LOCUS       NM_001368651            1072 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus endothelial cell surface expressed chemotaxis and
            apoptosis regulator (Ecscr), transcript variant 1, mRNA.
ACCESSION   NM_001368651
VERSION     NM_001368651.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1072)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 1072)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1072)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 1072)
  AUTHORS   Chen,X., Wang,L., Huang,R., Qiu,H., Wang,P., Wu,D., Zhu,Y.,
            Ming,J., Wang,Y., Wang,J. and Na,J.
  TITLE     Dgcr8 deletion in the primitive heart uncovered novel microRNA
            regulating the balance of cardiac-vascular gene program
  JOURNAL   Protein Cell 10 (5), 327-346 (2019)
   PUBMED   30128894
REFERENCE   5  (bases 1 to 1072)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1072)
  AUTHORS   Wu,W., Shi,C., Ma,F., Balducci,J., Huang,H., Ji,H.L., Chang,Y. and
            Huang,Y.
  TITLE     Structural and functional characterization of two alternative
            splicing variants of mouse Endothelial Cell-Specific Chemotaxis
            Regulator (ECSCR)
  JOURNAL   Int J Mol Sci 13 (4), 4920-4936 (2012)
   PUBMED   22606020
  REMARK    GeneRIF: two mouse ECSCR splicing variants/isoform precursors exist
            and are differentially expressed in a variety of tissue types and
            likely involved in modulation of vascular Endothelial cell
            migration.
REFERENCE   7  (bases 1 to 1072)
  AUTHORS   Koide,M., Ikeda,K., Akakabe,Y., Kitamura,Y., Ueyama,T., Matoba,S.,
            Yamada,H., Okigaki,M. and Matsubara,H.
  TITLE     Apoptosis regulator through modulating IAP expression (ARIA)
            controls the PI3K/Akt pathway in endothelial and endothelial
            progenitor cells
  JOURNAL   Proc Natl Acad Sci U S A 108 (23), 9472-9477 (2011)
   PUBMED   21593423
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2411. doi:
            10.1073/pnas.1506580112.. PMID: 25883266]
REFERENCE   8  (bases 1 to 1072)
  AUTHORS   Verissimo,A.R., Herbert,J.M., Heath,V.L., Legg,J.A., Sheldon,H.,
            Andre,M., Swain,R.K. and Bicknell,R.
  TITLE     Functionally defining the endothelial transcriptome, from Robo4 to
            ECSCR
  JOURNAL   Biochem Soc Trans 37 (Pt 6), 1214-1217 (2009)
   PUBMED   19909249
REFERENCE   9  (bases 1 to 1072)
  AUTHORS   Ikeda,K., Nakano,R., Uraoka,M., Nakagawa,Y., Koide,M., Katsume,A.,
            Minamino,K., Yamada,E., Yamada,H., Quertermous,T. and Matsubara,H.
  TITLE     Identification of ARIA regulating endothelial apoptosis and
            angiogenesis by modulating proteasomal degradation of cIAP-1 and
            cIAP-2
  JOURNAL   Proc Natl Acad Sci U S A 106 (20), 8227-8232 (2009)
   PUBMED   19416853
  REMARK    GeneRIF: ARIA was expressed in blood vessels during mouse
            embryogenesis, as well as in endothelial cells both in vitro and in
            vivo.
REFERENCE   10 (bases 1 to 1072)
  AUTHORS   Ma,F., Zhang,D., Yang,H., Sun,H., Wu,W., Gan,Y., Balducci,J.,
            Wei,Y.Q., Zhao,X. and Huang,Y.
  TITLE     Endothelial cell-specific molecule 2 (ECSM2) modulates actin
            remodeling and epidermal growth factor receptor signaling
  JOURNAL   Genes Cells 14 (3), 281-293 (2009)
   PUBMED   19267780
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132837.11 and CX567856.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX567856.1, CF586227.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC132837.11        53801-53877         c
            78-853              CX567856.1         45-820
            854-1072            AC132837.11        44590-44808         c
FEATURES             Location/Qualifiers
     source          1..1072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.22 cM"
     gene            1..1072
                     /gene="Ecscr"
                     /gene_synonym="1110006O17Rik; ARIA"
                     /note="endothelial cell surface expressed chemotaxis and
                     apoptosis regulator"
                     /db_xref="GeneID:68545"
                     /db_xref="MGI:MGI:1915795"
     exon            1..130
                     /gene="Ecscr"
                     /gene_synonym="1110006O17Rik; ARIA"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..732
                     /gene="Ecscr"
                     /gene_synonym="1110006O17Rik; ARIA"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; endothelial cell-specific molecule 2;
                     endothelial cell-specific chemotaxis regulator; apoptosis
                     regulator through modulating IAP expression"
                     /codon_start=1
                     /product="endothelial cell-specific chemotaxis regulator
                     isoform 1 precursor"
                     /protein_id="NP_001355580.1"
                     /db_xref="CCDS:CCDS89219.1"
                     /db_xref="GeneID:68545"
                     /db_xref="MGI:MGI:1915795"
                     /translation="MDREYTEEPATHPADLGTSGAMRLGSAILGLLLLQGYSSQPTTT
                     QTSQEILQKSSQVSLVSNQPVTPRSSTMDKQSLSLPDLMSFQPQKHTLGPGTGTPERS
                     SSSSSSSSSRRGEASLDATPSPETTSLQTKKMTILLTILPTPTSESVLTVAAFGVISF
                     IVILVVVVIILVSVVSLRFKCRKNKESEDPQKPGSSGLSESCSTANGEKDSITLISMR
                     NINVNNSKGSMSAEKIL"
     exon            131..169
                     /gene="Ecscr"
                     /gene_synonym="1110006O17Rik; ARIA"
                     /inference="alignment:Splign:2.1.0"
     exon            170..307
                     /gene="Ecscr"
                     /gene_synonym="1110006O17Rik; ARIA"
                     /inference="alignment:Splign:2.1.0"
     exon            308..367
                     /gene="Ecscr"
                     /gene_synonym="1110006O17Rik; ARIA"
                     /inference="alignment:Splign:2.1.0"
     exon            368..490
                     /gene="Ecscr"
                     /gene_synonym="1110006O17Rik; ARIA"
                     /inference="alignment:Splign:2.1.0"
     exon            491..589
                     /gene="Ecscr"
                     /gene_synonym="1110006O17Rik; ARIA"
                     /inference="alignment:Splign:2.1.0"
     exon            590..626
                     /gene="Ecscr"
                     /gene_synonym="1110006O17Rik; ARIA"
                     /inference="alignment:Splign:2.1.0"
     exon            627..723
                     /gene="Ecscr"
                     /gene_synonym="1110006O17Rik; ARIA"
                     /inference="alignment:Splign:2.1.0"
     exon            724..1072
                     /gene="Ecscr"
                     /gene_synonym="1110006O17Rik; ARIA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1048..1053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ecscr"
                     /gene_synonym="1110006O17Rik; ARIA"
                     /note="hexamer: ATTAAA"
     polyA_site      1072
                     /gene="Ecscr"
                     /gene_synonym="1110006O17Rik; ARIA"
                     /note="major polyA site"
ORIGIN      
        1 agtactccct ctctcttctc tactatggac agagaataca ctgaggagcc tgctacacac
       61 ccagctgatc tggggaccag cggagccatg aggctgggtt cagcaattct cggtttactc
      121 ctgctccaag gctacagctc tcaacctacg acaactcaga cctcgcagga aattctacag
      181 aagtcttctc aggtctcctt ggtatccaat cagcctgtga caccaaggtc aagcaccatg
      241 gataaacagt ccctttcctt gcctgacttg atgtccttcc agccacagaa gcacacactg
      301 ggacctggca caggaacccc agaaaggagc agcagcagca gcagcagcag cagcagcagg
      361 agaggagaag catctctgga tgctactccc agtccagaaa ccaccagcct tcagacaaaa
      421 aagatgacca tcctgctgac catcctgcct acccccacat cagagtcagt gctaactgtg
      481 gctgcctttg gtgtcatcag cttcattgtc atcctggtgg ttgtagtgat catcctggtc
      541 agtgtggtca gtctaagatt taagtgtcgg aagaacaagg agtctgaaga tccacagaaa
      601 ccagggagtt cagggctgtc tgaaagctgc tccacagcca atggagagaa agacagcatc
      661 acactcatct ccatgaggaa catcaacgtg aacaacagca aaggcagcat gtcagcagag
      721 aagattcttt aagagtgacc tggagtcgcc atgggtccac gtgtgatgcg gctgtcccct
      781 ggccatgagg aaggagagga gacgagattg ggggaggcag cggaccacac ataaattatt
      841 tgatgtcatg cctgctccca gttctaaagg acatgagatt cctctagatc cagaagaacc
      901 taccacacaa gagactcctt cccacttgga agccatgcta gacacttggc ctgctccccc
      961 tcctcctgct gctcagaaac tcaggaacga ggagtcaata gagcaagact taaggaaata
     1021 atgaggtaga ttgtccattc tactagaatt aaaattattt tctggcctgg aa
//
