LOCUS       NM_001177625            3954 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus ect2 oncogene (Ect2), transcript variant 2, mRNA.
ACCESSION   NM_001177625
VERSION     NM_001177625.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3954)
  AUTHORS   Khan,I.S., Molina,C., Ren,X., Auyeung,V.C., Cohen,M., Tsukui,T.,
            Atakilit,A. and Sheppard,D.
  TITLE     Impaired myofibroblast proliferation is a central feature of
            pathologic post-natal alveolar simplification
  JOURNAL   Elife 13, 94425 (2024)
   PUBMED   39660606
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3954)
  AUTHORS   Despin-Guitard,E., Rosa,V.S., Plunder,S., Mathiah,N., Van
            Schoor,K., Nehme,E., Merino-Aceituno,S., Egea,J., Shahbazi,M.N.,
            Theveneau,E. and Migeotte,I.
  TITLE     Non-apical mitoses contribute to cell delamination during mouse
            gastrulation
  JOURNAL   Nat Commun 15 (1), 7364 (2024)
   PUBMED   39198421
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3954)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3954)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3954)
  AUTHORS   Liberti,D.C., Kremp,M.M., Liberti,W.A. 3rd, Penkala,I.J., Li,S.,
            Zhou,S. and Morrisey,E.E.
  TITLE     Alveolar epithelial cell fate is maintained in a spatially
            restricted manner to promote lung regeneration after acute injury
  JOURNAL   Cell Rep 35 (6), 109092 (2021)
   PUBMED   33979629
REFERENCE   6  (bases 1 to 3954)
  AUTHORS   Saito,S., Liu,X.F., Kamijo,K., Raziuddin,R., Tatsumoto,T.,
            Okamoto,I., Chen,X., Lee,C.C., Lorenzi,M.V., Ohara,N. and Miki,T.
  TITLE     Deregulation and mislocalization of the cytokinesis regulator ECT2
            activate the Rho signaling pathways leading to malignant
            transformation
  JOURNAL   J Biol Chem 279 (8), 7169-7179 (2004)
   PUBMED   14645260
  REMARK    GeneRIF: ECT2 has a role in activating the Rho signaling pathways
            leading to malignant transformation
REFERENCE   7  (bases 1 to 3954)
  AUTHORS   Seibler,J., Zevnik,B., Kuter-Luks,B., Andreas,S., Kern,H.,
            Hennek,T., Rode,A., Heimann,C., Faust,N., Kauselmann,G., Schoor,M.,
            Jaenisch,R., Rajewsky,K., Kuhn,R. and Schwenk,F.
  TITLE     Rapid generation of inducible mouse mutants
  JOURNAL   Nucleic Acids Res 31 (4), e12 (2003)
   PUBMED   12582257
REFERENCE   8  (bases 1 to 3954)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3954)
  AUTHORS   Takai,S., Lorenzi,M.V., Long,J.E., Yamada,K. and Miki,T.
  TITLE     Assignment of the ect2 protooncogene to mouse chromosome band 3B by
            in situ hybridization
  JOURNAL   Cytogenet Cell Genet 81 (1), 83-84 (1998)
   PUBMED   9691182
REFERENCE   10 (bases 1 to 3954)
  AUTHORS   Miki,T., Smith,C.L., Long,J.E., Eva,A. and Fleming,T.P.
  TITLE     Oncogene ect2 is related to regulators of small GTP-binding
            proteins
  JOURNAL   Nature 362 (6419), 462-465 (1993)
   PUBMED   8464478
  REMARK    Erratum:[Nature 1993 Aug 19;364(6439):737]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121099.8 and AC165280.3.
            
            On Jul 21, 2022 this sequence version replaced NM_001177625.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.5132819.1,
                                           SRR17253011.5458876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC121099.8         62301-62406
            107-258             AC121099.8         65943-66094
            259-338             AC121099.8         67051-67130
            339-521             AC121099.8         69104-69286
            522-611             AC121099.8         70078-70167
            612-719             AC121099.8         71064-71171
            720-793             AC121099.8         74424-74497
            794-924             AC121099.8         76461-76591
            925-1040            AC121099.8         76994-77109
            1041-1103           AC121099.8         77213-77275
            1104-1326           AC121099.8         77399-77621
            1327-1463           AC121099.8         78962-79098
            1464-1583           AC121099.8         84219-84338
            1584-1652           AC121099.8         86001-86069
            1653-1763           AC165280.3         200466-200576       c
            1764-1860           AC165280.3         199611-199707       c
            1861-1942           AC165280.3         196635-196716       c
            1943-2021           AC165280.3         195129-195207       c
            2022-2141           AC165280.3         194693-194812       c
            2142-2280           AC165280.3         190510-190648       c
            2281-2435           AC165280.3         188128-188282       c
            2436-2543           AC165280.3         175127-175234       c
            2544-2687           AC165280.3         173560-173703       c
            2688-3954           AC165280.3         169954-171220       c
FEATURES             Location/Qualifiers
     source          1..3954
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 10.82 cM"
     gene            1..3954
                     /gene="Ect2"
                     /note="ect2 oncogene"
                     /db_xref="GeneID:13605"
                     /db_xref="MGI:MGI:95281"
     exon            1..106
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            107..258
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2777
                     /gene="Ect2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     epithelial cell-transforming sequence 2 oncogene"
                     /codon_start=1
                     /product="protein ECT2 isoform 2"
                     /protein_id="NP_001171096.1"
                     /db_xref="CCDS:CCDS50875.1"
                     /db_xref="GeneID:13605"
                     /db_xref="MGI:MGI:95281"
                     /translation="MADDSVLPSPSEITSLADSSVFDSKVAEMSKENLCLASTSNVDE
                     EMPQVEARVIMVQDAGKQEELLKALKEMKVPCVKMDSMEEFESLDSPEFENIFVVTDF
                     QNSVFNDLYKADCRIVGPPVILNCAQRGEPLPFSCRPLYCTSMLNLVLCFTGFRKKEE
                     LVKLVTLVHHMGGVIRKECNSKVTHLVANCTQGEKFRVAVSLGTPIMKPEWIYKAWER
                     RNEQCFCAAVDDFRNEFKVPPFQDCILSFLGFSDEEKHSMEEMTEMQGGSYLPVGDER
                     CTHLIVEENTVKDLPFEPSKKLFVVKQEWFWGSIQMDARAGETMYLYEKANTPELKKS
                     VSLLSLSTPNSNRKRRRLKETLAQLSRETDLSPFPPRKRPSAEHSLSIGSLLDISNTP
                     ESSIHYGETPKSCAKSSRSSTPVPPKQSARWQVAKELYQTESNYVNILATIIQLFQVP
                     LEEEGQRGGPILAPEEIKTIFGSIPDIFDVHMKIKDDLEDLIANWDESRSIGDIFLKY
                     AKDLVKTYPPFVNFFEMSKEMIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPV
                     QRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVV
                     YEVDGCPANLLSSHRSLVQRVETVSLGEHPCDRGEQVTLFLFNDCLEIARKRHKVIGT
                     FRSPHDRTRPPASLKHIHLMPLSQIKKVLDIRETEDCHNAFALLVRPPTEQANVLLSF
                     QMTSEELPKESWLKMLCRHVANTICKADAENLMYVADPESFEVNTKDMDSTLSRASRA
                     IKKTSKKVTRAFSFSKTPKRALRMALSSSHSSEGRSPPSSGKLAVSRLSSTSSLAGIP
                     SPSLVSLPSFFERRSHTLSRSTTHLI"
     exon            259..338
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            339..521
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..611
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..719
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..793
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            794..924
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1040
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1103
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1326
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1463
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1583
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1652
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1763
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1860
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1942
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2021
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2141
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2280
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2435
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2543
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2687
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..3954
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3930..3935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ect2"
                     /note="hexamer: AATAAA"
     polyA_site      3954
                     /gene="Ect2"
                     /note="major polyA site"
ORIGIN      
        1 agcctctctc gagccatggc ggcgcctgtg agggggagac ttagtgtttg agaaggataa
       61 gcgaggactg cgccgtcgtg gttccttttt aaaatctctg agcgtgcctt catcaagtag
      121 tgcaaacaat ggctgacgac agcgtgttac catctccttc tgagataact agcttggcag
      181 actcttcagt gtttgattct aaagttgctg aaatgtccaa ggaaaacttg tgcttggcgt
      241 ctacttcaaa tgttgatgaa gaaatgccgc aggttgaagc aagagtgata atggtccagg
      301 atgctgggaa acaagaagaa cttctaaagg ccttaaagga aatgaaagtg ccctgtgtaa
      361 agatggactc aatggaagaa tttgaaagtt tggattcccc agaatttgag aatatatttg
      421 tagttactga cttccagaat tctgtcttca atgacttata caaggctgat tgtaggattg
      481 ttgggccacc agttatactc aactgtgcac aaaggggaga gcccttgccg ttttcctgcc
      541 ggccgctgta ttgtacgagt atgctgaacc tggtgctctg cttcactgga ttcaggaaga
      601 aggaggagct tgtcaaattg gtgacgttgg ttcatcatat gggtggagtt attcgaaaag
      661 agtgtaattc caaagtaaca catctggtgg caaattgtac acaaggcgaa aaatttaggg
      721 ttgctgtgag cctgggcact ccaattatga agccagaatg gatttataaa gcgtgggaaa
      781 gacgcaatga acagtgtttc tgtgcagcag ttgatgactt tagaaatgaa tttaaagttc
      841 ctccattcca agattgcatt ttaagtttcc tgggattttc agatgaagag aaacatagta
      901 tggaagaaat gactgaaatg caaggaggta gctatttacc agttggggat gaaaggtgca
      961 ctcaccttat tgttgaagag aatacagtaa aggaccttcc attcgaacct tcaaagaaac
     1021 tttttgttgt caagcaagag tggttctggg gaagcattca gatggacgct cgtgcaggag
     1081 agactatgta tttgtatgaa aaggctaata ctcctgagct caagaaatcg gtgtctctgc
     1141 tttctctaag tactccaaac agcaaccgca agagacggag attgaaagag accctggctc
     1201 agctctccag ggagactgac ctctctcctt tccctccccg gaagcggccc tcagctgagc
     1261 actctctttc tattggctca ctcctggata tctccaacac acccgagtcc agcatccact
     1321 atggagaaac accgaagtcc tgtgctaagt cttctagaag ttctactcca gttcctccaa
     1381 agcagtcagc caggtggcag gtggcgaaag agctctacca gactgagagc aattatgtca
     1441 atatactggc cacaatcatt caattatttc aggtgccctt agaagaagaa ggacagcgtg
     1501 gtgggcctat tcttgcacct gaggagatca agactatttt tgggagcatc ccagatatct
     1561 ttgatgtgca tatgaagatc aaggatgatc ttgaagacct tattgctaac tgggatgaga
     1621 gcagaagtat tggtgacatc tttcttaaat atgcaaaaga tttggtaaaa acctaccctc
     1681 cgtttgtaaa cttctttgaa atgagcaagg aaatgatcat taaatgtgag aaacaaaagc
     1741 ccagatttca tgctttcctc aagataaatc aagctaaacc agaatgtgga cgacagagcc
     1801 ttgtggaact tctcatccgg ccagtgcaga ggctacccag tgtcgcttta cttttaaacg
     1861 atcttaaaaa gcatacagct gatgaaaatc cagacaaaag cactttagaa aaagctattg
     1921 gatcactaaa agaagtaatg acacatatca atgaggataa gagaaaaaca gaagcacaga
     1981 agcaaatttt tgatgttgtt tatgaagtag atggatgccc agctaatctc ttatcttctc
     2041 atcggagcct ggtgcaacga gtggaaacgg tttcccttgg tgagcaccct tgcgaccgag
     2101 gagaacaagt cactctcttc ctcttcaatg actgcctcga gatagcaaga aagcggcaca
     2161 aggttattgg cacttttaga agtcctcacg accgcacccg gccccccgct tctctgaagc
     2221 acattcatct catgcctctt tctcagatta agaaggtgct ggacatccga gagacagaag
     2281 attgtcacaa tgcctttgcc ttgcttgtaa ggccaccaac agaacaggcc aatgtactgc
     2341 tcagcttcca gatgacgtca gaggagcttc caaaggagag ctggctgaag atgctgtgcc
     2401 gacatgtagc caacaccatt tgtaaggcag atgctgagaa tcttatgtat gtggctgatc
     2461 cagaatcctt tgaagtaaat acaaaagata tggatagtac attgagtcga gcatctagag
     2521 caataaagaa gacttcaaaa aaggttacaa gggcattctc tttttccaaa actcccaaga
     2581 gagccctgcg gatggctctt tcatcatccc atagctcaga gggaaggagt cctccgagca
     2641 gtggcaagct tgctgtgagc cgtctgtcca gcacatcatc cttagcaggt attccatctc
     2701 cctcccttgt cagcctccct tctttctttg aacggagaag tcatacatta agtcgatcta
     2761 caactcactt gatatgaaac ttaagtcctg tgggacctat gcttcaacaa gacgctgact
     2821 taagtggtac tttgaattag cacttggtaa agttgtagag aagattagta acactaacca
     2881 acgccgtttt attttcttga aatacaattt tcaagatggt ctatgtaaaa aaaatatgga
     2941 ttttgatgta atttatcttt atttgaatct cacatctgaa gaccagtgac ttaagttatt
     3001 cctgataatc agtagctttg taaccctgat acagtaaaca gttggtgggt gcaaaatact
     3061 attgtgtatt tgtatagtat cttgaatttt tggaagtaca tatttgtgta tctcaatttg
     3121 tgcaaagact gaacagcaat gcaacacttg ctgaataaaa ccctctgatt aaattctaga
     3181 ggcttgttca gttcgattgt ttgatgtact taactgcgct tttgcagttt attttctttt
     3241 aaaataagag atctaacaca tgaattttaa aggatacacc attattaacc atacaattac
     3301 gatcgtttgg aattttcttt tgcaaattga gataagaaga gaaagattac aaaacattgt
     3361 atatgttgcg aagataagat attagtatgt actttataat tgtttcagag acttttattt
     3421 ttattttatt ttcttattct agacactagc aaatcttgat ttagttttga ctactgtatt
     3481 gaatttattt caaaggataa gaccacgtga aaactgtgtt aagaattgct tctgttcttt
     3541 gtacagttct gaagttgtct tcagttttgc taatcgcctg tgaaaagcat agatataatg
     3601 tgtggtgaac tttttattgt ggtcatatca ttaaaataag attggaaatt tattgtcaaa
     3661 aattttgtga atctgccatt atcttctact gcaatatttc ttttagtcag taatacagaa
     3721 tgactgggct actatggcca agaatatttt atttcttaca cgttcagagg agtgttacag
     3781 gtctccttgt tacataattt tcaataatct gctttaatag tttaactgac tggatttttt
     3841 tctataccat gtatgtacca attcacacgt tagtaaatga ccttgttttg ctatatttta
     3901 aaagcagtta tattagcaag aactttgtaa ataaatagct ttaaaataca agta
//
