LOCUS       NM_010100               3697 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus ectodysplasin-A receptor (Edar), mRNA.
ACCESSION   NM_010100 XM_489696
VERSION     NM_010100.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3697)
  AUTHORS   Fang,Z., Wang,Y., Huang,B., Chen,X., Jiang,R. and Yin,M.
  TITLE     Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis
            via targeting EDAR-NF-kappaB signaling in keratinocyte
  JOURNAL   Cell Death Dis 14 (9), 627 (2023)
   PUBMED   37739945
  REMARK    GeneRIF: Depletion of G9A attenuates imiquimod-induced psoriatic
            dermatitis via targeting EDAR-NF-kappaB signaling in keratinocyte.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3697)
  AUTHORS   Wark,A.R., Aldea,D., Tomizawa,R.R., Kokalari,B., Warder,B. and
            Kamberov,Y.G.
  TITLE     Ectodysplasin Signaling through XEDAR Is Required for Mammary Gland
            Morphogenesis
  JOURNAL   J Invest Dermatol 143 (8), 1529-1537 (2023)
   PUBMED   36804570
REFERENCE   3  (bases 1 to 3697)
  AUTHORS   Glover,J.D., Sudderick,Z.R., Shih,B.B., Batho-Samblas,C.,
            Charlton,L., Krause,A.L., Anderson,C., Riddell,J., Balic,A., Li,J.,
            Klika,V., Woolley,T.E., Gaffney,E.A., Corsinotti,A., Anderson,R.A.,
            Johnston,L.J., Brown,S.J., Wang,S., Chen,Y., Crichton,M.L. and
            Headon,D.J.
  TITLE     The developmental basis of fingerprint pattern formation and
            variation
  JOURNAL   Cell 186 (5), 940-956 (2023)
   PUBMED   36764291
REFERENCE   4  (bases 1 to 3697)
  AUTHORS   Mutabaruka,M.S., Pata,M. and Vacher,J.
  TITLE     A Foxo1-Klf2-S1pr1-Gnai1-Rac1 signaling axis is a critical mediator
            of Ostm1 regulatory network in T lymphopoiesis
  JOURNAL   iScience 25 (4), 104160 (2022)
   PUBMED   35434560
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3697)
  AUTHORS   Del-Pozo,J., Headon,D.J., Glover,J.D., Azar,A.,
            Schuepbach-Mallepell,S., Bhutta,M.F., Riddell,J., Maxwell,S.,
            Milne,E., Schneider,P. and Cheeseman,M.
  TITLE     The EDA-deficient mouse has Zymbal's gland hypoplasia and acute
            otitis externa
  JOURNAL   Dis Model Mech 15 (3) (2022)
   PUBMED   35107126
REFERENCE   6  (bases 1 to 3697)
  AUTHORS   Boyle,A.L., Feltquite,D.M., Dracopoli,N.C., Housman,D.E. and
            Ward,D.C.
  TITLE     Rapid physical mapping of cloned DNA on banded mouse chromosomes by
            fluorescence in situ hybridization
  JOURNAL   Genomics 12 (1), 106-115 (1992)
   PUBMED   1733847
REFERENCE   7  (bases 1 to 3697)
  AUTHORS   Crocker,M. and Cattanach,B.M.
  TITLE     The genetics of Sleek: a possible regulatory mutation of the
            tabby-crinkled-downless syndrome
  JOURNAL   Genet Res 34 (3), 231-238 (1979)
   PUBMED   544312
REFERENCE   8  (bases 1 to 3697)
  AUTHORS   Womack,J.E. and Auerbach,S.B.
  TITLE     An acid phosphatase locus expressed in mouse kidney (Apk) and its
            genetic location on chromosome 10
  JOURNAL   Biochem Genet 16 (3-4), 239-245 (1978)
   PUBMED   678292
REFERENCE   9  (bases 1 to 3697)
  AUTHORS   Green,M.C., Durham,D., Mayer,T.C. and Hoppe,P.C.
  TITLE     Evidence from chimaeras for the pattern of proliferation of
            epidermis in the mouse
  JOURNAL   Genet Res 29 (3), 279-284 (1977)
   PUBMED   892445
REFERENCE   10 (bases 1 to 3697)
  AUTHORS   Sofaer,J.A.
  TITLE     The teeth of the 'sleek' mouse
  JOURNAL   Arch Oral Biol 22 (4), 299-301 (1977)
   PUBMED   270322
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF160502.1, AK004576.2 and CO043197.1.
            
            [WARNING] On Mar 12, 2024 this sequence was replaced by
            NM_010100.4.
            
            On Jan 13, 2008 this sequence version replaced NM_010100.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF160502.1, BC068315.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2477              AF160502.1         1-2477
            2478-3063           AK004576.2         1607-2192
            3064-3679           AK004576.2         2195-2810
            3680-3697           CO043197.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 29.37 cM"
     gene            1..3697
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /note="ectodysplasin-A receptor"
                     /db_xref="GeneID:13608"
                     /db_xref="MGI:MGI:1343498"
     exon            1..241
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            242..310
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1606
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /note="anhidrotic ectodysplasin receptor 1; ectodermal
                     dysplasia receptor; tumor necrosis factor receptor
                     superfamily member EDAR; downless"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member EDAR precursor"
                     /protein_id="NP_034230.1"
                     /db_xref="CCDS:CCDS23862.1"
                     /db_xref="GeneID:13608"
                     /db_xref="MGI:MGI:1343498"
                     /translation="MAHVGDCKWMSWLPVLVVSLMCSAKAEDSNCGENEYHNQTTGLC
                     QQCPPCRPGEEPYMSCGYGTKDDDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVL
                     TPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGVSAHSS
                     STSGGSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMFYIMKTKPSAP
                     ACCSSPPGKSAEAPANTHEEKKEAPDSVVTFPENGEFQKLTATPTKTPKSENDASSEN
                     EQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSVTSNKSAGIQSRRKKILDVYA
                     NVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMT
                     DGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASPPPAAS"
     exon            311..433
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            434..615
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            616..701
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            702..788
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            789..914
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            915..989
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1062
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1222
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1283
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..3680
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3658..3663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
     polyA_site      3680
                     /gene="Edar"
                     /gene_synonym="dl; ED1R; ED3; ED5; EDA-A1R; EDA3"
ORIGIN      
        1 cagtccagac cgggaacagt caagagcgag ttcccgggag cccttcaaaa tagaaagtta
       61 gttgcgctgg cagcagaggt gtgcctggcc gctgtcaccc ggctggcccc aggattgtgg
      121 agctctgctt ttgagaggac accgacggac gcctgtgaag cctgcccccc atcccttacc
      181 tgctcgcctt ctccgtagac ccatcttctg ctgggaaaag ctaacctcat tcgggtacca
      241 ggtgtacttc caagagatca tggcccacgt cggggactgc aaatggatgt cctggctccc
      301 agtgctggtg gtgtctctga tgtgctcagc caaggcggag gactccaact gtggtgagaa
      361 cgaataccac aaccagacta ccgggctgtg ccagcagtgt cctccatgca gaccagggga
      421 ggagccctac atgtcctgtg gatacggcac taaagacgac gactatggct gtgtgccctg
      481 ccctgcagag aagttctcca aaggaggtta tcagatatgc aggcgccaca aagactgtga
      541 gggcttcttc cgggccactg tgctgacacc aggagacatg gaaaacgacg ctgagtgtgg
      601 cccatgtctc cctggctact acatgctgga aaacagaccc aggaacatct atggcatggt
      661 ctgctactcc tgtctcttgg cacctcccaa caccaaggaa tgtgtgggag ccacttctgg
      721 ggtttcagca cactcatcca gcacttccgg tggcagcacc ttgtctccct tccagcatgc
      781 tcacaaagag ctctcaggcc aaggacacct ggccaccgcc ctgattattg ccatgtctac
      841 gatcttcatc atggccattg ccatcgtcct catcatcatg ttctacatca tgaagactaa
      901 gccgtcagct ccagcctgct gtagcagtcc cccaggaaag agcgcagaag ccccagctaa
      961 cacacacgag gagaaaaaag aggccccaga cagtgtggtg acgttccctg agaatggtga
     1021 gttccagaag ctgacagcaa cacccacaaa gacccccaaa agtgagaatg atgcctcctc
     1081 tgagaacgag cagttgctaa gtcgcagtgt ggacagtgat gaagagccag ccccggacaa
     1141 gcaggggtcc ccagagctat gtctgctgtc gctagttcac ctggccaggg agaagtctgt
     1201 gaccagtaac aagtctgctg ggatccagag ccggaggaaa aagatactgg atgtgtatgc
     1261 caacgtgtgt ggtgttgttg aaggtctcag ccccaccgag ttgccgtttg actgccttga
     1321 gaagacaagc cgaatgctca gctctacata caactctgag aaggcggtcg tgaaaacatg
     1381 gcgccacctt gccgagagct ttggactgaa gagggatgag attgggggca tgactgatgg
     1441 catgcagctc tttgaccgca tcagcaccgc gggctacagc atcccagagc tgctcacaaa
     1501 gttggtgcag atcgagcggc tggatgctgt ggagtccttg tgtgcagaca tattggagtg
     1561 ggctggggtt gtaccacctg cctccccacc cccagctgcg tcctgaagag ttgtcttgga
     1621 ctgtcttccc tgggaccagc tggggatcca atgaagtcac gaccgacagc tgtgagtgat
     1681 gctatcagac tgccaaaact caaggcattt cctggtgggt cactgtattc cttaggctgc
     1741 cctaagtagt tcattgagca ctcaaatgaa ccaaaccatg tgggaaggac acaggtgaag
     1801 aatctgatcc tgtcttttaa ggaggcactt agtgagagat gggagcatgg tatagaccgt
     1861 gttaccaaaa catcacctag gcaaatgaag ggatgctttt ttaaaaagta gcaaaagtta
     1921 taagggtgat agagtctcaa ggggttgaaa gtgggaacat cctaatgaag aaaataactt
     1981 caaggtttta gtaaaacggt tacaaagtac aggcatccca catccttcat ggcctcagac
     2041 agagcatggt ttgctggcat gccctatggt ttcagaggta actcgacctg tgtttgcagt
     2101 cacacaccat ggtataagcc ttgcagtcac tagtggaaga actcaccatg tgtcactgac
     2161 atacaaggcg tgtgtctgtc cagtcacaag tgtgggcaga tctggcctcc agcaccactc
     2221 gcagccacag cagttacaat gtcaggcttg tcttgcttca aagggacgtg cgtcctatct
     2281 agagaaggaa atggtgactt gctcagagtt tgaccatgcc tgattcctgg gtgaggctcg
     2341 agtgagttca ggcacaacat cctgagccag tgaggggtgg tgcagcccga gacgcagtac
     2401 agagctgggg tctgaggtcc tgggcactgg gagagtcatt caaagtgtct gtctcctcca
     2461 gacttagctt ctcttagctg agagaggttg gtcttcacat ctgtagtcag gaatgttgag
     2521 gctccagtga gcgaaagggt gagtgaaaga acacggaggc agaagagaag aggccagagg
     2581 agcctccatg gggtaaatac agtgtgggtg gccacaaaaa atgagagtca agggaaacgc
     2641 agccgccatt ctcatataag ggcaactgta ggactgagcg tttacagggc ttataaacag
     2701 ccattgctct tggcatattc tcttactgca cctgtaactg ccaggaaatg ggagccaagg
     2761 aaacttcccc ggcagggggt taatgccaag ctggctgctg ggctccctcc cagagcgctg
     2821 actgcagaga atgcttcctt tcagtaaagc ctctggttta gaaggcggtt gggttttttt
     2881 gttttacaag gcctatgact gaacaaaggc tttggagagc aatcagtggt gtgtttaaaa
     2941 ccatcaagcc atttcccacc actgaatata gaccatactg tgagaggacc ataattaggt
     3001 cctgaatttt taatatgatc attttcctgt gtctgtctgt gcagtgtttt tttttttttt
     3061 tttaaagaag gcatttactc cattttgcaa gttaaatgtc tgcttaattg tccttttaat
     3121 tcctgagacc ctgcagtgtc ccttacccct ggtcttccat aatgacgctg cgattcccct
     3181 taattagact tgtaaatgtc atgcgtgatg agtgagcagg tcgaggacag caggctcttc
     3241 tccaactgtc attgtgctga agaatgggca gctgcagcca gcggtgtggg ctgccctcca
     3301 ttcacactac taggtttcaa ggcctgaggc agccagcatc cttgttgttt ccttgactcc
     3361 ctgcttgctg ctttagggga gccagtccct tgtcatttac tttacatggc aataaatcct
     3421 ggaagggttg gttggcttca gtgtgctttg ccaaccaaca agaccacagt gactcttgct
     3481 gaccaatgct ggaactccac gctgccatgt ttgtctggag actgttatta ttttttcagt
     3541 acttaaaggt atttagtaaa cacccaagct aggtctgagg gcctgagcca gtgaagtctt
     3601 aattgtgaat attttatata attctgttta tgtaacttat tatattttta taagctcaat
     3661 aaacatattg ataaaaagga aaaaaaaaaa aaaaaaa
//
