LOCUS       NM_001177937            4949 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus ectodysplasin-A (Eda), transcript variant 2, mRNA.
ACCESSION   NM_001177937
VERSION     NM_001177937.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4949)
  AUTHORS   Papagno,V., Sulic,A.M., Satta,J.P., Hoshiar,A.K., Kumar,V.,
            Jernvall,J. and Mikkola,M.L.
  TITLE     Wnt target gene Ascl4 is dispensable for skin appendage development
  JOURNAL   Int J Dev Biol (2024) In press
   PUBMED   38770834
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 4949)
  AUTHORS   Zonnefeld,A.G., Cui,C.Y., Tsitsipatis,D., Piao,Y., Fan,J.,
            Mazan-Mamczarz,K., Xue,Y., Indig,F.E., De,S. and Gorospe,M.
  TITLE     Characterization of age-associated gene expression changes in mouse
            sweat glands
  JOURNAL   Aging (Albany NY) 16 (8), 6717-6730 (2024)
   PUBMED   38637019
REFERENCE   3  (bases 1 to 4949)
  AUTHORS   Lan,Q., Trela,E., Lindstrom,R., Satta,J.P., Kaczynska,B.,
            Christensen,M.M., Holzenberger,M., Jernvall,J. and Mikkola,M.L.
  TITLE     Mesenchyme instructs growth while epithelium directs branching in
            the mouse mammary gland
  JOURNAL   Elife 13, e93326 (2024)
   PUBMED   38441552
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4949)
  AUTHORS   Wark,A.R., Aldea,D., Tomizawa,R.R., Kokalari,B., Warder,B. and
            Kamberov,Y.G.
  TITLE     Ectodysplasin Signaling through XEDAR Is Required for Mammary Gland
            Morphogenesis
  JOURNAL   J Invest Dermatol 143 (8), 1529-1537 (2023)
   PUBMED   36804570
  REMARK    GeneRIF: Ectodysplasin Signaling through XEDAR Is Required for
            Mammary Gland Morphogenesis.
REFERENCE   5  (bases 1 to 4949)
  AUTHORS   Sulic,A.M., Das Roy,R., Papagno,V., Lan,Q., Saikkonen,R.,
            Jernvall,J., Thesleff,I. and Mikkola,M.L.
  TITLE     Transcriptomic landscape of early hair follicle and epidermal
            development
  JOURNAL   Cell Rep 42 (6), 112643 (2023)
   PUBMED   37318953
REFERENCE   6  (bases 1 to 4949)
  AUTHORS   Sofaer,J.A.
  TITLE     Additive effects of the genes tabby and crinkled on tooth size in
            the mouse
  JOURNAL   Genet Res 33 (2), 169-174 (1979)
   PUBMED   478295
REFERENCE   7  (bases 1 to 4949)
  AUTHORS   Mayer,T.C. and Green,M.C.
  TITLE     Epidermis is the site of action of tabby (Ta) in the mouse
  JOURNAL   Genetics 90 (1), 125-131 (1978)
   PUBMED   359407
REFERENCE   8  (bases 1 to 4949)
  AUTHORS   Lusis,A.J. and West,J.D.
  TITLE     X-linked and autosomal genes controlling mouse alpha-galactosidase
            expression
  JOURNAL   Genetics 88 (2), 327-342 (1978)
   PUBMED   205481
REFERENCE   9  (bases 1 to 4949)
  AUTHORS   Eicher,E.M., Southard,J.L., Scriver,C.R. and Glorieux,F.H.
  TITLE     Hypophosphatemia: mouse model for human familial hypophosphatemic
            (vitamin D-resistant) rickets
  JOURNAL   Proc Natl Acad Sci U S A 73 (12), 4667-4671 (1976)
   PUBMED   188049
REFERENCE   10 (bases 1 to 4949)
  AUTHORS   Hoppe,P.C.
  TITLE     Genetic and endocrine studies of the pregnancy-blocking pheromone
            of mice
  JOURNAL   J Reprod Fertil 45 (1), 109-115 (1975)
   PUBMED   127839
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF016627.1, AJ243657.1, DQ168876.1 and CJ207760.1.
            
            Transcript Variant: This variant (2) lacks an in-frame small
            segment in the CDS, as compared to variant 1. The resulting isoform
            (2) lacks two internal aa, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ243657.1, SRR1660811.75847.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AF016627.1         1-13
            14-2913             AJ243657.1         1-2900
            2914-4948           DQ168876.1         2920-4954
            4949-4949           CJ207760.1         400-400
FEATURES             Location/Qualifiers
     source          1..4949
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.59 cM"
     gene            1..4949
                     /gene="Eda"
                     /gene_synonym="Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby;
                     Tnlg7c; XLHED"
                     /note="ectodysplasin-A"
                     /db_xref="GeneID:13607"
                     /db_xref="MGI:MGI:1195272"
     exon            1..571
                     /gene="Eda"
                     /gene_synonym="Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby;
                     Tnlg7c; XLHED"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1345
                     /gene="Eda"
                     /gene_synonym="Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby;
                     Tnlg7c; XLHED"
                     /note="isoform 2 is encoded by transcript variant 2; EDA
                     protein homolog; tumor necrosis factor ligand 7c"
                     /codon_start=1
                     /product="ectodysplasin-A isoform 2"
                     /protein_id="NP_001171408.1"
                     /db_xref="GeneID:13607"
                     /db_xref="MGI:MGI:1195272"
                     /translation="MGYPEVERREPLPAAAPRERGSQGCGCRGAPARAGEGNSCRLFL
                     GFFGLSLALHLLTLCCYLELRSELRRERGTESRLGGPGAPGTSGTLSSPGSLDPVGPI
                     TRHLGQPSFQQQPLEPGEDPLPPDSQDRHQMALLNFFFPDEKAYSEEESRRVRRNKRS
                     KSGEGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPG
                     PPGPPGPQGPPGLQGPSGAADKTGTRENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSR
                     ITMNPKVFKLHPRSGELEVLVDGTYFIYSQVYYINFTDFASYEVVVDEKPFLQCTRSI
                     ETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS"
     exon            572..677
                     /gene="Eda"
                     /gene_synonym="Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby;
                     Tnlg7c; XLHED"
                     /inference="alignment:Splign:2.1.0"
     exon            678..701
                     /gene="Eda"
                     /gene_synonym="Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby;
                     Tnlg7c; XLHED"
                     /inference="alignment:Splign:2.1.0"
     exon            702..881
                     /gene="Eda"
                     /gene_synonym="Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby;
                     Tnlg7c; XLHED"
                     /inference="alignment:Splign:2.1.0"
     exon            882..916
                     /gene="Eda"
                     /gene_synonym="Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby;
                     Tnlg7c; XLHED"
                     /inference="alignment:Splign:2.1.0"
     exon            917..968
                     /gene="Eda"
                     /gene_synonym="Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby;
                     Tnlg7c; XLHED"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1093
                     /gene="Eda"
                     /gene_synonym="Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby;
                     Tnlg7c; XLHED"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..4949
                     /gene="Eda"
                     /gene_synonym="Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby;
                     Tnlg7c; XLHED"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4929..4934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eda"
                     /gene_synonym="Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby;
                     Tnlg7c; XLHED"
                     /note="hexamer: AATAAA"
     polyA_site      4949
                     /gene="Eda"
                     /gene_synonym="Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby;
                     Tnlg7c; XLHED"
                     /note="major polyA site"
ORIGIN      
        1 tggagctgca catgcggctg ctccctgttc tgtcccgccc agccaccgtc gctcaggaac
       61 gggtccctgc agcccccagc cgatggcagg acagtagtcg cctgtcaggg gtcgtgaagg
      121 actgaggcag aggcagaggc tcccgggcct cagatagtgg ttgtctctgg aggccatggg
      181 ctacccagag gtagagcgca gggaacccct gcctgcggca gcgccaaggg agcggggcag
      241 ccagggctgc ggctgtcgcg gggcccctgc tcgggcgggc gaagggaaca gctgccggct
      301 cttcctgggt ttctttggcc tctcgctggc cctccacctg ctgacgctgt gctgctacct
      361 agagttgcgg tccgaattgc ggcgggaacg gggaaccgag tcccgcctcg gtggcccggg
      421 tgctcctggc acctctggca ccctaagcag ccctgggagc ctcgacccgg tgggtcccat
      481 cacccgccac ctggggcagc cgtcctttca acagcagcct ttggaaccgg gagaagatcc
      541 actcccccct gactcccagg accggcacca gatggccctc ctgaatttct tctttcctga
      601 tgaaaaggca tattctgaag aggaaagtag gcgtgttcgc cgcaataaga gaagcaaaag
      661 tggtgaagga gcagatggtc ctgttaaaaa caagaaaaag ggaaagaagg cagggccacc
      721 tgggcccaac ggccccccag gacctccagg acctccggga ccccagggac ctccagggat
      781 tccaggaatt cctgggattc caggaacaac tgttatggga ccacctggcc cacctggccc
      841 tcctggtcct caaggacccc ctggcctcca aggaccttct ggtgctgctg ataaaactgg
      901 aactcgggaa aatcagccag ctgtggtgca tctgcagggc caagggtcag caattcaagt
      961 caaaaatgat ctttcaggtg gagtgctcaa tgactggtct cgcatcacta tgaaccctaa
     1021 ggtgtttaaa ctacatcccc gcagcgggga gctggaggta ctggtggacg gcacctactt
     1081 catctatagt caggtctact acatcaactt cactgacttt gccagctacg aggtggtggt
     1141 ggatgagaag cccttcctgc agtgcacccg cagcattgag acagggaaga ccaactacaa
     1201 cacttgctat actgcaggcg tgtgcctcct caaggccagg cagaaaatcg ccgtgaagat
     1261 ggtgcacgct gacatctcta tcaatatgag caagcacacc accttcttcg gggccatcag
     1321 gctgggcgaa gcccctgcat cctagattct cccattccat cctggcccat gcccctgccc
     1381 caggtttggg agccaggact cccagaacct ctaagtgctg ctgtgtgtgg aatgaggtat
     1441 actggcgttg cagccacaaa gagaaatgcc ccatgctatt tattccccag tgactccagg
     1501 atgacaaggc ctatgtgact tcccagaaag accttgagtt gccaggacag ttgacggagc
     1561 cccagggttg tcaagaagca gaaccttctt aggctccctg ctgactggct tatggtgact
     1621 cctcaaccct taggtccctc atcagatgta tcatttgttg cactaaaatg aggatccaag
     1681 acagtaggcc acaaaaagaa aaggtgcact ccagattcta ggggtgatgg ggggcttctt
     1741 ctctcctggc tgggggtgcc attaggttgc aacttaagga gagggtcagg tcagaagaag
     1801 gcaagtcctt gtggcaaaga cctgggcaat aacctaccaa gtcaatatcc ttgacagaag
     1861 aggcattctt gctgcattgc actataacct actagaggct caaagaaaac ttcccactca
     1921 ggctgagagg tatactgtgg cagcttgctg gactccagag ctgggaactt tgctttggct
     1981 tggaatcatg caggaatgac cacatgcatg cctatgtaag aagctatatt tggggtcatg
     2041 catgtctcat tgtgtttaca gctatgttcc actctcagaa aactacctgg agtcttccca
     2101 cctgtcacca cccaccccag tctgactaga aattctatct tctttctcct cggtgcctac
     2161 ctctgcttta gacaggtgct tcacagtgta ctctttaaat tacttgggca caaagaattt
     2221 tccatttatt aggcatacaa ttcttctaat tctaatcaaa ctgtgtctgg gaacagatgg
     2281 ttaaactgga taacctccaa aagcccctta gagtttgaag atcggtggca ctcagcagtt
     2341 acctgccaca gtaaattttg gaattcccaa accctacact cccttgggca tcagcacagt
     2401 atagcttttc tacctttccc agggaggggg agaaagtggg gatagaacag gaaatgttgt
     2461 ccacttttgt tgagacccaa gctcttatct gaaagagcag caggccatgg cccactagcc
     2521 cagtctttct gcggtgcttt cctagagcat ctgtctgcta ttgagcaggg ctctcacacc
     2581 tacttcagat ccaaaggcac ctccaccagt tttcctgcat tgtcttatgc taggttcatg
     2641 agacttcttt ccaattgcct agcttcaggg taccaggcac agcctaaagc tggaaggatc
     2701 aacctggtcc agccggttcc tcttgctcct gaaatgtatt tctttttgag gagatgggaa
     2761 atgcatccct gaaatgcatc aagaatatca ggtactgagt tctcagctgt acctccattt
     2821 cccagtagcc acattgcttg gtccttcacg ggtcaggaca agaggtggta ggccaggact
     2881 cttttataca gtgctaatga cagccttaca accagaaatg aggtcgattt tagacatgca
     2941 tctgcccttg gaggccttga acaatcagca gtggtagcaa gaactaacag accctctcct
     3001 tagtgtttga aggttgcttc ctcttaattt cctttgaaga agacggggca gagaattatc
     3061 acagttacca ttgtataggt acggctggga gagaaagcac tttcattaag aactcaccca
     3121 taagtcacag accttagctt ttagtgaggt ctgactcccg agctagtgtc ttaccacaca
     3181 cttaccacac actgtgtgga atttgggttc cgaaagaaaa attaaaagtg atcacatgga
     3241 actgatatca tggcagagtc ctagggagaa acctagcaat gctatggtac tgcctagtct
     3301 cttggctgcc acaggctctg tggaagaagt cttggatgtt ttctaatcct gagttgagct
     3361 ctgggaccca cagaacttgg agccttcatg acctttcacc catctgataa aagcagcaac
     3421 catcacacaa cgagctgcta tgtggggcaa ggtcttctgt cttccattcc tgaccctagc
     3481 tactagttct gggagccagt ctgcttcctg gggttaggtg tgactcctcc tctcctcctg
     3541 ccatattaca aaggccttaa tgttgccaga acatcttcct ctgttgatgt tgagaggttg
     3601 ccctcccgag aatggaggga aaacctaaga gcaccattcc aaagccacat ggctatggag
     3661 aaatagagga agtttcctaa ctgtgcccct gcaggacatg ccaaccccat catatgctct
     3721 gtgcttggag atcatagggg aagtgggctt ctcactaccc tgtcttcatc ctgaatcctc
     3781 acaaggagcc ccagatgcag aaggctgggg gaggaaataa gaaagaatgg ggggcctgct
     3841 gtgctgtact cattggcaaa gtaatgaagc atttactgat aggaaaatag ggatatagat
     3901 ttacagtttg gaattgtcat gatgtgaagt tatcccaagg ttagcataga gaatgggatg
     3961 gggacatgtt tgtgtaagca gatgacatgt tagaagaaaa attgcaccgc aggagcctct
     4021 accagctgct tgagcttcaa aagccaagct ggcacaaaat tgtacctgct agatgttatg
     4081 tggctactgg ttccctggaa gatgtatcat tttgccttag ttgcccctgg acccatcctg
     4141 agcctaatct ctgcagctta gtaagaaaag gctaaggacc ctagagatga gggctttggt
     4201 cctcatgtga gtgattgcat tttatgcgtc ttctagtgga tgcaaacaga tgtagagaaa
     4261 tctttgacct agaaaggctt ttagagggaa tgcagcccaa cctacatccc atcctgttac
     4321 tcatatgcaa ttgatgtcca gacagggaaa ctggcccacc taggacagtg tgcaggcagg
     4381 cccccacctc cagactcagc aggagaagga ggcaaagcaa cctgtcccat ggggcctcct
     4441 ctttcataca cccacagaat caaagctaga agtgtttatc tcccttcagg agcctggtga
     4501 ggcagggagt gggtctacaa tctccatcac aacttgcctc cccacacata gtcccccaag
     4561 atatttgtgc acctcctgcc tctgggctgg aagctttagg ctggctctga gccagacaga
     4621 ttttaggctt ctcttgtgtt gcctgaggtc ccacccttgc ctgggctttc cctgggccat
     4681 gcctactaca gaacctgatt tgttttctta attcatttca gggctctctc caggagagcg
     4741 tgaggtgtgt catttctttc ttcaaaaagc ttccagctga tgaggataag gggagaatgg
     4801 cctggagcag gcccaatgct gctttgggga atcagcatcc tgtgtgagat actgtgtata
     4861 gaaactatat atataatgta tataaacagg gatgtaagtt tgtgtaaatt aatggtttat
     4921 tctttgcaaa taaagtgctc ccctcacca
//
