LOCUS       NP_001397000             508 aa            linear   ROD 02-MAY-2024
DEFINITION  enhancer of mRNA-decapping protein 3 isoform 1 [Mus musculus].
ACCESSION   NP_001397000 XP_011241062
VERSION     NP_001397000.1
DBSOURCE    REFSEQ: accession NM_001410071.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 508)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 508)
  AUTHORS   Zhou,Z., Shirakawa,T., Ohbo,K., Sada,A., Wu,Q., Hasegawa,K.,
            Saba,R. and Saga,Y.
  TITLE     RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering
            System to Retain Primitive State of Mouse Spermatogonial Stem Cells
  JOURNAL   Dev Cell 34 (1), 96-107 (2015)
   PUBMED   26120033
REFERENCE   3  (residues 1 to 508)
  AUTHORS   Larance,M., Rowland,A.F., Hoehn,K.L., Humphreys,D.T., Preiss,T.,
            Guilhaus,M. and James,D.E.
  TITLE     Global phosphoproteomics identifies a major role for AKT and 14-3-3
            in regulating EDC3
  JOURNAL   Mol Cell Proteomics 9 (4), 682-694 (2010)
   PUBMED   20051463
  REMARK    GeneRIF: Induction of 14-3-3 binding to EDC3 causes morphological
            changes in processing body structures, inhibition of
            microRNA-mediated mRNA post-transcriptional regulation, and
            alterations in the protein- protein interactions of EDC3.
REFERENCE   4  (residues 1 to 508)
  AUTHORS   McDaniel,A.H., Li,X., Tordoff,M.G., Bachmanov,A.A. and Reed,D.R.
  TITLE     A locus on mouse Chromosome 9 (Adip5) affects the relative weight
            of the gonadal but not retroperitoneal adipose depot
  JOURNAL   Mamm Genome 17 (11), 1078-1092 (2006)
   PUBMED   17103052
REFERENCE   5  (residues 1 to 508)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (residues 1 to 508)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122515.5.
            
            On Jul 27, 2022 this sequence version replaced XP_011241062.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.436557.1,
                                           SRR13422598.724331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.37 cM"
     Protein         1..508
                     /product="enhancer of mRNA-decapping protein 3 isoform 1"
                     /note="enhancer of mRNA-decapping protein 3; yjeF
                     domain-containing protein 1; enhancer of mRNA decapping 3
                     homolog"
                     /calculated_mol_wt=55826
     Region          1..79
                     /region_name="Required for P-body targeting and
                     interaction with DCP1A. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K2D3.1)"
     Region          4..66
                     /region_name="LSm16_N"
                     /note="Like-Sm protein 16, N-terminal domain; cd01737"
                     /db_xref="CDD:212484"
     Site            order(5,28,33,56,59..64)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212484"
     Site            order(10..15,19..30,33..36)
                     /site_type="other"
                     /note="Sm1 motif"
                     /db_xref="CDD:212484"
     Site            order(29,55)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:212484"
     Site            51..62
                     /site_type="other"
                     /note="Sm2 motif"
                     /db_xref="CDD:212484"
     Region          98..194
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K2D3.1)"
     Region          102..194
                     /region_name="Edc3_linker"
                     /note="Linker region of enhancer of mRNA-decapping protein
                     3; pfam16598"
                     /db_xref="CDD:465188"
     Site            131
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8K2D3.1)"
     Site            138
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96F86; propagated from
                     UniProtKB/Swiss-Prot (Q8K2D3.1)"
     Site            140
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96F86; propagated from
                     UniProtKB/Swiss-Prot (Q8K2D3.1)"
     Site            161
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96F86; propagated from
                     UniProtKB/Swiss-Prot (Q8K2D3.1)"
     Region          191..296
                     /region_name="Required for interaction with DDX6.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K2D3.1)"
     Region          198..301
                     /region_name="FDF"
                     /note="FDF domain; pfam09532"
                     /db_xref="CDD:430668"
     Region          302..455
                     /region_name="YjeF_N"
                     /note="YjeF-related protein N-terminus; pfam03853"
                     /db_xref="CDD:427546"
     CDS             1..508
                     /gene="Edc3"
                     /gene_synonym="Lsm16; Yjdc"
                     /coded_by="NM_001410071.1:259..1785"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="GeneID:353190"
                     /db_xref="MGI:MGI:2142951"
ORIGIN      
        1 mamdwlgsiv sincgdslgv yqgrvsavdq vsqtisltrp fhngvkclvp evtfragdit
       61 elkileipgp gdnqqvgdlh qtelgpsgvg yqmsisqngt gkvvkkpass ssapqsipkr
      121 tdvksqdvai spqqqqcsks yvdrhmesls qsksfrrrhn swssssrhpn qatpkksglk
      181 ngqmknkdde cfgddieelp dtdfdfegnl alfdkaavfe eidtyerrsg srsrgvpner
      241 paryrhdeni lesepivyrr itvphsvske fctdsglvvp svsyelhkkl lsvaekhglt
      301 lerrlemtgv casqmaltll ggpnrlnpkn vhqrptvall cgphvkgaqg iscgrhlanh
      361 dvqvilflpn fvkmlesitn elslfsktqg qqvsslrdlp aspvdlvinc ldcpenaflr
      421 dqpwykaava wanqnrapvl sidppvheve qgidakwsla lglplplgeh agrvylcdig
      481 ipqqvfqevg inyhspfgck fviplhsa
//
