LOCUS       NM_001404070            4758 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus enhancer of mRNA decapping 4 (Edc4), transcript
            variant 3, mRNA.
ACCESSION   NM_001404070 XM_006530901
VERSION     NM_001404070.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4758)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4758)
  AUTHORS   Wei,W., Chen,Q., Liu,M., Sheng,Y., OuYang,Q., Feng,W., Yang,X.,
            Ding,L., Su,S., Zhang,J., Fang,L., Vidal-Puig,A., Wang,H.Y. and
            Chen,S.
  TITLE     TRIM24 is an insulin-responsive regulator of P-bodies
  JOURNAL   Nat Commun 13 (1), 3972 (2022)
   PUBMED   35803934
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4758)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4758)
  AUTHORS   Kannan,M., Bayam,E., Wagner,C., Rinaldi,B., Kretz,P.F., Tilly,P.,
            Roos,M., McGillewie,L., Bar,S., Minocha,S., Chevalier,C., Po,C.,
            Chelly,J., Mandel,J.L., Borgatti,R., Piton,A., Kinnear,C., Loos,B.,
            Adams,D.J., Herault,Y., Collins,S.C., Friant,S., Godin,J.D. and
            Yalcin,B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
REFERENCE   5  (bases 1 to 4758)
  AUTHORS   Marnef,A., Maldonado,M., Bugaut,A., Balasubramanian,S., Kress,M.,
            Weil,D. and Standart,N.
  TITLE     Distinct functions of maternal and somatic Pat1 protein paralogs
  JOURNAL   RNA 16 (11), 2094-2107 (2010)
   PUBMED   20826699
REFERENCE   6  (bases 1 to 4758)
  AUTHORS   Glasmacher,E., Hoefig,K.P., Vogel,K.U., Rath,N., Du,L., Wolf,C.,
            Kremmer,E., Wang,X. and Heissmeyer,V.
  TITLE     Roquin binds inducible costimulator mRNA and effectors of mRNA
            decay to induce microRNA-independent post-transcriptional
            repression
  JOURNAL   Nat Immunol 11 (8), 725-733 (2010)
   PUBMED   20639877
REFERENCE   7  (bases 1 to 4758)
  AUTHORS   Unhavaithaya,Y., Hao,Y., Beyret,E., Yin,H., Kuramochi-Miyagawa,S.,
            Nakano,T. and Lin,H.
  TITLE     MILI, a PIWI-interacting RNA-binding protein, is required for germ
            line stem cell self-renewal and appears to positively regulate
            translation
  JOURNAL   J Biol Chem 284 (10), 6507-6519 (2009)
   PUBMED   19114715
REFERENCE   8  (bases 1 to 4758)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 4758)
  AUTHORS   Yu,J.H., Yang,W.H., Gulick,T., Bloch,K.D. and Bloch,D.B.
  TITLE     Ge-1 is a central component of the mammalian cytoplasmic mRNA
            processing body
  JOURNAL   RNA 11 (12), 1795-1802 (2005)
   PUBMED   16314453
  REMARK    GeneRIF: Ge-1, the human ortholog of mouse Edc4, was shown to
            localize to mRNA processing bodies (P-body)in a human cell line.
            The C-terminal region is required for this localization.
REFERENCE   10 (bases 1 to 4758)
  AUTHORS   Bloch,D.B., Rabkina,D., Quertermous,T. and Bloch,K.D.
  TITLE     The immunoreactive region in a novel autoantigen contains a nuclear
            localization sequence
  JOURNAL   Clin Immunol Immunopathol 72 (3), 380-389 (1994)
   PUBMED   7520377
  REMARK    GeneRIF: The human Ge-1 gene (also known as Hedls and Edc4)is an
            ortholog of mouse Edc4. The gene was identified by screening a cDNA
            expression library using serum from a patient with Sjogren's
            syndrome.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC159265.2.
            
            On Apr 7, 2022 this sequence version replaced XM_006530901.3.
            
            Summary: The protein encoded by this gene is thought to promote
            mRNA decay, and is known to interact with several mRNA decapping
            proteins. In humans, decreased expression of this gene prevents the
            accumulation of mRNA decapping proteins to mRNA processing bodies
            (P-body). Alternative splicing results in multiple protein
            isoforms. [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.286384.1,
                                           SRR14777535.1858926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AC159265.2         138469-138718
            251-407             AC159265.2         142061-142217
            408-519             AC159265.2         142593-142704
            520-619             AC159265.2         142994-143093
            620-809             AC159265.2         143343-143532
            810-957             AC159265.2         143648-143795
            958-1062            AC159265.2         143879-143983
            1063-1172           AC159265.2         144310-144419
            1173-1256           AC159265.2         144514-144597
            1257-1352           AC159265.2         144678-144773
            1353-1455           AC159265.2         144861-144963
            1456-1636           AC159265.2         145066-145246
            1637-1709           AC159265.2         145342-145414
            1710-1801           AC159265.2         145514-145605
            1802-1992           AC159265.2         145678-145868
            1993-2123           AC159265.2         145948-146078
            2124-2283           AC159265.2         146156-146315
            2284-2720           AC159265.2         146664-147100
            2721-2825           AC159265.2         147185-147289
            2826-2978           AC159265.2         147379-147531
            2979-3015           AC159265.2         147621-147657
            3016-3193           AC159265.2         147800-147977
            3194-3349           AC159265.2         148082-148237
            3350-3465           AC159265.2         148325-148440
            3466-3631           AC159265.2         148528-148693
            3632-3818           AC159265.2         148779-148965
            3819-4038           AC159265.2         149056-149275
            4039-4202           AC159265.2         149827-149990
            4203-4758           AC159265.2         150230-150785
FEATURES             Location/Qualifiers
     source          1..4758
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.05 cM"
     gene            1..4758
                     /gene="Edc4"
                     /note="enhancer of mRNA decapping 4"
                     /db_xref="GeneID:234699"
                     /db_xref="MGI:MGI:2446249"
     exon            1..250
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..4395
                     /gene="Edc4"
                     /note="isoform 3 is encoded by transcript variant 3;
                     enhancer of mRNA-decapping protein 4"
                     /codon_start=1
                     /product="enhancer of mRNA-decapping protein 4 isoform 3"
                     /protein_id="NP_001390999.1"
                     /db_xref="GeneID:234699"
                     /db_xref="MGI:MGI:2446249"
                     /translation="MASCASIDIEDATQHLRDILKLDRPAGGSNAESQRPSSAYNGDL
                     NGLLVPDPLSSGDGNSTNKPGIRTMPPINLQEKQVICLSGDDSSTCIGILAKEVEIVA
                     SSDSSISSKARGSNKVKIQPVAKYDWEQKYYYGNLIAVSNSFLAYAIRAANNGSAMVR
                     VISVSTSERTLLKGFTGSVADLAFAHLNSPQLACLDEAGNLFVWRLALVKGKIQEEIL
                     VHIRQPEGTALNHFRRIIWCPFIPEESEDCCEESSPTVALLHEDRAEVWDLDMLRSSH
                     NTWPVDVSQIKQGFIVVKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIYIEGQDEP
                     RCLHEWKPHDGRPLSCLLFCDNHKKQDPEVPFWRFLITGADQNRELKMWCTVSWTCLQ
                     TIRFSPDIFSSVSVPPSLKVCLDLSAEYLILSDVQRKVLYVMELLQNQDEGRACFSSI
                     SEFLLTHPVLSFGIQVVSRCRLRHTEVLPAEEENDSLGTESSHGAGALESAAGVLIKL
                     FCVHTKALQDVQIRFQPQLNPDVVAPLSTHTAHEDFTAFGESRPELGSEGLASAAHGS
                     QPDLRRIVELPAPADFLSLSSETKPKLMTPDAFMTPTASLQQISASPSSSSSSSSSSS
                     SSSSSSSSSLTAVSAVSSSSAMDPSLPSRPPEELTLSPKLQLDGSLTLNSSSSSLQAS
                     PRSLLPGLLPGPADKLISKGPGQVSTAASALSLDLQEVEPLGLPQASPSRTRSPDVIS
                     SASTALSQDIPEIASEALSRGFGSSVPEGLIEPDSMASAASALHLLSPRPRQGPELGS
                     QLGLDGGPGDGDRHSTPSLLEAALTQEVATPDSQVWPTAPDITRETCSTLTESPRNGL
                     QEKHKSLAFHRPPYHLLQQRDSQDTSAEQSDHDDEVASLASASGGFGSKIPTPRLPSK
                     DWKTKGSPRTSPKLKRKSKKDDGDSAVGSRLTEHQVAEPPEDWPALIWQQQRELAELW
                     HNQEELLQRLCAQLEGLQSTVTDHVERALETRHEQEQRRLERALAEGQQRGGQLQEQL
                     TQQLSQALSSAVAGRLERSVRDEIKKTVPPCVSRSLEPVAGQLSNSVATKLTAVEGSM
                     KENISKLLKSKNLTDAIARAAADTLQGPMQAAYREAFQSVVLPAFEKSCQAMFQQIND
                     SFRLGTQEYLQQLESHMKSRKAREQEAREPVLAQLRGLVSTLQSATEQMAATVSSSVR
                     AEVQHQLHVAVGSLQESILAQVQRIVKGEVSVALKEQQATVTSSIMQAMRSAAGTPVP
                     SAHLDCQAQQAHILQLLQQGHLNQAFQQALTAADLNLVLYVCETVDPAQVFGQPPCPL
                     SQPVLLSLIQQLASDLGTRSDLKLSYLEEAVMHLDHSDPITRDHMGSVMAQVRQKLFQ
                     FLQADPHNSLSKAARRLSLMLHGLVTPSLP"
     exon            251..407
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            408..519
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            520..619
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            620..809
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            810..957
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1062
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1172
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1256
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1352
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1455
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1636
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1709
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1801
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1992
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2123
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2283
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2720
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2825
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2978
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3015
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3193
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3349
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3465
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3631
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3818
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3819..4038
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            4039..4202
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            4203..4758
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4716..4721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Edc4"
                     /note="hexamer: ATTAAA"
     regulatory      4731..4736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Edc4"
                     /note="hexamer: AATAAA"
     polyA_site      4741
                     /gene="Edc4"
                     /note="major polyA site"
     polyA_site      4758
                     /gene="Edc4"
ORIGIN      
        1 ggggttggca gggctcacgg acgcagtccg ggcggcggtt tgcgaactgc ggctaggttt
       61 tgtgtagtgc tctgtctcct ctctagcggg gtcgtggctg ggcgaaattg gacactgcgg
      121 aggtagagga actaacgtcg ggcgagcagg actctcgtgg ctgggcccat ggcctcctgc
      181 gcgagcatcg acattgagga cgccacgcag catctgcggg acatactcaa actggaccgg
      241 cccgccggag gttccaatgc cgaaagccaa aggccatcca gtgcctacaa tggagacctc
      301 aatgggctcc tggtccccga cccgctcagt tcaggtgatg gtaactcaac gaacaaacct
      361 ggtatacgga ccatgccacc cattaacctg caggaaaagc aggtcatttg cctctctgga
      421 gatgacagct ccacctgcat tgggatttta gccaaggaag tggaaattgt ggccagcagt
      481 gattctagca tttccagcaa ggctcggggg agcaacaagg tgaaaatcca gcctgtcgcc
      541 aagtatgact gggagcagaa atactactat ggcaacctga ttgcagtgtc taactccttc
      601 ttggcatacg ccattagggc tgccaacaat ggctcagcaa tggtccgtgt gatcagtgtc
      661 agcacttcgg agcggaccct gctcaaaggt ttcacaggca gtgtggctga tcttgctttt
      721 gcacacctca actctccaca gctcgcctgc ctggatgagg ctggcaatct ttttgtgtgg
      781 cgcttggctc ttgttaaggg taaaattcaa gaagagattt tagtccatat ccggcagcca
      841 gagggtacag cgctgaacca cttccgaagg atcatctggt gccctttcat ccccgaggag
      901 agtgaggact gttgtgagga gagcagcccg acagtggccc tgctgcatga ggatcgggct
      961 gaggtgtggg acttggatat gcttcgctcc agccacaaca cctggcctgt ggatgtcagc
     1021 caaatcaagc aaggctttat tgtggtgaaa ggccatagca cgtgcctaag tgaaggagcc
     1081 ctctcccctg atgggactgt cctggctacc gcaagccatg atggctttgt caagttctgg
     1141 cagatctata ttgaaggtca ggatgagcca aggtgtctgc atgaatggaa gcctcatgat
     1201 gggaggcctc tttcttgcct cctgttctgt gataaccata agaaacagga tcctgaggtc
     1261 ccgttctgga ggttcctcat aaccggcgcc gaccagaatc gagagctgaa gatgtggtgc
     1321 acagtgtcct ggacctgcct gcaaaccatt cgcttctccc cagatatctt cagctcagtg
     1381 agtgtgcctc ccagcctcaa agtttgtttg gacctctcag cagagtattt gattcttagt
     1441 gatgtgcaac gaaaggtcct ctatgtgatg gagctgctgc agaaccagga cgagggccgc
     1501 gcgtgcttta gttctatctc tgagttcctg ctcacccacc ctgtgctgag ctttggcatc
     1561 caggttgtca gtcgctgccg gctacggcac actgaggtcc tgcctgctga ggaggagaat
     1621 gacagtctgg ggaccgagag ttcccatgga gctggagcct tggaatccgc agctggtgtg
     1681 cttatcaagc tcttttgtgt gcacactaag gcactacaag atgtgcagat ccgcttccag
     1741 ccacagctga accctgatgt ggtggcccca ctctctaccc acactgccca cgaggacttc
     1801 acagcatttg gagagtctcg acctgaacta ggctccgagg ggctagcttc agctgctcat
     1861 ggttcccagc ctgacctgcg gcgcattgtg gaactgcctg ctcctgcaga cttcctcagt
     1921 ctgagcagtg agaccaagcc caagttgatg acacctgatg ctttcatgac acctactgcc
     1981 tccctgcagc agatctctgc atcccctagt agtagcagca gcagtagcag cagcagcagt
     2041 agcagcagca gcagcagcag cagctctcta acagctgtgt ctgctgtgag cagctcctca
     2101 gccatggacc cttccttgcc cagtagacca cctgaggagc tgaccttgag ccccaagctg
     2161 cagctagatg gcagcctgac gctaaacagc agcagcagca gcctgcaggc aagccctcga
     2221 agcctccttc cgggcctgct cccaggccca gctgacaagt tgatttccaa gggacctggt
     2281 caggtatcca ctgctgcctc tgcactgtcc ttggatttgc aggaagtgga gccattaggg
     2341 ctaccccagg cctccccaag tcgaacccgt tctcctgatg tgatctcctc agcatccact
     2401 gccctgtccc aggacattcc tgaaatcgca tctgaggccc tgtcccgtgg ctttggctcc
     2461 tctgttcctg agggcctcat tgagccagac agcatggcct cagctgcctc agcactacac
     2521 ctactctctc ctcggcccag gcaaggccct gagcttggct ctcagctggg tctggatgga
     2581 ggccctggag atggggatag gcatagtacc ccttccctgc tggaagcagc cctgacccag
     2641 gaagttgcaa cccctgacag tcaagtctgg cctacggcac ctgacattac tcgtgagacc
     2701 tgtagcacac tgacagaaag ccccaggaat ggcctccagg aaaagcacaa aagtctggct
     2761 ttccacaggc caccttatca cttgctgcag caacgtgaca gtcaggacac aagtgctgag
     2821 caaagtgacc atgatgatga ggttgccagc cttgcctctg cctcaggagg ttttggcagc
     2881 aaaattccta ctccacggct gccttccaag gattggaaga cgaagggatc ccctcggacg
     2941 tcacctaagc tcaagagaaa aagcaagaag gatgatgggg attcagctgt gggatcccgg
     3001 ctcacagagc accaggtggc agagccccct gaagactggc cagcactaat ttggcagcag
     3061 caaagagagc tggcagagct atggcacaac caagaagaac tgctacagcg tctctgtgcc
     3121 cagcttgaag gtcttcagag tactgtcaca gaccatgtag agcgtgccct ggagacgcgg
     3181 catgagcagg agcaacggcg gctggaacgg gcactggctg aggggcagca acggggtggg
     3241 cagctgcagg agcagctgac acagcagcta tcccaggcat tgtcttcagc tgtggctggg
     3301 cggctagagc gcagcgtaag ggatgaaatc aagaaaacgg ttcctccatg tgtctccaga
     3361 agtctggagc ctgttgcagg tcaactaagc aactcagtgg ctaccaagct tacagctgtg
     3421 gaaggcagca tgaaagagaa tatctctaag ctactcaagt ccaagaactt aacagatgcc
     3481 attgcccgag cagctgcaga cacgttacag ggaccaatgc aggctgccta ccgggaagcc
     3541 ttccagagtg tggtactgcc agcttttgag aagagttgcc aggctatgtt ccagcaaatc
     3601 aatgacagct ttaggctggg cacacaggaa tatttgcagc agctggagag tcacatgaag
     3661 agccggaagg cccgtgaaca agaagctagg gagcctgtgc tggcccagct tcggggcctg
     3721 gtcagcacac tgcagagtgc caccgagcag atggcggcca ctgtatctag cagtgttcgg
     3781 gccgaggtgc aacaccagct gcatgtggct gtgggcagct tgcaggagtc aatcttagca
     3841 caagtacagc gcattgtcaa gggtgaagtg agtgtggcac ttaaggagca gcaggccacc
     3901 gtcacttcca gcatcatgca ggctatgcgt tcagctgctg gcacacctgt cccctctgcc
     3961 caccttgact gccaggccca acaagcccat atcttgcagt tactgcagca gggccacctc
     4021 aatcaggcct tccagcaggc actgactgct gctgatctca atctggtgct gtatgtgtgt
     4081 gaaactgtcg acccagccca ggtttttggg cagccgccct gtccactatc ccagcctgtt
     4141 ctcctttccc taatccagca gctagcatct gaccttggaa ctagaagtga cctcaagctc
     4201 agctacttgg aagaagctgt gatgcacctg gaccacagcg atcccatcac tcgagaccac
     4261 atgggctctg tcatggctca ggtgcgccag aagctcttcc agttcctgca ggctgatcca
     4321 cacaactcac ttagcaaagc tgcccgccgc ctcagcctaa tgttacacgg ccttgtgacc
     4381 cctagcctcc cttagccatt taaagaggga tgaggtgatg ctgaaggcca gttggcaggt
     4441 ttaggtcaag gcagggccat gtctgctgtt tccctgctca ggccttcctc tctggtgtgt
     4501 ggagggaggt atgcagcagg gctcacgggc agtgctctac tgattgtggt aaccagcagg
     4561 gtcaggcggg cccagggcac gtagtgtgcc ttcttgggtc ctaccatgcc tgaagcgtga
     4621 ccccaagatc gtgacaccac ttgagttgaa ttttccatgt tcctttttac ctataatttg
     4681 gatctttttg tttttgaaaa acattgagaa atgcaattaa aggcttttgg aataaaagaa
     4741 agtatgtgtg tgatttta
//
