LOCUS       NM_001161432            6271 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus ectodysplasin A2 receptor (Eda2r), transcript variant
            1, mRNA.
ACCESSION   NM_001161432
VERSION     NM_001161432.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6271)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6271)
  AUTHORS   Guan,Z.H., Yang,D., Wang,Y., Ma,J.B. and Wang,G.N.
  TITLE     Ectodysplasin-A2 receptor (EDA2R) knockdown alleviates myocardial
            ischemia/reperfusion injury through inhibiting the activation of
            the NF-kappaB signaling pathway
  JOURNAL   Exp Anim 73 (4), 376-389 (2024)
   PUBMED   38797667
  REMARK    GeneRIF: Ectodysplasin-A2 receptor (EDA2R) knockdown alleviates
            myocardial ischemia/reperfusion injury through inhibiting the
            activation of the NF-kappaB signaling pathway.
REFERENCE   3  (bases 1 to 6271)
  AUTHORS   Agca,S. and Kir,S.
  TITLE     EDA2R-NIK signaling in cancer cachexia
  JOURNAL   Curr Opin Support Palliat Care 18 (3), 126-131 (2024)
   PUBMED   38801457
  REMARK    GeneRIF: EDA2R-NIK signaling in cancer cachexia.
            Review article
REFERENCE   4  (bases 1 to 6271)
  AUTHORS   Lin,Y., Tang,W., Huang,P., Wang,Z., Duan,L., Jia,C., Sun,R., Liu,L.
            and Shen,J.
  TITLE     Denticleless E3 ubiquitin protein ligase (DTL) maintains the
            proliferation and differentiation of epidermis and hair follicles
            during skin development
  JOURNAL   Dev Dyn 253 (7), 635-647 (2024)
   PUBMED   38131461
REFERENCE   5  (bases 1 to 6271)
  AUTHORS   Bilgic,S.N., Domaniku,A., Toledo,B., Agca,S., Weber,B.Z.C.,
            Arabaci,D.H., Ozornek,Z., Lause,P., Thissen,J.P., Loumaye,A. and
            Kir,S.
  TITLE     EDA2R-NIK signalling promotes muscle atrophy linked to cancer
            cachexia
  JOURNAL   Nature 617 (7962), 827-834 (2023)
   PUBMED   37165186
  REMARK    GeneRIF: EDA2R-NIK signalling promotes muscle atrophy linked to
            cancer cachexia.
REFERENCE   6  (bases 1 to 6271)
  AUTHORS   Newton,K., French,D.M., Yan,M., Frantz,G.D. and Dixit,V.M.
  TITLE     Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR
            deficiency
  JOURNAL   Mol Cell Biol 24 (4), 1608-1613 (2004)
   PUBMED   14749376
  REMARK    GeneRIF: EDA-A2 transgenic mice exhibited multifocal
            myodegeneration; this phenotype was not observed in the absence of
            XEDAR
REFERENCE   7  (bases 1 to 6271)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   8  (bases 1 to 6271)
  AUTHORS   Ruiz,S., Segrelles,C., Bravo,A., Santos,M., Perez,P., Leis,H.,
            Jorcano,J.L. and Paramio,J.M.
  TITLE     Abnormal epidermal differentiation and impaired
            epithelial-mesenchymal tissue interactions in mice lacking the
            retinoblastoma relatives p107 and p130
  JOURNAL   Development 130 (11), 2341-2353 (2003)
   PUBMED   12702649
REFERENCE   9  (bases 1 to 6271)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 6271)
  AUTHORS   Naito,A., Yoshida,H., Nishioka,E., Satoh,M., Azuma,S., Yamamoto,T.,
            Nishikawa,S. and Inoue,J.
  TITLE     TRAF6-deficient mice display hypohidrotic ectodermal dysplasia
  JOURNAL   Proc Natl Acad Sci U S A 99 (13), 8766-8771 (2002)
   PUBMED   12060722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732487.10.
            
            On Feb 2, 2022 this sequence version replaced NM_001161432.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106845.1, SRR11927934.477989.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AL732487.10        83829-83908         c
            81-222              AL732487.10        77887-78028         c
            223-320             AL732487.10        68489-68586         c
            321-499             AL732487.10        50624-50802         c
            500-585             AL732487.10        50020-50105         c
            586-750             AL732487.10        48356-48520         c
            751-1150            AL732487.10        45531-45930         c
            1151-6271           AL732487.10        39058-44178         c
FEATURES             Location/Qualifiers
     source          1..6271
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 42.74 cM"
     gene            1..6271
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /note="ectodysplasin A2 receptor"
                     /db_xref="GeneID:245527"
                     /db_xref="MGI:MGI:2442860"
     exon            1..80
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /inference="alignment:Splign:2.1.0"
     exon            81..222
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /inference="alignment:Splign:2.1.0"
     exon            223..320
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1127
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /note="X linked ectodysplasin receptor; EDA-A2 receptor;
                     X-linked ectodysplasin-A2 receptor"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 27"
                     /protein_id="NP_001154904.1"
                     /db_xref="CCDS:CCDS30293.1"
                     /db_xref="GeneID:245527"
                     /db_xref="MGI:MGI:2442860"
                     /translation="MDCQENEYRDQWGRCVTCQQCGPGQELSKDCGYGEGGDAHCIVC
                     PPRKYKSTWGHHRCQTCITCAVINRVQKANCTNTSNAICGDCLPRFYRKTRIGGLQDQ
                     ECIPCTKQTPSSEVQCTFQLSLVKVDAHTVPPREATLVALVGSLLVVFALAFLGLFFL
                     YCKQIFNRHCQCRDSLQYEAEKTVEEDSLFPVPPGQETSPEFPANEGILEIKPLNSIL
                     DDDCSSTRGFPTQESFTMASCASESHSQWVHTPIECTELDLQKFSSSIPSTGPETLRE
                     NTAEHSGDRLELYVPFEVPSL"
     exon            321..499
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /inference="alignment:Splign:2.1.0"
     exon            500..585
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /inference="alignment:Splign:2.1.0"
     exon            586..750
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /inference="alignment:Splign:2.1.0"
     exon            751..1150
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..6271
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4743..4748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /note="hexamer: AATAAA"
     polyA_site      4764
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /note="major polyA site"
     regulatory      6249..6254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /note="hexamer: AATAAA"
     polyA_site      6271
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
ORIGIN      
        1 gatctgttgt tgctacacgt ggaagtgaaa tgactccagc agaaccttgg ttgcaacgga
       61 ttccacctat tgtgagagcg ataagtagat gtggccccat tcaagtatta attctacctc
      121 tacagtgaca actgccttga aaaagaacta tatatttcta cctacctcag atgggacatc
      181 acctcttgct gtgtgcactg gaataaaaga caaaggaaac agtttttttc atcatggatt
      241 gtcaagagaa tgagtaccgg gaccaatggg ggcgctgtgt cacctgccaa caatgtggcc
      301 ctggacagga gctctcgaag gattgtggtt atggagaagg tggagatgca cactgcatag
      361 tctgccctcc ccgaaagtat aaaagcactt ggggacatca cagatgtcag acatgcatca
      421 cttgtgctgt catcaatcgg gtccagaagg ccaactgcac aaatacctct aatgctatct
      481 gtggagactg tctgcccagg ttctaccgaa agacacgcat tgggggcctg caggaccaag
      541 aatgcatccc atgtacaaag cagactcctt cttccgaggt tcagtgtacc ttccagttga
      601 gcttagtgaa ggtagatgca cacactgttc cccctaggga agccacactt gttgcactgg
      661 tgggaagtct gctagtggta tttgctctgg ccttccttgg actcttcttc ctttattgca
      721 agcagatctt caacagacat tgtcaatgca gagattcgtt gcaatatgag gctgaaaaga
      781 cagtggagga ggattctctt ttccccgtac cacctggcca ggagaccagt cctgaatttc
      841 cagctaatga gggcatcttg gagatcaaac cacttaactc catcctggat gatgactgca
      901 gctccactcg cggcttcccc acccaggagt cctttaccat ggcctcctgt gcctcagaga
      961 gccattctca atgggtccat accccaattg aatgtacaga gctggacctg caaaagtttt
     1021 ccagctctat cccctctact ggacctgaaa ccttgagaga gaacacagct gaacactcag
     1081 gagacaggct ggagctctat gtaccttttg aagttcccag cctttaattc taccaaggtg
     1141 aactagaaag gtctctttca ctcttagcaa ccttgccatt gcttgttgct ggactttcct
     1201 gctcttcttt tactcaacaa aagtagcaag agcctgggat gtgggtccca caataaccag
     1261 cgttcaaaaa tggggtcttc agagccccat tctaagagag aactaagtct ccagtgactg
     1321 accttgaaca ctttttgttt tattattcta gtctggggat ccagattcca tagccatggg
     1381 actgctgggc ctgttctttc tctttaatta attatagaag tggggggagt aacaatgaat
     1441 gaggtggagt ttgcctgcct gtatatgttt catgcctata tttttgagaa gtagacctaa
     1501 aaaatggagt atacagtata aatattggca tctgcctacc atattgaaga gaatgaaata
     1561 ctttcccttt tagctatttt ctttgacccc cccctacgtc tacacacaca taaacatgta
     1621 catggagtga agggatattg aggaaggtat catggggagg cctgaagcct ggattttata
     1681 actcatatcc tagacttctg taaaaatgat agttgtcaag ccagtatatt tcttagactc
     1741 ttcattctta gagacaggct atcagtactc tctggtgggg attcaaatca gtgtcttcta
     1801 gatttttcta aattgttgtt tcttgaatgt ctttgcattt ttcttactcc aatattctta
     1861 ccttttcccc cttccagtca agtcctgact gtgatgtttc tgaggtgcag aagtagtacc
     1921 ctgtggagct acagggacca tttggtgctt tcttggctta gagaatagtc agtctatttc
     1981 tcttaagcct gaatcttcag ttttacatgc gtctaagcat gaattgaaac atttttcttc
     2041 ttcttttttt ttttccagaa tatgtcagac atgaccctca ggacttagat gtggctatca
     2101 tgtgttggct ttaagtatcc tggtatgttc aaaatgagcc actaggattg atgcccattt
     2161 cgttatagtg gttcaagttt tgacagggcg aagtggtcaa ctgagtaaag caactgaacc
     2221 ttttttgctt aggtgtaata tataatatcc tggaggctag tgtgacttag gttattaaaa
     2281 acaaattcaa gatgcacaca attattctgg gtcaaagagg taaagatgga ctaaagctgt
     2341 gggtgctgta ctttatatta ttcacattat agttgttctc tctgtgactc actatataaa
     2401 ctttgatata ggcagtgcag gggttgctca gtgaaatagg ggggcataca aaagttagaa
     2461 tgctttcttc agtcatttcc cttcatttga cacttaacta aggacatggc tgcatacaag
     2521 tattcctcca atatcaaggt ggcagaagca ggagtaatga aatttggaag caagcttacc
     2581 ttacattgta agactctttc tcaaaaacac aaggtacagg aatttagata gtgttggaat
     2641 acttgcattt ggcatgaaca aggtcttatt tttgatccta gcaaaaggaa gaaaggtgga
     2701 gaaaggggga aaggagggaa gtaaagaagg aaataaaaca tttccaacac caagaaatac
     2761 accagacccc atagtaggct aagtgctgct gaggctgtag tggagttttc cattggaaaa
     2821 tatcacatgt gttcatctta tattaggttt tcttgccttt agctcttaaa cactgtttac
     2881 aatatttttt cttcttattt cttggttccc tagactcata gcactctgtg agtctgctgg
     2941 aaggtttgat ggatgttcat agagctgtgt ttctgagttt tagcataaca cataaaggaa
     3001 ttttgatatg ggtctcctgg gccttatcta atctttgagg ttctgtattc ctctacccca
     3061 agcaaaaagc caggctacag tttgatcttt caggacccta cagtacagta cgtttctgag
     3121 tcaattttcc ctttcctatg tctgggctcc ccaagcaatc acccaccaga cctccaaaga
     3181 tacccacagc atttttcaag ttagctaagt gaggctgtga agggtccctc aaggtatgag
     3241 tatttctttt gacatgtcag ttagatgcct actttactgt ccgtttggtt ctttttgaaa
     3301 attcattttg cctttagctt ttacctgtac atctcaagag cagagacaaa caagaatctc
     3361 cttggagact ctattattcc tttttatctc tgaatcttta tgaagcttat gcagctagtt
     3421 tctatcctac tagcaattgg taggttaggt aaaatgtaga cttcctcacc aggacttatc
     3481 cttaagagag agtgctcgct acaagattct gttaaatgtg tctttaatta cagctcatcc
     3541 acaaacactg attaagggcc ttaaggtcaa actgctgata agagtgttaa aacaacaaga
     3601 gaaaaaatac taaaaggtcc cattgtactt ggcaggggat tagaagcaat tgaatcacaa
     3661 cactgtacca gacaacctgg tctcctgtaa gcattatcaa atgtgtctga gccaaggttt
     3721 agaccttggt ctttggtact ttttttctgg gacagcttat gcttatctca ccaactttaa
     3781 ttagccatat ctatacttct ggtgaagaag aactagcact aaatctgagg tggattcagc
     3841 ttgagtaggt tccagctgta gaaaggtcac tatgtgcttg gcaatgcttc aatctcaagt
     3901 ccattactgc ttcttagtga aaaggactat gatgataaaa cagcaaaaac aatgtgatta
     3961 aatgacccag gcaccctgct tcactgtgcc tatacataac aaggtcgtta tacatccatg
     4021 ccaagaatcg ccttggttcc agttttcttg aacagttgga gttaataact aaaataaggt
     4081 gaagttttat tttgctttgc tttctttggt ttcttgggta gaatcaaaga aaaggatgat
     4141 gttttgtttt ttctttataa ttgatatttg accttggctt acttcatatt tgcatatttg
     4201 atcaagtagt gtccttataa agtgggacca ctttgagcac tatgctttta tgtgtcttct
     4261 ctttgaagaa ttcatgagac atgtatataa cataactctg ggcctggaca gcaattgtgt
     4321 tttacatatt tgagctagca acagaaaata tttgtgtaca ggggatagag gtaggcgttt
     4381 agtggaggtg agtcaggcct cagggttcac tttatttccc ccacttatat cactggaata
     4441 ttgaaaggtt gtatgtagta tgggagatca actttcttcc ctaaggtcgt taatattaga
     4501 gtaagtaaaa atgtcaacac tacacctctc ttcccaatag acctggcaca gcctcatacc
     4561 cctcattcaa tttattaccg acgtctttga tgttttgtat ttaatgtagg caggttttaa
     4621 ttattgtttt cctttaaatg aactatttat agagattttg ttaaattttg agccatatgc
     4681 atgagtggat actgacaagt tgtgtctgat ttatgataat ctgcaaacaa ttcatattaa
     4741 tcaataaaca gaagtacgta caaatgcctt gtttattcct cggctttcag tgaacttgtg
     4801 tgactcattc aattgttttg tgtgtctgct tagtcagtac agaaagaaat gtgtttttaa
     4861 tcattgggtt tagcaccaga gctaaggcaa ttctgactcg taacccagga gatctgagtt
     4921 gtagactgtg ttctcctgct tacaaattgt ttatgacatt tagaatcttg tctgtctaca
     4981 gatctaccag atatgtttgt attctaaatt tagaattctt ttcttatttt gttgattttt
     5041 tctgttgtcg ttatttgttt gttgttgttg ttgttgtggt ggtggtggtg gtggtggtgg
     5101 tggtggtggt ggtggtggtg gttgttttga gacagggttt ctctgtgtaa tagccctaag
     5161 tgtcctggac ttacttttgt agaccatgct gccctcaagc tcacagagat ctgcttgact
     5221 ctgactccca agtgctggga ttaaaagtgt gtgccaccac acccagctct aaatttataa
     5281 ttcttaggga atgttgtata gtcttcatac tgtgtgcata tatttagacc tataaaccaa
     5341 tctcttgtgt ttatatgtgc acatttccat ttgatcttac tatttttaaa aaagaaaaca
     5401 tatacacaca tatgtatgca taccttcaca ttcaaacaca tacatgcata aaactagaca
     5461 gactataaga ttgcatctta agaacactgc tttgctatta tttgatctgt atttttgttt
     5521 atagtgttat tggattcgag gggctgctaa aggtacaaca tttgatttga atgttcttca
     5581 caactataat tttatttaaa accaggcaaa ttgaatttct ttctatctca aatattggct
     5641 aatcctaata gaaatacaca ctgacaagga tgtggaagaa agataattca tacaatgtta
     5701 gtgggattat aaaatggcat gacctttttg aaacagtcta gcagttcttg taaaattcaa
     5761 agcttcagtt gtcatatgat tcaataattc tatccatcaa tatatgatta agataattaa
     5821 aaacatgtgt atgtaatgca ttgactaaat actcttaaag aagagtgttt ataataatca
     5881 aaattgatag caatccaatt ttgtcaactg atgaatgaat aaagttgtaa tacaacataa
     5941 gatagtaaaa atttaaaata attgaaatta tgatacttga tatgtcagag ttcaagctca
     6001 aaatatgata agtgaaagaa tccaggtact agaaggtaca tcttatatat gtaagctagt
     6061 agtgacagaa ggtaagttag tggtctcttg gtactgagta caagaggaat aactaatgtt
     6121 agtaggcata tgtgatctta tttagaagaa aagaatgtca tgatggtagc tgcatttctc
     6181 agtaaattta ttaaaatatt gctgacaggc atactggaaa tggatgaatt ttattatata
     6241 aaatattcaa taaagctgtt ttaaaaatat a
//
