LOCUS       NM_001409697            4064 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus ect2 oncogene (Ect2), transcript variant 4, mRNA.
ACCESSION   NM_001409697
VERSION     NM_001409697.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4064)
  AUTHORS   Khan,I.S., Molina,C., Ren,X., Auyeung,V.C., Cohen,M., Tsukui,T.,
            Atakilit,A. and Sheppard,D.
  TITLE     Impaired myofibroblast proliferation is a central feature of
            pathologic post-natal alveolar simplification
  JOURNAL   Elife 13, 94425 (2024)
   PUBMED   39660606
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4064)
  AUTHORS   Despin-Guitard,E., Rosa,V.S., Plunder,S., Mathiah,N., Van
            Schoor,K., Nehme,E., Merino-Aceituno,S., Egea,J., Shahbazi,M.N.,
            Theveneau,E. and Migeotte,I.
  TITLE     Non-apical mitoses contribute to cell delamination during mouse
            gastrulation
  JOURNAL   Nat Commun 15 (1), 7364 (2024)
   PUBMED   39198421
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4064)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4064)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4064)
  AUTHORS   Liberti,D.C., Kremp,M.M., Liberti,W.A. 3rd, Penkala,I.J., Li,S.,
            Zhou,S. and Morrisey,E.E.
  TITLE     Alveolar epithelial cell fate is maintained in a spatially
            restricted manner to promote lung regeneration after acute injury
  JOURNAL   Cell Rep 35 (6), 109092 (2021)
   PUBMED   33979629
REFERENCE   6  (bases 1 to 4064)
  AUTHORS   Saito,S., Liu,X.F., Kamijo,K., Raziuddin,R., Tatsumoto,T.,
            Okamoto,I., Chen,X., Lee,C.C., Lorenzi,M.V., Ohara,N. and Miki,T.
  TITLE     Deregulation and mislocalization of the cytokinesis regulator ECT2
            activate the Rho signaling pathways leading to malignant
            transformation
  JOURNAL   J Biol Chem 279 (8), 7169-7179 (2004)
   PUBMED   14645260
  REMARK    GeneRIF: ECT2 has a role in activating the Rho signaling pathways
            leading to malignant transformation
REFERENCE   7  (bases 1 to 4064)
  AUTHORS   Seibler,J., Zevnik,B., Kuter-Luks,B., Andreas,S., Kern,H.,
            Hennek,T., Rode,A., Heimann,C., Faust,N., Kauselmann,G., Schoor,M.,
            Jaenisch,R., Rajewsky,K., Kuhn,R. and Schwenk,F.
  TITLE     Rapid generation of inducible mouse mutants
  JOURNAL   Nucleic Acids Res 31 (4), e12 (2003)
   PUBMED   12582257
REFERENCE   8  (bases 1 to 4064)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4064)
  AUTHORS   Takai,S., Lorenzi,M.V., Long,J.E., Yamada,K. and Miki,T.
  TITLE     Assignment of the ect2 protooncogene to mouse chromosome band 3B by
            in situ hybridization
  JOURNAL   Cytogenet Cell Genet 81 (1), 83-84 (1998)
   PUBMED   9691182
REFERENCE   10 (bases 1 to 4064)
  AUTHORS   Miki,T., Smith,C.L., Long,J.E., Eva,A. and Fleming,T.P.
  TITLE     Oncogene ect2 is related to regulators of small GTP-binding
            proteins
  JOURNAL   Nature 362 (6419), 462-465 (1993)
   PUBMED   8464478
  REMARK    Erratum:[Nature 1993 Aug 19;364(6439):737]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121099.8 and AC165280.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.1391367.1,
                                           SRR17253014.3237569.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC121099.8         62301-62420
            121-272             AC121099.8         65943-66094
            273-352             AC121099.8         67051-67130
            353-445             AC121099.8         67236-67328
            446-628             AC121099.8         69104-69286
            629-718             AC121099.8         70078-70167
            719-826             AC121099.8         71064-71171
            827-900             AC121099.8         74424-74497
            901-1031            AC121099.8         76461-76591
            1032-1147           AC121099.8         76994-77109
            1148-1210           AC121099.8         77213-77275
            1211-1436           AC121099.8         77399-77624
            1437-1573           AC121099.8         78962-79098
            1574-1693           AC121099.8         84219-84338
            1694-1762           AC121099.8         86001-86069
            1763-1873           AC165280.3         200466-200576       c
            1874-1970           AC165280.3         199611-199707       c
            1971-2052           AC165280.3         196635-196716       c
            2053-2131           AC165280.3         195129-195207       c
            2132-2251           AC165280.3         194693-194812       c
            2252-2390           AC165280.3         190510-190648       c
            2391-2545           AC165280.3         188128-188282       c
            2546-2653           AC165280.3         175127-175234       c
            2654-2797           AC165280.3         173560-173703       c
            2798-4064           AC165280.3         169954-171220       c
FEATURES             Location/Qualifiers
     source          1..4064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 10.82 cM"
     gene            1..4064
                     /gene="Ect2"
                     /note="ect2 oncogene"
                     /db_xref="GeneID:13605"
                     /db_xref="MGI:MGI:95281"
     exon            1..120
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            121..272
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            273..352
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            353..445
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            446..628
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..718
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..826
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..900
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1031
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1147
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1210
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1436
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1573
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1693
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1762
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1873
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1970
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2052
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2131
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2251
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2390
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2545
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2653
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2797
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..4064
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4040..4045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ect2"
                     /note="hexamer: AATAAA"
     polyA_site      4064
                     /gene="Ect2"
                     /note="major polyA site"
ORIGIN      
        1 agcctctctc gagccatggc ggcgcctgtg agggggagac ttagtgtttg agaaggataa
       61 gcgaggactg cgccgtcgtg gttccttttt aaaatctctg agcgtggtga ggactgcggg
      121 ccttcatcaa gtagtgcaaa caatggctga cgacagcgtg ttaccatctc cttctgagat
      181 aactagcttg gcagactctt cagtgtttga ttctaaagtt gctgaaatgt ccaaggaaaa
      241 cttgtgcttg gcgtctactt caaatgttga tgaagaaatg ccgcaggttg aagcaagagt
      301 gataatggtc caggatgctg ggaaacaaga agaacttcta aaggccttaa agactattaa
      361 gataatggaa gtccctgtta taaagataaa agaaagttgt cctggaaaat cggaggaaaa
      421 attaataaaa agtattatta atatggaaat gaaagtgccc tgtgtaaaga tggactcaat
      481 ggaagaattt gaaagtttgg attccccaga atttgagaat atatttgtag ttactgactt
      541 ccagaattct gtcttcaatg acttatacaa ggctgattgt aggattgttg ggccaccagt
      601 tatactcaac tgtgcacaaa ggggagagcc cttgccgttt tcctgccggc cgctgtattg
      661 tacgagtatg ctgaacctgg tgctctgctt cactggattc aggaagaagg aggagcttgt
      721 caaattggtg acgttggttc atcatatggg tggagttatt cgaaaagagt gtaattccaa
      781 agtaacacat ctggtggcaa attgtacaca aggcgaaaaa tttagggttg ctgtgagcct
      841 gggcactcca attatgaagc cagaatggat ttataaagcg tgggaaagac gcaatgaaca
      901 gtgtttctgt gcagcagttg atgactttag aaatgaattt aaagttcctc cattccaaga
      961 ttgcatttta agtttcctgg gattttcaga tgaagagaaa catagtatgg aagaaatgac
     1021 tgaaatgcaa ggaggtagct atttaccagt tggggatgaa aggtgcactc accttattgt
     1081 tgaagagaat acagtaaagg accttccatt cgaaccttca aagaaacttt ttgttgtcaa
     1141 gcaagagtgg ttctggggaa gcattcagat ggacgctcgt gcaggagaga ctatgtattt
     1201 gtatgaaaag gctaatactc ctgagctcaa gaaatcggtg tctctgcttt ctctaagtac
     1261 tccaaacagc aaccgcaaga gacggagatt gaaagagacc ctggctcagc tctccaggga
     1321 gactgacctc tctcctttcc ctccccggaa gcggccctca gctgagcact ctctttctat
     1381 tggctcactc ctggatatct ccaacacacc cgagtccagc atccactatg gaggtaaaac
     1441 accgaagtcc tgtgctaagt cttctagaag ttctactcca gttcctccaa agcagtcagc
     1501 caggtggcag gtggcgaaag agctctacca gactgagagc aattatgtca atatactggc
     1561 cacaatcatt caattatttc aggtgccctt agaagaagaa ggacagcgtg gtgggcctat
     1621 tcttgcacct gaggagatca agactatttt tgggagcatc ccagatatct ttgatgtgca
     1681 tatgaagatc aaggatgatc ttgaagacct tattgctaac tgggatgaga gcagaagtat
     1741 tggtgacatc tttcttaaat atgcaaaaga tttggtaaaa acctaccctc cgtttgtaaa
     1801 cttctttgaa atgagcaagg aaatgatcat taaatgtgag aaacaaaagc ccagatttca
     1861 tgctttcctc aagataaatc aagctaaacc agaatgtgga cgacagagcc ttgtggaact
     1921 tctcatccgg ccagtgcaga ggctacccag tgtcgcttta cttttaaacg atcttaaaaa
     1981 gcatacagct gatgaaaatc cagacaaaag cactttagaa aaagctattg gatcactaaa
     2041 agaagtaatg acacatatca atgaggataa gagaaaaaca gaagcacaga agcaaatttt
     2101 tgatgttgtt tatgaagtag atggatgccc agctaatctc ttatcttctc atcggagcct
     2161 ggtgcaacga gtggaaacgg tttcccttgg tgagcaccct tgcgaccgag gagaacaagt
     2221 cactctcttc ctcttcaatg actgcctcga gatagcaaga aagcggcaca aggttattgg
     2281 cacttttaga agtcctcacg accgcacccg gccccccgct tctctgaagc acattcatct
     2341 catgcctctt tctcagatta agaaggtgct ggacatccga gagacagaag attgtcacaa
     2401 tgcctttgcc ttgcttgtaa ggccaccaac agaacaggcc aatgtactgc tcagcttcca
     2461 gatgacgtca gaggagcttc caaaggagag ctggctgaag atgctgtgcc gacatgtagc
     2521 caacaccatt tgtaaggcag atgctgagaa tcttatgtat gtggctgatc cagaatcctt
     2581 tgaagtaaat acaaaagata tggatagtac attgagtcga gcatctagag caataaagaa
     2641 gacttcaaaa aaggttacaa gggcattctc tttttccaaa actcccaaga gagccctgcg
     2701 gatggctctt tcatcatccc atagctcaga gggaaggagt cctccgagca gtggcaagct
     2761 tgctgtgagc cgtctgtcca gcacatcatc cttagcaggt attccatctc cctcccttgt
     2821 cagcctccct tctttctttg aacggagaag tcatacatta agtcgatcta caactcactt
     2881 gatatgaaac ttaagtcctg tgggacctat gcttcaacaa gacgctgact taagtggtac
     2941 tttgaattag cacttggtaa agttgtagag aagattagta acactaacca acgccgtttt
     3001 attttcttga aatacaattt tcaagatggt ctatgtaaaa aaaatatgga ttttgatgta
     3061 atttatcttt atttgaatct cacatctgaa gaccagtgac ttaagttatt cctgataatc
     3121 agtagctttg taaccctgat acagtaaaca gttggtgggt gcaaaatact attgtgtatt
     3181 tgtatagtat cttgaatttt tggaagtaca tatttgtgta tctcaatttg tgcaaagact
     3241 gaacagcaat gcaacacttg ctgaataaaa ccctctgatt aaattctaga ggcttgttca
     3301 gttcgattgt ttgatgtact taactgcgct tttgcagttt attttctttt aaaataagag
     3361 atctaacaca tgaattttaa aggatacacc attattaacc atacaattac gatcgtttgg
     3421 aattttcttt tgcaaattga gataagaaga gaaagattac aaaacattgt atatgttgcg
     3481 aagataagat attagtatgt actttataat tgtttcagag acttttattt ttattttatt
     3541 ttcttattct agacactagc aaatcttgat ttagttttga ctactgtatt gaatttattt
     3601 caaaggataa gaccacgtga aaactgtgtt aagaattgct tctgttcttt gtacagttct
     3661 gaagttgtct tcagttttgc taatcgcctg tgaaaagcat agatataatg tgtggtgaac
     3721 tttttattgt ggtcatatca ttaaaataag attggaaatt tattgtcaaa aattttgtga
     3781 atctgccatt atcttctact gcaatatttc ttttagtcag taatacagaa tgactgggct
     3841 actatggcca agaatatttt atttcttaca cgttcagagg agtgttacag gtctccttgt
     3901 tacataattt tcaataatct gctttaatag tttaactgac tggatttttt tctataccat
     3961 gtatgtacca attcacacgt tagtaaatga ccttgttttg ctatatttta aaagcagtta
     4021 tattagcaag aactttgtaa ataaatagct ttaaaataca agta
//
