aagcatacta aggaatatct tgttctttga aatttattag gatttttatg
     5821 aataattttt attaaaagat tctctttttg agttgtca
//
