LOCUS       NM_024283                888 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus ECRG4 augurin precursor (Ecrg4), mRNA.
ACCESSION   NM_024283
VERSION     NM_024283.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 888)
  AUTHORS   Pool,K.D., Hemmat,G.J. and Dorschner,R.A.
  TITLE     ECRG4 mediates host response to cutaneous infection by regulating
            neutrophil recruitment and adhesion receptor expression
  JOURNAL   PLoS One 19 (11), e0310810 (2024)
   PUBMED   39509414
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 888)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 888)
  AUTHORS   Cabuzu,D., Ramakrishnan,S.K., Moor,M.B., Harmacek,D., Auberson,M.,
            Durussel,F. and Bonny,O.
  TITLE     Loss of Ecrg4 improves calcium oxalate nephropathy
  JOURNAL   PLoS One 17 (10), e0275972 (2022)
   PUBMED   36227903
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 888)
  AUTHORS   Kurabi,A., Hur,D.G., Pak,K., Gibson,M., Webster,N.J.G., Baird,A.,
            Eliceiri,B.P. and Ryan,A.F.
  TITLE     The ECRG4 cleavage product augurin binds the endotoxin receptor and
            influences the innate immune response during otitis media
  JOURNAL   Front Genet 13, 932555 (2022)
   PUBMED   36092940
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 888)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 888)
  AUTHORS   Gonzalez,A.M., Podvin,S., Lin,S.Y., Miller,M.C., Botfield,H.,
            Leadbeater,W.E., Roberton,A., Dang,X., Knowling,S.E.,
            Cardenas-Galindo,E., Donahue,J.E., Stopa,E.G., Johanson,C.E.,
            Coimbra,R., Eliceiri,B.P. and Baird,A.
  TITLE     Ecrg4 expression and its product augurin in the choroid plexus:
            impact on fetal brain development, cerebrospinal fluid homeostasis
            and neuroprogenitor cell response to CNS injury
  JOURNAL   Fluids Barriers CNS 8 (1), 6 (2011)
   PUBMED   21349154
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 888)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 888)
  AUTHORS   Kujuro,Y., Suzuki,N. and Kondo,T.
  TITLE     Esophageal cancer-related gene 4 is a secreted inducer of cell
            senescence expressed by aged CNS precursor cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (18), 8259-8264 (2010)
   PUBMED   20404145
  REMARK    GeneRIF: identified esophageal cancer-related gene 4 (Ecrg4) as a
            senescence inducer with implications for the senescence-like state
            of postmitotic cells in the aging brain.
REFERENCE   9  (bases 1 to 888)
  AUTHORS   Huh,Y.H., Ryu,J.H., Shin,S., Lee,D.U., Yang,S., Oh,K.S., Chun,C.H.,
            Choi,J.K., Song,W.K. and Chun,J.S.
  TITLE     Esophageal cancer related gene 4 (ECRG4) is a marker of articular
            chondrocyte differentiation and cartilage destruction
  JOURNAL   Gene 448 (1), 7-15 (2009)
   PUBMED   19735703
  REMARK    GeneRIF: ECRG4 level in differentiated chondrocytes is decreased
            during hypertrophic maturation
REFERENCE   10 (bases 1 to 888)
  AUTHORS   Mirabeau,O., Perlas,E., Severini,C., Audero,E., Gascuel,O.,
            Possenti,R., Birney,E., Rosenthal,N. and Gross,C.
  TITLE     Identification of novel peptide hormones in the human proteome by
            hidden Markov model screening
  JOURNAL   Genome Res 17 (3), 320-327 (2007)
   PUBMED   17284679
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK049805.1.
            
            On Apr 29, 2009 this sequence version replaced NM_024283.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049805.1, BE306202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-888               AK049805.1         2-889
FEATURES             Location/Qualifiers
     source          1..888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 23.44 cM"
     gene            1..888
                     /gene="Ecrg4"
                     /gene_synonym="1500015O10Rik"
                     /note="ECRG4 augurin precursor"
                     /db_xref="GeneID:78896"
                     /db_xref="MGI:MGI:1926146"
     exon            1..362
                     /gene="Ecrg4"
                     /gene_synonym="1500015O10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..730
                     /gene="Ecrg4"
                     /gene_synonym="1500015O10Rik"
                     /note="esophageal cancer related gene 4 protein; augurin;
                     esophageal cancer-related gene 4 protein homolog"
                     /codon_start=1
                     /product="augurin precursor"
                     /protein_id="NP_077245.2"
                     /db_xref="CCDS:CCDS14925.1"
                     /db_xref="GeneID:78896"
                     /db_xref="MGI:MGI:1926146"
                     /translation="MSTSSARPAVLALAGLALLLLLCLGPDGISGNKLKKMLQKREGP
                     VPSKTNVAVAENTAKEFLGGLKRAKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDVN
                     YWLNRNRNGHDYYGDYYQRHYDEDAAIGPHSRESFRHGASVNYNDY"
     exon            363..410
                     /gene="Ecrg4"
                     /gene_synonym="1500015O10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            411..568
                     /gene="Ecrg4"
                     /gene_synonym="1500015O10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            569..888
                     /gene="Ecrg4"
                     /gene_synonym="1500015O10Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagccaac attctctgtc caggctggtt gggctgtgcc tggcatcagt cttgccctct
       61 cccctttggc cacgcggccc ttctcagcga tttgcagcag acccgcaggg cagtgtgcct
      121 cggtggcatt gaactgaagc ttggctctcg gcctggcctg ctggctagtt gcccaccctg
      181 tgggtcccgc ccagagcaag gatactggag ctttcgcctg cctcactgag cctgggtctc
      241 cactccagtc atccctccag ctactttgca gcactctgtc gccatgagca cctcgtctgc
      301 gcggcctgca gtcctggccc ttgccgggct ggctctgctc cttctgctgt gcctgggtcc
      361 agatggcata agtggaaaca aactcaagaa gatgctccag aaacgagaag gacctgtccc
      421 gtcaaagact aatgtagctg tagccgagaa cacagcaaag gaattcctag gtggcctgaa
      481 gcgtgccaaa cgacagctgt gggaccgtac gcggcctgag gtacagcagt ggtaccagca
      541 gttcctctac atgggctttg atgaggctaa atttgaagat gatgtcaact attggctaaa
      601 cagaaatcga aacggccatg actactatgg tgactactac cagcgtcatt atgatgaaga
      661 tgcggccatt ggtccccaca gccgggaaag cttcaggcat ggagccagtg tcaactataa
      721 tgactattaa gcttcctgag gtgcccacag agcttgtgcc tgcttcagta ggccttctct
      781 acctatacca cgtgaccatc aggctaaagg aaagaatata agtgcttttt gcatttcatg
      841 catgtgctta acgatatgtc tcacttaaaa atagaaataa aagcattt
//
