LOCUS       NM_001301100            4752 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus enhancer of mRNA decapping 4 (Edc4), transcript
            variant 1, mRNA.
ACCESSION   NM_001301100 XM_006530903
VERSION     NM_001301100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4752)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4752)
  AUTHORS   Wei,W., Chen,Q., Liu,M., Sheng,Y., OuYang,Q., Feng,W., Yang,X.,
            Ding,L., Su,S., Zhang,J., Fang,L., Vidal-Puig,A., Wang,H.Y. and
            Chen,S.
  TITLE     TRIM24 is an insulin-responsive regulator of P-bodies
  JOURNAL   Nat Commun 13 (1), 3972 (2022)
   PUBMED   35803934
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4752)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4752)
  AUTHORS   Kannan,M., Bayam,E., Wagner,C., Rinaldi,B., Kretz,P.F., Tilly,P.,
            Roos,M., McGillewie,L., Bar,S., Minocha,S., Chevalier,C., Po,C.,
            Chelly,J., Mandel,J.L., Borgatti,R., Piton,A., Kinnear,C., Loos,B.,
            Adams,D.J., Herault,Y., Collins,S.C., Friant,S., Godin,J.D. and
            Yalcin,B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
REFERENCE   5  (bases 1 to 4752)
  AUTHORS   Marnef,A., Maldonado,M., Bugaut,A., Balasubramanian,S., Kress,M.,
            Weil,D. and Standart,N.
  TITLE     Distinct functions of maternal and somatic Pat1 protein paralogs
  JOURNAL   RNA 16 (11), 2094-2107 (2010)
   PUBMED   20826699
REFERENCE   6  (bases 1 to 4752)
  AUTHORS   Glasmacher,E., Hoefig,K.P., Vogel,K.U., Rath,N., Du,L., Wolf,C.,
            Kremmer,E., Wang,X. and Heissmeyer,V.
  TITLE     Roquin binds inducible costimulator mRNA and effectors of mRNA
            decay to induce microRNA-independent post-transcriptional
            repression
  JOURNAL   Nat Immunol 11 (8), 725-733 (2010)
   PUBMED   20639877
REFERENCE   7  (bases 1 to 4752)
  AUTHORS   Unhavaithaya,Y., Hao,Y., Beyret,E., Yin,H., Kuramochi-Miyagawa,S.,
            Nakano,T. and Lin,H.
  TITLE     MILI, a PIWI-interacting RNA-binding protein, is required for germ
            line stem cell self-renewal and appears to positively regulate
            translation
  JOURNAL   J Biol Chem 284 (10), 6507-6519 (2009)
   PUBMED   19114715
REFERENCE   8  (bases 1 to 4752)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 4752)
  AUTHORS   Yu,J.H., Yang,W.H., Gulick,T., Bloch,K.D. and Bloch,D.B.
  TITLE     Ge-1 is a central component of the mammalian cytoplasmic mRNA
            processing body
  JOURNAL   RNA 11 (12), 1795-1802 (2005)
   PUBMED   16314453
  REMARK    GeneRIF: Ge-1, the human ortholog of mouse Edc4, was shown to
            localize to mRNA processing bodies (P-body)in a human cell line.
            The C-terminal region is required for this localization.
REFERENCE   10 (bases 1 to 4752)
  AUTHORS   Bloch,D.B., Rabkina,D., Quertermous,T. and Bloch,K.D.
  TITLE     The immunoreactive region in a novel autoantigen contains a nuclear
            localization sequence
  JOURNAL   Clin Immunol Immunopathol 72 (3), 380-389 (1994)
   PUBMED   7520377
  REMARK    GeneRIF: The human Ge-1 gene (also known as Hedls and Edc4)is an
            ortholog of mouse Edc4. The gene was identified by screening a cDNA
            expression library using serum from a patient with Sjogren's
            syndrome.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC159265.2.
            
            On Apr 7, 2022 this sequence version replaced NM_001301100.1.
            
            Summary: The protein encoded by this gene is thought to promote
            mRNA decay, and is known to interact with several mRNA decapping
            proteins. In humans, decreased expression of this gene prevents the
            accumulation of mRNA decapping proteins to mRNA processing bodies
            (P-body). Alternative splicing results in multiple protein
            isoforms. [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146527.1, SRR7974084.19961.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AC159265.2         138469-138718
            251-407             AC159265.2         142061-142217
            408-519             AC159265.2         142593-142704
            520-619             AC159265.2         142994-143093
            620-809             AC159265.2         143343-143532
            810-957             AC159265.2         143648-143795
            958-1062            AC159265.2         143879-143983
            1063-1172           AC159265.2         144310-144419
            1173-1256           AC159265.2         144514-144597
            1257-1352           AC159265.2         144678-144773
            1353-1455           AC159265.2         144861-144963
            1456-1636           AC159265.2         145066-145246
            1637-1709           AC159265.2         145342-145414
            1710-1801           AC159265.2         145514-145605
            1802-1989           AC159265.2         145681-145868
            1990-2120           AC159265.2         145948-146078
            2121-2277           AC159265.2         146159-146315
            2278-2714           AC159265.2         146664-147100
            2715-2819           AC159265.2         147185-147289
            2820-2972           AC159265.2         147379-147531
            2973-3009           AC159265.2         147621-147657
            3010-3187           AC159265.2         147800-147977
            3188-3343           AC159265.2         148082-148237
            3344-3459           AC159265.2         148325-148440
            3460-3625           AC159265.2         148528-148693
            3626-3812           AC159265.2         148779-148965
            3813-4032           AC159265.2         149056-149275
            4033-4196           AC159265.2         149827-149990
            4197-4752           AC159265.2         150230-150785
FEATURES             Location/Qualifiers
     source          1..4752
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.05 cM"
     gene            1..4752
                     /gene="Edc4"
                     /note="enhancer of mRNA decapping 4"
                     /db_xref="GeneID:234699"
                     /db_xref="MGI:MGI:2446249"
     exon            1..250
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..4389
                     /gene="Edc4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     enhancer of mRNA-decapping protein 4"
                     /codon_start=1
                     /product="enhancer of mRNA-decapping protein 4 isoform 1"
                     /protein_id="NP_001288029.1"
                     /db_xref="CCDS:CCDS80923.1"
                     /db_xref="GeneID:234699"
                     /db_xref="MGI:MGI:2446249"
                     /translation="MASCASIDIEDATQHLRDILKLDRPAGGSNAESQRPSSAYNGDL
                     NGLLVPDPLSSGDGNSTNKPGIRTMPPINLQEKQVICLSGDDSSTCIGILAKEVEIVA
                     SSDSSISSKARGSNKVKIQPVAKYDWEQKYYYGNLIAVSNSFLAYAIRAANNGSAMVR
                     VISVSTSERTLLKGFTGSVADLAFAHLNSPQLACLDEAGNLFVWRLALVKGKIQEEIL
                     VHIRQPEGTALNHFRRIIWCPFIPEESEDCCEESSPTVALLHEDRAEVWDLDMLRSSH
                     NTWPVDVSQIKQGFIVVKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIYIEGQDEP
                     RCLHEWKPHDGRPLSCLLFCDNHKKQDPEVPFWRFLITGADQNRELKMWCTVSWTCLQ
                     TIRFSPDIFSSVSVPPSLKVCLDLSAEYLILSDVQRKVLYVMELLQNQDEGRACFSSI
                     SEFLLTHPVLSFGIQVVSRCRLRHTEVLPAEEENDSLGTESSHGAGALESAAGVLIKL
                     FCVHTKALQDVQIRFQPQLNPDVVAPLSTHTAHEDFTFGESRPELGSEGLASAAHGSQ
                     PDLRRIVELPAPADFLSLSSETKPKLMTPDAFMTPTASLQQISASPSSSSSSSSSSSS
                     SSSSSSSSLTAVSAVSSSSAMDPSLPRPPEELTLSPKLQLDGSLTLNSSSSSLQASPR
                     SLLPGLLPGPADKLISKGPGQVSTAASALSLDLQEVEPLGLPQASPSRTRSPDVISSA
                     STALSQDIPEIASEALSRGFGSSVPEGLIEPDSMASAASALHLLSPRPRQGPELGSQL
                     GLDGGPGDGDRHSTPSLLEAALTQEVATPDSQVWPTAPDITRETCSTLTESPRNGLQE
                     KHKSLAFHRPPYHLLQQRDSQDTSAEQSDHDDEVASLASASGGFGSKIPTPRLPSKDW
                     KTKGSPRTSPKLKRKSKKDDGDSAVGSRLTEHQVAEPPEDWPALIWQQQRELAELWHN
                     QEELLQRLCAQLEGLQSTVTDHVERALETRHEQEQRRLERALAEGQQRGGQLQEQLTQ
                     QLSQALSSAVAGRLERSVRDEIKKTVPPCVSRSLEPVAGQLSNSVATKLTAVEGSMKE
                     NISKLLKSKNLTDAIARAAADTLQGPMQAAYREAFQSVVLPAFEKSCQAMFQQINDSF
                     RLGTQEYLQQLESHMKSRKAREQEAREPVLAQLRGLVSTLQSATEQMAATVSSSVRAE
                     VQHQLHVAVGSLQESILAQVQRIVKGEVSVALKEQQATVTSSIMQAMRSAAGTPVPSA
                     HLDCQAQQAHILQLLQQGHLNQAFQQALTAADLNLVLYVCETVDPAQVFGQPPCPLSQ
                     PVLLSLIQQLASDLGTRSDLKLSYLEEAVMHLDHSDPITRDHMGSVMAQVRQKLFQFL
                     QADPHNSLSKAARRLSLMLHGLVTPSLP"
     exon            251..407
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            408..519
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            520..619
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            620..809
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            810..957
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1062
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1172
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1256
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1352
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1455
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1636
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1709
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1801
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1989
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2120
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2277
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2714
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2819
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2972
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3009
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3187
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..3343
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3459
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3625
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3626..3812
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3813..4032
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            4033..4196
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     exon            4197..4752
                     /gene="Edc4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4710..4715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Edc4"
                     /note="hexamer: ATTAAA"
     regulatory      4725..4730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Edc4"
                     /note="hexamer: AATAAA"
     polyA_site      4735
                     /gene="Edc4"
                     /note="major polyA site"
     polyA_site      4752
                     /gene="Edc4"
ORIGIN      
        1 ggggttggca gggctcacgg acgcagtccg ggcggcggtt tgcgaactgc ggctaggttt
       61 tgtgtagtgc tctgtctcct ctctagcggg gtcgtggctg ggcgaaattg gacactgcgg
      121 aggtagagga actaacgtcg ggcgagcagg actctcgtgg ctgggcccat ggcctcctgc
      181 gcgagcatcg acattgagga cgccacgcag catctgcggg acatactcaa actggaccgg
      241 cccgccggag gttccaatgc cgaaagccaa aggccatcca gtgcctacaa tggagacctc
      301 aatgggctcc tggtccccga cccgctcagt tcaggtgatg gtaactcaac gaacaaacct
      361 ggtatacgga ccatgccacc cattaacctg caggaaaagc aggtcatttg cctctctgga
      421 gatgacagct ccacctgcat tgggatttta gccaaggaag tggaaattgt ggccagcagt
      481 gattctagca tttccagcaa ggctcggggg agcaacaagg tgaaaatcca gcctgtcgcc
      541 aagtatgact gggagcagaa atactactat ggcaacctga ttgcagtgtc taactccttc
      601 ttggcatacg ccattagggc tgccaacaat ggctcagcaa tggtccgtgt gatcagtgtc
      661 agcacttcgg agcggaccct gctcaaaggt ttcacaggca gtgtggctga tcttgctttt
      721 gcacacctca actctccaca gctcgcctgc ctggatgagg ctggcaatct ttttgtgtgg
      781 cgcttggctc ttgttaaggg taaaattcaa gaagagattt tagtccatat ccggcagcca
      841 gagggtacag cgctgaacca cttccgaagg atcatctggt gccctttcat ccccgaggag
      901 agtgaggact gttgtgagga gagcagcccg acagtggccc tgctgcatga ggatcgggct
      961 gaggtgtggg acttggatat gcttcgctcc agccacaaca cctggcctgt ggatgtcagc
     1021 caaatcaagc aaggctttat tgtggtgaaa ggccatagca cgtgcctaag tgaaggagcc
     1081 ctctcccctg atgggactgt cctggctacc gcaagccatg atggctttgt caagttctgg
     1141 cagatctata ttgaaggtca ggatgagcca aggtgtctgc atgaatggaa gcctcatgat
     1201 gggaggcctc tttcttgcct cctgttctgt gataaccata agaaacagga tcctgaggtc
     1261 ccgttctgga ggttcctcat aaccggcgcc gaccagaatc gagagctgaa gatgtggtgc
     1321 acagtgtcct ggacctgcct gcaaaccatt cgcttctccc cagatatctt cagctcagtg
     1381 agtgtgcctc ccagcctcaa agtttgtttg gacctctcag cagagtattt gattcttagt
     1441 gatgtgcaac gaaaggtcct ctatgtgatg gagctgctgc agaaccagga cgagggccgc
     1501 gcgtgcttta gttctatctc tgagttcctg ctcacccacc ctgtgctgag ctttggcatc
     1561 caggttgtca gtcgctgccg gctacggcac actgaggtcc tgcctgctga ggaggagaat
     1621 gacagtctgg ggaccgagag ttcccatgga gctggagcct tggaatccgc agctggtgtg
     1681 cttatcaagc tcttttgtgt gcacactaag gcactacaag atgtgcagat ccgcttccag
     1741 ccacagctga accctgatgt ggtggcccca ctctctaccc acactgccca cgaggacttc
     1801 acatttggag agtctcgacc tgaactaggc tccgaggggc tagcttcagc tgctcatggt
     1861 tcccagcctg acctgcggcg cattgtggaa ctgcctgctc ctgcagactt cctcagtctg
     1921 agcagtgaga ccaagcccaa gttgatgaca cctgatgctt tcatgacacc tactgcctcc
     1981 ctgcagcaga tctctgcatc ccctagtagt agcagcagca gtagcagcag cagcagtagc
     2041 agcagcagca gcagcagcag ctctctaaca gctgtgtctg ctgtgagcag ctcctcagcc
     2101 atggaccctt ccttgcccag accacctgag gagctgacct tgagccccaa gctgcagcta
     2161 gatggcagcc tgacgctaaa cagcagcagc agcagcctgc aggcaagccc tcgaagcctc
     2221 cttccgggcc tgctcccagg cccagctgac aagttgattt ccaagggacc tggtcaggta
     2281 tccactgctg cctctgcact gtccttggat ttgcaggaag tggagccatt agggctaccc
     2341 caggcctccc caagtcgaac ccgttctcct gatgtgatct cctcagcatc cactgccctg
     2401 tcccaggaca ttcctgaaat cgcatctgag gccctgtccc gtggctttgg ctcctctgtt
     2461 cctgagggcc tcattgagcc agacagcatg gcctcagctg cctcagcact acacctactc
     2521 tctcctcggc ccaggcaagg ccctgagctt ggctctcagc tgggtctgga tggaggccct
     2581 ggagatgggg ataggcatag taccccttcc ctgctggaag cagccctgac ccaggaagtt
     2641 gcaacccctg acagtcaagt ctggcctacg gcacctgaca ttactcgtga gacctgtagc
     2701 acactgacag aaagccccag gaatggcctc caggaaaagc acaaaagtct ggctttccac
     2761 aggccacctt atcacttgct gcagcaacgt gacagtcagg acacaagtgc tgagcaaagt
     2821 gaccatgatg atgaggttgc cagccttgcc tctgcctcag gaggttttgg cagcaaaatt
     2881 cctactccac ggctgccttc caaggattgg aagacgaagg gatcccctcg gacgtcacct
     2941 aagctcaaga gaaaaagcaa gaaggatgat ggggattcag ctgtgggatc ccggctcaca
     3001 gagcaccagg tggcagagcc ccctgaagac tggccagcac taatttggca gcagcaaaga
     3061 gagctggcag agctatggca caaccaagaa gaactgctac agcgtctctg tgcccagctt
     3121 gaaggtcttc agagtactgt cacagaccat gtagagcgtg ccctggagac gcggcatgag
     3181 caggagcaac ggcggctgga acgggcactg gctgaggggc agcaacgggg tgggcagctg
     3241 caggagcagc tgacacagca gctatcccag gcattgtctt cagctgtggc tgggcggcta
     3301 gagcgcagcg taagggatga aatcaagaaa acggttcctc catgtgtctc cagaagtctg
     3361 gagcctgttg caggtcaact aagcaactca gtggctacca agcttacagc tgtggaaggc
     3421 agcatgaaag agaatatctc taagctactc aagtccaaga acttaacaga tgccattgcc
     3481 cgagcagctg cagacacgtt acagggacca atgcaggctg cctaccggga agccttccag
     3541 agtgtggtac tgccagcttt tgagaagagt tgccaggcta tgttccagca aatcaatgac
     3601 agctttaggc tgggcacaca ggaatatttg cagcagctgg agagtcacat gaagagccgg
     3661 aaggcccgtg aacaagaagc tagggagcct gtgctggccc agcttcgggg cctggtcagc
     3721 acactgcaga gtgccaccga gcagatggcg gccactgtat ctagcagtgt tcgggccgag
     3781 gtgcaacacc agctgcatgt ggctgtgggc agcttgcagg agtcaatctt agcacaagta
     3841 cagcgcattg tcaagggtga agtgagtgtg gcacttaagg agcagcaggc caccgtcact
     3901 tccagcatca tgcaggctat gcgttcagct gctggcacac ctgtcccctc tgcccacctt
     3961 gactgccagg cccaacaagc ccatatcttg cagttactgc agcagggcca cctcaatcag
     4021 gccttccagc aggcactgac tgctgctgat ctcaatctgg tgctgtatgt gtgtgaaact
     4081 gtcgacccag cccaggtttt tgggcagccg ccctgtccac tatcccagcc tgttctcctt
     4141 tccctaatcc agcagctagc atctgacctt ggaactagaa gtgacctcaa gctcagctac
     4201 ttggaagaag ctgtgatgca cctggaccac agcgatccca tcactcgaga ccacatgggc
     4261 tctgtcatgg ctcaggtgcg ccagaagctc ttccagttcc tgcaggctga tccacacaac
     4321 tcacttagca aagctgcccg ccgcctcagc ctaatgttac acggccttgt gacccctagc
     4381 ctcccttagc catttaaaga gggatgaggt gatgctgaag gccagttggc aggtttaggt
     4441 caaggcaggg ccatgtctgc tgtttccctg ctcaggcctt cctctctggt gtgtggaggg
     4501 aggtatgcag cagggctcac gggcagtgct ctactgattg tggtaaccag cagggtcagg
     4561 cgggcccagg gcacgtagtg tgccttcttg ggtcctacca tgcctgaagc gtgaccccaa
     4621 gatcgtgaca ccacttgagt tgaattttcc atgttccttt ttacctataa tttggatctt
     4681 tttgtttttg aaaaacattg agaaatgcaa ttaaaggctt ttggaataaa agaaagtatg
     4741 tgtgtgattt ta
//
